Research Topics
Species | Pierre J MagistrettiSummaryAffiliation: University of Lausanne Country: Switzerland Publications
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Detail Information
Publications
Neuron-glia metabolic coupling and plasticityPierre J Magistretti
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland and Centre de Neurosciences Psychiatriques, CHUV, Departement de Psychiatrie, Site de Cery, CH1008 Prilly Lausanne, Switzerland
J Exp Biol 209:2304-11. 2006..These data suggest that glial metabolic plasticity is likely to be concomitant with synaptic plasticity...
Brain energy metabolism: focus on astrocyte-neuron metabolic cooperationMireille Belanger
Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne CH 1015, Switzerland
Cell Metab 14:724-38. 2011..This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes...- Cell morphology and intracellular ionic homeostasis explored with a multimodal approach combining epifluorescence and digital holographic microscopyNicolas Pavillon
Advanced Photonics Laboratory MVD, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
J Biophotonics 3:432-6. 2010..This is demonstrated by the study of intracellular calcium homeostasis associated with the change in cell volume, which play a critical role in the excitotoxicity-induced neuronal death... - Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion mediumBenjamin Rappaz
Ecole Polytechnique Federale de Lausanne, Brain Mind Institute, Lausanne, Switzerland
Opt Lett 33:744-6. 2008..The two wavelengths are chosen in the vicinity of the absorption peak of the dye, where the absorption is accompanied by a significant variation of the RI as a function of the wavelength... - Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulatorsLuc Pellerin
Department of Physiology, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
J Neurochem 92:668-77. 2005..Our data suggest that astrocyte energetics represents a novel target for cognitive-enhancing drugs acting as AMPA receptor modulators... 
GABA uptake into astrocytes is not associated with significant metabolic cost: implications for brain imaging of inhibitory transmissionJean Yves Chatton
Institute of Physiology, Centre Hospitalier Universitaire Vaudois, University of Lausanne Medical School, 1005 Lausanne, Switzerland
Proc Natl Acad Sci U S A 100:12456-61. 2003....- Food for thought: challenging the dogmasLuc Pellerin
Institut de Physiologie, , Switzerland
J Cereb Blood Flow Metab 23:1282-6. 2003 - Neuroscience. Let there be (NADH) lightLuc Pellerin
Institut de Physiologie, 1005 Lausanne, Switzerland
Science 305:50-2. 2004 - Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytesIgor Allaman
Institut de Physiologie, Faculte de Medecine, Universite de Lausanne, 1005 Lausanne, Switzerland
J Neurochem 88:900-8. 2004..These results suggest that GC could have a significant influence on neuroenergetics as they could modulate activity-related changes in brain glycogen metabolism... - Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracyPierre Marquet
Department of Physiology, University of Lausanne, CH 1005 Lausanne, Switzerland
Opt Lett 30:468-70. 2005..These DHM images are compared with those obtained by use of the widely used phase contrast and Nomarski differential interference contrast techniques... - Aquaporins in brain: distribution, physiology, and pathophysiologyJerome Badaut
Departement de Neurochirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
J Cereb Blood Flow Metab 22:367-78. 2002..Facilitation of these movements may contribute to the development of edema formation after acute cerebral insults such as ischemia or traumatic injury... - Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenaseJocelyn D Laughton
Department of Psychiatry, Service of Neuropsychiatry, University Hospitals of Geneva, Belle Idee, Switzerland
BMC Neurosci 8:35. 2007..1.1.27) that catalyses the interconversion of lactate and pyruvate and the pyruvate dehydrogenase complex that irreversibly funnels pyruvate towards the mitochondrial TCA and oxydative phosphorylation... - How to balance the brain energy budget while spending glucose differentlyLuc Pellerin
Institut de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
J Physiol 546:325. 2003 - Activity-dependent regulation of energy metabolism by astrocytes: an updateLuc Pellerin
Departement de Physiologie, Universite de Lausanne, Switzerland
Glia 55:1251-62. 2007.... - Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viabilityIgor Allaman
Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
J Neurosci 30:3326-38. 2010..This set of observations indicates that Abeta aggregation and internalization into astrocytes profoundly alter their metabolic phenotype with deleterious consequences for neuronal viability... - Neuroenergetics: calling upon astrocytes to satisfy hungry neuronsLuc Pellerin
Institut de Physiologie, Universite de Lausanne, Switzerland
Neuroscientist 10:53-62. 2004..Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity... - Role of the glyoxalase system in astrocyte-mediated neuroprotectionMireille Belanger
Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
J Neurosci 31:18338-52. 2011..Accordingly, the neuroenergetic specialization taking place between these two cell types may serve as a protective mechanism against MG-induced neurotoxicity... - Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administrationJean Marie Petit
Laboratory of Neuroenergetic and Cellular Dynamics, Brain Mind Institute, Life Science Faculty, EPFL, Lausanne, Switzerland
Sleep 33:901-8. 2010..We also compared the effect of instrumentally and pharmacologically induced prolonged wakefulness, followed (or not) by 3 hours of sleep recovery, on the expression of genes related to brain energy metabolism... - Neuron-glia metabolic coupling and plasticityPierre J Magistretti
Brain Mind Institute, EPFL SV 2511, Station 19, CH 1015 Lausanne, Switzerland
Exp Physiol 96:407-10. 2011..Regarding metabolic plasticity during the sleep-wake cycle, we have observed that the level of expression of a panel of selected genes, which we know are key for neuron-glia metabolic coupling, is modulated by sleep deprivation... - Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzerBenjamin Rappaz
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Cytometry A 73:895-903. 2008..In conclusion, DHM in combination with a decoupling procedure allows measuring noninvasively volume, refractive index, and hemoglobin content of single-living RBCs with a high accuracy... - The role of astroglia in neuroprotectionMireille Belanger
Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Dialogues Clin Neurosci 11:281-95. 2009..Using neuroinflammation, Alzheimer's disease, and hepatic encephalopathy as examples, we discuss how astrocytic defense mechanisms may be overwhelmed in pathological conditions, contributing to disease progression... - Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytesIgor Allaman
Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, CH 1015, Switzerland
Psychopharmacology (Berl) 216:75-84. 2011..In this context, there is increasing evidence that astrocytes are involved in the pathophysiology of major depression... - Spatial analysis of erythrocyte membrane fluctuations by digital holographic microscopyBenjamin Rappaz
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Blood Cells Mol Dis 42:228-32. 2009..CMF amplitudes of 35.9+/-8.9 nm and 4.7+/-0.5 nm (averaged over the cell surface) were determined for normal and ethanol-fixed RBCs, respectively... - Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinaseCristina Granziera
Service de Neurologie, CHUV, Lausanne, Switzerland
Brain Res 1148:217-25. 2007..These results, from two different TPC models and with two distinct JNK inhibitors, show that JNK is likely to be involved in TPC... - Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdalaIgor Allaman
Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, CH 1015, Switzerland
Pharmacol Rep 60:1001-7. 2008..In addition, chronic administration of imipramine, which reversed CMS-induced anhedonia, did not alter BDNF mRNA expression in these limbic structures... - Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopyBenjamin Rappaz
Ecole Polytechnique Federale de Lausanne, Brain Mind Institute, CH 1015 Lausanne, Switzerland
J Biomed Opt 14:034049. 2009..Our study demonstrates the applicability of DHM as a tool for label-free quantitative analysis of the cell cycle and opens the possibility for its use in high-throughput screening... - Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrievalJacqueline Ros
Department of Physiology, University of Lausanne, Lausanne, Switzerland
J Cereb Blood Flow Metab 26:468-77. 2006.... - Long-term modulation of glucose utilization by IL-1 alpha and TNF-alpha in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanismsCéline Véga
Institut de Physiologie, Lausanne, Switzerland
Glia 39:10-8. 2002..These data suggest that Na(+) pump activity is a common target for both the long-term metabolic action of cytokines promoted by the activation of distinct signaling pathways and the enhanced metabolic response to glutamate... - MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brainKarin Pierre
Institut de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
J Cereb Blood Flow Metab 22:586-95. 2002.... - A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expressionIgor Allaman
Institut de Physiologie, , , Switzerland
Am J Physiol Cell Physiol 284:C696-704. 2003.... - Feeding active neurons: (re)emergence of a nursing role for astrocytesAnne Karine Bouzier-Sore
Institut de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
J Physiol Paris 96:273-82. 2002..The importance of this metabolic cooperation within the central nervous system, although not unique if compared to other organs, still remains to be explored... - Modulation of astrocytic metabolic phenotype by proinflammatory cytokinesMathilde Gavillet
Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, CH 1015 Switzerland
Glia 56:975-89. 2008..Taken together these results establish that a proinflammatory environment such as observed in several neuropathological conditions including Alzheimer's disease, markedly modifies the metabolic phenotype of astrocytes... - Lactate is a preferential oxidative energy substrate over glucose for neurons in cultureAnne Karine Bouzier-Sore
Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536 CNRS Université, Bordeaux, France
J Cereb Blood Flow Metab 23:1298-306. 2003..Results clearly indicate that when neurons are in the presence of both glucose and lactate, they preferentially use lactate as their main oxidative substrate... - TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticityKrisztián A Kovács
Center for Psychiatric Neuroscience and Service of Child and Adolescent Psychiatry, Department of Psychiatry, University Medical Center, University of Lausanne, CH 1008 Prilly Lausanne, Switzerland
Proc Natl Acad Sci U S A 104:4700-5. 2007..We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus... - Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor traffickingLinda Hildegard Bergersen
Anatomical Institute, Centre for Molecular Biology and Neuroscience, University of Oslo, Blindern, Oslo, Norway
Cereb Cortex 15:361-70. 2005..Altogether, the data presented provide evidence for MCT2 expression in the postsynaptic density area at specific subsets of glutamatergic synapses, and also suggest that MCT2, like AMPA receptors, could undergo membrane trafficking... - Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell culturesRuth Debernardi
Institut de Physiologie, Lausanne, Switzerland
J Neurosci Res 73:141-55. 2003..In addition to providing an extensive description of MCT distribution in cultured cells, our data underscore the potential of such preparations for future studies on the regulation of MCT expression... - Hypoxia/hypoglycemia preconditioning prevents the loss of functional electrical activity in organotypic slice culturesJerome Badaut
Neurosurgery Research Group, Centre Hospitalier Universitaire Vaudois CHUV, Pavillon 3 Beaumont, 1011 Lausanne, Switzerland
Brain Res 1051:117-22. 2005..The major interest and advantage of this system over both the acute slice preparation and primary cell cultures is the ability to simultaneously measure the delayed neuronal damage and neuronal function... - Astrocytes generate Na+-mediated metabolic wavesYann Bernardinelli
Department of Physiology, University of Lausanne, CH-1005 Lausanne, Switzerland
Proc Natl Acad Sci U S A 101:14937-42. 2004..Therefore, astrocytes appear to function as a network for concerted neurometabolic coupling through the generation of intercellular Na+ and metabolic waves... - Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activationAgnès Aubert
Departement de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
Proc Natl Acad Sci U S A 102:16448-53. 2005.... - Expression of the monocarboxylate transporter MCT1 in the adult human brain cortexOriana Chiry
Departement de Physiologie, Universite de Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland
Brain Res 1070:65-70. 2006..Moreover, the distinct laminar pattern of MCT1 expression between primary and non-primary cortical areas may reflect different types of neuronal activity requiring adequate supply of specific energy substrates... - [Is lactate a major energy substrate for neurons?]Robert Costalat
Med Sci (Paris) 22:356-7. 2006 - In vivo measurement of glucose utilization in rats using a beta-microprobe: direct comparison with autoradiographyPhilippe Millet
Unité de Neuroimagerie, Service de Neuropsychiatrie, Hopitaux Universitaires de Geneve, Chene Bourg, Switzerland
J Cereb Blood Flow Metab 24:1015-24. 2004..In addition, the betaP-derived input function was similar to that obtained by manual sampling. Our findings show that reliable rCMRglc values can be obtained using betaP... - Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortexBrigitte Voutsinos-Porche
CNRS FRE 2363, Paris, France
Neuron 37:275-86. 2003..These data suggest that a metabolic crosstalk takes place between neurons and astrocytes in the developing cortex, which would be regulated by synaptic activity and mediated by glial glutamate transporters... - Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscleSylvain Lengacher
Institut de Physiologie, , Switzerland
J Cereb Blood Flow Metab 24:780-8. 2004..These data provide a first quantitative assessment of UCP mRNA expression in mouse brain, showing the presence of all five isoforms with distinct proportions, thus suggesting specific roles in the central nervous system... - C/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neuronesKrisztián A Kovács
Center for Psychiatric Neuroscience, University Medical Center, University of Lausanne, Prilly, Switzerland
J Neurochem 98:1390-9. 2006.... - A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolismAgnès Aubert
Departement de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
Proc Natl Acad Sci U S A 104:4188-93. 2007..In summary, our results, obtained with such a modeling approach, support the concept that both neuronal and glial metabolic responses form essential components of neuroimaging signals... - Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulationKarin Pierre
Institut de Physiologie, Lausanne, Switzerland
J Neurochem 86:1468-76. 2003..These results suggest that regulation of MCT2 expression in neurons by NA occurs at the translational level despite the requirement for an as yet unknown transcriptional step... - Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cellsFayçal Boussouar
Institut National pour la Santé et la Recherche Médicale INSERM U 407, Faculté de médecine Lyon Sud, Oullins Cedex, France
Biol Reprod 69:1069-78. 2003.... - Sleep deprivation modulates brain mRNAs encoding genes of glycogen metabolismJean Marie Petit
Institute of Physiology and Department of Neurology, UNIL and CHUV, Rue du Bugnon 7, 1005 Lausanne CH, Switzerland
Eur J Neurosci 16:1163-7. 2002.... - Glycogen: a Trojan horse for neuronsPierre J Magistretti
Nat Neurosci 10:1341-2. 2007 - Patterns of calcium-binding proteins support parallel and hierarchical organization of human auditory areasOriana Chiry
Institut de Physiologie, Universite de Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland
Eur J Neurosci 17:397-410. 2003..In analogy to non-human primates, our results suggest differences in intrinsic organization between auditory areas that are compatible with parallel and hierarchical processing of auditory information...