Pierre J Magistretti

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. ncbi request reprint Neuron-glia metabolic coupling and plasticity
    Pierre J Magistretti
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland and Centre de Neurosciences Psychiatriques, CHUV, Departement de Psychiatrie, Site de Cery, CH1008 Prilly Lausanne, Switzerland
    J Exp Biol 209:2304-11. 2006
  2. doi request reprint Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation
    Mireille Belanger
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne CH 1015, Switzerland
    Cell Metab 14:724-38. 2011
  3. ncbi request reprint Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium
    Benjamin Rappaz
    Ecole Polytechnique Federale de Lausanne, Brain Mind Institute, Lausanne, Switzerland
    Opt Lett 33:744-6. 2008
  4. doi request reprint Cell morphology and intracellular ionic homeostasis explored with a multimodal approach combining epifluorescence and digital holographic microscopy
    Nicolas Pavillon
    Advanced Photonics Laboratory MVD, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    J Biophotonics 3:432-6. 2010
  5. ncbi request reprint Aquaporins in brain: distribution, physiology, and pathophysiology
    Jerome Badaut
    Departement de Neurochirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Cereb Blood Flow Metab 22:367-78. 2002
  6. ncbi request reprint Food for thought: challenging the dogmas
    Luc Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    J Cereb Blood Flow Metab 23:1282-6. 2003
  7. ncbi request reprint Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes
    Igor Allaman
    Institut de Physiologie, Faculte de Medecine, Universite de Lausanne, 1005 Lausanne, Switzerland
    J Neurochem 88:900-8. 2004
  8. ncbi request reprint Neuroenergetics: calling upon astrocytes to satisfy hungry neurons
    Luc Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Neuroscientist 10:53-62. 2004
  9. ncbi request reprint Neuroscience. Let there be (NADH) light
    Luc Pellerin
    Institut de Physiologie, 1005 Lausanne, Switzerland
    Science 305:50-2. 2004
  10. ncbi request reprint Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy
    Pierre Marquet
    Department of Physiology, University of Lausanne, CH 1005 Lausanne, Switzerland
    Opt Lett 30:468-70. 2005

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Neuron-glia metabolic coupling and plasticity
    Pierre J Magistretti
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland and Centre de Neurosciences Psychiatriques, CHUV, Departement de Psychiatrie, Site de Cery, CH1008 Prilly Lausanne, Switzerland
    J Exp Biol 209:2304-11. 2006
    ..These data suggest that glial metabolic plasticity is likely to be concomitant with synaptic plasticity...
  2. doi request reprint Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation
    Mireille Belanger
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne CH 1015, Switzerland
    Cell Metab 14:724-38. 2011
    ..This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes...
  3. ncbi request reprint Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium
    Benjamin Rappaz
    Ecole Polytechnique Federale de Lausanne, Brain Mind Institute, Lausanne, Switzerland
    Opt Lett 33:744-6. 2008
    ..The two wavelengths are chosen in the vicinity of the absorption peak of the dye, where the absorption is accompanied by a significant variation of the RI as a function of the wavelength...
  4. doi request reprint Cell morphology and intracellular ionic homeostasis explored with a multimodal approach combining epifluorescence and digital holographic microscopy
    Nicolas Pavillon
    Advanced Photonics Laboratory MVD, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    J Biophotonics 3:432-6. 2010
    ..This is demonstrated by the study of intracellular calcium homeostasis associated with the change in cell volume, which play a critical role in the excitotoxicity-induced neuronal death...
  5. ncbi request reprint Aquaporins in brain: distribution, physiology, and pathophysiology
    Jerome Badaut
    Departement de Neurochirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Cereb Blood Flow Metab 22:367-78. 2002
    ..Facilitation of these movements may contribute to the development of edema formation after acute cerebral insults such as ischemia or traumatic injury...
  6. ncbi request reprint Food for thought: challenging the dogmas
    Luc Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    J Cereb Blood Flow Metab 23:1282-6. 2003
  7. ncbi request reprint Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes
    Igor Allaman
    Institut de Physiologie, Faculte de Medecine, Universite de Lausanne, 1005 Lausanne, Switzerland
    J Neurochem 88:900-8. 2004
    ..These results suggest that GC could have a significant influence on neuroenergetics as they could modulate activity-related changes in brain glycogen metabolism...
  8. ncbi request reprint Neuroenergetics: calling upon astrocytes to satisfy hungry neurons
    Luc Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Neuroscientist 10:53-62. 2004
    ..Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity...
  9. ncbi request reprint Neuroscience. Let there be (NADH) light
    Luc Pellerin
    Institut de Physiologie, 1005 Lausanne, Switzerland
    Science 305:50-2. 2004
  10. ncbi request reprint Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy
    Pierre Marquet
    Department of Physiology, University of Lausanne, CH 1005 Lausanne, Switzerland
    Opt Lett 30:468-70. 2005
    ..These DHM images are compared with those obtained by use of the widely used phase contrast and Nomarski differential interference contrast techniques...
  11. pmc GABA uptake into astrocytes is not associated with significant metabolic cost: implications for brain imaging of inhibitory transmission
    Jean Yves Chatton
    Institute of Physiology, Centre Hospitalier Universitaire Vaudois, University of Lausanne Medical School, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 100:12456-61. 2003
    ....
  12. pmc Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase
    Jocelyn D Laughton
    Department of Psychiatry, Service of Neuropsychiatry, University Hospitals of Geneva, Belle Idee, Switzerland
    BMC Neurosci 8:35. 2007
    ..1.1.27) that catalyses the interconversion of lactate and pyruvate and the pyruvate dehydrogenase complex that irreversibly funnels pyruvate towards the mitochondrial TCA and oxydative phosphorylation...
  13. ncbi request reprint Activity-dependent regulation of energy metabolism by astrocytes: an update
    Luc Pellerin
    Departement de Physiologie, Universite de Lausanne, Switzerland
    Glia 55:1251-62. 2007
    ....
  14. pmc How to balance the brain energy budget while spending glucose differently
    Luc Pellerin
    Institut de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
    J Physiol 546:325. 2003
  15. doi request reprint Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability
    Igor Allaman
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Neurosci 30:3326-38. 2010
    ..This set of observations indicates that Abeta aggregation and internalization into astrocytes profoundly alter their metabolic phenotype with deleterious consequences for neuronal viability...
  16. ncbi request reprint Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators
    Luc Pellerin
    Department of Physiology, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    J Neurochem 92:668-77. 2005
    ..Our data suggest that astrocyte energetics represents a novel target for cognitive-enhancing drugs acting as AMPA receptor modulators...
  17. doi request reprint Role of the glyoxalase system in astrocyte-mediated neuroprotection
    Mireille Belanger
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Neurosci 31:18338-52. 2011
    ..Accordingly, the neuroenergetic specialization taking place between these two cell types may serve as a protective mechanism against MG-induced neurotoxicity...
  18. pmc Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration
    Jean Marie Petit
    Laboratory of Neuroenergetic and Cellular Dynamics, Brain Mind Institute, Life Science Faculty, EPFL, Lausanne, Switzerland
    Sleep 33:901-8. 2010
    ..We also compared the effect of instrumentally and pharmacologically induced prolonged wakefulness, followed (or not) by 3 hours of sleep recovery, on the expression of genes related to brain energy metabolism...
  19. doi request reprint Neuron-glia metabolic coupling and plasticity
    Pierre J Magistretti
    Brain Mind Institute, EPFL SV 2511, Station 19, CH 1015 Lausanne, Switzerland
    Exp Physiol 96:407-10. 2011
    ..Regarding metabolic plasticity during the sleep-wake cycle, we have observed that the level of expression of a panel of selected genes, which we know are key for neuron-glia metabolic coupling, is modulated by sleep deprivation...
  20. pmc The role of astroglia in neuroprotection
    Mireille Belanger
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Dialogues Clin Neurosci 11:281-95. 2009
    ..Using neuroinflammation, Alzheimer's disease, and hepatic encephalopathy as examples, we discuss how astrocytic defense mechanisms may be overwhelmed in pathological conditions, contributing to disease progression...
  21. doi request reprint Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer
    Benjamin Rappaz
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Cytometry A 73:895-903. 2008
    ..In conclusion, DHM in combination with a decoupling procedure allows measuring noninvasively volume, refractive index, and hemoglobin content of single-living RBCs with a high accuracy...
  22. doi request reprint Sustained sleep fragmentation affects brain temperature, food intake and glucose tolerance in mice
    Maxime O Baud
    LNDC, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    J Sleep Res 22:3-12. 2013
    ..Altogether, these results strongly suggest that sleep fragmentation is an aggravating factor for the development of metabolic dysfunctions that may be relevant for sleep disorders such as obstructive sleep apnea...
  23. doi request reprint Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes
    Igor Allaman
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, CH 1015, Switzerland
    Psychopharmacology (Berl) 216:75-84. 2011
    ..In this context, there is increasing evidence that astrocytes are involved in the pathophysiology of major depression...
  24. doi request reprint Spatial analysis of erythrocyte membrane fluctuations by digital holographic microscopy
    Benjamin Rappaz
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Blood Cells Mol Dis 42:228-32. 2009
    ..CMF amplitudes of 35.9+/-8.9 nm and 4.7+/-0.5 nm (averaged over the cell surface) were determined for normal and ethanol-fixed RBCs, respectively...
  25. ncbi request reprint Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase
    Cristina Granziera
    Service de Neurologie, CHUV, Lausanne, Switzerland
    Brain Res 1148:217-25. 2007
    ..These results, from two different TPC models and with two distinct JNK inhibitors, show that JNK is likely to be involved in TPC...
  26. ncbi request reprint Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala
    Igor Allaman
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, CH 1015, Switzerland
    Pharmacol Rep 60:1001-7. 2008
    ..In addition, chronic administration of imipramine, which reversed CMS-induced anhedonia, did not alter BDNF mRNA expression in these limbic structures...
  27. doi request reprint Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy
    Benjamin Rappaz
    Ecole Polytechnique Federale de Lausanne, Brain Mind Institute, CH 1015 Lausanne, Switzerland
    J Biomed Opt 14:034049. 2009
    ..Our study demonstrates the applicability of DHM as a tool for label-free quantitative analysis of the cell cycle and opens the possibility for its use in high-throughput screening...
  28. ncbi request reprint Feeding active neurons: (re)emergence of a nursing role for astrocytes
    Anne Karine Bouzier-Sore
    Institut de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    J Physiol Paris 96:273-82. 2002
    ..The importance of this metabolic cooperation within the central nervous system, although not unique if compared to other organs, still remains to be explored...
  29. pmc Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation
    Agnès Aubert
    Departement de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 102:16448-53. 2005
    ....
  30. ncbi request reprint A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression
    Igor Allaman
    Institut de Physiologie, Faculte de Medecine, Universite de Lausanne, Switzerland
    Am J Physiol Cell Physiol 284:C696-704. 2003
    ....
  31. ncbi request reprint Long-term modulation of glucose utilization by IL-1 alpha and TNF-alpha in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanisms
    Céline Véga
    Institut de Physiologie, Lausanne, Switzerland
    Glia 39:10-8. 2002
    ..These data suggest that Na(+) pump activity is a common target for both the long-term metabolic action of cytokines promoted by the activation of distinct signaling pathways and the enhanced metabolic response to glutamate...
  32. ncbi request reprint Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex
    Brigitte Voutsinos-Porche
    CNRS FRE 2363, Paris, France
    Neuron 37:275-86. 2003
    ..These data suggest that a metabolic crosstalk takes place between neurons and astrocytes in the developing cortex, which would be regulated by synaptic activity and mediated by glial glutamate transporters...
  33. doi request reprint Modulation of astrocytic metabolic phenotype by proinflammatory cytokines
    Mathilde Gavillet
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, CH 1015 Switzerland
    Glia 56:975-89. 2008
    ..Taken together these results establish that a proinflammatory environment such as observed in several neuropathological conditions including Alzheimer's disease, markedly modifies the metabolic phenotype of astrocytes...
  34. ncbi request reprint MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain
    Karin Pierre
    Institut de Physiologie, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    J Cereb Blood Flow Metab 22:586-95. 2002
    ....
  35. pmc Astrocytes generate Na+-mediated metabolic waves
    Yann Bernardinelli
    Department of Physiology, University of Lausanne, CH 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 101:14937-42. 2004
    ..Therefore, astrocytes appear to function as a network for concerted neurometabolic coupling through the generation of intercellular Na+ and metabolic waves...
  36. ncbi request reprint Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures
    Ruth Debernardi
    Institut de Physiologie, Lausanne, Switzerland
    J Neurosci Res 73:141-55. 2003
    ..In addition to providing an extensive description of MCT distribution in cultured cells, our data underscore the potential of such preparations for future studies on the regulation of MCT expression...
  37. ncbi request reprint Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation
    Karin Pierre
    Institut de Physiologie, Lausanne, Switzerland
    J Neurochem 86:1468-76. 2003
    ..These results suggest that regulation of MCT2 expression in neurons by NA occurs at the translational level despite the requirement for an as yet unknown transcriptional step...
  38. ncbi request reprint Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking
    Linda Hildegard Bergersen
    Anatomical Institute, Centre for Molecular Biology and Neuroscience, University of Oslo, Blindern, Oslo, Norway
    Cereb Cortex 15:361-70. 2005
    ..Altogether, the data presented provide evidence for MCT2 expression in the postsynaptic density area at specific subsets of glutamatergic synapses, and also suggest that MCT2, like AMPA receptors, could undergo membrane trafficking...
  39. ncbi request reprint In vivo measurement of glucose utilization in rats using a beta-microprobe: direct comparison with autoradiography
    Philippe Millet
    Unité de Neuroimagerie, Service de Neuropsychiatrie, Hopitaux Universitaires de Geneve, Chene Bourg, Switzerland
    J Cereb Blood Flow Metab 24:1015-24. 2004
    ..In addition, the betaP-derived input function was similar to that obtained by manual sampling. Our findings show that reliable rCMRglc values can be obtained using betaP...
  40. ncbi request reprint Hypoxia/hypoglycemia preconditioning prevents the loss of functional electrical activity in organotypic slice cultures
    Jerome Badaut
    Neurosurgery Research Group, Centre Hospitalier Universitaire Vaudois CHUV, Pavillon 3 Beaumont, 1011 Lausanne, Switzerland
    Brain Res 1051:117-22. 2005
    ..The major interest and advantage of this system over both the acute slice preparation and primary cell cultures is the ability to simultaneously measure the delayed neuronal damage and neuronal function...
  41. ncbi request reprint Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval
    Jacqueline Ros
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 26:468-77. 2006
    ....
  42. ncbi request reprint Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle
    Sylvain Lengacher
    Institut de Physiologie, Universite de Lausanne, Switzerland
    J Cereb Blood Flow Metab 24:780-8. 2004
    ..These data provide a first quantitative assessment of UCP mRNA expression in mouse brain, showing the presence of all five isoforms with distinct proportions, thus suggesting specific roles in the central nervous system...
  43. ncbi request reprint Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex
    Oriana Chiry
    Departement de Physiologie, Universite de Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland
    Brain Res 1070:65-70. 2006
    ..Moreover, the distinct laminar pattern of MCT1 expression between primary and non-primary cortical areas may reflect different types of neuronal activity requiring adequate supply of specific energy substrates...
  44. ncbi request reprint [Is lactate a major energy substrate for neurons?]
    Robert Costalat
    Med Sci (Paris) 22:356-7. 2006
  45. ncbi request reprint Lactate is a preferential oxidative energy substrate over glucose for neurons in culture
    Anne Karine Bouzier-Sore
    Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536 CNRS Université, Bordeaux, France
    J Cereb Blood Flow Metab 23:1298-306. 2003
    ..Results clearly indicate that when neurons are in the presence of both glucose and lactate, they preferentially use lactate as their main oxidative substrate...
  46. ncbi request reprint C/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neurones
    Krisztián A Kovács
    Center for Psychiatric Neuroscience, University Medical Center, University of Lausanne, Prilly, Switzerland
    J Neurochem 98:1390-9. 2006
    ....
  47. pmc A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism
    Agnès Aubert
    Departement de Physiologie, Universite de Lausanne, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 104:4188-93. 2007
    ..In summary, our results, obtained with such a modeling approach, support the concept that both neuronal and glial metabolic responses form essential components of neuroimaging signals...
  48. pmc TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity
    Krisztián A Kovács
    Center for Psychiatric Neuroscience and Service of Child and Adolescent Psychiatry, Department of Psychiatry, University Medical Center, University of Lausanne, CH 1008 Prilly Lausanne, Switzerland
    Proc Natl Acad Sci U S A 104:4700-5. 2007
    ..We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus...
  49. ncbi request reprint Patterns of calcium-binding proteins support parallel and hierarchical organization of human auditory areas
    Oriana Chiry
    Institut de Physiologie, Universite de Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland
    Eur J Neurosci 17:397-410. 2003
    ..In analogy to non-human primates, our results suggest differences in intrinsic organization between auditory areas that are compatible with parallel and hierarchical processing of auditory information...
  50. ncbi request reprint Sleep deprivation modulates brain mRNAs encoding genes of glycogen metabolism
    Jean Marie Petit
    Institute of Physiology and Department of Neurology, UNIL and CHUV, Rue du Bugnon 7, 1005 Lausanne CH, Switzerland
    Eur J Neurosci 16:1163-7. 2002
    ....
  51. ncbi request reprint Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cells
    Fayçal Boussouar
    Institut National pour la Santé et la Recherche Médicale INSERM U 407, Faculté de médecine Lyon Sud, Oullins Cedex, France
    Biol Reprod 69:1069-78. 2003
    ....
  52. ncbi request reprint Glycogen: a Trojan horse for neurons
    Pierre J Magistretti
    Nat Neurosci 10:1341-2. 2007