P J Magistretti

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. ncbi request reprint [Functional brain imaging: role metabolic coupling between astrocytes and neurons]
    P J Magistretti
    Institut de Physiologie, Faculte de Medecine, Universite de Lausanne
    Rev Med Suisse Romande 120:739-42. 2000
  2. ncbi request reprint VIP and PACAP in the CNS: regulators of glial energy metabolism and modulators of glutamatergic signaling
    P J Magistretti
    Laboratoire de Recherche Neurologique, Faculte de Medecine, Universite de Lausanne, Switzerland
    Ann N Y Acad Sci 865:213-25. 1998
  3. pmc Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging
    P J Magistretti
    Institut de Physiologie, Faculte de Medecine, Lausanne, Switzerland
    Philos Trans R Soc Lond B Biol Sci 354:1155-63. 1999
  4. ncbi request reprint Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
    L Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Dev Neurosci 20:291-9. 1998
  5. pmc Glycogen metabolism as a marker of astrocyte differentiation
    J F Brunet
    Neurosurgery Research Group, CHUV FBM UNIL, Lausanne, Switzerland
    J Cereb Blood Flow Metab 30:51-5. 2010
  6. pmc Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain
    L Pellerin
    Institut de Physiologie et Laboratoire de Recherche du Service de Neurologie du Centre Hospitalier Universitaire Vaudois, Faculte de Medecine, Universite de Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 95:3990-5. 1998
  7. ncbi request reprint Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons
    J Y Chatton
    Institute of Physiology and Laboratory of Neurological Research, Department of Neurology, University of Lausanne Medical School, Lausanne, Switzerland
    J Pharmacol Exp Ther 299:1161-8. 2001
  8. ncbi request reprint Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons
    F D Morgenthaler
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Neuroscience 141:157-65. 2006
  9. ncbi request reprint Role of neuron-glia interaction in the regulation of brain glucose utilization
    L Pellerin
    Institut de Physiologie, Universite de Lausanne, Lausanne, Switzerland
    Diabetes Nutr Metab 15:268-73; discussion 273. 2002
  10. ncbi request reprint Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats
    J Badaut
    Neurosurgery Research Group, CHUV UNIL, Lausanne, Switzerland
    Brain Res 1188:17-24. 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint [Functional brain imaging: role metabolic coupling between astrocytes and neurons]
    P J Magistretti
    Institut de Physiologie, Faculte de Medecine, Universite de Lausanne
    Rev Med Suisse Romande 120:739-42. 2000
    ..These data support the notion that astrocytes markedly contribute to the FDG-PET signal...
  2. ncbi request reprint VIP and PACAP in the CNS: regulators of glial energy metabolism and modulators of glutamatergic signaling
    P J Magistretti
    Laboratoire de Recherche Neurologique, Faculte de Medecine, Universite de Lausanne, Switzerland
    Ann N Y Acad Sci 865:213-25. 1998
    ..These effects indicate that VIP can actually increase the strength of glutamate-mediated neurotransmission...
  3. pmc Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging
    P J Magistretti
    Institut de Physiologie, Faculte de Medecine, Lausanne, Switzerland
    Philos Trans R Soc Lond B Biol Sci 354:1155-63. 1999
    ..This conclusion does not question the validity of the 2-DG-based techniques, rather it provides a cellular and molecular basis for these functional brain imaging techniques...
  4. ncbi request reprint Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
    L Pellerin
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Dev Neurosci 20:291-9. 1998
    ..This set of data is consistent with the existence of an activity-dependent astrocyte-neuron lactate shuttle for the supply of energy substrates to neurons...
  5. pmc Glycogen metabolism as a marker of astrocyte differentiation
    J F Brunet
    Neurosurgery Research Group, CHUV FBM UNIL, Lausanne, Switzerland
    J Cereb Blood Flow Metab 30:51-5. 2010
    ..These results show that glycogen metabolism constitutes a useful marker of astrocyte differentiation...
  6. pmc Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain
    L Pellerin
    Institut de Physiologie et Laboratoire de Recherche du Service de Neurologie du Centre Hospitalier Universitaire Vaudois, Faculte de Medecine, Universite de Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 95:3990-5. 1998
    ....
  7. ncbi request reprint Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons
    J Y Chatton
    Institute of Physiology and Laboratory of Neurological Research, Department of Neurology, University of Lausanne Medical School, Lausanne, Switzerland
    J Pharmacol Exp Ther 299:1161-8. 2001
    ..Both processes could provide the biochemical basis of the observed ifosfamide-associated encephalopathy...
  8. ncbi request reprint Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons
    F D Morgenthaler
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Neuroscience 141:157-65. 2006
    ..Thus, lactate appears to be equivalent to glucose for sustaining synaptic vesicle turnover in cultured cortical neurons during activity...
  9. ncbi request reprint Role of neuron-glia interaction in the regulation of brain glucose utilization
    L Pellerin
    Institut de Physiologie, Universite de Lausanne, Lausanne, Switzerland
    Diabetes Nutr Metab 15:268-73; discussion 273. 2002
  10. ncbi request reprint Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats
    J Badaut
    Neurosurgery Research Group, CHUV UNIL, Lausanne, Switzerland
    Brain Res 1188:17-24. 2008
    ..These results show that the level of expression of brain AQP9 is affected by variations of the concentration of insulin in a diabetic model and in vitro...
  11. ncbi request reprint Astrocytes as a predominant cellular site of (99m)Tc-HMPAO retention
    S Zerarka
    Institute of Physiology, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 21:456-68. 2001
    ..In addition, the data also suggest that specific alterations in glial cell metabolism could explain flow-independent changes in (99m)Tc-HMPAO retention in the brain as observed by SPECT in some pathologies...
  12. ncbi request reprint Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes
    J F Brunet
    Service of Neurosurgery, CHUV, Lausanne, Switzerland
    Glia 46:8-17. 2004
    ..Altogether, our results show that acquisition of some specific metabolic features by astrocytes occurs early in their differentiation process and that LIF represents a candidate signal to induce their expression...
  13. ncbi request reprint A quantitative analysis of L-glutamate-regulated Na+ dynamics in mouse cortical astrocytes: implications for cellular bioenergetics
    J Y Chatton
    Institute of Physiology and Laboratory of Neurological Research, Department of Neurology, University of Lausanne Medical School, Rue du Bugnon 7, CH 1005 Lausanne, Switzerland
    Eur J Neurosci 12:3843-53. 2000
    ..Indeed, extracellular glutamate concentrations of 10 microM already markedly increase the energetic demands of the astrocytes...
  14. ncbi request reprint Distribution of Aquaporin 9 in the adult rat brain: preferential expression in catecholaminergic neurons and in glial cells
    J Badaut
    Departement de Neurochirurgie, CHUV BH19 208, 1011 Lausanne, Switzerland
    Neuroscience 128:27-38. 2004
    ....
  15. ncbi request reprint Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes
    J Y Chatton
    Institute of Physiology and Laboratory of Neurological Research, Department of Neurology, University of Lausanne Medical School, Rue du Bugnon 7, CH 1005 Lausanne, Switzerland
    Brain Res 893:46-52. 2001
    ..In view of the complete reversibility of its effects, TBOA represents a very useful pharmacological tool for studies of glutamate transporters...
  16. ncbi request reprint Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy
    K Pierre
    Institut de Physiologie, Rue du Bugnon 7, 1005, Lausanne, Switzerland
    Neuroscience 100:617-27. 2000
    ..In conclusion, these observations are consistent with the possibility that lactate, produced and released by astrocytes (via MCT1), could be taken up (via MCT2) and used by neurons as an energy substrate...
  17. ncbi request reprint The contribution of astrocytes to the 18F-2-deoxyglucose signal in PET activation studies
    P J Magistretti
    Laboratoire de Recherche Neurologique, Institut de Physiologie et Service de Neurologie du CHUV, Faculte de Medecine, Universite de Lausanne, Switzerland
    Mol Psychiatry 1:445-52. 1996
    ..These data support the notion that astrocytes markedly contribute to the FDG-PET signal. This perspective may also provide renewed insights for the interpretation of FDG-PET studies in psychiatric disorders...
  18. ncbi request reprint Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes
    P J Magistretti
    Department of Physiology, University of Lausanne and CHUV, Lausanne, Switzerland
    J Neural Transm 112:77-85. 2005
    ..e. increased ATP). Taken together, this study demonstrates the tight correlation between glutamate transport, Na+ homeostasis and ATP levels in astrocytes...
  19. ncbi request reprint Cloning, localization and induction of mouse brain glycogen synthase
    G Pellegri
    Laboratoire de Recherche Neurologique, Institut de Physiologie et Service de Neurologie du CHUV, Faculté de Médecine Université de Lausanne, Switzerland
    Brain Res Mol Brain Res 38:191-9. 1996
    ..Vasoactive intestinal peptide and noradrenaline, two neurotransmitters previously shown to induce a glycogen resynthesis in cultured astrocytes, upregulate the expression of glycogen synthase mRNA in this cell type but not in neurons...
  20. ncbi request reprint Patterns of calcium-binding proteins in human inferior colliculus: identification of subdivisions and evidence for putative parallel systems
    E Tardif
    Institut de Physiologie, Universite de Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland
    Neuroscience 116:1111-21. 2003
    ....
  21. ncbi request reprint Aquaporin 1 and aquaporin 4 expression in human brain after subarachnoid hemorrhage and in peritumoral tissue
    J Badaut
    Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Acta Neurochir Suppl 86:495-8. 2003
    ..These results reinforce the hypothesis that AQPs may be involved in the dynamics of brain edema formation or resolution. Further studies are needed to understand their functional role...
  22. ncbi request reprint Noradrenaline reduces synaptic responses in normal and tottering mouse entorhinal cortex via alpha 2 receptors
    E Pralong
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Neurosci Lett 179:145-8. 1994
    ..It is concluded that NA can inhibit via an alpha 2 receptor-mediated action synaptic responses in the superficial layers of the EC...
  23. ncbi request reprint Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex
    N Cholet
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada, H3A 2B4
    Cereb Cortex 12:515-25. 2002
    ..Altogether these results demonstrate that alpha(2), GLAST and GLT-1 have comparable perisynaptic distribution within cortical astrocytes most likely associated with glutamatergic synapses...
  24. ncbi request reprint Brain energy metabolism in Alzheimer's disease: 99mTc-HMPAO SPECT imaging during verbal fluency and role of astrocytes in the cellular mechanism of 99mTc-HMPAO retention
    D O Slosman
    Division of Nuclear Medicine, Geneva University Hospital, Geneva, Switzerland
    Brain Res Brain Res Rev 36:230-40. 2001
    ..In particular, these observations suggest a key role of astrocytes in the signal detected with the imaging procedure, which is altered in the Alzheimer's cohort subjected to the verbal fluency activation task...
  25. ncbi request reprint Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia
    J Badaut
    Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Cereb Blood Flow Metab 21:477-82. 2001
    ....