Andrew J Macpherson

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
    Emma Slack
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada
    Science 325:617-20. 2009
  2. pmc Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses
    Siegfried Hapfelmeier
    DKF Maurice Müller Laboratories, MEM, Universitätsklinik für Viszerale Chirurgie und Medizin UVCM, University of Bern, 3013 Bern, Switzerland
    Science 328:1705-9. 2010
  3. doi The bilateral responsiveness between intestinal microbes and IgA
    Andrew J Macpherson
    Maurice Müller Laboratories DKF, Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland Electronic address
    Trends Immunol 36:460-70. 2015
  4. doi Independence Day for IgA
    Andrew J Macpherson
    Maurice Müller Laboratories, UVCM, University Hospital of Bern, 3010 Bern, Switzerland Electronic address
    Immunity 43:416-8. 2015
  5. doi Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes
    Andrew J Macpherson
    Maurice Müller Laboratories DKF, Universitätsklinik für Viszerale Chirurgie und Medizin, University Hospital of Bern, Switzerland Electronic address
    Semin Immunol 25:358-63. 2013
  6. doi Homeland security: IgA immunity at the frontiers of the body
    Andrew J Macpherson
    Maurice Müller Laboratories, DKF, Universitätsklinik für Viszerale Chirurgie und Medizin, University Hospital Inselspital, University of Bern, Bern, Switzerland
    Trends Immunol 33:160-7. 2012
  7. doi The habitat, double life, citizenship, and forgetfulness of IgA
    Andrew J Macpherson
    Mucosal Immunology Lab, Maurice Müller Laboratories, University Clinic for Visceral Surgery and Medicine, University of Bern, Bern, Switzerland
    Immunol Rev 245:132-46. 2012
  8. doi Immunoglobulin A: a bridge between innate and adaptive immunity
    Andrew J Macpherson
    Mucosal Immunology Lab, Maurice Müller Laboratories, University Clinic for Visceral Surgery and Medicine, University of Bern, Switzerland
    Curr Opin Gastroenterol 27:529-33. 2011
  9. doi The mucosal firewalls against commensal intestinal microbes
    Andrew J Macpherson
    DKF, Maurice Müller Laboratories, Department of Visceral Surgery and Medicine, University of Bern, Room G801, Bern, Switzerland
    Semin Immunopathol 31:145-9. 2009
  10. doi Intestinal bacterial colonization induces mutualistic regulatory T cell responses
    Markus B Geuking
    Maurice Müller Laboratories DKF, Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, Bern, Switzerland
    Immunity 34:794-806. 2011

Collaborators

Detail Information

Publications20

  1. pmc Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
    Emma Slack
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada
    Science 325:617-20. 2009
    ..Spontaneous hyper-activation of adaptive immunity against the intestinal microbiota, secondary to innate immune deficiency, may clarify the underlying mechanisms of inflammatory diseases where immune dysfunction is implicated...
  2. pmc Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses
    Siegfried Hapfelmeier
    DKF Maurice Müller Laboratories, MEM, Universitätsklinik für Viszerale Chirurgie und Medizin UVCM, University of Bern, 3013 Bern, Switzerland
    Science 328:1705-9. 2010
    ....
  3. doi The bilateral responsiveness between intestinal microbes and IgA
    Andrew J Macpherson
    Maurice Müller Laboratories DKF, Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland Electronic address
    Trends Immunol 36:460-70. 2015
    ..We examine why only certain intestinal microbes are coated with IgA, and discuss how understanding the determinants of this specific responsiveness may provide insight into diseases associated with dysbiosis. ..
  4. doi Independence Day for IgA
    Andrew J Macpherson
    Maurice Müller Laboratories, UVCM, University Hospital of Bern, 3010 Bern, Switzerland Electronic address
    Immunity 43:416-8. 2015
    ..2015) find that IgA coating promotes uptake of microbes into Peyer's patches and drives further induction in a positive-feedback loop. ..
  5. doi Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes
    Andrew J Macpherson
    Maurice Müller Laboratories DKF, Universitätsklinik für Viszerale Chirurgie und Medizin, University Hospital of Bern, Switzerland Electronic address
    Semin Immunol 25:358-63. 2013
    ..In this review we focus on the links between immune and microbial geography of the mammalian intestinal tract. ..
  6. doi Homeland security: IgA immunity at the frontiers of the body
    Andrew J Macpherson
    Maurice Müller Laboratories, DKF, Universitätsklinik für Viszerale Chirurgie und Medizin, University Hospital Inselspital, University of Bern, Bern, Switzerland
    Trends Immunol 33:160-7. 2012
    ....
  7. doi The habitat, double life, citizenship, and forgetfulness of IgA
    Andrew J Macpherson
    Mucosal Immunology Lab, Maurice Müller Laboratories, University Clinic for Visceral Surgery and Medicine, University of Bern, Bern, Switzerland
    Immunol Rev 245:132-46. 2012
    ..There is both a continuum between innate and adaptive immune mechanisms and compartmentalization of the mucosal immune system from systemic immunity that function to preserve host microbial mutualism...
  8. doi Immunoglobulin A: a bridge between innate and adaptive immunity
    Andrew J Macpherson
    Mucosal Immunology Lab, Maurice Müller Laboratories, University Clinic for Visceral Surgery and Medicine, University of Bern, Switzerland
    Curr Opin Gastroenterol 27:529-33. 2011
    ..Although IgA is by far the most abundant antibody produced by mammals, direct experimental evidence for its function is still lacking...
  9. doi The mucosal firewalls against commensal intestinal microbes
    Andrew J Macpherson
    DKF, Maurice Müller Laboratories, Department of Visceral Surgery and Medicine, University of Bern, Room G801, Bern, Switzerland
    Semin Immunopathol 31:145-9. 2009
    ..In this review article, we present the different mucosal firewalls that contain and allow mutualism with the intestinal microbiota...
  10. doi Intestinal bacterial colonization induces mutualistic regulatory T cell responses
    Markus B Geuking
    Maurice Müller Laboratories DKF, Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, Bern, Switzerland
    Immunity 34:794-806. 2011
    ..Thus, microbiota colonization-induced Treg cell responses are a fundamental intrinsic mechanism to induce and maintain host-intestinal microbial T cell mutualism...
  11. ncbi Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
    Karen Smith
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Immunol 19:59-69. 2007
    ....
  12. ncbi Innate and adaptive immunity in host-microbiota mutualism
    Andrew J Macpherson
    Maurice Müller Laboratories, University Clinic for Visceral Surgery and Medicine, University of Bern, Bern, Switzerland
    Front Biosci (Schol Ed) 4:685-98. 2012
    ..Here we summarize the mechanisms of mucosal immune compartmentalization and its importance for a healthy host-microbiota mutualism...
  13. doi Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling
    Maria L Balmer
    Division of Gastroenterology, Department of Clinical Research, University Clinic for Visceral Surgery and Medicine, University of Bern, 3010 Bern, Switzerland
    J Immunol 193:5273-83. 2014
    ..This suggests that microbiota changes observed in dysbiosis, obesity, or antibiotic therapy may affect the cross talk between hematopoiesis and the microbiota, potentially exacerbating inflammatory or infectious states in the host. ..
  14. pmc Metabolites from intestinal microbes shape Treg
    Markus B Geuking
    University of Bern, Maurice Müller Laboratories DKF, University Clinic for Visceral Surgery and Medicine, Murtenstrasse 35, CH 3010 Bern, Switzerland
    Cell Res 23:1339-40. 2013
    ....
  15. doi The continuum of intestinal CD4+ T cell adaptations in host-microbial mutualism
    Markus B Geuking
    Maurice Müller Laboratories, DKF, Bern, Switzerland
    Gut Microbes 2:353-7. 2011
    ..Therefore, Treg, IL-10 and Th17 are crucial regulatory mechanisms in the intestine not only for controlling inflammation, but also to establish a continuum of CD4(+) T cell homeostasis upon commensal colonization...
  16. ncbi The functional interactions of commensal bacteria with intestinal secretory IgA
    Andrew J Macpherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Curr Opin Gastroenterol 23:673-8. 2007
    ..The aim of this article is to describe the immune geography of IgA induction by commensal intestinal bacteria and the underlying mechanisms of cytokine and costimulatory signalling between dendritic cells, B cells and T cells...
  17. ncbi APRIL in the intestine: a good destination for immunoglobulin A(2)
    Andrew J Macpherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Immunity 26:755-7. 2007
    ..In this issue, He et al. (2007) find that bacterial molecules promote IgA(2) generation via the cytokine APRIL, produced by intestinal epithelial and dendritic cells...
  18. doi The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota
    Maria L Balmer
    Maurice Müller Laboratories DKF, Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
    Sci Transl Med 6:237ra66. 2014
    ..The liver may act as a functional vascular firewall that clears commensals that have penetrated either intestinal or systemic vascular circuits. ..
  19. pmc Mesenteric lymph nodes at the center of immune anatomy
    Andrew J Macpherson
    Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Exp Med 203:497-500. 2006
    ....
  20. doi The outer mucus layer hosts a distinct intestinal microbial niche
    Hai Li
    Maurice Müller Laboratories DKF, Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
    Nat Commun 6:8292. 2015
    ..Functional competition for existence in this intimate layer is likely to be a major determinant of microbiota composition and microbial molecular exchange with the host. ..