A J MacPherson

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Interactions between commensal intestinal bacteria and the immune system
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091 Zurich, Switzerland
    Nat Rev Immunol 4:478-85. 2004
  2. ncbi A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091, Zurich, Switzerland
    Science 288:2222-6. 2000
  3. ncbi Compartmentalization of the mucosal immune responses to commensal intestinal bacteria
    Andrew J Macpherson
    Institut für Experimentelle Immunologie, Universitatsspital Zurich, Schmelzbergstrasse, 12, CH8091 Zurich, Switzerland
    Ann N Y Acad Sci 1029:36-43. 2004
  4. ncbi Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, CH8091 Zurich, Switzerland
    Science 303:1662-5. 2004
  5. pmc Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, Zurich, Switzerland
    Immunology 115:153-62. 2005
  6. ncbi The donor splice site mutation in NFkappaB-inducing kinase of alymphoplasia (aly/aly) mice
    Andrew J Macpherson
    Institute of Experimental ImmunologyUniversitätsspital, Schmelzbergstrasse 12, 8091 Zurich Switzerland
    Immunogenetics 54:693-8. 2003
  7. ncbi IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091, Zurich, Switzerland
    Microbes Infect 3:1021-35. 2001
  8. ncbi IgA production without mu or delta chain expression in developing B cells
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091 Zurich, Switzerland
    Nat Immunol 2:625-31. 2001
  9. ncbi The functions of mucosal T cells in containing the indigenous commensal flora of the intestine
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Cell Mol Life Sci 59:2088-96. 2002
  10. pmc Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 6:e1000711. 2010

Collaborators

Detail Information

Publications24

  1. ncbi Interactions between commensal intestinal bacteria and the immune system
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091 Zurich, Switzerland
    Nat Rev Immunol 4:478-85. 2004
  2. ncbi A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091, Zurich, Switzerland
    Science 288:2222-6. 2000
    ....
  3. ncbi Compartmentalization of the mucosal immune responses to commensal intestinal bacteria
    Andrew J Macpherson
    Institut für Experimentelle Immunologie, Universitatsspital Zurich, Schmelzbergstrasse, 12, CH8091 Zurich, Switzerland
    Ann N Y Acad Sci 1029:36-43. 2004
    ..In this way the mucosal immune responses to commensals are geographically and functionally separated from systemic immunity...
  4. ncbi Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, CH8091 Zurich, Switzerland
    Science 303:1662-5. 2004
    ....
  5. pmc Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, Zurich, Switzerland
    Immunology 115:153-62. 2005
    ....
  6. ncbi The donor splice site mutation in NFkappaB-inducing kinase of alymphoplasia (aly/aly) mice
    Andrew J Macpherson
    Institute of Experimental ImmunologyUniversitätsspital, Schmelzbergstrasse 12, 8091 Zurich Switzerland
    Immunogenetics 54:693-8. 2003
    ....
  7. ncbi IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091, Zurich, Switzerland
    Microbes Infect 3:1021-35. 2001
    ..This review discusses the different mechanisms of induction of IgA, and its role in protecting mucosal surfaces against pathogenic and non-pathogenic microorganisms...
  8. ncbi IgA production without mu or delta chain expression in developing B cells
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091 Zurich, Switzerland
    Nat Immunol 2:625-31. 2001
    ..This muMT IgA pathway requires extrasplenic peripheral lymphoid tissues and may be an evolutionarily primitive system in which immature B cells switch to IgA production at peripheral sites...
  9. ncbi The functions of mucosal T cells in containing the indigenous commensal flora of the intestine
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Cell Mol Life Sci 59:2088-96. 2002
    ..In this review, we discuss the roles of intestinal T cells in initiating and regulating innate and adaptive mucosal immune responses of the mucosal immune system that avoid or limit penetration of the commensal intestinal bacteria...
  10. pmc Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 6:e1000711. 2010
    ..This might be of relevance for human enteropathogen infections as well as therapeutic use of probiotic commensal bacteria...
  11. ncbi Mechanisms of neonatal mucosal antibody protection
    Nicola L Harris
    Institute of Experimental Immunology, Universitatsspital, Zurich, Switzerland
    J Immunol 177:6256-62. 2006
    ..This immune IgG could either be delivered directly in milk or retrotransported via neonatal Fc receptor from the neonatal serum into the intestinal lumen to exert its protective effect...
  12. ncbi Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections
    Lukas Hunziker
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Immunol 4:343-9. 2003
    ..This nonspecific B cell activation may contribute to antibody-mediated autoimmunity...
  13. doi Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, CH8091 Zurich, Switzerland
    Cell Host Microbe 4:362-73. 2008
    ....
  14. ncbi Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies
    Katja Fink
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 38:90-101. 2008
    ....
  15. pmc Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, Wolfgang Paulistrasse 10, HCI G413, CH 8093 Zurich, Switzerland
    Infect Immun 73:3228-41. 2005
    ..One obvious difference was more pronounced damage and reduced regenerative response of the cecal epithelium in GF mice. Overall, StrSPF mice and GF mice provide similar but not identical models for Salmonella serovar Typhimurium colitis...
  16. pmc Overexpression of lymphotoxin in T cells induces fulminant thymic involution
    Mathias Heikenwalder
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Am J Pathol 172:1555-70. 2008
    ....
  17. ncbi The functional interactions of commensal bacteria with intestinal secretory IgA
    Andrew J Macpherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Curr Opin Gastroenterol 23:673-8. 2007
    ..The aim of this article is to describe the immune geography of IgA induction by commensal intestinal bacteria and the underlying mechanisms of cytokine and costimulatory signalling between dendritic cells, B cells and T cells...
  18. pmc Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
    Bärbel Stecher
    Institute of Microbiology, Swiss Institute of Technology Zurich, Zurich, Switzerland
    PLoS Biol 5:2177-89. 2007
    ..Triggering the host's immune defence can shift the balance between the protective microbiota and the pathogen in favour of the pathogen...
  19. ncbi APRIL in the intestine: a good destination for immunoglobulin A(2)
    Andrew J Macpherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Immunity 26:755-7. 2007
    ..In this issue, He et al. (2007) find that bacterial molecules promote IgA(2) generation via the cytokine APRIL, produced by intestinal epithelial and dendritic cells...
  20. ncbi The armed truce between the intestinal microflora and host mucosal immunity
    Andrew J Macpherson
    Semin Immunol 19:57-8. 2007
  21. ncbi Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
    Karen Smith
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Immunol 19:59-69. 2007
    ....
  22. ncbi Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling
    Oliver Pabst
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 177:6824-32. 2006
    ..In conclusion, our findings establish that intestinal microbes influence the manifestation of gut-associated lymphoid tissues and identify CCR7 signaling as an endogeneous factor that controls this process...
  23. ncbi BLySsful interactions between DCs and B cells
    Andrew J Macpherson
    Nat Immunol 3:798-800. 2002
  24. pmc Mesenteric lymph nodes at the center of immune anatomy
    Andrew J Macpherson
    Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Exp Med 203:497-500. 2006
    ....