Francois Mach

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Statins as novel immunomodulators: from cell to potential clinical benefit
    Francois Mach
    Cardiology Division, Department of Medicine, University Hospital, Geneva Medical School, Foundation for Medical Research, Geneva, Switzerland
    Thromb Haemost 90:607-10. 2003
  2. ncbi request reprint Statins as immunomodulatory agents
    Francois Mach
    Cardiology Division, Department of Medicine, University Hospital, Geneva Medical School, Foundation for Medical Research, Geneva, Switzerland
    Circulation 109:II15-7. 2004
  3. ncbi request reprint Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
    Sabine Steffens
    Division of Cardiology, Department of Medicine, Foundation for Medical Research, University Hospital, Faculty of Medicine, 1211 Geneva, Switzerland
    Nature 434:782-6. 2005
  4. ncbi request reprint Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells
    Flore Mulhaupt
    Cardiology Division, Department of Medicine, University Hospital, Geneva Medical School, Foundation for Medical Research, 64 Avenue Roseraie, 1211 Geneva 4, Switzerland
    Cardiovasc Res 59:755-66. 2003
  5. doi request reprint Single administration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reperfusion injury in mice
    Fabrizio Montecucco
    Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 30:1371-7. 2010
  6. doi request reprint Receptor activator of NF- κB ligand (RANKL) increases the release of neutrophil products associated with coronary vulnerability
    Alessandra Quercioli
    Division of Cardiology, Geneva University Hospital, Faculty of Medicine, Foundation for Medical Researches, Geneva, Switzerland
    Thromb Haemost 107:124-39. 2012
  7. ncbi request reprint Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages
    Niels R Veillard
    Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Atherosclerosis 188:51-8. 2006
  8. doi request reprint CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Eur Heart J 33:1964-74. 2012
  9. doi request reprint Coronary vasomotor control in obesity and morbid obesity: contrasting flow responses with endocannabinoids, leptin, and inflammation
    Alessandra Quercioli
    Department of Specialties in Medicine, University Hospitals of Geneva, Geneva, Switzerland
    JACC Cardiovasc Imaging 5:805-15. 2012
  10. doi request reprint A novel RANTES antagonist prevents progression of established atherosclerotic lesions in mice
    Vincent Braunersreuther
    Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 28:1090-6. 2008

Detail Information

Publications81

  1. ncbi request reprint Statins as novel immunomodulators: from cell to potential clinical benefit
    Francois Mach
    Cardiology Division, Department of Medicine, University Hospital, Geneva Medical School, Foundation for Medical Research, Geneva, Switzerland
    Thromb Haemost 90:607-10. 2003
    ..Indeed, two recent in vivo studies performed on different animal models provide further evidence that statin-treatment positively influence immunological disorders...
  2. ncbi request reprint Statins as immunomodulatory agents
    Francois Mach
    Cardiology Division, Department of Medicine, University Hospital, Geneva Medical School, Foundation for Medical Research, Geneva, Switzerland
    Circulation 109:II15-7. 2004
    ..This may explain the immunosuppressive effects of statins seen in two clinical trials of organ transplantation and suggest a potential role for statins as immunosuppressive agents...
  3. ncbi request reprint Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
    Sabine Steffens
    Division of Cardiology, Department of Medicine, Foundation for Medical Research, University Hospital, Faculty of Medicine, 1211 Geneva, Switzerland
    Nature 434:782-6. 2005
    ..Thus, THC or cannabinoids with activity at the CB2 receptor may be valuable targets for treating atherosclerosis...
  4. ncbi request reprint Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells
    Flore Mulhaupt
    Cardiology Division, Department of Medicine, University Hospital, Geneva Medical School, Foundation for Medical Research, 64 Avenue Roseraie, 1211 Geneva 4, Switzerland
    Cardiovasc Res 59:755-66. 2003
    ....
  5. doi request reprint Single administration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reperfusion injury in mice
    Fabrizio Montecucco
    Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 30:1371-7. 2010
    ..Evasins (chemokine-binding proteins) have been shown to selectively neutralize chemokine bioactivity. We investigated the potential benefits of Evasin-3 on mouse myocardial ischemia/reperfusion injury...
  6. doi request reprint Receptor activator of NF- κB ligand (RANKL) increases the release of neutrophil products associated with coronary vulnerability
    Alessandra Quercioli
    Division of Cardiology, Geneva University Hospital, Faculty of Medicine, Foundation for Medical Researches, Geneva, Switzerland
    Thromb Haemost 107:124-39. 2012
    ..Serum levels of RANKL might represent a potential biomarker of coronary calcification and related cardiovascular risk...
  7. ncbi request reprint Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages
    Niels R Veillard
    Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Atherosclerosis 188:51-8. 2006
    ....
  8. doi request reprint CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Eur Heart J 33:1964-74. 2012
    ..Thus, we investigated whether the treatment with a neutralizing monoclonal antibody (mAb) to mouse CCL5 would provide therapeutic benefit when provoking a coronary-associated ischaemic event...
  9. doi request reprint Coronary vasomotor control in obesity and morbid obesity: contrasting flow responses with endocannabinoids, leptin, and inflammation
    Alessandra Quercioli
    Department of Specialties in Medicine, University Hospitals of Geneva, Geneva, Switzerland
    JACC Cardiovasc Imaging 5:805-15. 2012
    ....
  10. doi request reprint A novel RANTES antagonist prevents progression of established atherosclerotic lesions in mice
    Vincent Braunersreuther
    Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 28:1090-6. 2008
    ..Recently, the chemokine variant [44AANA47]-RANTES was shown to impair inflammatory cell recruitment in vivo by interfering with heparin binding and oligomerization...
  11. doi request reprint Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability
    Fabrizio Montecucco
    Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, Geneva University Hospitals, Geneva, Switzerland
    Eur Heart J 32:412-21. 2011
    ..The potential relationship between anti-ApoA-1 IgG and plaque vulnerability remains elusive. Thus, we aimed to investigate the role of anti-ApoA-1 IgG in plaque vulnerability...
  12. ncbi request reprint Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins
    Claire Arnaud
    Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, Switzerland
    Arterioscler Thromb Vasc Biol 25:1231-6. 2005
    ..However, the mechanism by which statins reduce plasma CRP levels remains unknown...
  13. doi request reprint Chemokine CCL5/RANTES inhibition reduces myocardial reperfusion injury in atherosclerotic mice
    Vincent Braunersreuther
    Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    J Mol Cell Cardiol 48:789-98. 2010
    ..Our findings indicate that blocking chemokine receptor/ligand interactions might become a novel therapeutic strategy to reduce reperfusion injuries in patients during acute coronary syndromes...
  14. doi request reprint CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    J Mol Cell Cardiol 46:612-20. 2009
    ..Our data suggest that JWH-133 administration during ischemia reduces the infarct size in a mouse model of myocardial ischemia/reperfusion through a direct cardioprotective activity on cardiomyocytes and neutrophils...
  15. ncbi request reprint PPARgamma but not PPARalpha ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells
    Brenda R Kwak
    Division of Cardiology, Department of Medicine, University Hospital, Geneva Medical School, Foundation for Medical Research, Geneva, Switzerland
    Circ Res 90:356-62. 2002
    ..Thus, the beneficial effects of antidiabetic PPARgamma activators on atherosclerotic plaque development may be partly explained by their repression of MHC-II expression and subsequent inhibition of T-lymphocyte activation...
  16. ncbi request reprint Altered pattern of vascular connexin expression in atherosclerotic plaques
    Brenda R Kwak
    Division of Cardiology, Department of Medicine, University Hospital Geneva, Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 22:225-30. 2002
    ..In conclusion, vascular connexins are differentially expressed by atheroma-associated cells within lesions. These observations suggest a role for gap junctional intercellular communication during atherogenesis...
  17. ncbi request reprint Differential expression patterns of proinflammatory and antiinflammatory mediators during atherogenesis in mice
    Niels R Veillard
    Division of Cardiology, Foundation for Medical Research, University Hospital, Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 24:2339-44. 2004
    ..In this study, we investigated the correlation between atherosclerotic plaque development and expression of important pro- and antiinflammatory mediators during progression of atherosclerosis in ApoE-/- mice...
  18. ncbi request reprint Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice
    Vincent Braunersreuther
    Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 27:373-9. 2007
    ..Although general blockade of CCL5 receptors reduces atherosclerosis, specific roles of CCR1 and CCR5 have not been unequivocally determined...
  19. doi request reprint Regulation and possible role of endocannabinoids and related mediators in hypercholesterolemic mice with atherosclerosis
    Fabrizio Montecucco
    Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Atherosclerosis 205:433-41. 2009
    ....
  20. ncbi request reprint Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction
    Xiu Fen Ming
    Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, Fribourg, Switzerland
    Circulation 110:3708-14. 2004
    ..This study investigated regulatory mechanisms of arginase activity in endothelial cells and its role in atherosclerosis...
  21. ncbi request reprint Dual benefit of reduced Cx43 on atherosclerosis in LDL receptor-deficient mice
    Cindy W Wong
    Division of Cardiology, Department of Medicine, University Hospital, Geneva, Switzerland
    Cell Commun Adhes 10:395-400. 2003
    ..Thus, reducing Cx43 expression in mice provides beneficial effects on both the progression and composition of the atherosclerotic lesions...
  22. doi request reprint Mass spectrometry for the evaluation of cardiovascular diseases based on proteomics and lipidomics
    Aurélien Thomas
    Unit of Toxicology, CURML, Geneva University Hospitals, Geneva, Switzerland
    Thromb Haemost 106:20-33. 2011
    ..This review will be of broad interest to the medical community by providing a tutorial of how mass spectrometric strategies can support clinical trials...
  23. ncbi request reprint Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia
    Catherine M Pastor
    Division of Gastroenterology and Hepatology, Department of Pediatrics MC, Geneva University Hospitals, Geneva, Switzerland
    Crit Care Med 32:1759-63. 2004
    ....
  24. doi request reprint Matching between regional coronary vasodilator capacity and corresponding circumferential strain in individuals with normal and increasing body weight
    Gabriella M Vincenti
    Division of Cardiology, Nuclear Cardiology and Cardiac PET CT, Department of Specialities in Medicine, University Hospital of Geneva, Geneva, Switzerland
    J Nucl Cardiol 19:693-703. 2012
    ..To define the relationship between regional coronary vasodilator capacity and myocardial circumferential strain at rest in normal weight, overweight, and obese individuals with normal global left-ventricular function...
  25. doi request reprint Anti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis
    Nicolas Vuilleumier
    Geneva University Hospitals, Geneva, Switzerland
    Arthritis Rheum 62:2640-50. 2010
    ..To determine whether anti-apolipoprotein A-1 (anti-Apo A-1) IgG are associated with major cardiovascular events in patients with rheumatoid arthritis (RA)...
  26. doi request reprint Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity
    Alessandra Quercioli
    Department of Internal Medicine, Cardiovascular Center, University Hospitals of Geneva, Geneva, Switzerland
    Eur Heart J 32:1369-78. 2011
    ..Aim of this study was to evaluate a possible association between endocannabinoid (EC) plasma levels, such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and coronary circulatory function in obesity...
  27. pmc Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, Faculty of Medicine, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    Antioxid Redox Signal 18:630-41. 2013
    ..Here, we investigated the potential effects of pharmacological Nampt inhibition with FK866 in a mouse myocardial ischemia/reperfusion model. In vivo and ex vivo mouse myocardial ischemia/reperfusion procedures were performed...
  28. doi request reprint Manganese kinetics demonstrated double contrast in acute but not in chronic infarction in a mouse model of myocardial occlusion reperfusion
    Bénédicte M A Delattre
    Division of Radiology, Geneva University Hospital, University of Geneva, Faculty of Medicine, Geneva, Switzerland
    NMR Biomed 25:489-97. 2012
    ....
  29. ncbi request reprint Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo
    Niels R Veillard
    Division of Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
    Circulation 112:870-8. 2005
    ..We investigated whether the deletion of both of these 2 important receptors expressed on the principal inflammatory cells present in atheroma would further affect atherogenesis in vivo...
  30. ncbi request reprint Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice
    Niels R Veillard
    Division Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
    Circ Res 94:253-61. 2004
    ..Thus, our findings indicate that blockade of chemokine receptor/ligand interactions might become a novel therapeutic strategy to reduce the evolution of this common disease...
  31. doi request reprint Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice
    Vincent Braunersreuther
    Fabrizio Montecucco, MD, PhD, Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland, Tel 41 223827238, Fax 41 223827245, E mail
    Thromb Haemost 110:807-25. 2013
    ..Therefore, early inhibition of CC chemokines might represent a promising therapeutic approach to reduce the development of post-infarction heart failure in mice. ..
  32. ncbi request reprint Immunosuppressive effects of statins
    Francois Mach
    Medicine Department, Cardiology Division, Foundation for Medical Research, Geneva Medical School, University Hospital, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Atheroscler Suppl 3:17-20. 2002
    ..This unexpected effect provides a scientific rationale for suggesting the use of statins as novel immunosuppressors, not only in organ transplantation but in numerous other pathologies as well...
  33. ncbi request reprint Atorvastatin treatment and vaccination efficacy
    René R S Packard
    Division of Cardiology, Department of Medicine, Geneva University Hospital, 24 Micheli du Crest, 1211 Geneva, Switzerland
    J Clin Pharmacol 47:1022-7. 2007
  34. doi request reprint Molecular imaging of matrix metalloproteinases in atherosclerotic plaques
    Sebastien Lenglet
    Cardiology Division, Foundation for Medical Research, Department of Medical Specialties, University of Geneva, Geneva, Switzerland
    Thromb Haemost 107:409-16. 2012
    ..In this review, we summarize experimental findings of the currently available invasive and noninvasive imaging techniques, used to detect the presence and activity of MMPs in atherosclerotic plaques...
  35. doi request reprint Elevated E-selectin and diastolic blood pressure in diabetic children
    Albane B R Maggio
    Paediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva, rue Willy Donze, Geneva, Switzerland
    Eur J Clin Invest 42:303-9. 2012
    ..Cardiovascular risk markers are related to micro-angiopathy in children with type 1 diabetes (T1DM), but there is no information about their relationship with blood pressure (BP) and endothelial function...
  36. doi request reprint The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury
    Sabine Steffens
    Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, 1211 Geneva, Switzerland
    Thromb Haemost 102:240-7. 2009
    ..Already approved and novel therapies might directly reduce these inflammatory processes. Treatments modulating chemokine secretion and activity should be considered as very promising approaches to reduce myocardial reperfusion injury...
  37. ncbi request reprint Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice
    Sabine Steffens
    Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Circulation 114:1977-84. 2006
    ..We hypothesized that treatment with anti-CD3-specific antibodies might inhibit atherosclerosis development and progression in mice...
  38. doi request reprint Role of CCL-2, CCR-2 and CCR-4 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury
    Jean Louis Frossard
    Service of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland
    J Clin Pathol 64:387-93. 2011
    ..To address the role of CCL-2, CCR-2 and CCR-4 that attracts leucocytes cells in inflamed tissues, pancreatitis was induced by administering supramaximal doses of cerulein in mice that do not express CCL-2, CCR-2 or CCR-4...
  39. doi request reprint Systemic and intraplaque mediators of inflammation are increased in patients symptomatic for ischemic stroke
    Fabrizio Montecucco
    Division of Cardiology, University Hospital Geneva, Faculty of Medicine, Foundation for Medical Researches, Geneva, Switzerland
    Stroke 41:1394-404. 2010
    ..Thus, we investigated the possible role of systemic and intraplaque inflammation in patients asymptomatic versus symptomatic for ischemic stroke...
  40. doi request reprint Coronary artery calcification and cardiovascular risk: the role of RANKL/OPG signalling
    Alessandra Quercioli
    Division of Cardiology, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, Geneva, Switzerland
    Eur J Clin Invest 40:645-54. 2010
    ..During the last decades, a strong research effort has been performed to identify more selective markers and better assess the cardiovascular risk in both primary and secondary prevention...
  41. ncbi request reprint Drug insight: Immunomodulatory effects of statins--potential benefits for renal patients?
    Sabine Steffens
    Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Research, Geneva, Switzerland
    Nat Clin Pract Nephrol 2:378-87. 2006
    ..Experimental and clinical data provide evidence to support these broader applications of statins; however, more large-scale trials are needed to clarify the therapeutic benefit...
  42. ncbi request reprint Inflammation in the pathophysiology of essential hypertension
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, University Hospital, Geneva, Switzerland
    J Nephrol 24:23-34. 2011
    ..The present review gives an update regarding the latest research on the possible direct role of inflammation in the pathophysiology of essential hypertension...
  43. ncbi request reprint Cholesterol-independent effects of statins in inflammation, immunomodulation and atherosclerosis
    Claire Arnaud
    Division of Cardiology, Foundation for Medical Research, 64, Avenue de la Roseraie, 1211 Geneva University Hospital, Switzerland
    Curr Drug Targets Cardiovasc Haematol Disord 5:127-34. 2005
    ..Thus, inhibition of these prenylated proteins might account for the non-lipid lowering effects of statins. In this review, we describe the numerous beneficial pleiotropic effects of statins that could modulate atherogenesis...
  44. pmc Treatment with Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke, but not brain injury in mice
    Jean Christophe Copin
    Division of Neurosurgery, University Hospitals of Geneva, Geneva, Switzerland
    J Cereb Blood Flow Metab 33:490-8. 2013
    ..We concluded that Evasin-3 treatment was associated with reduction in neutrophilic inflammation in both mouse models. However, Evasin-3 administration after cerebral ischemia onset failed to improve poststroke outcomes...
  45. doi request reprint High time-resolved cardiac functional imaging using temporal regularization for small animal on a clinical 3T scanner
    Bénédicte M A Delattre
    Division of Radiology, Faculty of Medicine, Foundation for medical researchers, Geneva University Hospital, University of Geneva, Geneva, Switzerland
    IEEE Trans Biomed Eng 59:929-35. 2012
    ..This sequence was successfully validated with mass and function measurements on relevant mice models of cardiovascular diseases...
  46. ncbi request reprint Effect of blockage of the endocannabinoid system by CB(1) antagonism on cardiovascular risk
    Francois Mach
    Division of Cardiology, Foundation for Medical Researches, University Hospital, Geneva, Switzerland
    Pharmacol Rep 61:13-21. 2009
    ..In the present review, we focused on the most important experimental investigations into the role of the endocannabinoid system in atherosclerosis and cardiovascular risk...
  47. ncbi request reprint Immunization of LDL receptor-deficient mice with beta2-glycoprotein 1 or human serum albumin induces a more inflammatory phenotype in atherosclerotic plaques
    Sylvie Dunoyer-Geindre
    Service of Angiology and Hemostasis, University Hospital, Switzerland
    Thromb Haemost 97:129-38. 2007
    ..Statin treatment partially prevents these changes...
  48. ncbi request reprint Anti-inflammatory properties of statins
    Sabine Steffens
    Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Research, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Semin Vasc Med 4:417-22. 2004
    ..Indeed, promising new preclinical data indicate that statins might be useful in the treatment of multiple sclerosis and rheumatoid arthritis...
  49. doi request reprint Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS)
    Alessandra Quercioli
    Division of Cardiology, Geneva University Hospital, Geneva, Switzerland
    Sleep Breath 14:261-9. 2010
    ..The present review is focused on the possible pathophysiological mediators which could favor atherosclerosis in OSAS...
  50. doi request reprint Update on statin-mediated anti-inflammatory activities in atherosclerosis
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, University Hospital, Geneva, Switzerland
    Semin Immunopathol 31:127-42. 2009
    ..The same intracellular mechanisms might also cause statin-induced myotoxicity. In the present review, we will update evidence on statin-mediated regulation of inflammatory pathways in atherogenesis...
  51. doi request reprint Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury
    Vincent Braunersreuther
    Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland Division of Clinical Pathology, Department of Genetic Medicine and Laboratories, University Hospital, 1 rue Michel Servet, 1211 Geneva, Switzerland Electronic address
    J Mol Cell Cardiol 64:99-107. 2013
    ..Consequently, NOX1 and NOX2 represent interesting drug targets for controlling reperfusion damage associated with revascularization in coronary disease. ..
  52. ncbi request reprint Toward immunomodulatory and anti-inflammatory properties of statins
    Claire Arnaud
    Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, 1211 Geneva, Switzerland
    Trends Cardiovasc Med 15:202-6. 2005
    ..This review summarizes in vitro and in vivo evidence of immunomodulatory properties of statins...
  53. doi request reprint Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
    Anna Pfenniger
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    J Mol Cell Cardiol 53:299-309. 2012
    ..Therefore, this effect of shear stress on Cx37 expression may contribute to the synchronization of ECs and participate in the protective effect of HLSS...
  54. doi request reprint Antiapolipoprotein A-1 IgG chronotropic effects require nongenomic action of aldosterone on L-type calcium channels
    Michel F Rossier
    Service of Endocrinology and Diabetology, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    Endocrinology 153:1269-78. 2012
    ..In conclusion, our results indicate that, on NRVC, the aldosterone-dependent chronotropic effects of antiapoA-1 IgG involve the nongenomic activation of L-type calcium channels...
  55. ncbi request reprint Toward a role for statins in immunomodulation
    Francois Mach
    Division of Cardiology, Department of Medicine, Foundation for Medical Research, University Hospital, Faculty of Medicine, Geneva, Switzerland
    Mol Interv 2:478-80. 2002
    ..The possible clinical use of statins as anti-inflammatory drugs has also been demonstrated in other published reports. These provocative results suggest a role for statins in relieving autoimmune diseases such as multiple sclerosis...
  56. doi request reprint Myocardial infarction quantification with Manganese-Enhanced MRI (MEMRI) in mice using a 3T clinical scanner
    Bénédicte M A Delattre
    Faculty of Medicine, University of Geneva, Geneva, Switzerland
    NMR Biomed 23:503-13. 2010
    ..This study is the first step for further longitudinal studies of cardiac disease in mice on a clinical 3T scanner, a widely available platform...
  57. ncbi request reprint The specific role of chemokines in atherosclerosis
    Vincent Braunersreuther
    Division of Cardiology, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Thromb Haemost 97:714-21. 2007
    ..Likewise, chemokine antagonists that inhibit leukocyte recruitment could particularly be interesting to treat inflammation in response to myocardial infarction, the major consequence of atherosclerosis...
  58. ncbi request reprint Atherosclerosis: anti-inflammatory and immunomodulatory activities of statins
    Brenda R Kwak
    Division of Cardiology, University Hospital, Foundation for Medical Research, Faculty of Medicine, 64 Avenue de la Roseraie, 1211 Geneva 4, Switzerland
    Autoimmun Rev 2:332-8. 2003
    ..These include endothelial dysfunction, leukocyte recruitment and inflammation, smooth muscle cell activation/proliferation, and finally plaque rupture and thrombosis...
  59. doi request reprint Receptor activator of nuclear factor kappa B ligand/osteoprotegerin pathway is a promising target to reduce atherosclerotic plaque calcification
    Alessandra Quercioli
    Division of Cardiology, Cardiovascular Center, University Hospital, Geneva, Switzerland
    Crit Pathw Cardiol 9:227-30. 2010
    ..Despite that clinical evidence is needed, this therapeutic approach might be of particular benefit in selective populations (such as rheumatoid arthritis patients) with an increased cardiovascular risk...
  60. doi request reprint Ezetimibe/simvastatin
    Fabrizio Montecucco
    University of Geneva, Department of Medicine, Switzerland
    Expert Opin Drug Saf 8:715-25. 2009
    ..Treatments with ezetimibe/simvastatin (combined or alone) have been indicated as very promising approaches to strongly reduce cholesterol levels in hyperlipidemic patients...
  61. ncbi request reprint Statins in the treatment of acute ischemic stroke
    Fabrizio Montecucco
    Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Curr Pharm Biotechnol 13:68-76. 2012
    ..In the present review, we will update evidence on the promising results with statins to improve ischemic stroke outcomes...
  62. doi request reprint CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, University Hospital, Geneva, Switzerland
    Am J Physiol Heart Circ Physiol 294:H1145-55. 2008
    ..In conclusion, selective activation of CB2 receptors modulates chemotaxis of human monocytes, which might have crucial effects in chronic inflammatory disorders such as atherosclerosis or rheumatoid arthritis...
  63. pmc The renin-angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studies
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, University Hospital of Geneva, Geneva, Switzerland
    Mediators Inflamm 2009:752406. 2009
    ....
  64. doi request reprint In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium
    Karin Montet-Abou
    Radiology Department, Geneva University Hospital, Geneva, Switzerland
    Eur Heart J 31:1410-20. 2010
    ..v.) injection of fluorescent iron oxide nanoparticles prior to injury and tracking of these cells in the very same animal to myocardial infarction (MI) by magnetic resonance imaging (MRI) and optical imaging...
  65. doi request reprint Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT
    Ines Valenta
    Department of Internal Medicine, Cardiovascular Center, Nuclear Cardiology, University Hospital of Geneva, Geneva, Switzerland
    J Nucl Cardiol 17:1023-33. 2010
    ....
  66. doi request reprint Stairs instead of elevators at workplace: cardioprotective effects of a pragmatic intervention
    Philippe Meyer
    Cardiology Service, University Hospital of Geneva, Geneva, Switzerland
    Eur J Cardiovasc Prev Rehabil 17:569-75. 2010
    ..However, little data exist on lifestyle interventions that are easy to integrate into everyday life such as using stairs instead of elevators at the workplace...
  67. ncbi request reprint High-throughput phospholipidic fingerprinting by online desorption of dried spots and quadrupole-linear ion trap mass spectrometry: evaluation of atherosclerosis biomarkers in mouse plasma
    Aurélien Thomas
    Unit of Toxicology, CURML, Geneva University Hospitals, Geneva, Switzerland
    Anal Chem 82:6687-94. 2010
    ..The results presented in this work demonstrate the sample processing and analysis potential of the developed strategy to evaluate new biomarkers and the state of a disease...
  68. doi request reprint New evidence for nicotinic acid treatment to reduce atherosclerosis
    Fabrizio Montecucco
    Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 64 Avenue Roseraie, Geneva, Switzerland
    Expert Rev Cardiovasc Ther 8:1457-67. 2010
    ..Promising research developments are warranted in the near future...
  69. doi request reprint Statins, ACE inhibitors and ARBs in cardiovascular disease
    Fabrizio Montecucco
    Division of Cardiology, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, Geneva, Switzerland
    Best Pract Res Clin Endocrinol Metab 23:389-400. 2009
    ..In this review we focus on statins, angiotensin-converting-enzyme (ACE) inhibitors, and angiotensin-II receptor blockers (ARBs), updating therapeutic evidence from the last clinical trials with particular relevance to diabetic patients...
  70. ncbi request reprint Statins as immunomodulators
    Francois Mach
    Department of Medicine, University Hospital Geneva, Foundation for Medical Research, Switzerland
    Transpl Immunol 9:197-200. 2002
    ..This unexpected effect provides a scientific rationale for suggesting the use of statins as novel immunosuppressors, not only in organ transplantation but in numerous other pathologies as well...
  71. pmc Matrix metalloproteinase-9: A deleterious link between hepatic ischemia-reperfusion and colorectal cancer
    Sebastien Lenglet
    Sébastien Lenglet, François Mach, Fabrizio Montecucco, Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 1211 Geneva, Switzerland
    World J Gastroenterol 18:7131-3. 2012
    ....
  72. pmc Alpha-fetoprotein: a controversial prognostic biomarker for small hepatocellular carcinoma
    Mohamed Asrih
    Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 1211 Geneva, Switzerland
    World J Gastroenterol 19:328-30. 2013
    ..Since the study presents some limitations, a larger clinical trial is needed to clarify the potential prognostic role of serum AFP levels in these patients...
  73. ncbi request reprint Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice
    Brenda R Kwak
    Division of Cardiology, University Hospital, Geneva, Switzerland
    Circulation 107:1033-9. 2003
    ..Because the development of atherosclerosis depends critically on paracrine cell-to-cell interactions, we hypothesized that direct intercellular communication via gap junctions may be another factor controlling atherogenesis...
  74. doi request reprint Methylene blue: potential use of an antique molecule in vasoplegic syndrome during cardiac surgery
    Sebastien Lenglet
    Division of Cardiology, Faculty of Medicine, Foundation for Medical Research, Geneva University Hospitals, Avenue de la Roseraie 64, 1211 Geneva 4, Switzerland
    Expert Rev Cardiovasc Ther 9:1519-25. 2011
    ..In this article, we will update evidence on the potential therapeutic use of methylene blue in vasoplegic syndrome...
  75. pmc Insulin resistance: a proinflammatory state mediated by lipid-induced signaling dysfunction and involved in atherosclerotic plaque instability
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, University Hospital, 1211 Geneva, Switzerland
    Mediators Inflamm 2008:767623. 2008
    ..Therefore, reduction of FFA levels represents a selective target for modulating insulin resistance...
  76. pmc New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Research, University Hospital, Geneva, Switzerland
    Clin Interv Aging 3:341-9. 2008
    ..The measure of serum CRP might be useful only for patients who are considered at intermediate risk...
  77. ncbi request reprint Does non-alcoholic fatty liver disease (NAFLD) increase cardiovascular risk?
    Fabrizio Montecucco
    Division of Cardiology, Foundation for Medical Researches, University Hospital, Geneva, Switzerland
    Endocr Metab Immune Disord Drug Targets 8:301-7. 2008
    ..Further investigations are needed to better understand the role of NAFLD, as an independent active factor in metabolic syndrome and associated cardiovascular disease...
  78. ncbi request reprint New anti-inflammatory agents to reduce atherosclerosis
    Francois Mach
    Cardiology Division, Geneva University Hospital, Geneva, Switzerland
    Arch Physiol Biochem 112:130-7. 2006
    ..This presentation reviews two types of molecules associated with the diagnosis, development, or treatment of atherosclerosis: C-reactive protein (CRP), and cannabis...
  79. ncbi request reprint Cannabinoid receptors in atherosclerosis
    Sabine Steffens
    Division of Cardiology, Department of Medicine, University Hospital, Foundation for Medical Research, 64 Avenue Roseraie, 1211 Geneva, Switzerland
    Curr Opin Lipidol 17:519-26. 2006
    ..Recent findings suggesting that cannabinoid receptors are potential targets for the treatment of atherosclerosis are reviewed...
  80. doi request reprint Prehospital emergency physician activation of interventional cardiology team reduces door-to-balloon time in ST-elevation myocardial infarction
    Olivier Grosgurin
    Emergency Department, Geneva University Hospitals, Geneva, Switzerland
    Swiss Med Wkly 140:228-32. 2010
    ..To explore whether early activation of an interventional cardiology team, by prehospital emergency physicians, reduces door-to-balloon time (DTBT) in patients with ST-elevation myocardial infarction (STEMI) diagnosed with prehospital ECG...
  81. ncbi request reprint Anti-(apolipoprotein A-1) IgGs are associated with high levels of oxidized low-density lipoprotein in acute coronary syndrome
    Nicolas Vuilleumier
    Division of Immunology and Allergy, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Clin Sci (Lond) 115:25-33. 2008
    ..These results emphasize the role of humoral autoimmunity as a mediator of inflammation and coronary atherogenesis...