Carsten Lundby

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. doi request reprint The role of haemoglobin mass on VO(2)max following normobaric 'live high-train low' in endurance-trained athletes
    Paul Robach
    Département médical, Ecole Nationale de Ski et d Alpinisme, site de l Ecole Nationale des Sports de Montagne, Chamonix, France
    Br J Sports Med 46:822-7. 2012
  2. doi request reprint Does 'altitude training' increase exercise performance in elite athletes?
    Carsten Lundby
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Br J Sports Med 46:792-5. 2012
  3. pmc The evolving science of detection of 'blood doping'
    Carsten Lundby
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Switzerland
    Br J Pharmacol 165:1306-15. 2012
  4. doi request reprint Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes
    R A Jacobs
    Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland
    J Appl Physiol (1985) 111:1422-30. 2011
  5. pmc Effects of recombinant human erythropoietin in normal humans
    Carsten Lundby
    Center for Integrative Human Physiology, University of Zurich, Institute of Physiology, Room 23 H 6, Winterthurerstr 190, 8057 Zurich, Switzerland
    J Physiol 589:1265-71. 2011
  6. doi request reprint Assessment of total haemoglobin mass: can it detect erythropoietin-induced blood manipulations?
    Carsten Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen Ø, Denmark
    Eur J Appl Physiol 108:197-200. 2010
  7. pmc GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance
    Rasmus S Biensø
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Diabetes 61:1090-9. 2012
  8. doi request reprint Human muscle net K(+) release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m
    Nikolai B Nordsborg
    Copenhagen Muscle Research Center, Rigshospitalet Section, Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 299:R306-13. 2010
  9. ncbi request reprint Cutaneous vasoconstriction affects near-infrared spectroscopy determined cerebral oxygen saturation during administration of norepinephrine
    Henrik Sørensen
    Department of Anesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Anesthesiology 117:263-70. 2012
  10. pmc Optimal hematocrit for maximal exercise performance in acute and chronic erythropoietin-treated mice
    Beat Schuler
    Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 107:419-23. 2010

Detail Information

Publications44

  1. doi request reprint The role of haemoglobin mass on VO(2)max following normobaric 'live high-train low' in endurance-trained athletes
    Paul Robach
    Département médical, Ecole Nationale de Ski et d Alpinisme, site de l Ecole Nationale des Sports de Montagne, Chamonix, France
    Br J Sports Med 46:822-7. 2012
    ....
  2. doi request reprint Does 'altitude training' increase exercise performance in elite athletes?
    Carsten Lundby
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Br J Sports Med 46:792-5. 2012
    ..Another aim is to encourage investigators to design well-controlled studies that will enhance our understanding of the mechanisms and potential benefits of altitude training...
  3. pmc The evolving science of detection of 'blood doping'
    Carsten Lundby
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Switzerland
    Br J Pharmacol 165:1306-15. 2012
    ..We propose that WADA strengthens the quality and capacities of the National Anti-Doping Agencies and that they work more efficiently with the international sports federations in an attempt to limit blood doping...
  4. doi request reprint Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes
    R A Jacobs
    Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland
    J Appl Physiol (1985) 111:1422-30. 2011
    ....
  5. pmc Effects of recombinant human erythropoietin in normal humans
    Carsten Lundby
    Center for Integrative Human Physiology, University of Zurich, Institute of Physiology, Room 23 H 6, Winterthurerstr 190, 8057 Zurich, Switzerland
    J Physiol 589:1265-71. 2011
    ..The metabolic, hormonal and renal effects of EPO do not seem to range beyond physiologically acceptable limits and are reversible. Taken together, EPO seems safe to use for experimental purposes in healthy volunteers...
  6. doi request reprint Assessment of total haemoglobin mass: can it detect erythropoietin-induced blood manipulations?
    Carsten Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen Ø, Denmark
    Eur J Appl Physiol 108:197-200. 2010
    ..In our opinion the variability observed over time when assessing tHb is not justifiable in an anti-doping setting...
  7. pmc GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance
    Rasmus S Biensø
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Diabetes 61:1090-9. 2012
    ..The present findings demonstrate that physical inactivity-induced insulin resistance in muscle is associated with lower content/activity of key proteins in glucose transport/phosphorylation and storage...
  8. doi request reprint Human muscle net K(+) release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m
    Nikolai B Nordsborg
    Copenhagen Muscle Research Center, Rigshospitalet Section, Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 299:R306-13. 2010
    ..9 +/- 0.8% in normoxia and -10.0 +/- 0.4% in hypoxia). It is concluded that leg net K(+) release is unrelated to anaerobic energy production and that acclimatization reduces leg net K(+) release during exercise...
  9. ncbi request reprint Cutaneous vasoconstriction affects near-infrared spectroscopy determined cerebral oxygen saturation during administration of norepinephrine
    Henrik Sørensen
    Department of Anesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Anesthesiology 117:263-70. 2012
    ..We hypothesized that norepinephrine-induced reduction in scO2 is influenced by cutaneous vasoconstriction...
  10. pmc Optimal hematocrit for maximal exercise performance in acute and chronic erythropoietin-treated mice
    Beat Schuler
    Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 107:419-23. 2010
    ..Of note, blood viscosity plays a critical role in limiting exercise capacity...
  11. doi request reprint "Live high-train low" using normobaric hypoxia: a double-blinded, placebo-controlled study
    Christoph Siebenmann
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland
    J Appl Physiol (1985) 112:106-17. 2012
    ..In conclusion, 4 wk of LHTL, using 16 h/day of normobaric hypoxia, did not improve endurance performance or any of the measured, associated physiological variables...
  12. ncbi request reprint Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara natives
    Carsten Lundby
    The Copenhagen Muscle Research Centre, Rigshospitalet, Sect 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 287:R1202-8. 2004
    ..4 mmHg). In conclusion, lowlanders substantially improve pulmonary gas exchange with acclimatization, but even acclimatization for 8 wk is insufficient to achieve levels reached by high-altitude natives...
  13. doi request reprint Red blood cell volume and the capacity for exercise at moderate to high altitude
    Robert A Jacobs
    Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Sports Med 42:643-63. 2012
    ..The current review summarizes past literature that has examined the effect of RCV changes on maximal exercise capacity at moderate to high altitudes, and discusses the explanation elucidating these seemingly paradoxical observations...
  14. doi request reprint Testing for recombinant human erythropoietin in urine: problems associated with current anti-doping testing
    Carsten Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet section 7652, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 105:417-9. 2008
    ..Recently the test has met serious critiques, and the aims of the present study were to investigate the detection power of the test as well as the variability in the test power comparing the results of two WADA-accredited laboratories...
  15. doi request reprint Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans
    Peter Rasmussen
    Department of Physiology, Winterthurerstrasse 190, CH8057 Zurich, Switzerland
    FASEB J 26:1831-4. 2012
    ..Thus, neither dermal oxygen exposure nor cerebral EPO production appears to be important for the systemic EPO response to acute hypoxia in healthy humans...
  16. ncbi request reprint Red cell volume expansion at altitude: a meta-analysis and Monte Carlo simulation
    Peter Rasmussen
    Zurich Center of Integrative Human Physiology, Institute of Physiology, Zurich, Switzerland
    Med Sci Sports Exerc 45:1767-72. 2013
    ..The time course and the contribution of the red cell volume expansion are not clear. The purpose of the present meta-analysis was to explore how much altitude exposure is required to induce polycythemia in healthy lowlanders...
  17. doi request reprint Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models
    Peter Møller
    Institute of Public Health, University of Copenhagen, The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen K, Denmark
    IUBMB Life 60:707-23. 2008
    ..Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity...
  18. doi request reprint Mitochondrial function in human skeletal muscle following high-altitude exposure
    Robert A Jacobs
    Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrase 190, 8057 Zurich, Switzerland
    Exp Physiol 98:245-55. 2013
    ....
  19. pmc During hypoxic exercise some vasoconstriction is needed to match O2 delivery with O2 demand at the microcirculatory level
    Carsten Lundby
    Copenhagen Muscle Research Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    J Physiol 586:123-30. 2008
    ..Peak cardiac output at altitude is not limited by excessive mean arterial pressure. Exercising leg .VO(2peak) is not limited by restricted vasodilatation in the altitude-acclimatized human...
  20. doi request reprint Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle
    Stine Ringholm
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 301:E649-58. 2011
    ....
  21. doi request reprint Both acute and prolonged administration of EPO reduce cerebral and systemic vascular conductance in humans
    Peter Rasmussen
    University of Zurich, Building 23, Winterthurerstrasse 190, CH8057, Zurich, Switzerland
    FASEB J 26:1343-8. 2012
    ..05), therefore, reflected vasoconstriction. Thus, administration of EPO to healthy humans lowers systemic and cerebral conductance independent of its effect on hematocrit...
  22. doi request reprint Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin
    Jorge Soliz
    nstitute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich CH 8057, Switzerland
    Am J Physiol Regul Integr Comp Physiol 296:R1837-46. 2009
    ..Our data provides an explanation as to why women are less susceptible to hypoxia-associated syndromes than men...
  23. pmc Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans
    Ronan Mg Berg
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Crit Care 14:R16. 2010
    ..We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation...
  24. doi request reprint Skeletal muscle adaptations to prolonged exposure to extreme altitude: a role of physical activity?
    Masao Mizuno
    The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
    High Alt Med Biol 9:311-7. 2008
    ..Muscle enzyme activity was unaffected with altitude exposure in both groups, whereas muscle buffer capacity was increased...
  25. pmc Erythropoietin down-regulates proximal renal tubular reabsorption and causes a fall in glomerular filtration rate in humans
    Niels Vidiendal Olsen
    Department of Neuroanaesthesia, The Neuroscience Centre, Investigation, Rigshospitalet, Copenhagen, Denmark
    J Physiol 589:1273-81. 2011
    ..Therefore, treatment with rHuEPO may result in suppression of endogenous EPO synthesis secondary to a decrease in intrarenal oxygen consumption...
  26. pmc Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle
    Kristian Kiilerich
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Diabetes 59:26-32. 2010
    ..To test the hypothesis that free fatty acid (FFA) and muscle glycogen modify exercise-induced regulation of PDH (pyruvate dehydrogenase) in human skeletal muscle through regulation of PDK4 expression...
  27. ncbi request reprint Screening for recombinant human erythropoietin using [Hb], reticulocytes, the OFF(hr score), OFF(z score) and Hb(z score): status of the Blood Passport
    Andreas Bornø
    Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Copenhagen Ø, Denmark
    Eur J Appl Physiol 109:537-43. 2010
    ..However, 42% of our rHuEpo-injected subjects were not detected. It should be emphasised that the test frequency in real world anti-doping is far less than the present study, and hence the detection rate will be lower...
  28. ncbi request reprint The carbon monoxide re-breathing method can underestimate Hbmass due to incomplete blood mixing
    Stefanie Keiser
    Zurich Center of Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Eur J Appl Physiol 113:2425-30. 2013
    ..This may lead to an underestimation of Hbmass as blood in lower extremity veins while seated may not be tagged with carbon monoxide (CO) during the re-breathing period...
  29. doi request reprint The C57Bl/6 mouse serves as a suitable model of human skeletal muscle mitochondrial function
    Robert A Jacobs
    Institute of Physiology and Zurich Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Exp Physiol 98:908-21. 2013
    ....
  30. doi request reprint Twenty-eight days at 3454-m altitude diminishes respiratory capacity but enhances efficiency in human skeletal muscle mitochondria
    Robert A Jacobs
    Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    FASEB J 26:5192-200. 2012
    ..This data demonstrate that 1 mo of exposure to HA reduces respiratory capacity in human skeletal muscle; however, the efficiency of electron transport improves...
  31. doi request reprint Dexamethasone improves maximal exercise capacity of individuals susceptible to high altitude pulmonary edema at 4559 m
    Christoph Siebenmann
    Institute of Physiology, Y23 J64, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    High Alt Med Biol 12:169-77. 2011
    ..This might be explained by a sustained effect of dexamethasone on maximal cardiac output and pulmonary O(2) diffusion, both resulting in enhanced convectional O(2) transport to the locomotor muscles...
  32. ncbi request reprint Relative workload determines exercise-induced increases in PGC-1alpha mRNA
    Nikolai Baastrup Nordsborg
    Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    Med Sci Sports Exerc 42:1477-84. 2010
    ..The hypothesis that brief intermittent exercise-induced increases in human skeletal muscle metabolic mRNA is dependent on relative workload was investigated...
  33. doi request reprint Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle
    Carsten Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 3, 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 104:1154-60. 2008
    ..However, in contrast to our hypothesis, prolonged Epo administration had no apparent effect on capillarization or muscle fiber hypertrophy...
  34. ncbi request reprint Effects of darbepoetin injections on erythrocyte membrane transport protein expressions in humans
    Rikke Louise Rentsch
    Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, The August Krogh Bldg, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen, Denmark
    J Appl Physiol 101:164-8. 2006
    ..However, increased incorporation of membrane proteins during erythrocyte formation may also be involved. We suggest that NESP improves the quality of erythrocyte membrane transport through these mechanisms...
  35. ncbi request reprint Interleukin-6 response to exercise during acute and chronic hypoxia
    Carsten Lundby
    The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Eur J Appl Physiol 91:88-93. 2004
    ..We conclude that the plasma IL-6 concentration during exercise in hypoxia is intensity dependent, and that factors other than catecholamine levels are more important for its regulation...
  36. doi request reprint Hypocapnia during hypoxic exercise and its impact on cerebral oxygenation, ventilation and maximal whole body O₂ uptake
    Christoph Siebenmann
    Zurich Centre for Integrative Human Physiology, Zurich, Switzerland
    Respir Physiol Neurobiol 185:461-7. 2013
    ..99). We conclude that although hypocapnia promotes a decrease in MCAv(mean) and cerebral oxygenation, this does not limit maximal O(2)-uptake. Furthermore, hypocapnia does not restrict ventilation during maximal hypoxic exercise...
  37. ncbi request reprint Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies
    Carsten Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Eur J Appl Physiol 95:351-60. 2005
    ..In addition, the present study shows that multiple muscle biopsies obtained from the same muscle do not influence the mRNA response induced by an acute exercise bout for any of the genes examined...
  38. ncbi request reprint Erythropoietin augments the cytokine response to acute endotoxin-induced inflammation in humans
    Pernille Hojman
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cytokine 45:154-7. 2009
    ..In contrast to our hypothesis, we find that EPO augments the acute inflammatory effect...
  39. ncbi request reprint Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions
    Carsten Lundby
    Copenhagen Muscle Research Centre, Copenhagen, Denmark
    Eur J Appl Physiol 96:363-9. 2006
    ..We propose that HIFs expression is upregulated with exercise and that it may be an important transcription factor that regulates adaptive gene responses to exercise...
  40. ncbi request reprint Detection of darbepoetin alfa misuse in urine and blood: a preliminary investigation
    Jakob Morkeberg
    The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Med Sci Sports Exerc 39:1742-7. 2007
    ..The main objectives were to establish the period of detection of darbepoetin alfa by isoelectric focusing (IEF) and examine the applicability of blood algorithms and individual variations in blood variables in an antidoping context...
  41. ncbi request reprint Kidney-synthesized erythropoietin is the main source for the hypoxia-induced increase in plasma erythropoietin in adult humans
    Anne Kristine Meinild Lundby
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Eur J Appl Physiol 114:1107-11. 2014
    ..However, to what extent non-kidney produced EPO contributes to the hypoxia-induced increase in circulating EPO in adult humans remains unclear...
  42. doi request reprint Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans
    Peter Rasmussen
    Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    FASEB J 25:2865-73. 2011
    ....
  43. ncbi request reprint Oxidative DNA damage and repair in skeletal muscle of humans exposed to high-altitude hypoxia
    Carsten Lundby
    The Copenhagen Muscle Research Centre, Rigshospitalet, DK 2200 Copenhagen N, Denmark
    Toxicology 192:229-36. 2003
    ....
  44. ncbi request reprint Skiing across the Greenland icecap: divergent effects on limb muscle adaptations and substrate oxidation
    Jørn W Helge
    Copenhagen Muscle Research Centre, National University Hospital, Denmark
    J Exp Biol 206:1075-83. 2003
    ..Although the number of subjects is limited, these results imply that the adaptation pattern after long-term, prolonged, low-intensity, whole body exercise may vary dramatically among muscles...