Research Topics
Genomes and GenesSpecies | Carsten LundbySummaryAffiliation: University of Zurich Country: Switzerland Publications
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Publications
Does 'altitude training' increase exercise performance in elite athletes?Carsten Lundby
Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Br J Sports Med 46:792-5. 2012..Another aim is to encourage investigators to design well-controlled studies that will enhance our understanding of the mechanisms and potential benefits of altitude training...- The role of haemoglobin mass on VO(2)max following normobaric 'live high-train low' in endurance-trained athletesPaul Robach
Département médical, Ecole Nationale de Ski et d Alpinisme, site de l Ecole Nationale des Sports de Montagne, Chamonix, France
Br J Sports Med 46:822-7. 2012.... 
The evolving science of detection of 'blood doping'Carsten Lundby
Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Switzerland
Br J Pharmacol 165:1306-15. 2012..We propose that WADA strengthens the quality and capacities of the National Anti-Doping Agencies and that they work more efficiently with the international sports federations in an attempt to limit blood doping...- Assessment of total haemoglobin mass: can it detect erythropoietin-induced blood manipulations?Carsten Lundby
Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen Ø, Denmark
Eur J Appl Physiol 108:197-200. 2010..In our opinion the variability observed over time when assessing tHb is not justifiable in an anti-doping setting... - Effects of recombinant human erythropoietin in normal humansCarsten Lundby
Center for Integrative Human Physiology, University of Zurich, Institute of Physiology, Room 23 H 6, Winterthurerstr 190, 8057 Zurich, Switzerland
J Physiol 589:1265-71. 2011..The metabolic, hormonal and renal effects of EPO do not seem to range beyond physiologically acceptable limits and are reversible. Taken together, EPO seems safe to use for experimental purposes in healthy volunteers... - Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletesR A Jacobs
Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland
J Appl Physiol 111:1422-30. 2011.... - GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistanceRasmus S Biensø
Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
Diabetes 61:1090-9. 2012..The present findings demonstrate that physical inactivity-induced insulin resistance in muscle is associated with lower content/activity of key proteins in glucose transport/phosphorylation and storage... - Human muscle net K(+) release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 mNikolai B Nordsborg
Copenhagen Muscle Research Center, Rigshospitalet Section, Copenhagen Ø, Denmark
Am J Physiol Regul Integr Comp Physiol 299:R306-13. 2010..9 +/- 0.8% in normoxia and -10.0 +/- 0.4% in hypoxia). It is concluded that leg net K(+) release is unrelated to anaerobic energy production and that acclimatization reduces leg net K(+) release during exercise... 
Cutaneous vasoconstriction affects near-infrared spectroscopy determined cerebral oxygen saturation during administration of norepinephrineHenrik Sørensen
Department of Anesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Anesthesiology 117:263-70. 2012..We hypothesized that norepinephrine-induced reduction in scO2 is influenced by cutaneous vasoconstriction...- Optimal hematocrit for maximal exercise performance in acute and chronic erythropoietin-treated miceBeat Schuler
Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 107:419-23. 2010..Of note, blood viscosity plays a critical role in limiting exercise capacity... - Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara nativesCarsten Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet, Sect 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
Am J Physiol Regul Integr Comp Physiol 287:R1202-8. 2004..4 mmHg). In conclusion, lowlanders substantially improve pulmonary gas exchange with acclimatization, but even acclimatization for 8 wk is insufficient to achieve levels reached by high-altitude natives... - "Live high-train low" using normobaric hypoxia: a double-blinded, placebo-controlled studyChristoph Siebenmann
Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland
J Appl Physiol 112:106-17. 2012..In conclusion, 4 wk of LHTL, using 16 h/day of normobaric hypoxia, did not improve endurance performance or any of the measured, associated physiological variables... - Red blood cell volume and the capacity for exercise at moderate to high altitudeRobert A Jacobs
Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
Sports Med 42:643-63. 2012..The current review summarizes past literature that has examined the effect of RCV changes on maximal exercise capacity at moderate to high altitudes, and discusses the explanation elucidating these seemingly paradoxical observations... - Testing for recombinant human erythropoietin in urine: problems associated with current anti-doping testingCarsten Lundby
Copenhagen Muscle Research Centre, Rigshospitalet section 7652, Blegdamsvej 9, 2100 Copenhagen, Denmark
J Appl Physiol 105:417-9. 2008..Recently the test has met serious critiques, and the aims of the present study were to investigate the detection power of the test as well as the variability in the test power comparing the results of two WADA-accredited laboratories... - Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humansPeter Rasmussen
Department of Physiology, Winterthurerstrasse 190, CH8057 Zurich, Switzerland
FASEB J 26:1831-4. 2012..Thus, neither dermal oxygen exposure nor cerebral EPO production appears to be important for the systemic EPO response to acute hypoxia in healthy humans... - During hypoxic exercise some vasoconstriction is needed to match O2 delivery with O2 demand at the microcirculatory levelCarsten Lundby
Copenhagen Muscle Research Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
J Physiol 586:123-30. 2008..Peak cardiac output at altitude is not limited by excessive mean arterial pressure. Exercising leg .VO(2peak) is not limited by restricted vasodilatation in the altitude-acclimatized human... - Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscleStine Ringholm
Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
Am J Physiol Endocrinol Metab 301:E649-58. 2011.... - Both acute and prolonged administration of EPO reduce cerebral and systemic vascular conductance in humansPeter Rasmussen
University of Zurich, Building 23, Winterthurerstrasse 190, CH8057, Zurich, Switzerland
FASEB J 26:1343-8. 2012..05), therefore, reflected vasoconstriction. Thus, administration of EPO to healthy humans lowers systemic and cerebral conductance independent of its effect on hematocrit... - Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietinJorge Soliz
nstitute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich CH 8057, Switzerland
Am J Physiol Regul Integr Comp Physiol 296:R1837-46. 2009..Our data provides an explanation as to why women are less susceptible to hypoxia-associated syndromes than men... - Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental modelsPeter Møller
Institute of Public Health, University of Copenhagen, The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen K, Denmark
IUBMB Life 60:707-23. 2008..Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity... - Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humansRonan Mg Berg
Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
Crit Care 14:R16. 2010..We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation... - Skeletal muscle adaptations to prolonged exposure to extreme altitude: a role of physical activity?Masao Mizuno
The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
High Alt Med Biol 9:311-7. 2008..Muscle enzyme activity was unaffected with altitude exposure in both groups, whereas muscle buffer capacity was increased... - Erythropoietin down-regulates proximal renal tubular reabsorption and causes a fall in glomerular filtration rate in humansNiels Vidiendal Olsen
Department of Neuroanaesthesia, The Neuroscience Centre, Investigation, Rigshospitalet, Copenhagen, Denmark
J Physiol 589:1273-81. 2011..Therefore, treatment with rHuEPO may result in suppression of endogenous EPO synthesis secondary to a decrease in intrarenal oxygen consumption... - Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscleKristian Kiilerich
Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
Diabetes 59:26-32. 2010..To test the hypothesis that free fatty acid (FFA) and muscle glycogen modify exercise-induced regulation of PDH (pyruvate dehydrogenase) in human skeletal muscle through regulation of PDK4 expression... - Screening for recombinant human erythropoietin using [Hb], reticulocytes, the OFF(hr score), OFF(z score) and Hb(z score): status of the Blood PassportAndreas Bornø
Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Copenhagen Ø, Denmark
Eur J Appl Physiol 109:537-43. 2010..However, 42% of our rHuEpo-injected subjects were not detected. It should be emphasised that the test frequency in real world anti-doping is far less than the present study, and hence the detection rate will be lower... - Twenty-eight days at 3454-m altitude diminishes respiratory capacity but enhances efficiency in human skeletal muscle mitochondriaRobert A Jacobs
Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
FASEB J 26:5192-200. 2012..This data demonstrate that 1 mo of exposure to HA reduces respiratory capacity in human skeletal muscle; however, the efficiency of electron transport improves... - Dexamethasone improves maximal exercise capacity of individuals susceptible to high altitude pulmonary edema at 4559 mChristoph Siebenmann
Institute of Physiology, Y23 J64, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
High Alt Med Biol 12:169-77. 2011..This might be explained by a sustained effect of dexamethasone on maximal cardiac output and pulmonary O(2) diffusion, both resulting in enhanced convectional O(2) transport to the locomotor muscles... - Relative workload determines exercise-induced increases in PGC-1alpha mRNANikolai Baastrup Nordsborg
Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
Med Sci Sports Exerc 42:1477-84. 2010..The hypothesis that brief intermittent exercise-induced increases in human skeletal muscle metabolic mRNA is dependent on relative workload was investigated... - Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscleCarsten Lundby
Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 3, 2100 Copenhagen Ø, Denmark
J Appl Physiol 104:1154-60. 2008..However, in contrast to our hypothesis, prolonged Epo administration had no apparent effect on capillarization or muscle fiber hypertrophy... - Interleukin-6 response to exercise during acute and chronic hypoxiaCarsten Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
Eur J Appl Physiol 91:88-93. 2004..We conclude that the plasma IL-6 concentration during exercise in hypoxia is intensity dependent, and that factors other than catecholamine levels are more important for its regulation... - The C57Bl/6 mouse serves as a suitable model of human skeletal muscle mitochondrial functionRobert A Jacobs
Institute of Physiology and Zurich Center for Integrative Human Physiology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Exp Physiol 98:908-21. 2013.... - Mitochondrial function in human skeletal muscle following high-altitude exposureRobert A Jacobs
Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrase 190, 8057 Zurich, Switzerland
Exp Physiol 98:245-55. 2013.... - Hypocapnia during hypoxic exercise and its impact on cerebral oxygenation, ventilation and maximal whole body O₂ uptakeChristoph Siebenmann
Zurich Centre for Integrative Human Physiology, Zurich, Switzerland
Respir Physiol Neurobiol 185:461-7. 2013..99). We conclude that although hypocapnia promotes a decrease in MCAv(mean) and cerebral oxygenation, this does not limit maximal O(2)-uptake. Furthermore, hypocapnia does not restrict ventilation during maximal hypoxic exercise... - Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsiesCarsten Lundby
Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 9, 2100, Copenhagen, Denmark
Eur J Appl Physiol 95:351-60. 2005..In addition, the present study shows that multiple muscle biopsies obtained from the same muscle do not influence the mRNA response induced by an acute exercise bout for any of the genes examined... - Erythropoietin augments the cytokine response to acute endotoxin-induced inflammation in humansPernille Hojman
Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Cytokine 45:154-7. 2009..In contrast to our hypothesis, we find that EPO augments the acute inflammatory effect... - Effects of darbepoetin injections on erythrocyte membrane transport protein expressions in humansRikke Louise Rentsch
Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, The August Krogh Bldg, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark
J Appl Physiol 101:164-8. 2006..However, increased incorporation of membrane proteins during erythrocyte formation may also be involved. We suggest that NESP improves the quality of erythrocyte membrane transport through these mechanisms... - Detection of darbepoetin alfa misuse in urine and blood: a preliminary investigationJakob Morkeberg
The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Med Sci Sports Exerc 39:1742-7. 2007..The main objectives were to establish the period of detection of darbepoetin alfa by isoelectric focusing (IEF) and examine the applicability of blood algorithms and individual variations in blood variables in an antidoping context... - Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditionsCarsten Lundby
Copenhagen Muscle Research Centre, Copenhagen, Denmark
Eur J Appl Physiol 96:363-9. 2006..We propose that HIFs expression is upregulated with exercise and that it may be an important transcription factor that regulates adaptive gene responses to exercise... - Cerebral glucose and lactate consumption during cerebral activation by physical activity in humansPeter Rasmussen
Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
FASEB J 25:2865-73. 2011.... - Oxidative DNA damage and repair in skeletal muscle of humans exposed to high-altitude hypoxiaCarsten Lundby
The Copenhagen Muscle Research Centre, Rigshospitalet, DK-2200 Copenhagen N, Denmark
Toxicology 192:229-36. 2003.... - Skiing across the Greenland icecap: divergent effects on limb muscle adaptations and substrate oxidationJørn W Helge
Copenhagen Muscle Research Centre, National University Hospital, Denmark
J Exp Biol 206:1075-83. 2003..Although the number of subjects is limited, these results imply that the adaptation pattern after long-term, prolonged, low-intensity, whole body exercise may vary dramatically among muscles...