Research Topics
Genomes and GenesSpecies | Christian LüscherSummaryAffiliation: University of Geneva Country: Switzerland Publications
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Detail Information
Publications
Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and diseaseChristian Lüscher
Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1 Michel Servet, CH 1211 Geneva, Switzerland
Nat Rev Neurosci 11:301-15. 2010..GIRK channels may therefore prove to be a valuable new therapeutic target...- Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and diseaseChristian Lüscher
Department of Basic Neurosciences, Medical Faculty, and Clinic of Neurology, Geneva University Hospital, CH 1211 Geneva, Switzerland
Neuron 65:445-59. 2010..We discuss how mGluRs lead to plasticity of neural circuits and how the understanding of the molecular mechanisms of mGluR plasticity provides insight into brain disease... 
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodelingChristian Lüscher
Department of Basic Neuroscience, University of Geneva, 1211 Geneva, Switzerland
Neuron 69:650-63. 2011..While in most cases these early changes are not sufficient to induce the disease, with repetitive drug exposure, they may add up and contribute to addictive behavior...- Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAcManuel Mameli
Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
Nat Neurosci 12:1036-41. 2009..Impaired mGluR1 function in vulnerable individuals could represent a first step in the recruitment of the neuronal network that underlies drug addiction... - In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTACamilla Bellone
Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
Nat Neurosci 14:1439-46. 2011..These data identify the molecular target through which in utero cocaine delays postnatal synaptic maturation, reveal the underlying expression mechanism of this impairment and propose a potential rescue strategy... - Neural bases for addictive properties of benzodiazepinesKelly R Tan
Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
Nature 463:769-74. 2010..The data also indicate that subunit-selective benzodiazepines sparing alpha1 may be devoid of addiction liability... - Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulationMatthew T C Brown
Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
PLoS ONE 5:e15870. 2010..However it remains elusive which molecular target of cocaine drives such AMPAR redistribution and whether other addictive drugs (morphine and nicotine) cause similar changes through their effects on the mesolimbic DA system... - Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental areaManuel Mameli
Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
Nat Neurosci 14:414-6. 2011..Our data suggest that early cocaine-evoked plasticity in the ventral tegmental area inverts the rules for activity-dependent plasticity, eventually leading to addictive behavior... - GABA neurons of the VTA drive conditioned place aversionKelly R Tan
Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland
Neuron 73:1173-83. 2012..Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion... - In vivo reprogramming of circuit connectivity in postmitotic neocortical neuronsAndres De la Rossa
Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland
Nat Neurosci 16:193-200. 2013..These findings reveal a high degree of plasticity in the identity of postmitotic neocortical neurons and provide a proof of principle for postnatal re-engineering of specific neural microcircuits in vivo... - Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learningMatthew T C Brown
Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
Nature 492:452-6. 2012..VTA GABA projection neurons thus emerge as orchestrators of dopaminergic and cholinergic modulation in the NAc... - Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviourVincent Pascoli
Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
Nature 481:71-5. 2012.... - Hooked on benzodiazepines: GABAA receptor subtypes and addictionKelly R Tan
Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
Trends Neurosci 34:188-97. 2011..Such findings have important implications for the future design of benzodiazepines with reduced or even absent addiction liability... - Mimicking synaptic effects of addictive drugs with selective dopamine neuron stimulationMatthew T C Brown
University of Geneva, Switzerland
Channels (Austin) 5:461-3. 2011..Here we discuss literature that expands on these observations in an attempt to further clarify the synaptic changes following early drug use... - Is there a way to curb benzodiazepine addiction?Arnaud L Lalive
Department of Basic Neurosciences, University of Geneva, Switzerland
Swiss Med Wkly 141:w13277. 2011..Such knowledge calls for future developments of new receptor subtype specific benzodiazepines with a reduced addiction liability... - Addictive drugs modulate GIRK-channel signaling by regulating RGS proteinsMarta Lomazzi
Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1, Michel Servet, CH 1211 Geneva, Switzerland
Trends Pharmacol Sci 29:544-9. 2008..The regulation of RGS protein in the reward pathway might underlie adaptation to different types of addictive drugs... - Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out miceHans G Cruz
Department of Basic Neurosciences, University of Geneva, CH 1211 Geneva, Switzerland
J Neurosci 28:4069-77. 2008..Our data suggest that inhibition of adrenergic tone is required for the induction of dependence, and that channels containing GIRK2 and GIRK3 serve as an inhibitory gate... 
RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental areaGwenael Labouèbe
Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1, Michel Servet, CH 1211 Geneva, Switzerland
Nat Neurosci 10:1559-68. 2007..Finally, oral self-administration of GHB at a concentration that is normally rewarding becomes aversive after chronic exposure. On the basis of these results, we propose a mechanism that might underlie tolerance to GHB...- Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depressionCamilla Bellone
Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH-1211 Geneva, Switzerland
Nat Neurosci 9:636-41. 2006.... - Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental areaManuel Mameli
Department of Basic Neuroscience, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
Science 317:530-3. 2007..The synaptic insertion of GluR2 depends on de novo protein synthesis via rapid messenger RNA translation of GluR2. Regulated synthesis of GluR2 in the VTA is therefore required to reverse cocaine-induced synaptic plasticity... - The mechanistic classification of addictive drugsChristian Lüscher
Department of Basic Neurosciences and Clinic of Neurology, University of Geneva, Geneva, Switzerland
PLoS Med 3:e437. 2006 - Drug-evoked plasticity: do addictive drugs reopen a critical period of postnatal synaptic development?Camilla Bellone
Medical Faculty, Department of Basic Neurosciences, University of Geneva Geneva, Switzerland
Front Mol Neurosci 5:75. 2012..Here we review the experimental evidence for this hypothesis and discuss the implications for circuit function... - Bi-directional effect of increasing doses of baclofen on reinforcement learningJean Terrier
Department of Basic Neurosciences, Medical Faculty, University of Geneva Geneva, Switzerland
Front Behav Neurosci 5:40. 2011..55 ± 1.39 vs. 81.07 ± 1.55%, p = 0.002). Our results support a model where baclofen, at low concentrations, causes a disinhibition of DA neurons, increases DA levels and thus facilitates reinforcement learning... - mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptorsCamilla Bellone
Department of Basic Neurosciences, University Geneva, 1 Michel Servet, 1211 Geneva, Switzerland
Eur J Neurosci 21:1280-8. 2005..We conclude that activation of mGluR1s triggers a redistribution exchanging native receptors for GluR2 containing AMPARs, ultimately causing LTD that may oppose pathological neuroadaptation... - beta-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioidsAmyaouch Bradaia
Department of Basic Neurosciences, University of Geneva, CH 1211 Geneva, Switzerland
Proc Natl Acad Sci U S A 102:3034-9. 2005..Thus, beta-arrestin2 attenuates presynaptic inhibition by opioids independent of mu-opioid receptor-driven recruitment, which may make beta-arrestin2 a promising target for regulating analgesia... - Applications of two-photon microscopy in the neurosciencesHans G Cruz
Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland
Front Biosci 10:2263-78. 2005..In the present review we give an overview of the current achievements and discuss emerging applications of the technique... - Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine systemHans G Cruz
Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH-1211 Geneva 4, Switzerland
Nat Neurosci 7:153-9. 2004..Thus GABA(B) receptor agonists exert parallel cellular and behavioral effects due to the cell-specific expression of GIRK subunits...