Christian Lüscher

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc Cocaine-evoked synaptic plasticity of excitatory transmission in the ventral tegmental area
    Christian Lüscher
    Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland
    Cold Spring Harb Perspect Med 3:a012013. 2013
  2. pmc Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease
    Christian Lüscher
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1 Michel Servet, CH 1211 Geneva, Switzerland
    Nat Rev Neurosci 11:301-15. 2010
  3. pmc Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease
    Christian Lüscher
    Department of Basic Neurosciences, Medical Faculty, and Clinic of Neurology, Geneva University Hospital, CH 1211 Geneva, Switzerland
    Neuron 65:445-59. 2010
  4. doi request reprint Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
    Christian Lüscher
    Department of Basic Neuroscience, University of Geneva, 1211 Geneva, Switzerland
    Neuron 69:650-63. 2011
  5. ncbi request reprint Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
    Camilla Bellone
    Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH 1211 Geneva, Switzerland
    Nat Neurosci 9:636-41. 2006
  6. doi request reprint Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
    Manuel Mameli
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Nat Neurosci 12:1036-41. 2009
  7. ncbi request reprint mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors
    Camilla Bellone
    Department of Basic Neurosciences, University Geneva, 1 Michel Servet, 1211 Geneva, Switzerland
    Eur J Neurosci 21:1280-8. 2005
  8. ncbi request reprint Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system
    Hans G Cruz
    Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH 1211 Geneva 4, Switzerland
    Nat Neurosci 7:153-9. 2004
  9. doi request reprint In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA
    Camilla Bellone
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Nat Neurosci 14:1439-46. 2011
  10. pmc Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation
    Matthew T C Brown
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    PLoS ONE 5:e15870. 2010

Collaborators

Detail Information

Publications33

  1. pmc Cocaine-evoked synaptic plasticity of excitatory transmission in the ventral tegmental area
    Christian Lüscher
    Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland
    Cold Spring Harb Perspect Med 3:a012013. 2013
    ..We review the literature that has examined the induction requirements as well as the expression mechanism of this form of plasticity and ask the question about its functional significance...
  2. pmc Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease
    Christian Lüscher
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1 Michel Servet, CH 1211 Geneva, Switzerland
    Nat Rev Neurosci 11:301-15. 2010
    ..GIRK channels may therefore prove to be a valuable new therapeutic target...
  3. pmc Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease
    Christian Lüscher
    Department of Basic Neurosciences, Medical Faculty, and Clinic of Neurology, Geneva University Hospital, CH 1211 Geneva, Switzerland
    Neuron 65:445-59. 2010
    ..We discuss how mGluRs lead to plasticity of neural circuits and how the understanding of the molecular mechanisms of mGluR plasticity provides insight into brain disease...
  4. doi request reprint Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
    Christian Lüscher
    Department of Basic Neuroscience, University of Geneva, 1211 Geneva, Switzerland
    Neuron 69:650-63. 2011
    ..While in most cases these early changes are not sufficient to induce the disease, with repetitive drug exposure, they may add up and contribute to addictive behavior...
  5. ncbi request reprint Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
    Camilla Bellone
    Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH 1211 Geneva, Switzerland
    Nat Neurosci 9:636-41. 2006
    ....
  6. doi request reprint Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
    Manuel Mameli
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Nat Neurosci 12:1036-41. 2009
    ..Impaired mGluR1 function in vulnerable individuals could represent a first step in the recruitment of the neuronal network that underlies drug addiction...
  7. ncbi request reprint mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors
    Camilla Bellone
    Department of Basic Neurosciences, University Geneva, 1 Michel Servet, 1211 Geneva, Switzerland
    Eur J Neurosci 21:1280-8. 2005
    ..We conclude that activation of mGluR1s triggers a redistribution exchanging native receptors for GluR2 containing AMPARs, ultimately causing LTD that may oppose pathological neuroadaptation...
  8. ncbi request reprint Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system
    Hans G Cruz
    Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH 1211 Geneva 4, Switzerland
    Nat Neurosci 7:153-9. 2004
    ..Thus GABA(B) receptor agonists exert parallel cellular and behavioral effects due to the cell-specific expression of GIRK subunits...
  9. doi request reprint In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA
    Camilla Bellone
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Nat Neurosci 14:1439-46. 2011
    ..These data identify the molecular target through which in utero cocaine delays postnatal synaptic maturation, reveal the underlying expression mechanism of this impairment and propose a potential rescue strategy...
  10. pmc Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation
    Matthew T C Brown
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    PLoS ONE 5:e15870. 2010
    ..However it remains elusive which molecular target of cocaine drives such AMPAR redistribution and whether other addictive drugs (morphine and nicotine) cause similar changes through their effects on the mesolimbic DA system...
  11. pmc Neural bases for addictive properties of benzodiazepines
    Kelly R Tan
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
    Nature 463:769-74. 2010
    ..The data also indicate that subunit-selective benzodiazepines sparing alpha1 may be devoid of addiction liability...
  12. doi request reprint Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area
    Manuel Mameli
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Nat Neurosci 14:414-6. 2011
    ..Our data suggest that early cocaine-evoked plasticity in the ventral tegmental area inverts the rules for activity-dependent plasticity, eventually leading to addictive behavior...
  13. doi request reprint Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors
    Tifei Yuan
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1 rue Michel Servet, CH 1211 Geneva, Switzerland
    Neuron 80:1025-38. 2013
    ..Our data provide insight into the early cocaine-driven reorganization of glutamatergic transmission onto DA neurons and offer GluN3A-containing NMDARs as new targets in drug addiction...
  14. doi request reprint GABA neurons of the VTA drive conditioned place aversion
    Kelly R Tan
    Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland
    Neuron 73:1173-83. 2012
    ..Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion...
  15. doi request reprint Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area
    Christina Bocklisch
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
    Science 341:1521-5. 2013
    ..Cocaine-evoked potentiation of GABA release from D1R-MSNs affected drug-adaptive behavior, which identifies these neurons as a promising target for novel addiction treatments. ..
  16. doi request reprint In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons
    Andres De la Rossa
    Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland
    Nat Neurosci 16:193-200. 2013
    ..These findings reveal a high degree of plasticity in the identity of postmitotic neocortical neurons and provide a proof of principle for postnatal re-engineering of specific neural microcircuits in vivo...
  17. doi request reprint Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning
    Matthew T C Brown
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
    Nature 492:452-6. 2012
    ..VTA GABA projection neurons thus emerge as orchestrators of dopaminergic and cholinergic modulation in the NAc...
  18. doi request reprint Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour
    Vincent Pascoli
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
    Nature 481:71-5. 2012
    ....
  19. doi request reprint Hooked on benzodiazepines: GABAA receptor subtypes and addiction
    Kelly R Tan
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Trends Neurosci 34:188-97. 2011
    ..Such findings have important implications for the future design of benzodiazepines with reduced or even absent addiction liability...
  20. ncbi request reprint Two distinct forms of desensitization of G-protein coupled inwardly rectifying potassium currents evoked by alkaloid and peptide mu-opioid receptor agonists
    Christophe Blanchet
    Department of Pharmacology APSIC, University of Geneva, CH 1211 Geneva, Switzerland
    Mol Cell Neurosci 24:517-23. 2003
    ..Peptide agonists induce receptor-mediated desensitization while alkaloid agonists lead to apparent desensitization by receptor-independent inhibition of GIRK channels...
  21. ncbi request reprint Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area
    Manuel Mameli
    Department of Basic Neuroscience, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
    Science 317:530-3. 2007
    ..The synaptic insertion of GluR2 depends on de novo protein synthesis via rapid messenger RNA translation of GluR2. Regulated synthesis of GluR2 in the VTA is therefore required to reverse cocaine-induced synaptic plasticity...
  22. ncbi request reprint Projection of the Grüneberg ganglion to the mouse olfactory bulb
    Daniele Roppolo
    Department of Zoology and Animal Biology and NCCR Frontiers in Genetics, University of Geneva, 1211 Geneva, Switzerland
    Eur J Neurosci 23:2887-94. 2006
    ..These observations strongly suggest that this peculiar olfactory neuronal population plays a sensory role, possibly linked to chemoperception...
  23. doi request reprint Mimicking synaptic effects of addictive drugs with selective dopamine neuron stimulation
    Matthew T C Brown
    University of Geneva, Switzerland
    Channels (Austin) 5:461-3. 2011
    ..Here we discuss literature that expands on these observations in an attempt to further clarify the synaptic changes following early drug use...
  24. doi request reprint Is there a way to curb benzodiazepine addiction?
    Arnaud L Lalive
    Department of Basic Neurosciences, University of Geneva, Switzerland
    Swiss Med Wkly 141:w13277. 2011
    ..Such knowledge calls for future developments of new receptor subtype specific benzodiazepines with a reduced addiction liability...
  25. ncbi request reprint RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area
    Gwenael Labouèbe
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1, Michel Servet, CH 1211 Geneva, Switzerland
    Nat Neurosci 10:1559-68. 2007
    ..Finally, oral self-administration of GHB at a concentration that is normally rewarding becomes aversive after chronic exposure. On the basis of these results, we propose a mechanism that might underlie tolerance to GHB...
  26. pmc Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice
    Hans G Cruz
    Department of Basic Neurosciences, University of Geneva, CH 1211 Geneva, Switzerland
    J Neurosci 28:4069-77. 2008
    ..Our data suggest that inhibition of adrenergic tone is required for the induction of dependence, and that channels containing GIRK2 and GIRK3 serve as an inhibitory gate...
  27. pmc Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins
    Marta Lomazzi
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, 1, Michel Servet, CH 1211 Geneva, Switzerland
    Trends Pharmacol Sci 29:544-9. 2008
    ..The regulation of RGS protein in the reward pathway might underlie adaptation to different types of addictive drugs...
  28. pmc Desensitization of mu-opioid receptor-evoked potassium currents: initiation at the receptor, expression at the effector
    Christophe Blanchet
    Pharmacology, Department of Physiology, and Neurology, University of Geneva, CH 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 99:4674-9. 2002
    ..This implies that MORs exert a bidirectional action on GIRK channels...
  29. ncbi request reprint Applications of two-photon microscopy in the neurosciences
    Hans G Cruz
    Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland
    Front Biosci 10:2263-78. 2005
    ..In the present review we give an overview of the current achievements and discuss emerging applications of the technique...
  30. pmc The mechanistic classification of addictive drugs
    Christian Lüscher
    Department of Basic Neurosciences and Clinic of Neurology, University of Geneva, Geneva, Switzerland
    PLoS Med 3:e437. 2006
  31. pmc Drug-evoked plasticity: do addictive drugs reopen a critical period of postnatal synaptic development?
    Camilla Bellone
    Medical Faculty, Department of Basic Neurosciences, University of Geneva Geneva, Switzerland
    Front Mol Neurosci 5:75. 2012
    ..Here we review the experimental evidence for this hypothesis and discuss the implications for circuit function...
  32. pmc Bi-directional effect of increasing doses of baclofen on reinforcement learning
    Jean Terrier
    Department of Basic Neurosciences, Medical Faculty, University of Geneva Geneva, Switzerland
    Front Behav Neurosci 5:40. 2011
    ..55 ± 1.39 vs. 81.07 ± 1.55%, p = 0.002). Our results support a model where baclofen, at low concentrations, causes a disinhibition of DA neurons, increases DA levels and thus facilitates reinforcement learning...
  33. pmc beta-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids
    Amyaouch Bradaia
    Department of Basic Neurosciences, University of Geneva, CH 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 102:3034-9. 2005
    ..Thus, beta-arrestin2 attenuates presynaptic inhibition by opioids independent of mu-opioid receptor-driven recruitment, which may make beta-arrestin2 a promising target for regulating analgesia...