Genomes and Genes
Affiliation: University of Geneva
- A brief history of TORRobbie Loewith
Department of Molecular Biology, National Centres of Competence in Research Frontiers in Genetics and Chemical Biology, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneva, Switzerland
Biochem Soc Trans 39:437-42. 2011..These studies emphasize the central importance of TOR and highlight its many previously unrecognized functions. One of these, the regulation of intermediary metabolism, is discussed...
- Target of rapamycin (TOR) in nutrient signaling and growth controlRobbie Loewith
Department of Molecular Biology and National Centers of Competence in Research and Frontiers in Genetics and Chemical Biology, University of Geneva, Geneva, CH 1211, Switzerland
Genetics 189:1177-201. 2011..The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae...
- Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signalingHarri Lempiäinen
Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
Mol Cell 33:704-16. 2009..Finally, we show that the Sfp1-interacting protein Mrs6, a Rab escort protein involved in membrane trafficking, regulates both Sfp1 nuclear localization and TORC1 signaling...
- Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesisAlexandre Huber
Department of Molecular Biology, University of Geneva, Geneva, Switzerland
Genes Dev 23:1929-43. 2009..This demonstrates that Sch9 is a master regulator of protein synthesis...
- Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3LAlexandre Huber
Department of Molecular Biology and National Center for Competence in Research Program Frontiers in Genetics, University of Geneva, Geneva, Switzerland
EMBO J 30:3052-64. 2011..Taken together with previous studies, these results suggest that Sch9 is a master regulator of ribosome biogenesis through the control of Ribi, RP, ribosomal RNA and tRNA gene transcription...
- The TOR signalling network from yeast to manClaudio De Virgilio
Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland
Int J Biochem Cell Biol 38:1476-81. 2006..Consequently the efficacies of rapamycin and related compounds in treating such diseases are being evaluated in clinical trials...
- Sch9 is a major target of TORC1 in Saccharomyces cerevisiaeJörg Urban
Department of Molecular Biology, University of Geneva, Geneva, CH 1211, Switzerland
Mol Cell 26:663-74. 2007..Our results suggest that Sch9 functions analogously to the mammalian TORC1 substrate S6K1 rather than the mTORC2 substrate PKB/Akt...