Pius Loetscher

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3
    P Loetscher
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Biol Chem 276:2986-91. 2001
  2. ncbi request reprint Agonistic and antagonistic activities of chemokines
    P Loetscher
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    J Leukoc Biol 69:881-4. 2001
  3. pmc Homing chemokines in rheumatoid arthritis
    Pius Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    Arthritis Res 4:233-6. 2002
  4. pmc A skin-selective homing mechanism for human immune surveillance T cells
    Patrick Schaerli
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Exp Med 199:1265-75. 2004
  5. ncbi request reprint Chemokines: multiple levels of leukocyte migration control
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Trends Immunol 25:75-84. 2004
  6. ncbi request reprint Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes
    Giuseppe Bardi
    Theodor Kocher Institute, P O Box, CH 3000 9 Bern, Switzerland
    FEBS Lett 542:79-83. 2003
  7. ncbi request reprint CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, 3000 Bern 9, Switzerland
    Trends Immunol 23:250-4. 2002
  8. ncbi request reprint Structure-function relationship between the human chemokine receptor CXCR3 and its ligands
    Ian Clark-Lewis
    Biomedical Research Centre and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 278:289-95. 2003
  9. ncbi request reprint Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor
    Urs O Gilli
    Laboratory for Transplantation Immunology, Department for Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Transplantation 79:1324-31. 2005
  10. ncbi request reprint Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis
    Laszlo Revesz
    Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Autoimmunity and Transplantation, CH 4002 Basel, Switzerland
    Bioorg Med Chem Lett 15:5160-4. 2005

Collaborators

Detail Information

Publications12

  1. ncbi request reprint The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3
    P Loetscher
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Biol Chem 276:2986-91. 2001
    ..These results suggest that chemokines that attract Th1 cells via CXCR3 can concomitantly block the migration of Th2 cells in response to CCR3 ligands, thus enhancing the polarization of T cell recruitment...
  2. ncbi request reprint Agonistic and antagonistic activities of chemokines
    P Loetscher
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    J Leukoc Biol 69:881-4. 2001
    ..These observations suggest a new mechanism for the regulation of leukocyte recruitment during inflammatory and immune reactions, which are based on the combination of agonistic and antagonistic effects...
  3. pmc Homing chemokines in rheumatoid arthritis
    Pius Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    Arthritis Res 4:233-6. 2002
    ..Here, we comment on recent studies highlighting the importance of chemokines in rheumatoid arthritis, in particular of B-cell-activating chemokine-1 in lymphoid neogenesis in the inflamed synovium...
  4. pmc A skin-selective homing mechanism for human immune surveillance T cells
    Patrick Schaerli
    Theodor Kocher Institute, University of Bern, P O Box 99, CH 3000 Bern 9, Switzerland
    J Exp Med 199:1265-75. 2004
    ..For the first time, these findings define a chemokine system for homeostatic T cell traffic in normal human skin...
  5. ncbi request reprint Chemokines: multiple levels of leukocyte migration control
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    Trends Immunol 25:75-84. 2004
    ....
  6. ncbi request reprint Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes
    Giuseppe Bardi
    Theodor Kocher Institute, P O Box, CH 3000 9 Bern, Switzerland
    FEBS Lett 542:79-83. 2003
    ..This study indicates an important role of Rho kinase in CCR7-mediated polarization and migration of T lymphocytes, whereas ERK-2 is not involved in these processes...
  7. ncbi request reprint CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses
    Bernhard Moser
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, 3000 Bern 9, Switzerland
    Trends Immunol 23:250-4. 2002
  8. ncbi request reprint Structure-function relationship between the human chemokine receptor CXCR3 and its ligands
    Ian Clark-Lewis
    Biomedical Research Centre and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 278:289-95. 2003
    ..Structure-activity studies with Mig showed that the extended basic COOH-terminal region, which is not present in I-TAC and IP10, is important for binding and activity...
  9. ncbi request reprint Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor
    Urs O Gilli
    Laboratory for Transplantation Immunology, Department for Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Transplantation 79:1324-31. 2005
    ..Since little is known about the initiation of PMN recruitment, the present study investigated whether activated porcine endothelial cells (EC) release factors that induce human PMN recruitment...
  10. ncbi request reprint Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis
    Laszlo Revesz
    Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Autoimmunity and Transplantation, CH 4002 Basel, Switzerland
    Bioorg Med Chem Lett 15:5160-4. 2005
    ..Cinnamides as novel CCR1 antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis...
  11. ncbi request reprint A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis
    Jasper J Haringman
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 54:2387-92. 2006
    ..The objective of this study was to evaluate the effects of human anti-CCL2/MCP-1 monoclonal antibody (ABN912) treatment in patients with rheumatoid arthritis (RA)...
  12. pmc The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice
    Volha Ninichuk
    Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
    Am J Pathol 170:1267-76. 2007
    ..These data identify oral treatment with the CCR1 antagonist BL5923 as a potential therapy for late-stage diabetic nephropathy...