Research Topics
Species | K LippunerSummaryAffiliation: University Hospital Country: Switzerland Publications
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Detail Information
Publications
How well do radiographic absorptiometry and quantitative ultrasound predict osteoporosis at spine or hip? A cost-effectiveness analysisK Lippuner
Osteoporosis Unit, University Hospital of Berne, Switzerland
J Clin Densitom 3:241-9. 2000..CALC), 42% (SOS.PHAL), and 25% (SOS.TIB). In conclusion, RA, QUS.CALC, SOS.PHAL, and SOS.TIB may be useful to preselect postmenopausal women in whom axial DXA is indicated to confirm/exclude osteoporosis at spine or hip...- Epidemiology and direct medical costs of osteoporotic fractures in men and women in SwitzerlandKurt Lippuner
Osteoporosis Policlinic, University Hospital of Berne, Switzerland
Osteoporos Int 16:S8-S17. 2005..Lack of awareness of the disease and its consequences prevents widespread use of drugs with anti-fracture efficacy. This limits their potential to reduce costs... 
Recommendations for raloxifene use in daily clinical practice in the Swiss settingKurt Lippuner
Universitätspoliklinik für Osteoporose, Inselspital Bern, 3010 Bern, Switzerland
Eur Spine J 21:2407-17. 2012..The aim was to characterize the clinical profiles of postmenopausal women expected to benefit most from therapy with raloxifene based on published scientific evidence to date...
Cost-effective intervention thresholds against osteoporotic fractures based on FRAX® in SwitzerlandK Lippuner
Osteoporosis Policlinic, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
Osteoporos Int 23:2579-89. 2012..Assuming a willingness to pay at 2× Gross Domestic Product per capita, an intervention aimed at reducing fracture risk in women and men with a 10-year probability for a major osteoporotic fracture at or above 15% is cost-effective...- The future of osteoporosis treatment - a research updateKurt Lippuner
Osteoporosis Policlinic, Inselspital, Bern University Hospital and University of Bern, Switzerland
Swiss Med Wkly 142:w13624. 2012..The WHO fracture risk assessment tool FRAX® and improved access to bone mineral density measurements by DXA will play a key role in this regard... - [Epidemiology and burden of osteoporosis in Switzerland]Kurt Lippuner
Universitätspoliklinik für Osteoporose, Inselspital, Bern
Ther Umsch 69:137-44. 2012..Should appropriate measures not be implemented in the near future, so will osteoporosis become one of the key challenges for the Swiss healthcare system within the coming years... - [Osteoporosis - whom to treat? The importance of FRAX® in Switzerland]Kurt Lippuner
Universitätspoliklinik für Osteoporose, Inselspital, Bern
Ther Umsch 69:207-13. 2012.... - Comparative trends in hospitalizations for osteoporotic fractures and other frequent diseases between 2000 and 2008K Lippuner
Osteoporosis Policlinic, Inselspital, Bern University Hospital and University of Bern, CH 3010 Bern, Switzerland
Osteoporos Int 23:829-39. 2012..Similar trend patterns were observed for hip fractures and strokes (decrease) and nonhip fractures and acute myocardial infarctions (increase)... - Fracture hospitalizations between years 2000 and 2007 in Switzerland: a trend analysisK Lippuner
Osteoporosis Policlinic, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland
Osteoporos Int 22:2487-97. 2011..The cost impact of shorter hospital stays was offset by the increasing cost per day of hospitalization... - [Epidemiology of osteoporotic fractures in Switzerland]K Lippuner
Policlinique pour l ostéoporose, Hôpital de l lle de Berne, Hôpital universitaire et Université de Berne, Berne
Rev Med Suisse 5:1304-8. 2009..With FRAX (fracture risk assessment tool), validated for Switzerland in tight collaboration with the World Heath Organization, the individual probability of fracture during the next 10 years can be predicted... - FRAX assessment of osteoporotic fracture probability in SwitzerlandK Lippuner
Osteoporosis Policlinic, Inselspital, Bern University Hospital and University of Bern, 3010, Bern, Switzerland
Osteoporos Int 21:381-9. 2010..Patient profiles at increased probability of fracture beyond currently accepted reimbursement thresholds for bone mineral density (BMD) measurement by dual X-ray absorptiometry (DXA), and osteoporosis treatment were identified... - Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and womenK Lippuner
Osteoporosis Policlinic, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
Osteoporos Int 20:1131-40. 2009..Remaining lifetime probability at age 50 years was 20.2% in men and 51.3% in women and increased with advancing age and decreasing BMD. The study validates the elements required to populate a Swiss-specific FRAX model... - Medical treatment of vertebral osteoporosisK Lippuner
Osteoporosis Policlinic, University Hospital of Berne, 3010, Berne, Switzerland
Eur Spine J 12:S132-41. 2003..Although reduction of vertebral fracture risk is an important criterion for decision making, drugs with proven additional fracture risk reduction at all clinically relevant sites (especially at the hip) should be the preferred options... - Tibial or hip BMD predict clinical fracture risk equally well: results from a prospective study in 700 elderly Swiss womenA W Popp
Osteoporosis Policlinic, Inselspital, Bern University Hospital and University of Bern, CH 3010 Bern, Switzerland
Osteoporos Int 20:1393-9. 2009..Bone mineral density (BMD) measured at tibial diaphysis (T-DIA) and tibial epiphysis (T-EPI) using dual-energy X-ray absorptiometry (DXA) was shown to be a valid alternative to lumbar spine or hip BMD in predicting fractures... - Experimental arthritis: effect on growth parameters and total skeletal calciumE Del Pozo
Osteoporosis Policlinic, University Hospital, Bern, Switzerland
Growth Horm IGF Res 19:442-6. 2009..Generalized osteopenia is a prominent feature seemingly connected with the growth abnormalities as they parallel each other during the evolution of the disease and respond equally to therapy... - Augmentation of mechanical properties in osteoporotic vertebral bones--a biomechanical investigation of vertebroplasty efficacy with different bone cementsP F Heini
Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland
Eur Spine J 10:164-71. 2001..Both PMMA and EBC augmentation reliably and significantly raised the stiffness and maximal tolerable force until failure in osteoporotic vertebral bodies. In non-porotic specimens, no significant increase was achieved... - Imipramine and diet counseling with psychological support in the treatment of obese binge eaters: a randomized, placebo-controlled double-blind studyK Laederach-Hofmann
Unit for Psychosomatic and Psychosocial Medicine, University of Berne, Berne, Switzerland
Int J Eat Disord 26:231-44. 1999..This was followed by an open medication-free phase of 6 months of continuous diet counseling with psychological support... - Graded doses of recombinant interleukin-1beta induce generalized osteopenia in rats without altering skeletal growth and joint integrityE Del Pozo
Osteoporosis Policlinic, University Hospital of Bern, Switzerland
Horm Res 64:88-95. 2005..This is in contrast with the experience recorded in experimental arthritis in which growth retardation, in addition to osteopenia, may be caused by factors other than circulating IL-1beta... - Postpartum osteoporosis associated with proximal tibial stress fractureI A Clemetson
Department of Radiology, University Hospital of Bern, Inselspital, 3010, Bern, Switzerland
Skeletal Radiol 33:96-8. 2004..We discuss the presence of a postpartum stress fracture in a hitherto undescribed site in a patient who had lactated following an uncomplicated pregnancy and had no other identifiable cause for a stress fracture... - The relative importance of vertebral bone density and disc degeneration in spinal flexibility and interbody implant performance. An in vitro studyT R Oxland
, University of Bern, Switzerland
Spine (Phila Pa 1976) 21:2558-69. 1996.... - Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhoodP E Mullis
Division of Paediatric Endocrinology, University Children s Hospital, Bern, Switzerland
J Clin Endocrinol Metab 82:1739-45. 1997.... - Which factors account for renal stone formation in cystic fibrosis?R von der Heiden
Department of Pediatrics, University Hospital, Berne, Switzerland
Clin Nephrol 59:160-3. 2003..It is well recognized, however, that low urine volume, hypocitraturia and perhaps even hypercalciuria are further risk factors for stone formation... - Cortical and trabecular bone mineral density in transsexuals after long-term cross-sex hormonal treatment: a cross-sectional studyAdrian G Ruetsche
Osteoporosis Unit, University Hospital of Berne, CH-3010 Berne, Switzerland
Osteoporos Int 16:791-8. 2005..6 years of androgen treatment in this cross sectional study. IGF-1 could play a role in the mediation of the effect of androgens on bone in F-M transsexuals... - Glucocorticosteroid-induced spinal osteoporosis: scientific update on pathophysiology and treatmentAlbrecht W Popp
Osteoporosis Policlinic, University Hospital of Berne, 3010 Berne, Switzerland
Eur Spine J 15:1035-49. 2006..Kyphoplasty performed in appropriately selected osteoporotic patients with painful vertebral fractures is a promising addition to current medical treatment... - Osteoporosis case finding in the general practice: phalangeal radiographic absorptiometry with and without risk factors for osteoporosis to select postmenopausal women eligible for lumbar spine and hip densitometryKatharina M Gasser
Osteoporosis Policlinic, University Hospital of Berne, Switzerland
Osteoporos Int 16:1353-62. 2005..In the Swiss environment, RA is a valid case finding tool for patients with risk factors for osteoporosis, especially for those who do not qualify for DXA reimbursement... - Alendronate with and without cholecalciferol for osteoporosis: results of a 15-week randomized controlled trialRobert Recker
Creighton University, Osteoporosis Research Center, Omaha, NE, USA
Curr Med Res Opin 22:1745-55. 2006..This study assessed the efficacy, safety, and tolerability of a once-weekly tablet containing alendronate 70 mg and cholecalciferol 70 microg (2800 IU) (ALN + D) versus alendronate 70 mg alone (ALN)... - A model of osteoporosis impact in Switzerland 2000-2020Matthias Schwenkglenks
ECPM Executive Office, University Hospital, 4031, Basle, Switzerland
Osteoporos Int 16:659-71. 2005..Corresponding absolute fracture numbers will rise by 36%, 31%, and 23%. Related direct medical inpatient costs are predicted to increase by 33%; however, this estimate is subject to uncertainty due to limited availability of input data... - Biologically relevant sex differences for fitness-related parameters in active octogenariansFabian Lötscher
Institute of Anatomy, University of Bern, Baltzerstrasse 2, 3000, Bern 9, Switzerland
Eur J Appl Physiol 99:533-40. 2007.... - Long-term changes in bone metabolism, bone mineral density, quantitative ultrasound parameters, and fracture incidence after spinal cord injury: a cross-sectional observational study in 100 paraplegic menYvonne Zehnder
Swiss Paraplegic Center, CH-6207, Nottwil, Switzerland
Osteoporos Int 15:180-9. 2004..In paraplegic men early (trabecular) and persistent (cortical) bone loss occurs at the lower limbs and leads to an increasing fracture incidence with time-after-SCI... - 1,25-(OH)2-16ene-23yne-D3 reduces secondary hyperparathyroidism in uremic rats with little calcemic effectKurt Lippuner
Osteoporosis Unit/Policlinic of Medicine, University Hospital of Berne, Berne, Switzerland
Horm Res 61:7-16. 2004..CONCLUSION: 1,25-(OH)(2)-16ene-23yne-D(3) (RO(2)) may represent a novel candidate for the treatment of renal osteodystrophy in humans... - Prediction of hip fracture risk by quantitative ultrasound in more than 7000 Swiss women > or =70 years of age: comparison of three technologically different bone ultrasound devices in the SEMOF studyMarc Antoine Krieg
Department of Internal Medicine, University Hospital, Lausanne, Switzerland
J Bone Miner Res 21:1457-63. 2006..Heel QUSs were both predictive of hip fracture risk, whereas the phalanges QUS was not... - Changes in bone mineral density over 18 months following kidney transplantation: the respective roles of prednisone and parathyroid hormoneJean-Paul Casez
Department of Nephrology, University of Nice, France
Nephrol Dial Transplant 17:1318-26. 2002..8+/-0.9%, P<0.0002). CONCLUSIONS: High cumulative prednisone doses are deleterious for the axial skeleton. Low levels of PTH observed 1 week after kidney transplantation are predictive of continuous cortical bone loss... - Prevention of postmenopausal bone loss with long-cycle hormone replacement therapyAlbrecht W E Popp
Osteoporosis Policlinic, University Hospital of Berne, Switzerland
Maturitas 53:191-200. 2006..There were no endometrial or breast related adverse events reported. CONCLUSION: Long-cycle HRT may be a valid alternative to conventional HRT with regard to protection against postmenopausal bone loss...