Michael Linnebank

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc A possible genetic link between MTHFR genotype and smoking behavior
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    PLoS ONE 7:e53322. 2012
  2. pmc Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma
    M Linnebank
    Department Neurology, University Hospital Bonn, Bonn, Germany
    Br J Cancer 107:1840-3. 2012
  3. doi request reprint Antiepileptic drugs and vitamin B6 plasma levels in adult patients
    Michael Linnebank
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, Switzerland
    Epilepsy Res 101:182-4. 2012
  4. doi request reprint S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease
    Michael Linnebank
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Neurodegener Dis 7:373-8. 2010
  5. pmc The methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences overall survival of patients with glioblastoma multiforme
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Neuro Oncol 10:548-52. 2008
  6. pmc Haplotype analysis of the 5,10-methylenetetrahydrofolate reductase (MTHFR) c.1298A>C (E429A) polymorphism
    Alexander Semmler
    Department of Neurology, University Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland
    BMC Res Notes 4:439. 2011
  7. pmc Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Neuro Oncol 11:2-8. 2009
  8. doi request reprint Antiepileptic drugs interact with folate and vitamin B12 serum levels
    Michael Linnebank
    Department of Neurology, University Hospital Zurich, Switzerland
    Ann Neurol 69:352-9. 2011
  9. doi request reprint Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population
    Delia Kurzwelly
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
    J Neurooncol 100:187-92. 2010
  10. doi request reprint The G allele of transcobalamin 2 c.776C→G is associated with an unfavorable lipoprotein profile
    Alexander Semmler
    Department of Neurology, University of Zurich, Frauenklinikstrasse 26, Zurich, Switzerland
    Ann Nutr Metab 57:112-5. 2010

Detail Information

Publications47

  1. pmc A possible genetic link between MTHFR genotype and smoking behavior
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    PLoS ONE 7:e53322. 2012
    ..However, MTHFR variants have also been reported to be associated with smoking behavior, which could be an important confounder...
  2. pmc Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma
    M Linnebank
    Department Neurology, University Hospital Bonn, Bonn, Germany
    Br J Cancer 107:1840-3. 2012
    ..Here, we investigated whether such variants are associated with MTX efficacy in terms of overall survival in MTX-treated PCNSL patients...
  3. doi request reprint Antiepileptic drugs and vitamin B6 plasma levels in adult patients
    Michael Linnebank
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, Switzerland
    Epilepsy Res 101:182-4. 2012
    ..1; p=0.093) and the untreated patients (15.6±12.4; p=0.664) were not significantly different from the controls (13.9±15.2). These observations do not support the hypothesis that vitamin B6 blood levels are influenced by AED treatment...
  4. doi request reprint S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease
    Michael Linnebank
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Neurodegener Dis 7:373-8. 2010
    ..Increased plasma homocysteine levels have been described as an independent risk factor for Alzheimer's disease (AD), but the underlying pathophysiology is unclear...
  5. pmc The methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences overall survival of patients with glioblastoma multiforme
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Neuro Oncol 10:548-52. 2008
    ..89, p = 0.015). These data suggest the MTHFR c.677C>T variant is a risk factor for survival in GBM patients...
  6. pmc Haplotype analysis of the 5,10-methylenetetrahydrofolate reductase (MTHFR) c.1298A>C (E429A) polymorphism
    Alexander Semmler
    Department of Neurology, University Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland
    BMC Res Notes 4:439. 2011
    ..abstract:..
  7. pmc Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Neuro Oncol 11:2-8. 2009
    ..73; p < 0.001), in addition to male gender (chi(2) = 11.95; p = 0.001). These data strengthen the hypothesis that MTX effects are influenced by methionine metabolism, which may offer new strategies to improve MTX-based therapies...
  8. doi request reprint Antiepileptic drugs interact with folate and vitamin B12 serum levels
    Michael Linnebank
    Department of Neurology, University Hospital Zurich, Switzerland
    Ann Neurol 69:352-9. 2011
    ..Antiepileptic drugs (AEDs) are important for the treatment of epilepsy, psychiatric diseases, and pain syndromes. Small studies have suggested that AED treatment reduces serum levels of folate and vitamin B12...
  9. doi request reprint Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population
    Delia Kurzwelly
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
    J Neurooncol 100:187-92. 2010
    ..Our results suggest the hypothesis that folate and methionine metabolism is relevant to susceptibility to PCNSL...
  10. doi request reprint The G allele of transcobalamin 2 c.776C→G is associated with an unfavorable lipoprotein profile
    Alexander Semmler
    Department of Neurology, University of Zurich, Frauenklinikstrasse 26, Zurich, Switzerland
    Ann Nutr Metab 57:112-5. 2010
    ....
  11. doi request reprint Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms
    Alexander Semmler
    Department of Neurology, University of Bonn, Bonn, Germany
    Cerebrovasc Dis 26:425-9. 2008
    ..We analyzed the possible association of nine genetic variants of homocysteine metabolism with the occurrence of intracranial aneurysms...
  12. doi request reprint Genetic variants of methionine metabolism and X-ALD phenotype generation: results of a new study sample
    Alexander Semmler
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Neurol 256:1277-80. 2009
    ..Whereas the influence of other polymorphisms of methionine metabolism was not confirmed, the present study supports the previously made observation that the Tc2 genotype contributes to X-ALD phenotype generation...
  13. ncbi request reprint The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme
    Alexander Semmler
    Department of Neurology, University Hospital Bonn, Sigmund Freud Strasse, 25, 53105 Bonn, Germany
    Cancer Epidemiol Biomarkers Prev 15:2314-6. 2006
    ..72/0.26/0.02 and controls AA/AG/GG: 0.57/0.38/0.05, degrees of freedom = 2; chi(2) = 17.86 (Pearson); P < 0.001]. No association between glioblastoma multiforme and the two other polymorphisms was observed...
  14. doi request reprint Homocysteine plasma levels in patients treated with antiepileptic drugs depend on folate and vitamin B12 serum levels, but not on genetic variants of homocysteine metabolism
    Alexander Semmler
    Department of Neurology, University of Zurich, Switzerland
    Clin Chem Lab Med 51:665-9. 2013
    ..Here, we aimed to determine whether there is a pharmacogenetic interaction between folate, vitamin B12 and genetic variants and homocysteine plasma level in AED-treated patients...
  15. doi request reprint Polymorphisms of methionine metabolism and susceptibility to meningioma formation: laboratory investigation
    Alexander Semmler
    Department of Neurology, University Hospital of Bonn, Germany
    J Neurosurg 108:999-1004. 2008
    ..The authors investigated the association of 7 functional polymorphisms of methionine metabolism with meningioma formation...
  16. ncbi request reprint The effect of MTHFR c.677C>T on plasma homocysteine levels depends on health, age and smoking
    Alexander Semmler
    University Zurich, Department Neurology, 8091 Zurich, Switzerland
    Clin Invest Med 32:E310. 2009
    ..The aim of the present study was to examine whether the influence of MTHFR c.677C > T on homocysteine levels depends on individual factors...
  17. pmc Plasma folate levels are associated with the lipoprotein profile: a retrospective database analysis
    Alexander Semmler
    University Zurich, Department of Neurology, Switzerland
    Nutr J 9:31. 2010
    ..This cross-sectional pilot study aimed at analyzing whether blood levels of the two important cofactors of homocysteine metabolism, folate and vitamin B12, coincide with the lipoprotein profile...
  18. pmc Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis
    Katrin Patrij
    Center for Integrated Oncology, University of Bonn, Bonn, Germany
    Ger Med Sci 9:Doc11. 2011
    ....
  19. doi request reprint Methionine metabolism in an animal model of sepsis
    Alexander Semmler
    Neurology Department, University Hospital Zurich, Zurich, Switzerland
    Clin Chem Lab Med 46:1398-402. 2008
    ..The degradation product and antagonist of SAM is S-adenosylhomocysteine (SAH). In this study, we investigated changes in methionine metabolism in a rodent model of sepsis...
  20. doi request reprint Common genetic coagulation variants are not associated with ischemic stroke in a case-control study
    Susanna Moskau
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurol Res 32:519-22. 2010
    ..Abnormalities in the coagulation pathway are often included in the diagnostic work-up of stroke patients, especially in young adults with cryptogenic stroke...
  21. doi request reprint Hyperhomocysteinemia in Alzheimer's disease: the hen and the egg?
    Melinda Farkas
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Alzheimers Dis 33:1097-104. 2013
    ..e., represent both a cause and a consequence of neurodegeneration. Such a vicious cycle may be breakable by dietary or supplementation strategies increasing the availability of 5-MTHF...
  22. doi request reprint Alterations of homocysteine serum levels during alcohol withdrawal are influenced by folate and riboflavin: results from the German Investigation on Neurobiology in Alcoholism (GINA)
    Peter Heese
    Department of Addiction and Psychotherapy, LVR Clinic Bonn, Bonn, Germany
    Alcohol Alcohol 47:497-500. 2012
    ..Hyperhomocysteinemia has been associated not only with blood alcohol concentration (BAC), but also with deficiency of different B-vitamins, particularly folate, pyridoxine and cobalamin...
  23. doi request reprint Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphoma
    Annika Juergens
    Department of Neurology, Knappschaftskrankenhaus, University of Bochum, Bochum, Germany
    Ann Neurol 67:182-9. 2010
    ..To evaluate long-term progression-free survival and overall survival, quality of life, and cognitive function in primary central nervous system lymphoma after systemic and intraventricular chemotherapy without radiotherapy...
  24. ncbi request reprint The cystathionine beta-synthase variant c.844_845ins68 protects against CNS demyelination in X-linked adrenoleukodystrophy
    Michael Linnebank
    University Hospital Bonn, Department of Neurology, Bonn, Germany
    Hum Mutat 27:1063-4. 2006
    ..Since methionine metabolism can easily be influenced by vitamin and amino acid substitution, this observation could be a basis of novel treatment strategies in this yet untreatable disease. (c) 2006 Wiley-Liss, Inc...
  25. ncbi request reprint Homocysteine and carotid intima-media thickness in a german population: lack of clinical relevance
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Stroke 37:2840-2. 2006
    ..Common carotid artery intima-media thickness (CCA IMT) is a predictor of stroke. This study aimed to analyze whether homocysteine (Hcys) metabolism influences CCA IMT...
  26. doi request reprint Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients
    Delia Kurzwelly
    Clinical Neurooncology Unit, Department of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Neurooncol 90:53-5. 2008
    ..No significant difference between these two groups was found using Pearson's chi(2) test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL...
  27. doi request reprint Methylation metabolism in sepsis and systemic inflammatory response syndrome
    Alexander Semmler
    University Zurich, Department of Neurology, Switzerland
    Scand J Clin Lab Invest 73:368-72. 2013
    ..Further studies may explore the clinical relevance of the observed changes. ..
  28. doi request reprint Sustained efficacy of natalizumab in the treatment of relapsing-remitting multiple sclerosis independent of disease activity and disability at baseline: real-life data from a Swiss cohort
    Ulf Kallweit
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Clin Neuropharmacol 35:77-80. 2012
    ..However, real-life longitudinal data, including years before baseline, are rare...
  29. ncbi request reprint Adult index patient with Currarino syndrome due to a novel HLXB9 mutation, c.336dupG (p.P113fsX224), presenting with Hirschsprung's disease, cephalgia, and lumbodynia
    Alexander Volk
    Department of Neurology, University Bonn, Bonn, Germany
    Birth Defects Res A Clin Mol Teratol 79:249-51. 2007
    ..Mutations in the homeoboxHLXB9 gene have already been described in a subset of sacrococcygeal anomalies characterized by partial sacral agenesis...
  30. doi request reprint Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II study
    Hendrik Pels
    Department of Neurology, Knappschaftskrankenhaus, University of Bochum, In der Schornau 23 25, Bochum, Germany
    J Neurooncol 91:299-305. 2009
    ..Here, the efficacy and toxicity of this regimen without intraventricular treatment was evaluated in PCNSL...
  31. doi request reprint The thermolabile variant of 5,10-methylenetetrahydrofolate reductase is a possible risk factor for amyotrophic lateral sclerosis
    Peter Kühnlein
    Department of Neurology, University of Ulm, Germany
    Amyotroph Lateral Scler 12:136-9. 2011
    ..594+59del19bp are involved in homocysteine metabolism. Homocysteine is neurotoxic and binds copper. Thus, the individual variability of homocysteine metabolism, e.g. due to genetic variants, may contribute to the vulnerability of ALS...
  32. doi request reprint Therapy of X-linked adrenoleukodystrophy
    Alexander Semmler
    University Hospital Zurich, Department of Neurology, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Expert Rev Neurother 8:1367-79. 2008
    ....
  33. doi request reprint ACNU-based chemotherapy for recurrent glioma in the temozolomide era
    Caroline Happold
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Medical School, Tubingen, Germany
    J Neurooncol 92:45-8. 2009
    ..This study does not commend ACNU as a therapy of first choice for patients with recurrent glioblastomas pretreated with temozolomide...
  34. ncbi request reprint Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, 53125 Bonn, Germany
    Neurobiol Dis 23:725-30. 2006
    ..The Cu(2+) chelating action of HCys and impairement of COX activity represent novel mechanisms of HCys neurotoxicity, which might be preventable by supplementation of Cu(2+)...
  35. doi request reprint An efficient method for fractionated whole rodent brain radiation
    Alexander Semmler
    Department of Neurology, University Zurich, Switzerland
    Neurol Res 35:355-9. 2013
    ..We describe an efficient method to perform repetitive, fractionated whole brain radio therapy to the rat brain...
  36. ncbi request reprint The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Int J Mol Med 16:759-61. 2005
    ..Separate analysis of female and male subjects revealed that the influence of the MTR genotype on male subjects became relevant at a younger age as opposed to female subjects suggesting a gender-dependent effect...
  37. ncbi request reprint Progressive multifocal leukoencephalopathy with selective involvement of the pyramidal tracts
    Alexander Semmler
    University Hospital Bonn, Dept of Neurology, Bonn, Germany
    Neurology 68:871. 2007
  38. ncbi request reprint Hereditary hyper-ACE-emia due to the Pro1199Leu mutation of somatic ACE as a potential pitfall in diagnosis: a first family outside Europe
    Alexander Semmler
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Clin Chem Lab Med 44:1088-9. 2006
    ..Benign autosomal-dominant hyper-ACE-emia should be considered for differential diagnosis of elevated ACE levels worldwide...
  39. pmc Familial occipital and nervus intermedius neuralgia in a Swiss family
    Franz Riederer
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Headache Pain 11:335-8. 2010
    ..This is suggestive of an X-linked dominant or an autosomal dominant mode of inheritance...
  40. doi request reprint Chronic homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons
    Christina Schaub
    Department of Neurology, University of Bonn, Bonn, Germany
    Exp Brain Res 225:527-34. 2013
    ..We conclude that homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons as a mechanism of neurological symptoms of hyperhomocysteinemia...
  41. doi request reprint Plasma homocysteine levels increase following stress in older but not younger men
    Ulrike Kuebler
    Department of Clinical Psychology and Psychotherapy, University of Zurich, Zurich, Switzerland
    Psychoneuroendocrinology 38:1381-7. 2013
    ..The objective of this study was (a) to investigate whether Hcy reactivity to psychosocial stress differs between younger and middle-aged to older men and (b) to study whether psychosocial stress induces Hcy increases independent of age...
  42. pmc Autoimmune myasthenia gravis after sternal fracture
    Jens A Petersen
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Case Rep Neurol 4:20-2. 2012
    ..Speculatively, the damage of retrosternal thymic remnants due to a sternal fracture might have precipitated the condition or exacerbated subclinical disease...
  43. doi request reprint Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease
    Aleksandar Rakovic
    Department of Neurology, University of Lubeck, Lubeck, Germany
    Mov Disord 24:429-33. 2009
    ..7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD...
  44. doi request reprint Sinus venous thrombosis: a differential diagnosis of postpartum headache
    Maria Wittmann
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Arch Gynecol Obstet 285:93-7. 2012
    ..This case highlights the difficulty of differential diagnosis of headache in the postnatal period in patients after EDA and stresses the necessity of considering alternative pathologies...
  45. ncbi request reprint Lack of genetic dispositions to hyperhomocysteinemia in Alzheimer disease
    Michael Linnebank
    Am J Med Genet A 131:101-2. 2004
  46. ncbi request reprint Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27 patients and a completed structure of the human ASL gene
    Michael Linnebank
    Universitatsklinikum Munster, Klinik und Poliklinik fuer Kinderheilkunde, 48149 Munster, Germany
    Hum Genet 111:350-9. 2002
    ..346C-->T (6), c.1153C-->T (4). This study introduces a system for mutation analysis in the ASL gene, thereby elucidating the genetic background of ASL deficiency, which was found to be associated with considerable allelic heterogeneity...
  47. ncbi request reprint The cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype
    Michael Linnebank
    University Hospital Muenster, Dept Pediatrics, Muenster, Germany
    Hum Mutat 24:352-3. 2004
    ..862G>C (p.Ala288Pro) and c.1135C>T (p.Arg379Trp). In summary, the data of this study suggest that the CBS c.1224-2A>C allele confers vitamin B6 nonresponsiveness and that this mutant allele came from a common ancestor...