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Genomes and GenesSpecies | Michael LinnebankSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
A possible genetic link between MTHFR genotype and smoking behaviorMichael Linnebank
Department of Neurology, University Hospital Bonn, Bonn, Germany
PLoS ONE 7:e53322. 2012..However, MTHFR variants have also been reported to be associated with smoking behavior, which could be an important confounder...- Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphomaM Linnebank
Department Neurology, University Hospital Bonn, Bonn, Germany
Br J Cancer 107:1840-3. 2012..Here, we investigated whether such variants are associated with MTX efficacy in terms of overall survival in MTX-treated PCNSL patients... 
Antiepileptic drugs and vitamin B6 plasma levels in adult patientsMichael Linnebank
Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, Switzerland
Epilepsy Res 101:182-4. 2012..1; p=0.093) and the untreated patients (15.6±12.4; p=0.664) were not significantly different from the controls (13.9±15.2). These observations do not support the hypothesis that vitamin B6 blood levels are influenced by AED treatment...- Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphomaMichael Linnebank
University Hospital Bonn, Department of Neurology, Bonn, Germany
Neuro Oncol 11:2-8. 2009..73; p < 0.001), in addition to male gender (chi(2) = 11.95; p = 0.001). These data strengthen the hypothesis that MTX effects are influenced by methionine metabolism, which may offer new strategies to improve MTX-based therapies... - The methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences overall survival of patients with glioblastoma multiformeMichael Linnebank
University Hospital Bonn, Department of Neurology, Bonn, Germany
Neuro Oncol 10:548-52. 2008..89, p = 0.015). These data suggest the MTHFR c.677C>T variant is a risk factor for survival in GBM patients... - Haplotype analysis of the 5,10-methylenetetrahydrofolate reductase (MTHFR) c.1298A>C (E429A) polymorphismAlexander Semmler
Department of Neurology, University Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland
BMC Res Notes 4:439. 2011..abstract:.. - S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's diseaseMichael Linnebank
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
Neurodegener Dis 7:373-8. 2010..Increased plasma homocysteine levels have been described as an independent risk factor for Alzheimer's disease (AD), but the underlying pathophysiology is unclear... - Antiepileptic drugs interact with folate and vitamin B12 serum levelsMichael Linnebank
Department of Neurology, University Hospital Zurich, Switzerland
Ann Neurol 69:352-9. 2011..Antiepileptic drugs (AEDs) are important for the treatment of epilepsy, psychiatric diseases, and pain syndromes. Small studies have suggested that AED treatment reduces serum levels of folate and vitamin B12... - Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient populationDelia Kurzwelly
Division of Clinical Neurooncology, Department of Neurology, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
J Neurooncol 100:187-92. 2010..Our results suggest the hypothesis that folate and methionine metabolism is relevant to susceptibility to PCNSL... - The G allele of transcobalamin 2 c.776C→G is associated with an unfavorable lipoprotein profileAlexander Semmler
Department of Neurology, University of Zurich, Frauenklinikstrasse 26, Zurich, Switzerland
Ann Nutr Metab 57:112-5. 2010.... - Polymorphisms of homocysteine metabolism are associated with intracranial aneurysmsAlexander Semmler
Department of Neurology, University of Bonn, Bonn, Germany
Cerebrovasc Dis 26:425-9. 2008..We analyzed the possible association of nine genetic variants of homocysteine metabolism with the occurrence of intracranial aneurysms... - Genetic variants of methionine metabolism and X-ALD phenotype generation: results of a new study sampleAlexander Semmler
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
J Neurol 256:1277-80. 2009..Whereas the influence of other polymorphisms of methionine metabolism was not confirmed, the present study supports the previously made observation that the Tc2 genotype contributes to X-ALD phenotype generation... 
The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiformeAlexander Semmler
Department of Neurology, University Hospital Bonn, Sigmund Freud Strasse, 25, 53105 Bonn, Germany
Cancer Epidemiol Biomarkers Prev 15:2314-6. 2006..72/0.26/0.02 and controls AA/AG/GG: 0.57/0.38/0.05, degrees of freedom = 2; chi(2) = 17.86 (Pearson); P < 0.001]. No association between glioblastoma multiforme and the two other polymorphisms was observed...- Polymorphisms of methionine metabolism and susceptibility to meningioma formation: laboratory investigationAlexander Semmler
Department of Neurology, University Hospital of Bonn, Germany
J Neurosurg 108:999-1004. 2008..The authors investigated the association of 7 functional polymorphisms of methionine metabolism with meningioma formation... - Plasma folate levels are associated with the lipoprotein profile: a retrospective database analysisAlexander Semmler
University Zurich, Department of Neurology, Switzerland
Nutr J 9:31. 2010..This cross-sectional pilot study aimed at analyzing whether blood levels of the two important cofactors of homocysteine metabolism, folate and vitamin B12, coincide with the lipoprotein profile... - The effect of MTHFR c.677C>T on plasma homocysteine levels depends on health, age and smokingAlexander Semmler
University Zurich, Department Neurology, 8091 Zurich, Switzerland
Clin Invest Med 32:E310. 2009..The aim of the present study was to examine whether the influence of MTHFR c.677C > T on homocysteine levels depends on individual factors... - Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysisKatrin Patrij
Center for Integrated Oncology, University of Bonn, Bonn, Germany
Ger Med Sci 9:Doc11. 2011.... - Common genetic coagulation variants are not associated with ischemic stroke in a case-control studySusanna Moskau
Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Neurol Res 32:519-22. 2010..Abnormalities in the coagulation pathway are often included in the diagnostic work-up of stroke patients, especially in young adults with cryptogenic stroke... - Methionine metabolism in an animal model of sepsisAlexander Semmler
Neurology Department, University Hospital Zurich, Zurich, Switzerland
Clin Chem Lab Med 46:1398-402. 2008..The degradation product and antagonist of SAM is S-adenosylhomocysteine (SAH). In this study, we investigated changes in methionine metabolism in a rodent model of sepsis... - Hyperhomocysteinemia in Alzheimer's disease: the hen and the egg?Melinda Farkas
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
J Alzheimers Dis 33:1097-104. 2013..e., represent both a cause and a consequence of neurodegeneration. Such a vicious cycle may be breakable by dietary or supplementation strategies increasing the availability of 5-MTHF... - Alterations of homocysteine serum levels during alcohol withdrawal are influenced by folate and riboflavin: results from the German Investigation on Neurobiology in Alcoholism (GINA)Peter Heese
Department of Addiction and Psychotherapy, LVR Clinic Bonn, Bonn, Germany
Alcohol Alcohol 47:497-500. 2012..Hyperhomocysteinemia has been associated not only with blood alcohol concentration (BAC), but also with deficiency of different B-vitamins, particularly folate, pyridoxine and cobalamin... - Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphomaAnnika Juergens
Department of Neurology, Knappschaftskrankenhaus, University of Bochum, Bochum, Germany
Ann Neurol 67:182-9. 2010..To evaluate long-term progression-free survival and overall survival, quality of life, and cognitive function in primary central nervous system lymphoma after systemic and intraventricular chemotherapy without radiotherapy... - The cystathionine beta-synthase variant c.844_845ins68 protects against CNS demyelination in X-linked adrenoleukodystrophyMichael Linnebank
University Hospital Bonn, Department of Neurology, Bonn, Germany
Hum Mutat 27:1063-4. 2006..Since methionine metabolism can easily be influenced by vitamin and amino acid substitution, this observation could be a basis of novel treatment strategies in this yet untreatable disease. (c) 2006 Wiley-Liss, Inc... - Homocysteine and carotid intima-media thickness in a german population: lack of clinical relevanceMichael Linnebank
Department of Neurology, University Hospital Bonn, Bonn, Germany
Stroke 37:2840-2. 2006..Common carotid artery intima-media thickness (CCA IMT) is a predictor of stroke. This study aimed to analyze whether homocysteine (Hcys) metabolism influences CCA IMT... - Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patientsDelia Kurzwelly
Clinical Neurooncology Unit, Department of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
J Neurooncol 90:53-5. 2008..No significant difference between these two groups was found using Pearson's chi(2) test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL... - Sustained efficacy of natalizumab in the treatment of relapsing-remitting multiple sclerosis independent of disease activity and disability at baseline: real-life data from a Swiss cohortUlf Kallweit
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
Clin Neuropharmacol 35:77-80. 2012..However, real-life longitudinal data, including years before baseline, are rare... - The thermolabile variant of 5,10-methylenetetrahydrofolate reductase is a possible risk factor for amyotrophic lateral sclerosisPeter Kühnlein
Department of Neurology, University of Ulm, Germany
Amyotroph Lateral Scler 12:136-9. 2011..594+59del19bp are involved in homocysteine metabolism. Homocysteine is neurotoxic and binds copper. Thus, the individual variability of homocysteine metabolism, e.g. due to genetic variants, may contribute to the vulnerability of ALS... - Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II studyHendrik Pels
Department of Neurology, Knappschaftskrankenhaus, University of Bochum, In der Schornau 23 25, Bochum, Germany
J Neurooncol 91:299-305. 2009..Here, the efficacy and toxicity of this regimen without intraventricular treatment was evaluated in PCNSL... - Adult index patient with Currarino syndrome due to a novel HLXB9 mutation, c.336dupG (p.P113fsX224), presenting with Hirschsprung's disease, cephalgia, and lumbodyniaAlexander Volk
Department of Neurology, University Bonn, Bonn, Germany
Birth Defects Res A Clin Mol Teratol 79:249-51. 2007..Mutations in the homeoboxHLXB9 gene have already been described in a subset of sacrococcygeal anomalies characterized by partial sacral agenesis... - Therapy of X-linked adrenoleukodystrophyAlexander Semmler
University Hospital Zurich, Department of Neurology, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
Expert Rev Neurother 8:1367-79. 2008.... - ACNU-based chemotherapy for recurrent glioma in the temozolomide eraCaroline Happold
Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Medical School, Tubingen, Germany
J Neurooncol 92:45-8. 2009..This study does not commend ACNU as a therapy of first choice for patients with recurrent glioblastomas pretreated with temozolomide... - An efficient method for fractionated whole rodent brain radiationAlexander Semmler
Department of Neurology, University Zurich, Switzerland
Neurol Res 35:355-9. 2013..We describe an efficient method to perform repetitive, fractionated whole brain radio therapy to the rat brain... - The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevityMichael Linnebank
Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Int J Mol Med 16:759-61. 2005..Separate analysis of female and male subjects revealed that the influence of the MTR genotype on male subjects became relevant at a younger age as opposed to female subjects suggesting a gender-dependent effect... - Familial occipital and nervus intermedius neuralgia in a Swiss familyFranz Riederer
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
J Headache Pain 11:335-8. 2010..This is suggestive of an X-linked dominant or an autosomal dominant mode of inheritance... - Progressive multifocal leukoencephalopathy with selective involvement of the pyramidal tractsAlexander Semmler
University Hospital Bonn, Dept. of Neurology, Bonn, Germany
Neurology 68:871. 2007 - Hereditary hyper-ACE-emia due to the Pro1199Leu mutation of somatic ACE as a potential pitfall in diagnosis: a first family outside EuropeAlexander Semmler
Department of Neurology, University Hospital Bonn, Bonn, Germany
Clin Chem Lab Med 44:1088-9. 2006..Benign autosomal-dominant hyper-ACE-emia should be considered for differential diagnosis of elevated ACE levels worldwide... - Homocysteine plasma levels in patients treated with antiepileptic drugs depend on folate and vitamin B12 serum levels, but not on genetic variants of homocysteine metabolismAlexander Semmler
Department of Neurology, University of Zurich, Switzerland
Clin Chem Lab Med 51:665-9. 2013..Here, we aimed to determine whether there is a pharmacogenetic interaction between folate, vitamin B12 and genetic variants and homocysteine plasma level in AED-treated patients... - Autoimmune myasthenia gravis after sternal fractureJens A Petersen
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
Case Rep Neurol 4:20-2. 2012..Speculatively, the damage of retrosternal thymic remnants due to a sternal fracture might have precipitated the condition or exacerbated subclinical disease... - Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cellsMichael Linnebank
Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, 53125 Bonn, Germany
Neurobiol Dis 23:725-30. 2006..The Cu(2+) chelating action of HCys and impairement of COX activity represent novel mechanisms of HCys neurotoxicity, which might be preventable by supplementation of Cu(2+)... - Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's diseaseAleksandar Rakovic
Department of Neurology, University of Lubeck, Lubeck, Germany
Mov Disord 24:429-33. 2009..7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD... - Sinus venous thrombosis: a differential diagnosis of postpartum headacheMaria Wittmann
Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
Arch Gynecol Obstet 285:93-7. 2012..This case highlights the difficulty of differential diagnosis of headache in the postnatal period in patients after EDA and stresses the necessity of considering alternative pathologies... - Lack of genetic dispositions to hyperhomocysteinemia in Alzheimer diseaseMichael Linnebank
Am J Med Genet A 131:101-2. 2004 - Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27 patients and a completed structure of the human ASL geneMichael Linnebank
Universitatsklinikum Munster, Klinik und Poliklinik fuer Kinderheilkunde, 48149 Munster, Germany
Hum Genet 111:350-9. 2002..346C-->T (6), c.1153C-->T (4). This study introduces a system for mutation analysis in the ASL gene, thereby elucidating the genetic background of ASL deficiency, which was found to be associated with considerable allelic heterogeneity... - The cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotypeMichael Linnebank
University Hospital Muenster, Dept Pediatrics, Muenster, Germany
Hum Mutat 24:352-3. 2004..862G>C (p.Ala288Pro) and c.1135C>T (p.Arg379Trp). In summary, the data of this study suggest that the CBS c.1224-2A>C allele confers vitamin B6 nonresponsiveness and that this mutant allele came from a common ancestor...