P Linder

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint A comprehensive web resource on RNA helicases from the baker's yeast Saccharomyces cerevisiae
    P Linder
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    Yeast 16:507-9. 2000
  2. ncbi request reprint The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis
    N Kyle Tanner
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    Mol Cell 11:127-38. 2003
  3. ncbi request reprint Molecular biology. The life of RNA with proteins
    Patrick Linder
    Department of Microbiology and Molecular Medecine, CMU, 1 rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Science 304:694-5. 2004
  4. pmc Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs
    Sanda Rocak
    Département de Microbiologie et Médecine Moléculaire, Centre Médical Universitaire 1, rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Nucleic Acids Res 33:999-1009. 2005
  5. ncbi request reprint From RNA helicases to RNPases
    P Linder
    Dept de Biochimie Médicale, Centre Medical Universitaire, 1 rue Michel Servet, CH1211 Genève, Switzerland
    Trends Biochem Sci 26:339-41. 2001
  6. ncbi request reprint mRNA export: travelling with DEAD box proteins
    P Linder
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
    Curr Biol 11:R961-3. 2001
  7. doi request reprint mRNA export: RNP remodeling by DEAD-box proteins
    Patrick Linder
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, CH 1211, Geneve 4, Switzerland
    Curr Biol 18:R297-9. 2008
  8. ncbi request reprint Yeast RNA helicases of the DEAD-box family involved in translation initiation
    Patrick Linder
    Departement de Biochimie Medicale, CMU, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    Biol Cell 95:157-67. 2003
  9. pmc Dead-box proteins: a family affair--active and passive players in RNP-remodeling
    Patrick Linder
    Department of Microbiology and Molecular Medicine, CMU 1, rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Nucleic Acids Res 34:4168-80. 2006
  10. ncbi request reprint Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa
    Patrick Linder
    Department of Microbiology and Molecular Medicine, Centre Medical Universitaire, University of Geneva, CH 1211 Geneve 4, Switzerland
    Cell 125:219-21. 2006

Collaborators

Detail Information

Publications37

  1. ncbi request reprint A comprehensive web resource on RNA helicases from the baker's yeast Saccharomyces cerevisiae
    P Linder
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    Yeast 16:507-9. 2000
    ..It includes descriptions of RNA helicases and their functions, links to sequence- and yeast-specific databases, an extensive list of references, and links to non-yeast helicase web resources...
  2. ncbi request reprint The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis
    N Kyle Tanner
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    Mol Cell 11:127-38. 2003
    ..These results are consistent with computer studies of the solved crystal structures...
  3. ncbi request reprint Molecular biology. The life of RNA with proteins
    Patrick Linder
    Department of Microbiology and Molecular Medecine, CMU, 1 rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Science 304:694-5. 2004
  4. pmc Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs
    Sanda Rocak
    Département de Microbiologie et Médecine Moléculaire, Centre Médical Universitaire 1, rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Nucleic Acids Res 33:999-1009. 2005
    ..Finally, rRNAs and poly(A) RNA serve as the best stimulators of the ATPase activity of Has1p among the tested RNAs...
  5. ncbi request reprint From RNA helicases to RNPases
    P Linder
    Dept de Biochimie Médicale, Centre Medical Universitaire, 1 rue Michel Servet, CH1211 Genève, Switzerland
    Trends Biochem Sci 26:339-41. 2001
    ..However, recent reports provide evidence indicating that these proteins might also be involved in the active disruption of RNA-protein interactions...
  6. ncbi request reprint mRNA export: travelling with DEAD box proteins
    P Linder
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
    Curr Biol 11:R961-3. 2001
    ....
  7. doi request reprint mRNA export: RNP remodeling by DEAD-box proteins
    Patrick Linder
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, CH 1211, Geneve 4, Switzerland
    Curr Biol 18:R297-9. 2008
    ..A recent study on Dbp5 shows, however, that its ADP-bound form may also perform an important function in displacing export factors from mRNA...
  8. ncbi request reprint Yeast RNA helicases of the DEAD-box family involved in translation initiation
    Patrick Linder
    Departement de Biochimie Medicale, CMU, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    Biol Cell 95:157-67. 2003
    ..We discuss here our present knowledge of the function of eIF4A and Ded1p, two DEAD-box proteins required for translation in eukaryotic cells...
  9. pmc Dead-box proteins: a family affair--active and passive players in RNP-remodeling
    Patrick Linder
    Department of Microbiology and Molecular Medicine, CMU 1, rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Nucleic Acids Res 34:4168-80. 2006
    ..Here, I shall give a general overview of the DEAD-box protein family...
  10. ncbi request reprint Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa
    Patrick Linder
    Department of Microbiology and Molecular Medicine, Centre Medical Universitaire, University of Geneva, CH 1211 Geneve 4, Switzerland
    Cell 125:219-21. 2006
    ..In this issue of Cell, Sengoku et al. (2006) solve the structure of the DEAD-box protein Vasa in the presence of RNA and a nonhydrolyzable ATP analog and provide important insights into how this family of helicases unwinds RNA...
  11. pmc The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae
    J De la Cruz
    Departement de Biochimie Medicale, CMU, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    Proc Natl Acad Sci U S A 94:5201-6. 1997
    ..cerevisiae...
  12. pmc Synthetic lethality with conditional dbp6 alleles identifies rsa1p, a nucleoplasmic protein involved in the assembly of 60S ribosomal subunits
    D Kressler
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    Mol Cell Biol 19:8633-45. 1999
    ..Finally, a hemagglutinin epitope-tagged Rsa1p localizes predominantly to the nucleoplasm. Together, these results point towards a function for Rsa1p in a late nucleoplasmic step of 60S-ribosomal-subunit assembly...
  13. pmc Dbp9p, a putative ATP-dependent RNA helicase involved in 60S-ribosomal-subunit biogenesis, functionally interacts with Dbp6p
    M C Daugeron
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, Switzerland
    RNA 7:1317-34. 2001
    ..Furthermore, Dbp6p and Dbp9p weakly interact in a yeast two-hybrid assay. Altogether, our findings indicate an intimate functional interaction between Dbp6p and Dbp9p during the process of 60S-ribosomal-subunit assembly...
  14. pmc Dbp6p is an essential putative ATP-dependent RNA helicase required for 60S-ribosomal-subunit assembly in Saccharomyces cerevisiae
    D Kressler
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, Geneva, Switzerland
    Mol Cell Biol 18:1855-65. 1998
    ..We propose that Dbp6p is required for the proper assembly of preribosomal particles during the biogenesis of 60S ribosomal subunits, probably by acting as an rRNA helicase...
  15. ncbi request reprint Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase
    I Iost
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, 1211 Geneva 4, Switzerland
    J Biol Chem 274:17677-83. 1999
    ..Finally, RNA binding measurements indicate that the presence of ATP, but not ADP, increases the affinity of Ded1p for duplex versus single-stranded RNA; we discuss how this differential effect might drive the unwinding reaction...
  16. pmc Dbp7p, a putative ATP-dependent RNA helicase from Saccharomyces cerevisiae, is required for 60S ribosomal subunit assembly
    M C Daugeron
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, Geneva, Switzerland
    RNA 4:566-81. 1998
    ..Finally, an HA epitope-tagged Dbp7 protein is localized in the nucleolus. We propose that Dbp7p is involved in the assembly of the pre-ribosomal particle during the biogenesis of the 60S ribosomal subunit...
  17. pmc Characterization and mutational analysis of yeast Dbp8p, a putative RNA helicase involved in ribosome biogenesis
    M C Daugeron
    Departement de Biochimie Medicale, CMU, 1 rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Nucleic Acids Res 29:1144-55. 2001
    ....
  18. pmc Spb4p, an essential putative RNA helicase, is required for a late step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae
    J De la Cruz
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, Geneva, Switzerland
    RNA 4:1268-81. 1998
    ..We propose that Spb4p is involved directly in a late and essential step during assembly of 60S ribosomal subunits, presumably by acting as an rRNA helicase...
  19. pmc Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3' end formation of 5.8S rRNA in Saccharomyces cerevisiae
    J De la Cruz
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, Switzerland
    EMBO J 17:1128-40. 1998
    ..We propose that Dob1p functions as a cofactor for the exosome complex that unwinds secondary structures in the pre-rRNA that otherwise block the progression of the 3'-->5' exonucleases...
  20. pmc Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae
    D Kressler
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
    Nucleic Acids Res 27:4598-608. 1999
    ..We propose that Spb1p is required for proper assembly of pre-ribosomal particles during the biogenesis of 60S ribosomal subunits...
  21. pmc Dbp10p, a putative RNA helicase from Saccharomyces cerevisiae, is required for ribosome biogenesis
    F Burger
    Departement de Biochimie Medicale, CMU, 1 rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Nucleic Acids Res 28:2315-23. 2000
    ..8S mature rRNAs, thus explaining the final deficit in 60S subunit and the formation of half-mer polysomes. Consistent with a direct role in ribosome biogenesis, Dbp10p was found to be located predominantly in the nucleolus...
  22. ncbi request reprint DExD/H box RNA helicases: from generic motors to specific dissociation functions
    N K Tanner
    , , rue Michel Servet, CH-1211 4, , Switzerland
    Mol Cell 8:251-62. 2001
    ..In this review, we discuss our current understanding of RNA helicases and their biological function...
  23. pmc Fal1p is an essential DEAD-box protein involved in 40S-ribosomal-subunit biogenesis in Saccharomyces cerevisiae
    D Kressler
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, Switzerland
    Mol Cell Biol 17:7283-94. 1997
    ..Consequently, depletion of Fal1p leads to decreased 18S rRNA levels and to an overall deficit in 40S ribosomal subunits. Together, these results implicate Fal1p in the 18S rRNA maturation pathway rather than in translation initiation...
  24. ncbi request reprint Leishmania infantum LeIF protein is an ATP-dependent RNA helicase and an eIF4A-like factor that inhibits translation in yeast
    Mourad Barhoumi
    Laboratoire d Epidémiologie et d Ecologie Parasitaire, Institut Pasteur de Tunis, Tunisia
    FEBS J 273:5086-100. 2006
    ..Furthermore, the 25 amino terminal residues were shown to enhance the ability of LeIF to interfere with the translation machinery in yeast...
  25. ncbi request reprint Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells
    Loic De Filippi
    Département de Microbiologie et Médecine Moléculaire, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Curr Genet 52:171-85. 2007
    ....
  26. ncbi request reprint Unwinding single RNA molecules using helicases involved in eukaryotic translation initiation
    Steven Marsden
    Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK
    J Mol Biol 361:327-35. 2006
    ..These single molecule experiments indicate that Ded1 is likely to act as the more potent unwinding factor on natural mRNA substrates...
  27. ncbi request reprint The DEAD-box protein family of RNA helicases
    Olivier Cordin
    Département de Microbiologie et Médecine Moléculaire, Centre Medical Universitaire, 1 rue Michel Servet, 1211, Geneve 4, Switzerland
    Gene 367:17-37. 2006
    ..This review will focus on the description of the molecular characteristics of members of the DEAD-box protein family and on the enzymatic activities they possess...
  28. pmc A conserved phenylalanine of motif IV in superfamily 2 helicases is required for cooperative, ATP-dependent binding of RNA substrates in DEAD-box proteins
    Josette Banroques
    Départmente de Microbiologie et Médecine Moléculaire, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Mol Cell Biol 28:3359-71. 2008
    ....
  29. ncbi request reprint Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing
    Viviana Volta
    Molecular Histology and Cell Growth, DiBiT HSR, 20132 Milan, Italy
    Biochem Biophys Res Commun 337:89-94. 2005
    ..Finally, we confirm that Tif6p accompanies 27S pre-rRNA maturation to 25S rRNA and we suggest that Sen34p endonuclease in Tif6p complex may affect also rRNA maturation...
  30. pmc Crystal structure of the human ATP-dependent splicing and export factor UAP56
    Hang Shi
    W M Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 101:17628-33. 2004
    ..The detailed structural information provides important mechanistic insights into the splicing function of UAP56/Sub2. The structures also will be useful for the analysis of other spliceosomal DExD-box ATPases/helicases...
  31. ncbi request reprint Belle is a Drosophila DEAD-box protein required for viability and in the germ line
    Oona Johnstone
    Department of Biology, McGill University, Montreal, Quebec, Canada H3A 1B1
    Dev Biol 277:92-101. 2005
    ..However, unlike Vas, Bel is not specifically enriched in embryonic pole cells. We conclude that the DEAD-box protein Bel has evolutionarily conserved roles in fertility and development...
  32. pmc The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activity
    Olivier Cordin
    Département Microbiologie et Médecine Moléculaire, Centre Medical Universitaire, Geneva, Switzerland
    EMBO J 23:2478-87. 2004
    ..We find that the Q motif not only regulates ATP binding and hydrolysis but also regulates the affinity of the protein for RNA substrates and ultimately the helicase activity...
  33. pmc The putative RNA helicase Dbp6p functionally interacts with Rpl3p, Nop8p and the novel trans-acting Factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces cerevisiae
    Jesus de la Cruz
    Departamento de Genetica, Facultad de Biologia, Universidad de Sevilla, E 41012 Sevilla, Spain
    Genetics 166:1687-99. 2004
    ..This extensive genetic analysis reveals that the rsa3 null mutant displays some specificity by being synthetically lethal with dbp6 alleles and by showing some synthetic enhancement with the nop8-101 and the rsa1 null allele...
  34. ncbi request reprint Has1p, a member of the DEAD-box family, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae
    Bertrand Emery
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Mol Microbiol 52:141-58. 2004
    ..Finally, sequence comparisons suggest that Has1p homologues exist in all eukaryotes, and we show that a has1 null strain can be fully complemented by the Candida albicans homologue...
  35. ncbi request reprint DEAD-box proteins: the driving forces behind RNA metabolism
    Sanda Rocak
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Nat Rev Mol Cell Biol 5:232-41. 2004
  36. ncbi request reprint A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae
    Olivier Deloche
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, CH 1211 Geneve 4, Switzerland
    Mol Cell 13:357-66. 2004
    ..Altogether, our results suggest that yeast cells not only evolved a transcriptional but also a translational control to assure efficient attenuation of protein synthesis when membranes are stressed...
  37. doi request reprint Impact of oleic acid (cis-9-octadecenoic acid) on bacterial viability and biofilm production in Staphylococcus aureus
    Ludwig Stenz
    Genomic Research Laboratory, Infectious Diseases Service, Geneva University Hospitals, Geneva 14, Switzerland
    FEMS Microbiol Lett 287:149-55. 2008
    ..Our results suggest a natural protective effect of oleic acid against primary adhesion...