Ning Li

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?
    Ning Li
    Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Oxid Med Cell Longev 2012:740849. 2012
  2. doi Role of mitochondria in beta-cell function and dysfunction
    Pierre Maechler
    Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, CH 1211 Geneva 4, Switzerland
    Adv Exp Med Biol 654:193-216. 2010
  3. pmc Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction
    Ning Li
    Department of Cell Physiology, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH 1211 Geneva 4, Switzerland
    J Biol Chem 284:23602-12. 2009
  4. doi Mitochondrial dysfunction in pancreatic β cells
    Sachin Supale
    Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1211 Geneva 4, Switzerland
    Trends Endocrinol Metab 23:477-87. 2012
  5. pmc NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion
    Ning Li
    Department of Cell Physiology and Metabolism, University of Geneva Medical Center, Geneva, Switzerland
    Diabetes 61:2842-50. 2012
  6. doi The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress
    Ning Li
    Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH 1211 Geneva 4, Switzerland
    Biochem Soc Trans 36:930-4. 2008
  7. pmc Changes in Mitochondrial Carriers Exhibit Stress-Specific Signatures in INS-1Eβ-Cells Exposed to Glucose Versus Fatty Acids
    Thierry Brun
    Department of Cell Physiology and Metabolism, University of Geneva, Medical Center, Geneva, Switzerland
    PLoS ONE 8:e82364. 2013

Detail Information

Publications7

  1. pmc Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?
    Ning Li
    Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Oxid Med Cell Longev 2012:740849. 2012
    ..When overexpressed in nonstressed naïve cells, UCP2 confers resistance to oxidative stress. Whether treatment with mitohormetic inducers is sufficient to restore or ameliorate secretory function of β cells remains to be determined...
  2. doi Role of mitochondria in beta-cell function and dysfunction
    Pierre Maechler
    Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, CH 1211 Geneva 4, Switzerland
    Adv Exp Med Biol 654:193-216. 2010
    ..Mitochondrial defects, such as mutations and reactive oxygen species production, are discussed in the context of beta-cell failure that may participate to the etiology of diabetes...
  3. pmc Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction
    Ning Li
    Department of Cell Physiology, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH 1211 Geneva 4, Switzerland
    J Biol Chem 284:23602-12. 2009
    ..In conclusion, one acute oxidative stress induces beta-cell dysfunction lasting over days, explained by persistent damages in mitochondrial components...
  4. doi Mitochondrial dysfunction in pancreatic β cells
    Sachin Supale
    Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, 1211 Geneva 4, Switzerland
    Trends Endocrinol Metab 23:477-87. 2012
    ..Better comprehension of the molecular mechanisms contributing to mitochondrial dysfunction will help drive the development of effective therapeutic approaches...
  5. pmc NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion
    Ning Li
    Department of Cell Physiology and Metabolism, University of Geneva Medical Center, Geneva, Switzerland
    Diabetes 61:2842-50. 2012
    ..Results also show reciprocal inhibition between the cAMP/PKA pathway and ROS...
  6. doi The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress
    Ning Li
    Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH 1211 Geneva 4, Switzerland
    Biochem Soc Trans 36:930-4. 2008
    ..The present review presents the current knowledge of lipotoxicity related to oxidative stress in the context of mitochondrial function in the beta-cell...
  7. pmc Changes in Mitochondrial Carriers Exhibit Stress-Specific Signatures in INS-1Eβ-Cells Exposed to Glucose Versus Fatty Acids
    Thierry Brun
    Department of Cell Physiology and Metabolism, University of Geneva, Medical Center, Geneva, Switzerland
    PLoS ONE 8:e82364. 2013
    ..Expression profiles of energy sensors and mitochondrial carriers were selectively modified by the different conditions, exhibiting stress-specific signatures. ..