Pascal Launois

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. doi request reprint Cutaneous leishmaniasis: progress towards a vaccine
    Pascal Launois
    WHO Immunology Research and Training Center, Department of Biochemistry, University of Lausanne, Chemin des Boveresses, 155, CH 1066 Epalinges, Switzerland
    Expert Rev Vaccines 7:1277-87. 2008
  2. ncbi request reprint Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major
    Pascal Launois
    WHO Immunology Research and Training Centre, Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Microbes Infect 9:1260-6. 2007
  3. ncbi request reprint LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major
    Alain Gumy
    World Health Organization Immunology Research and Training Centre, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 36:1465-73. 2006
  4. ncbi request reprint Leishmania major-specific B cells are necessary for Th2 cell development and susceptibility to L. major LV39 in BALB/c mice
    Catherine Ronet
    World Health Organization Immunology Research and Training Centre, University of Lausanne, Epalinges, Switzerland
    J Immunol 180:4825-35. 2008
  5. doi request reprint Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production
    Catherine Ronet
    World Health Organization Immunology Research and Training Center, University of Lausanne, Epalinges, Switzerland
    J Immunol 184:886-94. 2010
  6. doi request reprint An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection
    Cindy Allenbach
    WHO Immunology Research and Training Center, Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 38:720-31. 2008
  7. ncbi request reprint The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells
    Abraham Aseffa
    World Health Organization Immunology Research and Training Center, Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    J Immunol 169:3232-41. 2002
  8. ncbi request reprint Leishmania major induces distinct neutrophil phenotypes in mice that are resistant or susceptible to infection
    Mélanie Charmoy
    WHO Immunology Research and Training Center, Department of Biochemistry, Epalinges, Switzerland
    J Leukoc Biol 82:288-99. 2007
  9. ncbi request reprint Experimental cutaneous Leishmaniasis: a powerful model to study in vivo the mechanisms underlying genetic differences in Th subset differentiation
    Jacques Louis
    World Health Organization Immunology Research and Training Centre, Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Eur J Dermatol 12:316-8. 2002
  10. pmc Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice
    Mélanie Charmoy
    Department of Biochemistry, WHO Immunology Research and Training Center, University of Lausannne, Epalinges, Switzerland
    PLoS Pathog 6:e1000755. 2010

Collaborators

Detail Information

Publications22

  1. doi request reprint Cutaneous leishmaniasis: progress towards a vaccine
    Pascal Launois
    WHO Immunology Research and Training Center, Department of Biochemistry, University of Lausanne, Chemin des Boveresses, 155, CH 1066 Epalinges, Switzerland
    Expert Rev Vaccines 7:1277-87. 2008
    ..Finally, vaccination using dendritic cells was recently demonstrated as a possible tool for Leishmania vaccination...
  2. ncbi request reprint Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major
    Pascal Launois
    WHO Immunology Research and Training Centre, Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Microbes Infect 9:1260-6. 2007
    ..Stringently, the early IL-4 response to the H-2d (AA 156-173) or the H-2b (AA 293-305) epitopes occurred in V beta 4 V alpha 8 CD4+ T cells from either H-2d or H-2b susceptible mice, respectively...
  3. ncbi request reprint LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major
    Alain Gumy
    World Health Organization Immunology Research and Training Centre, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 36:1465-73. 2006
    ..Thus, in C57BL/6 mice, the inability of LACK-reactive CD4(+) T cells to express early IL-4 mRNA transcription, important for disease progression, appears due to an incapacity of these cells to produce IL-2...
  4. ncbi request reprint Leishmania major-specific B cells are necessary for Th2 cell development and susceptibility to L. major LV39 in BALB/c mice
    Catherine Ronet
    World Health Organization Immunology Research and Training Centre, University of Lausanne, Epalinges, Switzerland
    J Immunol 180:4825-35. 2008
    ..These data suggest that direct Ag presentation by specific B cells and not Ig effector functions is involved in susceptibility of BALB/c mice to infection with L. major LV39...
  5. doi request reprint Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production
    Catherine Ronet
    World Health Organization Immunology Research and Training Center, University of Lausanne, Epalinges, Switzerland
    J Immunol 184:886-94. 2010
    ..Altogether these results demonstrate that the IL-10 produced by regulatory CD1d+ CD5+ B cells in response to L. major is critical for Th2 cell development in BALB/c mice...
  6. doi request reprint An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection
    Cindy Allenbach
    WHO Immunology Research and Training Center, Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 38:720-31. 2008
    ..major, enabling the regulation of inflammation, and the optimal killing of Leishmania parasites at the site of infection...
  7. ncbi request reprint The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells
    Abraham Aseffa
    World Health Organization Immunology Research and Training Center, Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    J Immunol 169:3232-41. 2002
    ..These results demonstrate that CD4+CD25+ regulatory T cells play a role in regulating the early IL-4 mRNA and the subsequent development of a Th2 response in this model of infection...
  8. ncbi request reprint Leishmania major induces distinct neutrophil phenotypes in mice that are resistant or susceptible to infection
    Mélanie Charmoy
    WHO Immunology Research and Training Center, Department of Biochemistry, Epalinges, Switzerland
    J Leukoc Biol 82:288-99. 2007
    ..These distinct PMN phenotypes may thus influence the development of L. major-specific immune response...
  9. ncbi request reprint Experimental cutaneous Leishmaniasis: a powerful model to study in vivo the mechanisms underlying genetic differences in Th subset differentiation
    Jacques Louis
    World Health Organization Immunology Research and Training Centre, Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Eur J Dermatol 12:316-8. 2002
    ....
  10. pmc Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice
    Mélanie Charmoy
    Department of Biochemistry, WHO Immunology Research and Training Center, University of Lausannne, Epalinges, Switzerland
    PLoS Pathog 6:e1000755. 2010
    ..major, suggesting that the selective release of neutrophil-secreted chemokines may regulate the development of immune response to pathogens...
  11. ncbi request reprint The murine model of infection with Leishmania major and its importance for the deciphering of mechanisms underlying differences in Th cell differentiation in mice from different genetic backgrounds
    Alain Gumy
    World Health Organization Immunology Research and Training Centre, Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Int J Parasitol 34:433-44. 2004
    ....
  12. ncbi request reprint Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in non
    Pascal Launois
    World Health Organization Immunology Research and Training Center, Institute of Biochemistry, University of Lausanne, Lausanne, Switzerland
    J Immunol 168:4628-35. 2002
    ..Together these results suggest that a deficiency in mechanisms capable of down-regulating the early IL-4 response to L. major contributes to the exquisite susceptibility of BALB/c mice to L. major...
  13. doi request reprint A new function of the Fas-FasL pathway in macrophage activation
    Reza Chakour
    World Health Organization Immunology Research and Training Centre, University of Lausanne, Epalinges, Switzerland
    J Leukoc Biol 86:81-90. 2009
    ..major infection...
  14. ncbi request reprint Macrophages induce neutrophil apoptosis through membrane TNF, a process amplified by Leishmania major
    Cindy Allenbach
    World Health Organization WHO Immunology Research and Training Center, Department of Biochemistry, Epalinges, Switzerland
    J Immunol 176:6656-64. 2006
    ..Our results emphasize the importance of MPhi-induced neutrophil apoptosis, and membrane TNF in the early control of inflammation...
  15. pmc Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis
    Annette Ives
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Science 331:775-8. 2011
    ..Thus, LRV1 in the metastasizing parasites subverted the host immune response to Leishmania and promoted parasite persistence...
  16. pmc Does T Helper Differentiation Correlate with Resistance or Susceptibility to Infection with L. major? Some Insights From the Murine Model
    Fabienne Tacchini-Cottier
    Department of Biochemistry, WHO Immunology Research and Training Center, University of Lausanne Epalinges, Switzerland
    Front Immunol 3:32. 2012
    ..major inoculation, emphasizing recent advances in the field, such as the impact of different substrains of L. major on the pathogenesis of disease...
  17. ncbi request reprint IFN-gamma-producing CD45RA+CD8+ and IL-10-producing CD45RA-CD4+ T cells generated in response to LACK in naive subjects never exposed to Leishmania
    Eliane Bourreau
    Immunologie des Leishmanioses, Institut Pasteur de la Guyane Francaise, BP 6010, 97304 Cayenne, French Guiana
    Eur J Immunol 32:510-20. 2002
    ..While the IFN-gamma-producing cells are present among CD45RA+CD8+ T cells that are CD62L-CDR7- and CLA-, the LACK-reactive IL-10-producing cells are CD4+ T cells that are CD62L+CCR7- and CLA-...
  18. pmc Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis
    Herve Pascalis
    Immunologie des Leishmanioses, Institut Pasteur de le Guyane Française, Institut d Etudes Supérieures de la Guyane, Universite Antilles Guyane, Cayenne, French Guiana
    Infect Immun 71:2924-6. 2003
    ..The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species...
  19. pmc LACK-specific CD4(+) T cells that induce gamma interferon production in patients with localized cutaneous leishmaniasis during an early stage of infection
    Eliane Bourreau
    Immunologie des Leishmanioses Service d Epidémiologie, Institut Pasteur de Cayenne, 97306 Cayenne Cedex, France
    Infect Immun 70:3122-9. 2002
    ..These findings show that SLA and LACK induce both type 1 (IFN-gamma) and type 2 (IL-10 or IL-13) cell responses...
  20. pmc Differential production of systemic and intralesional gamma interferon and interleukin-10 in nodular and ulcerative forms of Buruli disease
    Ghislaine Prévot
    Immunologie des Leishmanies, Institut Pasteur de la Guyane, Cayenne, French Guyana
    Infect Immun 72:958-65. 2004
    ..ulcerans-specific IFN-gamma response in Buruli disease patients...
  21. ncbi request reprint American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the T-helper 1 cell response
    Pierre Delobel
    Department of Infectious and Tropical Diseases, Purpan University Hospital, Toulouse, France
    Clin Infect Dis 37:628-33. 2003
    ....
  22. ncbi request reprint Selective expression of the V beta 14 T cell receptor on Leishmania guyanensis--specific CD8+ T cells during human infection
    Amina Kariminia
    Immunologie des Leishmanioses, Institut Pasteur de la Guyane, Cayenne, French Guyana
    J Infect Dis 195:739-47. 2007
    ..During the infection, these cells migrate to the skin at the site of the parasitic infection. The role of these V beta 14 CD8(+) T cells in resistance to infection remains to be determined conclusively...