Tuuli Lappalainen

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc Epistatic selection between coding and regulatory variation in human evolution and disease
    Tuuli Lappalainen
    Department of Genetic Medicine and Development, University of Geneva Medical School, Switzerland
    Am J Hum Genet 89:459-63. 2011
  2. doi request reprint Identification and removal of low-complexity sites in allele-specific analysis of ChIP-seq data
    Sebastian M Waszak
    Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland, Department of Genetic Medicine and Development, University of Geneva Medical School, Institute of Genetics and Genomics in Geneva, University of Geneva, 1211, Geneva, Switzerland and Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1011, Lausanne, Switzerland
    Bioinformatics 30:165-71. 2014
  3. pmc Tissue-specific effects of genetic and epigenetic variation on gene regulation and splicing
    Maria Gutierrez-Arcelus
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland Institute of Genetics and Genomics in Geneva iGE3, Geneva, Switzerland Swiss Institute of Bioinformatics SIB, Geneva, Switzerland
    PLoS Genet 11:e1004958. 2015
  4. pmc Sex-biased genetic effects on gene regulation in humans
    Antigone S Dimas
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland
    Genome Res 22:2368-75. 2012
  5. pmc Rare and common regulatory variation in population-scale sequenced human genomes
    Stephen B Montgomery
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    PLoS Genet 7:e1002144. 2011
  6. pmc Passive and active DNA methylation and the interplay with genetic variation in gene regulation
    Maria Gutierrez-Arcelus
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland Institute of Genetics and Genomics in Geneva, Geneva, Switzerland corrected Swiss Institute of Bioinformatics, Geneva, Switzerland
    elife 2:e00523. 2013
  7. pmc Gene age predicts the strength of purifying selection acting on gene expression variation in humans
    Konstantin Y Popadin
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211 Geneva, Switzerland Institute of Genetics and Genomics in Geneva, 1211 Geneva, Switzerland Institute for Information Transmission Problems Kharkevich Institute, Russian Academy of Sciences, Moscow 127994, Russia Electronic address
    Am J Hum Genet 95:660-74. 2014
  8. pmc Transcriptome and genome sequencing uncovers functional variation in humans
    Tuuli Lappalainen
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
    Nature 501:506-11. 2013
  9. doi request reprint Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription
    Helena Kilpinen
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
    Science 342:744-7. 2013
  10. doi request reprint Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
    Alfonso Buil
    1 Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland 2 Institute of Genetics and Genomics in Geneva, University of Geneva, Geneva, Switzerland 3 Swiss Institute of Bioinformatics, Geneva, Switzerland
    Nat Genet 47:88-91. 2015

Collaborators

Detail Information

Publications10

  1. pmc Epistatic selection between coding and regulatory variation in human evolution and disease
    Tuuli Lappalainen
    Department of Genetic Medicine and Development, University of Geneva Medical School, Switzerland
    Am J Hum Genet 89:459-63. 2011
    ....
  2. doi request reprint Identification and removal of low-complexity sites in allele-specific analysis of ChIP-seq data
    Sebastian M Waszak
    Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland, Department of Genetic Medicine and Development, University of Geneva Medical School, Institute of Genetics and Genomics in Geneva, University of Geneva, 1211, Geneva, Switzerland and Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1011, Lausanne, Switzerland
    Bioinformatics 30:165-71. 2014
    ..However, although powerful, these technologies can also introduce unexpected artifacts...
  3. pmc Tissue-specific effects of genetic and epigenetic variation on gene regulation and splicing
    Maria Gutierrez-Arcelus
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland Institute of Genetics and Genomics in Geneva iGE3, Geneva, Switzerland Swiss Institute of Bioinformatics SIB, Geneva, Switzerland
    PLoS Genet 11:e1004958. 2015
    ..Furthermore, the details of how this tissue-specificity may vary across inter-relations of molecular traits, and where these are occurring, can yield further insights into gene regulation and cellular biology as a whole. ..
  4. pmc Sex-biased genetic effects on gene regulation in humans
    Antigone S Dimas
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland
    Genome Res 22:2368-75. 2012
    ..This study illustrates that sex provides important context that can modify the effects of functional genetic variants...
  5. pmc Rare and common regulatory variation in population-scale sequenced human genomes
    Stephen B Montgomery
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    PLoS Genet 7:e1002144. 2011
    ..Our results demonstrate that integration of genomic and RNA sequencing analyses allows for the joint assessment of genome sequence and genome function...
  6. pmc Passive and active DNA methylation and the interplay with genetic variation in gene regulation
    Maria Gutierrez-Arcelus
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland Institute of Genetics and Genomics in Geneva, Geneva, Switzerland corrected Swiss Institute of Bioinformatics, Geneva, Switzerland
    elife 2:e00523. 2013
    ..DOI:http://dx.doi.org/10.7554/eLife.00523.001...
  7. pmc Gene age predicts the strength of purifying selection acting on gene expression variation in humans
    Konstantin Y Popadin
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211 Geneva, Switzerland Institute of Genetics and Genomics in Geneva, 1211 Geneva, Switzerland Institute for Information Transmission Problems Kharkevich Institute, Russian Academy of Sciences, Moscow 127994, Russia Electronic address
    Am J Hum Genet 95:660-74. 2014
    ..In summary, we show that gene age shapes key gene properties during evolution and is therefore an important component of genome function. ..
  8. pmc Transcriptome and genome sequencing uncovers functional variation in humans
    Tuuli Lappalainen
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
    Nature 501:506-11. 2013
    ..Altogether, this study provides a deep understanding of the cellular mechanisms of transcriptome variation and of the landscape of functional variants in the human genome...
  9. doi request reprint Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription
    Helena Kilpinen
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
    Science 342:744-7. 2013
    ..Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event. ..
  10. doi request reprint Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
    Alfonso Buil
    1 Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland 2 Institute of Genetics and Genomics in Geneva, University of Geneva, Geneva, Switzerland 3 Swiss Institute of Bioinformatics, Geneva, Switzerland
    Nat Genet 47:88-91. 2015
    ....