P O Lang

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi [Early indicators of prolonged hospitalization of the elderly: pilot study at Strasbourg University Hospital]
    Pierre Olivier Lang
    Département de réhabilitation et gériatrie, hôpital des Trois Chêne, Hopitaux Universitaires de Geneve, Thonex Geneve, Suisse
    Presse Med 36:389-98. 2007
  2. pmc Influenza vaccination in the face of immune exhaustion: is herd immunity effective for protecting the elderly?
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, CH 1226 Thonex Geneva, Switzerland Translational Medicine Research Group, Cranfield Health, Cranfield University, Cranfield MK43 0AL, UK
    Influenza Res Treat 2011:419216. 2011
  3. pmc Aging adults and seasonal influenza: does the vitamin d status (h)arm the body?
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois Chêne, Chemin du Pont Bochet 3, CH 1226 Thonex Geneva, Switzerland
    J Aging Res 2012:806198. 2012
  4. doi Testosterone replacement therapy in reversing "andropause": what is the proof-of-principle?
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Geneva, Switzerland
    Rejuvenation Res 15:453-65. 2012
  5. pmc Reversing T cell immunosenescence: why, who, and how
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois Chêne, Chemin du Pont Bochet 3, CH 1226, Thonex, Geneva, Switzerland
    Age (Dordr) 35:609-20. 2013
  6. doi Interdisciplinary geriatric and psychiatric care reduces potentially inappropriate prescribing in the hospital: interventional study in 150 acutely ill elderly patients with mental and somatic comorbid conditions
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Geneva, Switzerland
    J Am Med Dir Assoc 13:406.e1-7. 2012
  7. pmc Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, University Hospitals and Medical School of Geneva, Geneva, Switzerland
    Clin Interv Aging 7:55-64. 2012
  8. doi Immunosenescence and herd immunity: with an ever-increasing aging population do we need to rethink vaccine schedules?
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois Chêne, Chemin du Pont Bochet 3, CH 1226 Thonex Geneva, Geneva, Switzerland
    Expert Rev Vaccines 11:167-76. 2012
  9. ncbi [Vaccination: a programme for the whole life]
    Pierre Olivier Lang
    Département de réhabilitation et gériatrie, hôpital des Trois Chêne, HUG
    Rev Med Suisse 6:2118-24. 2010
  10. doi Vaccine effectiveness in older individuals: what has been learned from the influenza-vaccine experience
    Pierre Olivier Lang
    Translational Medicine Group, Cranfield University, Cranfield, UK
    Ageing Res Rev 10:389-95. 2011

Detail Information

Publications37

  1. ncbi [Early indicators of prolonged hospitalization of the elderly: pilot study at Strasbourg University Hospital]
    Pierre Olivier Lang
    Département de réhabilitation et gériatrie, hôpital des Trois Chêne, Hopitaux Universitaires de Geneve, Thonex Geneve, Suisse
    Presse Med 36:389-98. 2007
    ..The aim of this study was to identify early indicators of prolonged hospital stays by elderly patients...
  2. pmc Influenza vaccination in the face of immune exhaustion: is herd immunity effective for protecting the elderly?
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, CH 1226 Thonex Geneva, Switzerland Translational Medicine Research Group, Cranfield Health, Cranfield University, Cranfield MK43 0AL, UK
    Influenza Res Treat 2011:419216. 2011
    ..Furthermore, consideration will be given to how herd immunity may provide an effective strategy in preventing the burden of seasonal influenza infection within the aged population...
  3. pmc Aging adults and seasonal influenza: does the vitamin d status (h)arm the body?
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois Chêne, Chemin du Pont Bochet 3, CH 1226 Thonex Geneva, Switzerland
    J Aging Res 2012:806198. 2012
    ....
  4. doi Testosterone replacement therapy in reversing "andropause": what is the proof-of-principle?
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Geneva, Switzerland
    Rejuvenation Res 15:453-65. 2012
    ..Considerations will be given both to clinical symptoms, biochemical and clinical diagnostic criteria, and to the risk-to-benefit ratio of reversing late-onset hypogonadism in aging and older men...
  5. pmc Reversing T cell immunosenescence: why, who, and how
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois Chêne, Chemin du Pont Bochet 3, CH 1226, Thonex, Geneva, Switzerland
    Age (Dordr) 35:609-20. 2013
    ....
  6. doi Interdisciplinary geriatric and psychiatric care reduces potentially inappropriate prescribing in the hospital: interventional study in 150 acutely ill elderly patients with mental and somatic comorbid conditions
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Geneva, Switzerland
    J Am Med Dir Assoc 13:406.e1-7. 2012
    ..Potentially inappropriate medications and prescription omissions (PO) are highly prevalent in older patients with mental comorbidities...
  7. pmc Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, University Hospitals and Medical School of Geneva, Geneva, Switzerland
    Clin Interv Aging 7:55-64. 2012
    ..Furthermore, consideration is given to strategies that should be adopted in order to optimize influenza vaccine effectiveness in the face of immune exhaustion...
  8. doi Immunosenescence and herd immunity: with an ever-increasing aging population do we need to rethink vaccine schedules?
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois Chêne, Chemin du Pont Bochet 3, CH 1226 Thonex Geneva, Geneva, Switzerland
    Expert Rev Vaccines 11:167-76. 2012
    ....
  9. ncbi [Vaccination: a programme for the whole life]
    Pierre Olivier Lang
    Département de réhabilitation et gériatrie, hôpital des Trois Chêne, HUG
    Rev Med Suisse 6:2118-24. 2010
    ....
  10. doi Vaccine effectiveness in older individuals: what has been learned from the influenza-vaccine experience
    Pierre Olivier Lang
    Translational Medicine Group, Cranfield University, Cranfield, UK
    Ageing Res Rev 10:389-95. 2011
    ..Finally this review concludes with possible strategies to improve the ability of the senescent immune system to respond to vaccination...
  11. doi Immunosenescence: Implications for vaccination programmes in adults
    Pierre Olivier Lang
    Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Geneva, Switzerland
    Maturitas 68:322-30. 2011
    ....
  12. doi [Adverse effects of the herd immunity or when childhood vaccination becomes deleterious for the epidemiology of infectious diseases in adults]
    Pierre Olivier Lang
    Département de réhabilitation et gériatrie, hôpital des Trois Chêne, Thonex Geneve, Suisse
    Geriatr Psychol Neuropsychiatr Vieil 9:11-9. 2011
    ....
  13. doi Real time-PCR assay estimating the naive T-cell pool in whole blood and dried blood spot samples: pilot study in young adults
    P O Lang
    Translational Medicine Research Group, Cranfield Health, Cranfield University, Cranfield, England, United Kingdom
    J Immunol Methods 369:133-40. 2011
    ..In this pilot study, we have compared the sj-TREC ratio we obtained with this novel method in whole blood and in DBS samples of 10 healthy volunteers with those obtained with the technique of reference and found that they are comparable...
  14. doi [Frailty: learnings from the SAFEs cohort study and future perspectives for the research]
    Pierre Olivier Lang
    Departement de Medecine Interne, réhabilitation et gériatrie, hôpitaux universitaires et faculté de médecine de Genève, Suisse
    Geriatr Psychol Neuropsychiatr Vieil 9:135-49. 2011
    ..Finally we give rise to the imperative necessity to detect frailty at a preclinical stage with the help of biological and more particularly inflammatory markers...
  15. ncbi [What do we learn from the SAFEs cohort to fit hospital care models for aged inpatient?]
    Pierre Olivier Lang
    Hopitaux Universitaires de Geneve, hôpital des Trois Chêne, Département de réhabilitation et gériatrie, 1226 Genève, Suisse
    Presse Med 39:1132-42. 2010
    ..Such health policy will have to target the care networks as a whole and lead to specific and adequate financing assistances...
  16. doi Potentially inappropriate prescribing including under-use amongst older patients with cognitive or psychiatric co-morbidities
    Pierre Olivier Lang
    Department of Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Geneva, Switzerland
    Age Ageing 39:373-81. 2010
    ..the study aimed to determine the prevalence of and risk factors for inappropriate prescribing (IP) and prescribing omission (PO) in elderly with mental co-morbidities...
  17. ncbi [STOPP-START: adaptation of a French language screening tool for detecting inappropriate prescriptions in older people]
    Pierre Olivier Lang
    Service de Geriatrie, Département de réhabilitation et gériatrie, hôpitaux universitaires et faculté de médecine de Genève, Suisse
    Can J Public Health 100:426-31. 2009
    ..An adaptation of the tool into French language is presented here...
  18. ncbi [Non-paraneoplastic limbic encephalitis revealed by anterograde amnesia]
    Pierre Olivier Lang
    Service de médecine interne et réadaptation, Département de réhabilitation et gériatrie, Hopitaux Universitaires de Geneve, hôpital des Trois Chêne, 3 chemin du Pont Bochet, CH 1226 Thônex Genève, Suisse
    Presse Med 37:775-82. 2008
    ..Limbic encephalitis is a syndrome, most commonly paraneoplastic, related to an often undiagnosed cancer of unpredictable prognosis. Neurological symptoms are progressive for a few weeks before stabilizing...
  19. doi [Serotonin syndrome as a result of escitalopram and cyclosporin combination in an 84-year-old woman]
    P O Lang
    Service de médecine interne et réadaptation, Département de réhabilitation et gériatrie, hôpital des Trois Chêne, Hopitaux Universitaires de Geneve, 3, chemin du Pont Bochet, 1226 Thonex, Suisse
    Rev Med Interne 29:583-6. 2008
    ..After the discontinuation of escitalopram, the patient's condition improved rapidly. This report is a reminder of the clinical and pharmacological features of the serotonin syndrome from a recent literature review...
  20. doi [Herpes zoster in old adults]
    Pierre Olivier Lang
    Département de réhabilitation et gériatrie, Faculté de médecine et Hôpitaux universitaires de Genève, CH 1226 Thônex Genève, Suisse
    Presse Med 38:571-83. 2009
    ..A recent advance in primary prevention is approval of a vaccine (Zostavax) to prevent herpes zoster and postherpetic neuralgia in subjects 60 years or older...
  21. ncbi [Launois-Bensaude syndrome (Madelung's disease)]
    Pierre Olivier Lang
    Service de médecine interne et réadaptation, Département de réhabilitation et gériatrie, hôpital des Trois Chêne, Hopitaux Universitaires de Geneve, CH 1226 Thônex Genève, Suisse
    Presse Med 37:732-3. 2008
  22. ncbi [Herpes zoster and post-herpetic neuralgia in older adults]
    P O Lang
    Département de réhabilitation et gériatrie, hôpital des Trois Chêne, Ch Pont Bochet 3, 1226 Thonex
    Rev Med Suisse 4:2398-402, 2404. 2008
    ..However, their application in old, frail, co-morbid and often poly-medicated patients have to be carefully considered as their use may be contraindicated. A specific vaccine is enable to reduce herpes zoster-related morbidity...
  23. ncbi You missed the 5th EUGMS Congress? All the things which you would have been able to learn!
    P O Lang
    Department of Rehabilitation and Geriatrics, hôpital des Trois Chêne, Chemin du Pont Bochet 3, Thonex Geneva, Switzerland
    J Nutr Health Aging 13:396-400. 2009
  24. doi Frailty syndrome: a transitional state in a dynamic process
    Pierre Olivier Lang
    Department of Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois Chêne, Geneva, Switzerland
    Gerontology 55:539-49. 2009
    ..We therefore provide an update of the physiopathology and clinical and biological characteristics of the frailty process and speculate on possible preventative approaches...
  25. ncbi Stop shingles in its tracks
    Pierre Olivier Lang
    University Hospitals and Medical School of Geneva, Thonex Geneva, Switzerland
    J Fam Pract 58:531-4. 2009
    ..Do not prescribe tricyclic antidepressants or corticosteroids in the acute phase of HZ...
  26. ncbi Early markers of prolonged hospital stay in demented inpatients: a multicentre and prospective study
    P O Lang
    Department of Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Geneva, Switzerland
    J Nutr Health Aging 14:141-7. 2010
    ..Dementia is a serious, chronic, and costly public health problem. Prior studies have described dementia as increasing length of hospital stay, but so far no explanations have been proposed...
  27. ncbi Loss of independence in Katz's ADL ability in connection with an acute hospitalization: early clinical markers in French older people
    Pierre Olivier Lang
    Department of Rehabilitation and Geriatrics, Hospital of Trois Chêne, University Hospitals of Geneva, Chemin du Pont Bochet 3, Thonex Geneve, 1226 Geneva, Switzerland
    Eur J Epidemiol 22:621-30. 2007
    ..The preservation of autonomy and the ability of elderly to carry out the basic activities of daily living, beyond the therapeutic care of any pathologies, appears as one of the main objectives of care during hospitalization...
  28. doi [Disabled elderly people waiting for institutionalization to a hospital ward: prospective study in the administrative district of Strasbourg (France)]
    P O Lang
    Service de médecine interne et réadaptation, Département de réhabilitation et gériatrie, hôpital des Trois Chêne, Hopitaux Universitaires de Geneve, 3, chemin du Pont Bochet, 1226 Thônex Genève, Switzerland
    Rev Epidemiol Sante Publique 56:87-95. 2008
    ..Our aim was to estimate the number of non-satisfied instutionalization requests for inpatients and to describe the strategies elaborated to compensate for the waiting time...
  29. ncbi Is obesity a marker of robustness in vulnerable hospitalized aged populations? Prospective, multicenter cohort study of 1 306 acutely ill patients
    P O Lang
    Pierre Olivier Lang, MD, MPH, PD, PhD Nescens Centre of Preventive Medicine, Clinic of Genolier, route du Muids, 3, CH 1272 Genolier, Switzerland, Phone 412236693 09 fax 4122 36693 49 E mail
    J Nutr Health Aging 18:66-74. 2014
    ..The "obesity paradox" is poorly understood in vulnerable older hospitalized populations...
  30. ncbi Rapid cognitive decline, one-year institutional admission and one-year mortality: analysis of the ability to predict and inter-tool agreement of four validated clinical frailty indexes in the SAFEs cohort
    M Drame
    University of Reims Champagne Ardenne, Faculty of Medicine, E A 3797, Reims, F 51092, France
    J Nutr Health Aging 15:699-705. 2011
    ....
  31. doi How important is vitamin D in preventing infections?
    P O Lang
    Nescens Centre of Preventive Medicine, Clinic of Genolier, route du Muids, 3, 1272 Genolier, Switzerland
    Osteoporos Int 24:1537-53. 2013
    ..Furthermore, we discuss how it may play a role in host resistance to common pathogens and how effective is its supplementation for treatment or prevention of infectious diseases in humans...
  32. pmc Tracing thymic output in older individuals
    W A Mitchell
    Department of Immunology, Imperial College, London Translational Medicine Group, Cranfield University, Beds, UK
    Clin Exp Immunol 161:497-503. 2010
    ..Our results provide information about the potential end-point for thymic output and suggest that sjTREC analysis may be a biomarker of effective ageing...
  33. doi Measuring the TREC ratio in dried blood spot samples: intra- and inter-filter paper cards reproducibility
    P O Lang
    Translational Medicine Research Group, Cranfield Health, Cranfield University, Cranfield, UK
    J Immunol Methods 389:1-8. 2013
    ..In conclusion we describe a fully automated procedure for extracting DNA and qPCR set up, which offers a high-precision, robust qPCR assay for the quantification of both TREC:T-cell ratio and TREC:PBMC from DBS samples...
  34. ncbi A respiratory monitoring device based on clavicular motion
    D G Pitts
    Telemedicine Unit, Translational Medicine Group, Cranfield Health, Cranfield University, Cranfield, Bedford MK43 0AL, UK
    Physiol Meas 34:N51-61. 2013
    ..With relatively basic signal conditioning and processing requirements, it could provide an ideal platform for a low-cost respiratory monitor. ..
  35. ncbi [Chronic obstructive pulmonary disease: risk and benefit of testosterone therapy]
    N Samaras
    Service de Geriatrie, Departement de Medecine Interne, rehabilitation et gériatrie HUG, 1226 Thônex Genève
    Rev Med Suisse 8:2224-7. 2012
    ..Future studies should better define appropriate dosage and treatment duration. In the meantime, testosterone should be administered to COPD patients with overt hypogonadism, or in multidisciplinary specialized programmes...
  36. ncbi [Delirium in old age. Difficulties in diagnosis]
    M Zarate-Lagunes
    Département de réhabilitation et gériatrie, hôpital des Trois Chêne, Ch Pont Bochet 3, 1226 Thonex
    Rev Med Suisse 4:2392-7. 2008
    ..Identification and treatment of the underlying cause of delirium is essential with a focus on non pharmacological approach. Antipsychotic agents are reserved for severe forms and where non pharmacological intervention fracases...
  37. doi Incidence and main factors associated with early unplanned hospital readmission among French medical inpatients aged 75 and over admitted through emergency units
    Isabelle Lanièce
    Clinic of Geriatric Medicine, Hopital Michallon, University Hospital of Grenoble, Grenoble, France
    Age Ageing 37:416-22. 2008
    ..While previous studies have identified risk factors of early readmission, geriatric syndromes, as markers of frailty have not been assessed as potential predictors...