Karl S Lang

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    J Clin Invest 116:2456-63. 2006
  2. ncbi Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
    Luisa Cervantes-Barragan
    Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
    Blood 109:1131-7. 2007
  3. doi Aggravation of viral hepatitis by platelet-derived serotonin
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzberstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 14:756-61. 2008
  4. ncbi Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology
    Karl S Lang
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 175:5524-31. 2005
  5. ncbi Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation
    Karl S Lang
    Institute of Experimental Immunology, Zurich, Switzerland
    Eur J Immunol 35:738-45. 2005
  6. ncbi Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland
    Nat Med 11:138-45. 2005
  7. ncbi MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus
    Karl S Lang
    Institutes of Experimental Immunology, Neuropathology and Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland
    Eur J Immunol 37:2434-40. 2007
  8. ncbi The role of the innate immune response in autoimmune disease
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Autoimmun 29:206-12. 2007
  9. ncbi Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses
    Katja Fink
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 36:2094-105. 2006
  10. ncbi Extralymphatic virus sanctuaries as a consequence of potent T-cell activation
    Mike Recher
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 13:1316-23. 2007

Detail Information

Publications32

  1. pmc Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    J Clin Invest 116:2456-63. 2006
    ..Thus, nonspecific activation of innate immunity can drastically enhance susceptibility to immune destruction of a solid organ...
  2. ncbi Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
    Luisa Cervantes-Barragan
    Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
    Blood 109:1131-7. 2007
    ..Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections...
  3. doi Aggravation of viral hepatitis by platelet-derived serotonin
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzberstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 14:756-61. 2008
    ..Thus, vasoactive serotonin supports virus persistence in the liver and aggravates virus-induced immunopathology...
  4. ncbi Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology
    Karl S Lang
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 175:5524-31. 2005
    ..These data underscore the in vivo efficacy and immunopathological "safety" of neutralizing antibodies...
  5. ncbi Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation
    Karl S Lang
    Institute of Experimental Immunology, Zurich, Switzerland
    Eur J Immunol 35:738-45. 2005
    ..Persistent antigen also suppressed IL-7Ralpha expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate...
  6. ncbi Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland
    Nat Med 11:138-45. 2005
    ..These data identify the 'inflammatory status' of the target organ as a separate and limiting factor determining the development of autoimmune disease...
  7. ncbi MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus
    Karl S Lang
    Institutes of Experimental Immunology, Neuropathology and Surgical Pathology, University Hospital of Zurich, Zurich, Switzerland
    Eur J Immunol 37:2434-40. 2007
    ..Susceptibility of myd88(-/-) mice correlated with impaired recruitment of immune cells to the site of infection. In the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis...
  8. ncbi The role of the innate immune response in autoimmune disease
    Karl S Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Autoimmun 29:206-12. 2007
    ..Here we review examples to illustrate how innate immune activation influences autoimmune disease and point to the implications for the treatment of human autoimmune disease...
  9. ncbi Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses
    Katja Fink
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 36:2094-105. 2006
    ..These findings indicate that IFN-alpha-mediated augmentation of specific B cell responses is a partially TLR7- and virus dose-dependent mechanism...
  10. ncbi Extralymphatic virus sanctuaries as a consequence of potent T-cell activation
    Mike Recher
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 13:1316-23. 2007
    ..Our results suggest that sanctuary-site formation depends both on organ anatomy and on the induction of different adaptive immune effector mechanisms. Boosting T-cell responses alone may not reduce virus persistence...
  11. doi Hematopoietic cell-derived interferon controls viral replication and virus-induced disease
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Blood 113:1045-52. 2009
    ..These data suggest that during systemic viral infection primarily hematopoietic cell-derived IFN-I controls viral replication and viral-induced disease...
  12. pmc Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
    Alexander A Navarini
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:15535-9. 2006
    ..The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease...
  13. pmc "Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses
    Karl S Lang
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 2:e1162. 2007
    ..Likewise, partial depletion of the CD4+ T cell compartment by using anti-CD4 antibodies enhanced protective antibodies...
  14. pmc Overexpression of lymphotoxin in T cells induces fulminant thymic involution
    Mathias Heikenwalder
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Am J Pathol 172:1555-70. 2008
    ....
  15. pmc Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors
    Max Löhning
    Institute of Experimental Immunology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Exp Med 205:53-61. 2008
    ..These findings demonstrate the efficiency of linear memory T cell differentiation and encourage the design of vaccines and immune cell therapies based on differentiated effector T cells...
  16. ncbi Deliberate removal of T cell help improves virus-neutralizing antibody production
    Mike Recher
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Immunol 5:934-42. 2004
    ..These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found...
  17. pmc Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus
    Bruno Eschli
    Institute of Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Virol 81:11650-7. 2007
    ..Second, affinity maturation of the available low-affinity non-neutralizing antibodies is impaired...
  18. doi Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Hepatology 52:25-32. 2010
    ..In the absence of Kupffer cells, hepatocytes were not able to suppress virus replication, even in the presence of IFN-I, leading to prolonged viral replication and severe T cell-dependent immunopathology...
  19. pmc Induced prion protein controls immune-activated retroviruses in the mouse spleen
    Marius Lötscher
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    PLoS ONE 2:e1158. 2007
    ..The interaction between PrP and ubiquitous endogenous retroviruses may allow new interpretations of TSE pathophysiology and explain the evolutionary conservation of PrP...
  20. pmc Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections
    Alexander A Navarini
    Institute for Experimental Immunology and Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:7107-12. 2009
    ..These data implicate systemic innate immune stimulation as a mechanism of bone marrow neutrophil exhaustion which negatively influences the outcome of bacterial infections...
  21. doi Long-lasting immunity by early infection of maternal-antibody-protected infants
    Alexander A Navarini
    Institute for Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 40:113-6. 2010
    ..This implies that both the absence of exposure to infection during early infancy or of effective vaccination renders the population highly susceptible to new or old re-emerging pathogens...
  22. ncbi Public, private and non-specific antibodies induced by non-cytopathic viral infections
    Mike Recher
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Curr Opin Microbiol 7:426-33. 2004
    ..These findings provide novel insights to aid our understanding of clinically relevant observations that are recorded following human infection with HIV, HCV and dengue viruses...
  23. pmc Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome
    Heiko Wurdak
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, CH 8093, Switzerland
    Genes Dev 19:530-5. 2005
    ..Thus, TGFbeta signal modulation in neural crest differentiation might play a crucial role in the etiology of DiGeorge syndrome...
  24. doi Erythropoietin requires endothelial nitric oxide synthase to counteract TNF-[alpha]-induced microcirculatory dysfunction in murine striated muscle
    Claudio Contaldo
    Division of Plastic and Reconstructive Surgery, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Shock 35:315-21. 2011
    ..We conclude that EPO treatment elicits protection against TNF-[alpha]-induced microcirculatory dysfunction, depending on NO derived from endothelial cells, but not on the inducible isoform...
  25. pmc Antigen kinetics determines immune reactivity
    Pål Johansen
    Unit Experimental Immunotherapy, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:5189-94. 2008
    ..In conclusion, stimulation kinetics per se was shown to be a separate parameter of immunogenicity. These findings warrant a revision of current immunization models and have implications for vaccine development and immunotherapy...
  26. ncbi Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma
    Lars M Ittner
    Laboratory for Orthopedic Research, Orthopedic University Hospital Balgrist, University of Zurich, Ch 8008 Zurich, Switzerland
    Clin Sci (Lond) 114:49-58. 2008
    ..The CLR transgenic mice used in the present study provide a model for acute angle-closure glaucoma...
  27. ncbi Enhanced programmed cell death of iron-deficient erythrocytes
    Daniela S Kempe
    Department of Physiology, University of Tubingen, Tubingen, Germany
    FASEB J 20:368-70. 2006
    ..Thus, the experiments reveal a novel mechanism triggered by iron deficiency, which presumably contributes to accelerated clearance of erythrocytes in iron deficiency anemia...
  28. ncbi Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte
    Stephan M Huber
    Departments of Physiology and Parasitology, Institute of Tropical Medicine, University of Tubingen, 72076 Germany
    J Biol Chem 279:41444-52. 2004
    ..In conclusion, activation of host ClC-2 channels participates in the altered permeability of Plasmodium-infected erythrocytes but is not required for intraerythrocytic parasite survival...
  29. ncbi Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl-
    Karl S Lang
    Physiologisches Institut, der Universität Tübingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Renal Physiol 286:F1046-53. 2004
    ..Whereas Cl(-) is effective through inhibition of the cation conductance, urea exerts its effect through inhibition of sphingomyelinase, thus blunting formation of ceramide...
  30. ncbi Cytotoxic activity of natural killer cells lacking killer-inhibitory receptors for self-HLA class I molecules against autologous hematopoietic stem cells in healthy individuals
    Roger Grau
    Department of Hematology, Children s University Hospital, Tuebingen, Germany
    Exp Mol Pathol 76:90-8. 2004
    ..Our findings demonstrate the presence of potentially autoreactive natural killer cells in otherwise healthy individuals...
  31. ncbi Inhibition of erythrocyte cation channels by erythropoietin
    Svetlana Myssina
    Department of Physiology, University of Tubingen, Germany
    J Am Soc Nephrol 14:2750-7. 2003
    ..The effect could prolong the erythrocyte lifespan and may contribute to the enhancement of the erythrocyte number during erythropoietin therapy in dialysis patients...
  32. ncbi Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency
    Karl S Lang
    Department of Physiology, University of Tuebingen, Germany
    Cell Physiol Biochem 12:365-72. 2002
    ..The accelerated apoptosis then contributes to the shortened life span of the defective erythrocytes...