Hans Peter Landolt

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi request reprint Functional EEG topography in sleep and waking: state-dependent and state-independent features
    Gilberte Tinguely
    Section of Psychopharmacology and Sleep Research, Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neuroimage 32:283-92. 2006
  2. ncbi request reprint Age-dependent changes in sleep EEG topography
    H P Landolt
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Clin Neurophysiol 112:369-77. 2001
  3. ncbi request reprint Sleep and sleep electroencephalogram in depressed patients treated with phenelzine
    H P Landolt
    University of California at San Diego, Mental Health Clinical Research Center, Psychiatry Service 116 A, VAMC, 3350 La Jolla Village Dr, San Diego, CA 92161
    Arch Gen Psychiatry 58:268-76. 2001
  4. ncbi request reprint Effect of chronic phenelzine treatment on REM sleep: report of three patients
    H P Landolt
    University of California at San Diego, Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA
    Neuropsychopharmacology 25:S63-7. 2001
  5. ncbi request reprint Different effects of phenelzine treatment on EEG topography in waking and sleep in depressed patients
    Hans Peter Landolt
    University of California at San Diego, Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA
    Neuropsychopharmacology 27:462-9. 2002
  6. ncbi request reprint Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep
    Hans Peter Landolt
    Department of Psychiatry, University of California at San Diego, VA San Diego Healthcare System, San Diego, CA, USA
    J Sleep Res 12:13-8. 2003
  7. ncbi request reprint Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans
    Hans Peter Landolt
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Neuropsychopharmacology 29:1933-9. 2004
  8. ncbi request reprint Similar sleep EEG topography in middle-aged depressed patients and healthy controls
    Hans Peter Landolt
    University of California at San Diego, Department of Psychiatry, VA San Diego Healthcare System, San Diego, California, USA
    Sleep 28:239-47. 2005
  9. ncbi request reprint Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic activity
    Julia V Rétey
    Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland
    J Neurosci 26:10472-9. 2006
  10. pmc Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT
    Sereina Bodenmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Sleep 33:1027-35. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Functional EEG topography in sleep and waking: state-dependent and state-independent features
    Gilberte Tinguely
    Section of Psychopharmacology and Sleep Research, Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neuroimage 32:283-92. 2006
    ..The frequency-specific clustering of power maps suggests that distinct generators underlie EEG frequency bands. Although EEG power is modulated by state and sleep pressure, basic topographic features appear to be state-independent...
  2. ncbi request reprint Age-dependent changes in sleep EEG topography
    H P Landolt
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Clin Neurophysiol 112:369-77. 2001
    ..To assess age-related topographic changes in the sleep electroencephalogram (EEG)...
  3. ncbi request reprint Sleep and sleep electroencephalogram in depressed patients treated with phenelzine
    H P Landolt
    University of California at San Diego, Mental Health Clinical Research Center, Psychiatry Service 116 A, VAMC, 3350 La Jolla Village Dr, San Diego, CA 92161
    Arch Gen Psychiatry 58:268-76. 2001
    ..Use of the monoamine oxidase inhibitor phenelzine sulfate can eliminate REM sleep. We studied the relation between REM sleep suppression and antidepressant response and the effect of phenelzine therapy on sleep EEG power spectra...
  4. ncbi request reprint Effect of chronic phenelzine treatment on REM sleep: report of three patients
    H P Landolt
    University of California at San Diego, Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA
    Neuropsychopharmacology 25:S63-7. 2001
    ..06). This observation indicates that compensatory REM sleep mechanisms may occur in wakefulness during chronic MAOI treatment...
  5. ncbi request reprint Different effects of phenelzine treatment on EEG topography in waking and sleep in depressed patients
    Hans Peter Landolt
    University of California at San Diego, Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA
    Neuropsychopharmacology 27:462-9. 2002
    ..Rank correlation analyses revealed no association between the antidepressant treatment response and the changes in sleep and EEG power spectra during administration of phenelzine...
  6. ncbi request reprint Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep
    Hans Peter Landolt
    Department of Psychiatry, University of California at San Diego, VA San Diego Healthcare System, San Diego, CA, USA
    J Sleep Res 12:13-8. 2003
    ..It opens up a novel strategy for investigating the functions of REM sleep, and the roles of serotonin and REM sleep in the regulation of NREM sleep and mood...
  7. ncbi request reprint Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans
    Hans Peter Landolt
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Neuropsychopharmacology 29:1933-9. 2004
    ..These findings suggest that caffeine attenuated the build-up of sleep propensity associated with wakefulness, and support an important role of adenosine and adenosine receptors in the homeostatic regulation of sleep...
  8. ncbi request reprint Similar sleep EEG topography in middle-aged depressed patients and healthy controls
    Hans Peter Landolt
    University of California at San Diego, Department of Psychiatry, VA San Diego Healthcare System, San Diego, California, USA
    Sleep 28:239-47. 2005
    ..We aimed to test this hypothesis by assessing topographic changes in the sleep electroencephalogram associated with depression...
  9. ncbi request reprint Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic activity
    Julia V Rétey
    Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland
    J Neurosci 26:10472-9. 2006
    ..These findings suggest that adenosinergic mechanisms contribute to individual differences in waking-induced impairment of neurobehavioral performance and functional aspects of EEG topography associated with sleep deprivation...
  10. pmc Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT
    Sereina Bodenmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Sleep 33:1027-35. 2010
    ..Employing a novel sleep-pharmacogenetic approach, we investigated the interaction of modafinil with sleep deprivation to study dopaminergic mechanisms of sleep homeostasis...
  11. doi request reprint Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans
    Valérie Bachmann
    Institute of Pharmacology and Toxicology University of Zurich, Zurich, Switzerland
    Cereb Cortex 22:962-70. 2012
    ..5-12 Hz), sleepiness, fatigue, and α-amylase in saliva were enhanced. These convergent data demonstrate that genetic reduction of ADA activity elevates sleep pressure and plays a key role in sleep and waking quality in humans...
  12. ncbi request reprint Pulsed radio frequency radiation affects cognitive performance and the waking electroencephalogram
    Sabine J Regel
    University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland
    Neuroreport 18:803-7. 2007
    ..No effects were observed for continuous-wave radio frequency electromagnetic fields. These findings provide further evidence for a nonthermal biological effect of pulsed radio frequency electromagnetic fields...
  13. ncbi request reprint Age-related changes in the time course of vigilant attention during 40 hours without sleep in men
    Martin Adam
    Institute of Pharmacology and Toxicology and Center for Integrative Human Physiology CIHP, University of Zurich, Switzerland
    Sleep 29:55-7. 2006
    ..To examine whether vigilant attention and sleepiness develop differently during prolonged wakefulness in young and older men...
  14. pmc The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity
    Valérie Bachmann
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Sleep 35:335-44. 2012
    ..We investigated whether this polymorphism contributes to the pronounced inter-individual variation in sleep slow wave activity (SWA) in humans...
  15. ncbi request reprint Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy
    Julie M Gottselig
    Section of Psychopharmacology and Sleep Research, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Sleep Res 15:31-40. 2006
    ..They support the conclusion that caffeine preserves simple aspects of cognitive performance during sleep deprivation, whereas caffeine may not prevent detrimental effects of sleep deprivation on some complex cognitive functions...
  16. ncbi request reprint Sleep inertia: performance changes after sleep, rest and active waking
    Gilberte Hofer-Tinguely
    Institute of Pharmacology and Toxicology, Section of Psychopharmacology and Sleep Research, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Brain Res Cogn Brain Res 22:323-31. 2005
    ..They highlight the importance of employing multiple control groups and various objective and subjective measures to assess sleep inertia...
  17. doi request reprint Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans
    Sebastian C Holst
    Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland, Institute of Medical Molecular Genetics, University of Zurich, CH 8952 Schlieren, Switzerland, Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland, and Neuroscience Center Zurich, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland
    J Neurosci 34:566-73. 2014
    ..Together, the data suggest that the dopamine transporter contributes to homeostatic sleep-wake regulation in humans. ..
  18. ncbi request reprint Pulsed radio-frequency electromagnetic fields: dose-dependent effects on sleep, the sleep EEG and cognitive performance
    Sabine J Regel
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Sleep Res 16:253-8. 2007
    ..In summary, this study reveals first indications of a dose-response relationship between EMF field intensity and its effects on brain physiology as demonstrated by changes in the sleep EEG and in cognitive performance...
  19. doi request reprint Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults
    Amandine Valomon
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Chronobiol Int 31:705-14. 2014
    ..The differential associations of DAT1 and COMT polymorphisms may reflect the distinct local expression of the encoded proteins in the brain. ..
  20. pmc Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans
    Oliver G Bosch
    Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zurich, 8032 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:19597-602. 2013
    ..These findings are consistent with resolution of dysfunctional brain network connectivity changes observed in depression and suggest changes in prefrontal connectivity with the DN as a brain mechanism of antidepressant therapy action. ..
  21. doi request reprint Sleep homeostasis: a role for adenosine in humans?
    Hans Peter Landolt
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Biochem Pharmacol 75:2070-9. 2008
    ....
  22. doi request reprint Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep
    Katharina Hefti
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Biol Psychiatry 73:161-8. 2013
    ..We hypothesized that prolonged wakefulness would increase mGluR5 availability in human brain...
  23. doi request reprint Asymmetric prefrontal cortex functions predict asymmetries in number space
    Valérie Bachmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Brain Cogn 74:306-11. 2010
    ..Random number generation may be a helpful method to further explore these associations uncontaminated by the asymmetric involvement of response effectors...
  24. doi request reprint Genetic determination of sleep EEG profiles in healthy humans
    Hans Peter Landolt
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Prog Brain Res 193:51-61. 2011
    ..It is concluded that the search for genetic contributions to slow sleep EEG oscillations constitutes a promising avenue to identify molecular mechanisms underlying sleep-wake regulation in humans...
  25. ncbi request reprint Genotype-dependent differences in sleep, vigilance, and response to stimulants
    Hans Peter Landolt
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Curr Pharm Des 14:3396-407. 2008
    ..They disclose molecular mechanisms contributing to normal sleep-wake regulation in humans, and have potentially important implications for the neurobiology of sleep-wake disorders and their pharmacological treatment...
  26. ncbi request reprint A case-control field study on the relationships among type 2 diabetes, sleepiness and habitual caffeine intake
    Emily Urry
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zurich Center for Interdisciplinary Sleep Research, University of Zurich, Zurich, Switzerland Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
    J Psychopharmacol . 2016
    ..The purpose of this study was to examine the possible links between type 2 diabetes, daytime sleepiness, sleep quality and caffeine consumption...
  27. pmc Reduced neurobehavioral impairment from sleep deprivation in older adults: contribution of adenosinergic mechanisms
    Hans Peter Landolt
    Institute of Pharmacology and Toxicology, University of Zurich Zurich, Switzerland
    Front Neurol 3:62. 2012
    ..Based upon this evidence, we propose that age-related differences in A(2A) receptor-mediated signal transduction could be involved in age-related changes in the vulnerability to acute sleep deprivation...
  28. doi request reprint The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men
    Sereina Bodenmann
    Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland
    J Neurosci 29:10855-62. 2009
    ....
  29. pmc Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation
    Ramin Khatami
    Department of Neurology, University Hospital Zurich, Switzerland
    Sleep 31:859-67. 2008
    ..To test this hypothesis, we investigated the effect of physiologically intensified NREMS in recovery sleep following sleep deprivation...
  30. pmc Insufficient non-REM sleep intensity in narcolepsy-cataplexy
    Ramin Khatami
    Department ofNeurology, University Hospital Zurich, Switzerland
    Sleep 30:980-9. 2007
    ..Only 3 studies have addressed changes in homeostatic sleep regulation as a possible mechanism underlying nocturnal sleep fragmentation in narcolepsy-cataplexy...