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Genomes and GenesSpecies | Ruth LandauSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Pharmacogenetics and obstetric anesthesiaRuth Landau
Service d anesthésiologie, Département APSI, Hopitaux Universitaires de Geneve, Rue Micheli du Crest 24, Geneve 14, Switzerland
Anesthesiol Clin 26:183-95, viii-ix. 2008....
Combined spinal-epidural analgesia for labor: breakthrough or unjustified invasion?Ruth Landau
Département d Anesthésiologie, Pharmacologie et Soins Intensifs de Chirurgie, Hĵpitaux Universitaires de Genève, Suisse
Semin Perinatol 26:109-21. 2002....
[Recent data on the physiopathology of preeclampsia and recommendations for treatment]R Landau
Service d anesthésiologie, Departement APSIC, HUG, 1211 Geneve 4
Rev Med Suisse 1:290, 292-5. 2005..Preeclampsia has been named the "disease of theories" and remains to date a challenging enigma for the scientific community...
Arg16 homozygosity of the beta2-adrenergic receptor improves the outcome after beta2-agonist tocolysis for preterm laborRuth Landau
Division of Anesthesiology and Department of Obstetrics and Gynecology, University Hospital of Geneva, University of Geneva Medical School, Geneva, Switzerland
Clin Pharmacol Ther 78:656-63. 2005..We have demonstrated that homozygosity for Arg16 protects against preterm delivery. Our goal was to determine whether beta(2)-agonists are more effective in women with the Arg16 genotype and preterm labor...
Sequential combined spinal-epidural anesthesia for cesarean section in a woman with a double-outlet right ventricleR Landau
Division d Anesthésiologie, Departement APSIC, Hopitaux Universitaires de Geneve, Geneva, Switzerland
Acta Anaesthesiol Scand 48:922-6. 2004....
[Initial training in obstetric anaesthesia]R Landau
Service d anesthésiologie, Hopitaux Universitaires de Geneve, Geneve, Suisse
Ann Fr Anesth Reanim 25:589-92. 2006..The physiology of pregnancy and the physiopathology of pregnancy-related disorders justify a thorough and rigorous teaching in order to reduce both maternal and neonatal morbidity and mortality...
Women need to be told ALL the risks before regional techniques are performedRuth Landau
Chef de Clinique Scientifique, , , Switzerland
Int J Obstet Anesth 15:301-3. 2006
Pharmacogenetics and obstetric anesthesiaRuth Landau
Department APSI, University Hospital of Geneva Geneva, Switzerland
Int Anesthesiol Clin 45:1-15. 2007
Spinal anesthesia for cesarean delivery in a woman with a surgically corrected type I Arnold Chiari malformationRuth Landau
Division d Anesthésiologie, Département d Anesthésiologie, Pharmacologie et Soins Intensifs de Chirurgie APSIC, Hopitaux Universitaires de Geneve, Suisse
Anesth Analg 97:253-5, table of contents. 2003....
Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring womenRuth Landau
Department of Anesthesia, University Hospital of Geneva, Geneva, Switzerland
Pain 139:5-14. 2008..These findings for intrathecal fentanyl pharmacogenetics may have implications for patients receiving opioids in other settings...
The dose-sparing effect of clonidine added to ropivacaine for labor epidural analgesiaRuth Landau
Division d Anesthésiologie, Département d Anesthésiologie, Pharmacologie et Soins Intensifs de Chirurgie APSIC, Hopitaux Universitaires de Geneve HUG, Rue Micheli du Crest 12, 1211 Geneva 14, Switzerland
Anesth Analg 95:728-34, table of contents. 2002..Clonidine increased analgesia duration and produced dose sparing compared with ropivacaine alone. Despite a tendency for hypotension in women receiving clonidine, there was no apparent effect on delivery mode or neonatal outcome...
[Genetic polymorphisms and opioid therapies]Ruth Landau
Service d anesthésiologie, Département APSI, Hopitaux Universitaires de Geneve, CH 1211 Geneve 14, Suisse, France
Presse Med 37:1415-22. 2008....
Pharmacogenetics: implications for obstetric anesthesiaRuth Landau
, , Geneva, Switzerland
Int J Obstet Anesth 14:316-23. 2005
Genetic variability of mu-opioid receptor in an obstetric populationRuth Landau
, , Pharmacology, and Surgical Intensive Care, , Geneva, Switzerland
Anesthesiology 100:1030-3. 2004
The digital pen and paper. Evaluation and acceptance of a new data acquisition device in clinical settingsC Despont-Gros
Service d Informatique Médicale, Hopitaux Universitaires de Geneve, Suisse
Methods Inf Med 44:359-68. 2005..To evaluate the efficiency and acceptance of digital pen and paper technology for real-time clinical data acquisition...
[Is preeclampsia a new cardiovascular and end-stage renal diseases risk marker?]G Martillotti
Départment de Gynécologie et Obstétrique, HUG, Geneve
Rev Med Suisse 5:1752-4, 1756-7. 2009..Women with early onset/severe preeclampsia, recurrent preeclampsia, or preeclampsia with onset as a multipara appear to be at highest risk of cardiovascular disease later in life, including during the premenopausal period...
GRP78 as a marker of pre-eclampsia: an exploratory studyA Laverriere
Laboratoire d Hormonologie, Department of Obstetrics and Gynaecology, Maternity, University of Geneva, 1211 Geneva 14, Switzerland
Mol Hum Reprod 15:569-74. 2009..004) and at term (P < 0.0001). Our findings suggest that circulating C-terminal GRP78 reflect the invasive properties of cells, and could be used as a predictive marker for pre-eclampsia early in pregnancy...
A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesiaAlex T Sia
Department of Women s Anaesthesia, KK Women s and Children s Hospital, 100 Bukit Timah Road, Singapore
Anesthesiology 109:520-6. 2008..The purpose of this study was to investigate whether this polymorphism contributes to the variability in response to morphine for postcesarean analgesia...
beta2-Adrenergic receptor genotype and preterm deliveryRuth Landau
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Am J Obstet Gynecol 187:1294-8. 2002..Our purpose was to determine whether the functional genetic polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) that result in changes in amino acid residues 16 and 27 are associated with preterm delivery...
Magnesium-induced vasodilation in the dorsal hand veinRuth Landau
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York, USA
BJOG 111:446-51. 2004..Studies of the effect of systemically administered therapeutic doses of magnesium on vascular reactivity in pre-eclampsia will be of interest...
No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsiaRuth Landau
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Am J Hypertens 17:391-4. 2004..Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene affect NO production and have been associated with hypertension and preeclampsia in a Japanese population...
One size does not fit all: genetic variability of mu-opioid receptor and postoperative morphine consumptionRuth Landau
Anesthesiology 105:235-7. 2006
beta2-adrenoceptor genotype affects vasopressor requirements during spinal anesthesia for cesarean deliveryRichard M Smiley
Clinical Anesthesiology, Department of Anesthesiology, Columbia University, New York, New York, USA
Anesthesiology 104:644-50. 2006..The goal of this study was to determine whether genetic variants of the beta2AR alter incidence of hypotension or the amount of vasopressor treatment required during spinal anesthesia for cesarean delivery...
Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivoVictor Dishy
Division of Clinical Pharmacology and General Clinical Research Center Division of General Internal Medicine, Department of Medicine and the Department of Biostatistics, Vanderbilt University Medical Center, Nashville TN, USA
Pharmacogenetics 14:517-22. 2004..Altered adrenergic vascular sensitivity may contribute to the decreased survival observed in patients with congestive heart failure carrying the Ile164 allele...
G-protein beta(3) subunit 825 C/T polymorphism is associated with weight gain during pregnancyVictor Dishy
Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville Tennessee 37232 6602, USA
Pharmacogenetics 13:241-2. 2003..006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy...
Alpha 1A-adrenergic receptor polymorphism and vascular responseGbenga G Sofowora
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Clin Pharmacol Ther 75:539-45. 2004..Variability in sensitivity to phenylephrine, an alpha(1A) adrenergic agonist, has a large genetic component. We examined the hypothesis that a common polymorphism of alpha(1A)-adrenergic receptor (Arg347Cys) affects in vivo response...
Disproportionate decrease in alpha- compared with beta-adrenergic sensitivity in the dorsal hand vein in pregnancy favors vasodilationRuth Landau
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY, USA
Circulation 106:1116-20. 2002..The greater decrease in alpha1 compared with beta2 response may contribute to the vasodilated state characteristic of human pregnancy...
Different platelet activation levels in non-pregnant, normotensive pregnant, pregnancy-induced hypertensive and pre-eclamptic women. A pilot study of flow cytometric analysisKrisztina Bagamery
Eur J Obstet Gynecol Reprod Biol 121:117-8. 2005
