Research Topics
| Paul Henri LambertSummaryAffiliation: University of Geneva Country: Switzerland Publications
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Detail Information
Publications
Intradermal vaccine delivery: will new delivery systems transform vaccine administration?Paul Henri Lambert
CMU, Centre of Vaccinology, Geneva 4, Switzerland
Vaccine 26:3197-208. 2008..New delivery systems currently in development facilitate convenient intradermal vaccination, unlocking the potential advantages of this delivery route, and potentially transforming vaccine delivery...
Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccinesNadine Schallert
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
Eur J Immunol 32:752-60. 2002....- Can successful vaccines teach us how to induce efficient protective immune responses?Paul Henri Lambert
Centre of Vaccinology, Department of Immunology Pathology, University of Geneva CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
Nat Med 11:S54-62. 2005.... - CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal miceMaria Pihlgren
Department of Pathology and Pediatrics, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
Vaccine 21:2492-9. 2003..In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool... - Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responsesMaria Pihlgren
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
Vaccine 23:329-35. 2004..Altogether, this identifies C3 as one of the factors limiting early life antibody response and emphasizes the potential interest of immunization strategies overcoming this limitation... - Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigensMaria Pihlgren
Department of Pathology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
J Immunol 170:2824-32. 2003..Thus, unresponsiveness to lymphoid-mediated signals at the level of neonatal FDC precursors delays FDC maturation and GC induction, thus limiting primary Ab-secreting cell responses to T-dependent Ags in early postnatal life... - Potential use of inflammation and early immunological event biomarkers in assessing vaccine safetyBeatris Mastelic
WHO Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Biologicals 41:115-24. 2013..More information on the conference output can be found on the IABS website, http://www.iabs.org/... - Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine responseClaire Anne Siegrist
Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Vaccine 23:615-22. 2004..This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity... - Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infectionMatthias Regner
WHO Collaborating Center for Vaccinology, Department of Pathology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Microbes Infect 6:666-75. 2004..Thus, the identification of hRSV antigen delivery systems with an age-appropriate adjuvanticity/reactogenicity balance may be feasible even in the vulnerable early-life period... - Mode of action of adjuvants: implications for vaccine safety and designBeatris Mastelic
WHO Center for Vaccinology and Neonatal Immunology, CMU, 1 rue Michel Servet, 1211 Geneva, 4, Switzerland
Biologicals 38:594-601. 2010..More information on the conference output can be found on the IABS website, http://www.iabs.org/... - New vaccines against tuberculosisPaul Henri Lambert
Centre of Vaccinology, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland University of Geneva, Switzerland
Clin Chest Med 30:811-26, x. 2009..This article discusses progress in the field and issues surrounding safety, reactogenicity, immunogenicity, and efficacy testing of new TB vaccines... - Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cellsArun T Kamath
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
Eur J Immunol 38:1247-56. 2008..Thus, potent protective IFN-gamma-producing responses may be elicited by the exquisite activation of a minute number of in vivo targeted DC... 
Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cellsElodie Belnoue
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Centre Medical Universitaire, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
J Virol 81:7338-50. 2007..Under these early life conditions, viral control and clearance are eventually achieved only through LCMV-specific B cells that contribute to protect infant mice from early death or chronic infection...- Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infantsArnaud Marchant
Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
J Infect Dis 193:1598-605. 2006..CONCLUSIONS: Genetic determinants control the early phase of the vaccine antibody response in Gambian infants, whereas environmental determinants predominantly influence antibody persistence and avidity maturation... - Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survivalMaria Pihlgren
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Geneva, Switzerland
J Immunol 176:165-72. 2006..Thus, early-life BM stromal cells fail to provide the molecular signals that support plasmablast survival and differentiation into surviving plasma cells... - Immunogenicity and protective efficacy of neonatal vaccination against Bordetella pertussis in a murine model: evidence for early control of pertussisCaroline Roduit
World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology and Pediatrics, University of Geneva, Geneva, Switzerland
Infect Immun 70:3521-8. 2002..pertussis challenge. Thus, neonatal priming with antipertussis vaccines should be considered to reduce the window of vulnerability to pertussis at the time of its greatest severity... - CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particlesXavier Martinez
W.H.O. Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
Virology 305:428-35. 2003.... - Influence of Mycobacterium bovis bacillus Calmette-Guérin on antibody and cytokine responses to human neonatal vaccinationMartin O C Ota
Medical Research Council Laboratories, Banjul, The Gambia
J Immunol 168:919-25. 2002..These results demonstrate that BCG influences the immune response to unrelated Ags in early life, likely through its influence on the maturation of dendritic cells... - Vaccine safety controversies and the future of vaccination programsGuido François
Viral Hepatitis Prevention Board, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, Department of Epidemiology and Social Medicine, University of Antwerpen, Antwerp, Belgium
Pediatr Infect Dis J 24:953-61. 2005.... - Vaccination and autoimmune disease: what is the evidence?David C Wraith
Department of Pathology and Microbiology, University of Bristol, Bristol, UK
Lancet 362:1659-66. 2003..Indeed there are numerous claims and counter claims relating to such a risk. Here we review the mechanisms involved in the induction of autoimmunity and assess the implications for vaccination in human beings... - A global perspective on vaccine safety and public health: the Global Advisory Committee on Vaccine SafetyPeter I Folb
Medical Research Council, PO Box 19070, Tygerberg 7505, Cape Town, South Africa
Am J Public Health 94:1926-31. 2004.... - Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheresMatthias Regner
World Health Organization Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
J Immunol 173:2669-74. 2004....