Paul Henri Lambert

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. doi Intradermal vaccine delivery: will new delivery systems transform vaccine administration?
    Paul Henri Lambert
    CMU, Centre of Vaccinology, Geneva 4, Switzerland
    Vaccine 26:3197-208. 2008
  2. ncbi Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines
    Nadine Schallert
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    Eur J Immunol 32:752-60. 2002
  3. ncbi Can successful vaccines teach us how to induce efficient protective immune responses?
    Paul Henri Lambert
    Centre of Vaccinology, Department of Immunology Pathology, University of Geneva CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Nat Med 11:S54-62. 2005
  4. ncbi CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice
    Maria Pihlgren
    Department of Pathology and Pediatrics, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 21:2492-9. 2003
  5. ncbi Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infection
    Matthias Regner
    WHO Collaborating Center for Vaccinology, Department of Pathology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Microbes Infect 6:666-75. 2004
  6. doi Potential use of inflammation and early immunological event biomarkers in assessing vaccine safety
    Beatris Mastelic
    WHO Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Biologicals 41:115-24. 2013
  7. ncbi Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigens
    Maria Pihlgren
    Department of Pathology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 170:2824-32. 2003
  8. ncbi Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responses
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 23:329-35. 2004
  9. ncbi New live mycobacterial vaccines: the Geneva consensus on essential steps towards clinical development
    Arun T Kamath
    Department of Pathology and Immunology, Center for Vaccinology and Neonatal Immunology, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Vaccine 23:3753-61. 2005
  10. ncbi Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response
    Claire Anne Siegrist
    Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 23:615-22. 2004

Collaborators

Detail Information

Publications23

  1. doi Intradermal vaccine delivery: will new delivery systems transform vaccine administration?
    Paul Henri Lambert
    CMU, Centre of Vaccinology, Geneva 4, Switzerland
    Vaccine 26:3197-208. 2008
    ..New delivery systems currently in development facilitate convenient intradermal vaccination, unlocking the potential advantages of this delivery route, and potentially transforming vaccine delivery...
  2. ncbi Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines
    Nadine Schallert
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    Eur J Immunol 32:752-60. 2002
    ....
  3. ncbi Can successful vaccines teach us how to induce efficient protective immune responses?
    Paul Henri Lambert
    Centre of Vaccinology, Department of Immunology Pathology, University of Geneva CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Nat Med 11:S54-62. 2005
    ....
  4. ncbi CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice
    Maria Pihlgren
    Department of Pathology and Pediatrics, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 21:2492-9. 2003
    ..In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool...
  5. ncbi Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infection
    Matthias Regner
    WHO Collaborating Center for Vaccinology, Department of Pathology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Microbes Infect 6:666-75. 2004
    ..Thus, the identification of hRSV antigen delivery systems with an age-appropriate adjuvanticity/reactogenicity balance may be feasible even in the vulnerable early-life period...
  6. doi Potential use of inflammation and early immunological event biomarkers in assessing vaccine safety
    Beatris Mastelic
    WHO Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Biologicals 41:115-24. 2013
    ..More information on the conference output can be found on the IABS website, http://www.iabs.org/...
  7. ncbi Unresponsiveness to lymphoid-mediated signals at the neonatal follicular dendritic cell precursor level contributes to delayed germinal center induction and limitations of neonatal antibody responses to T-dependent antigens
    Maria Pihlgren
    Department of Pathology, World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 170:2824-32. 2003
    ..Thus, unresponsiveness to lymphoid-mediated signals at the level of neonatal FDC precursors delays FDC maturation and GC induction, thus limiting primary Ab-secreting cell responses to T-dependent Ags in early postnatal life...
  8. ncbi Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responses
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, CMU, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    Vaccine 23:329-35. 2004
    ..Altogether, this identifies C3 as one of the factors limiting early life antibody response and emphasizes the potential interest of immunization strategies overcoming this limitation...
  9. ncbi New live mycobacterial vaccines: the Geneva consensus on essential steps towards clinical development
    Arun T Kamath
    Department of Pathology and Immunology, Center for Vaccinology and Neonatal Immunology, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Vaccine 23:3753-61. 2005
    ..The proposed criteria suggested in this consensus document may facilitate the movement of the most promising vaccine candidates to the clinic and towards control of tuberculosis...
  10. ncbi Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response
    Claire Anne Siegrist
    Department of Pediatrics, Center for Vaccinology and Neonatal Immunology, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Vaccine 23:615-22. 2004
    ..This is the first demonstration that a novel human adjuvant may induce antibodies with higher antigen-binding affinity...
  11. doi Mode of action of adjuvants: implications for vaccine safety and design
    Beatris Mastelic
    WHO Center for Vaccinology and Neonatal Immunology, CMU, 1 rue Michel Servet, 1211 Geneva, 4, Switzerland
    Biologicals 38:594-601. 2010
    ..More information on the conference output can be found on the IABS website, http://www.iabs.org/...
  12. doi New vaccines against tuberculosis
    Paul Henri Lambert
    Centre of Vaccinology, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland University of Geneva, Switzerland
    Clin Chest Med 30:811-26, x. 2009
    ..This article discusses progress in the field and issues surrounding safety, reactogenicity, immunogenicity, and efficacy testing of new TB vaccines...
  13. ncbi Influence of Mycobacterium bovis bacillus Calmette-Guérin on antibody and cytokine responses to human neonatal vaccination
    Martin O C Ota
    Medical Research Council Laboratories, Banjul, The Gambia
    J Immunol 168:919-25. 2002
    ..These results demonstrate that BCG influences the immune response to unrelated Ags in early life, likely through its influence on the maturation of dendritic cells...
  14. doi Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cells
    Arun T Kamath
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
    Eur J Immunol 38:1247-56. 2008
    ..Thus, potent protective IFN-gamma-producing responses may be elicited by the exquisite activation of a minute number of in vivo targeted DC...
  15. pmc Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells
    Elodie Belnoue
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Centre Medical Universitaire, Rue Michel Servet 1, 1211 Geneva 4, Switzerland
    J Virol 81:7338-50. 2007
    ..Under these early life conditions, viral control and clearance are eventually achieved only through LCMV-specific B cells that contribute to protect infant mice from early death or chronic infection...
  16. ncbi Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants
    Arnaud Marchant
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    J Infect Dis 193:1598-605. 2006
    ..We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses...
  17. ncbi Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival
    Maria Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 176:165-72. 2006
    ..Thus, early-life BM stromal cells fail to provide the molecular signals that support plasmablast survival and differentiation into surviving plasma cells...
  18. pmc Immunogenicity and protective efficacy of neonatal vaccination against Bordetella pertussis in a murine model: evidence for early control of pertussis
    Caroline Roduit
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology and Pediatrics, University of Geneva, Geneva, Switzerland
    Infect Immun 70:3521-8. 2002
    ..pertussis challenge. Thus, neonatal priming with antipertussis vaccines should be considered to reduce the window of vulnerability to pertussis at the time of its greatest severity...
  19. ncbi CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particles
    Xavier Martinez
    W H O Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
    Virology 305:428-35. 2003
    ....
  20. ncbi Vaccine safety controversies and the future of vaccination programs
    Guido François
    Viral Hepatitis Prevention Board, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, Department of Epidemiology and Social Medicine, University of Antwerpen, Antwerp, Belgium
    Pediatr Infect Dis J 24:953-61. 2005
    ....
  21. ncbi Vaccination and autoimmune disease: what is the evidence?
    David C Wraith
    Department of Pathology and Microbiology, University of Bristol, Bristol, UK
    Lancet 362:1659-66. 2003
    ..Indeed there are numerous claims and counter claims relating to such a risk. Here we review the mechanisms involved in the induction of autoimmunity and assess the implications for vaccination in human beings...
  22. ncbi Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheres
    Matthias Regner
    World Health Organization Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Geneva, Switzerland
    J Immunol 173:2669-74. 2004
    ....
  23. pmc A global perspective on vaccine safety and public health: the Global Advisory Committee on Vaccine Safety
    Peter I Folb
    Medical Research Council, PO Box 19070, Tygerberg 7505, Cape Town, South Africa
    Am J Public Health 94:1926-31. 2004
    ....