Affiliation: University of Lausanne
- Comparative modular analysis of gene expression in vertebrate organsBarbara Piasecka
Department of Ecology and Evolution, University of Lausanne, Biophore, CH 1005 Lausanne, Switzerland
BMC Genomics 13:124. 2012..Several recent studies reported some evidence in favor of such conservation. Most studies compute organs' similarity across all orthologous genes, whereas the expression level of many genes are not informative about organ specificity...
- S-system parameter estimation for noisy metabolic profiles using newton-flow analysisZ Kutalik
Department of Medical Genetics, University of Lausanne, Rue de Bugnon 27, Lausanne 1005, Switzerland
IET Syst Biol 1:174-80. 2007..We show that the performance of this method compares favorably with competing methods for ideal profiles, and that it also allows the determination of parameters for noisy profiles...
- Methods for testing association between uncertain genotypes and quantitative traitsZoltan Kutalik
Department of Medical Genetics, University of Lausanne, Rue du Bugnon 27, 1005 Lausanne, Switzerland
Biostatistics 12:1-17. 2011..5 M single nucleotide polymorphisms and 5000 individuals...
- Novel method to estimate the phenotypic variation explained by genome-wide association studies reveals large fraction of the missing heritabilityZoltan Kutalik
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
Genet Epidemiol 35:341-9. 2011..This methodology also enables us to predict the benefit of future GWA studies that aim to reveal more associated genetic markers via increased sample size...
- Genome-wide association study identifies two loci strongly affecting transferrin glycosylationZoltan Kutalik
Department of Medical Genetics, University of Lausanne, Lausanne, 1005, Switzerland
Hum Mol Genet 20:3710-7. 2011..8% of the variation in CDT%. These allelic effects are postulated to be caused by variation in availability of glucose-1-phosphate as a precursor of the glycan (PGM1), and variation in transferrin (TF) structure...