Robert Kralovics

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders
    Robert Kralovics
    Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland
    Blood Rev 19:1-13. 2005
  2. ncbi request reprint Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
    Robert Kralovics
    Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland
    Blood 108:1377-80. 2006
  3. ncbi request reprint Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2
    Robert Kralovics
    Experimental Hematology, Department of Research, Division of Clinical Hematology, Division of Pneumology, Basel University Hospital, Switzerland
    Blood 106:3374-6. 2005
  4. doi request reprint Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F
    Franz X Schaub
    Department of Biomedicine, Experimental Hematology, University Hospital Basel, Basel, Switzerland
    Blood 113:2022-7. 2009
  5. ncbi request reprint A gain-of-function mutation of JAK2 in myeloproliferative disorders
    Robert Kralovics
    Department of Research, Experimental Hematology, University Hospital Basel, Basel, Switzerland
    N Engl J Med 352:1779-90. 2005
  6. doi request reprint Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations
    Sai Li
    Department of Research, Experimental Hematology, University Hospital Basel, Switzerland
    Blood 111:3863-6. 2008
  7. doi request reprint A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family
    Kun Liu
    Department of Biomedicine, Experimental Hematology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland
    Haematologica 93:706-14. 2008
  8. ncbi request reprint Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders
    Robert Kralovics
    Department of Research, Experimental Hematology, Basel University Hospitals, Hebelstrasse 20, 4031 Basel, Switzerland
    Blood 102:1869-71. 2003
  9. ncbi request reprint Clonal hematopoiesis in familial polycythemia vera suggests the involvement of multiple mutational events in the early pathogenesis of the disease
    Robert Kralovics
    Department of Research, Experimental Hematology, Basel University Hospital, Switzerland
    Blood 102:3793-6. 2003
  10. ncbi request reprint Endemic polycythemia in Russia: mutation in the VHL gene
    Sonny O Ang
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Blood Cells Mol Dis 28:57-62. 2002

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders
    Robert Kralovics
    Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland
    Blood Rev 19:1-13. 2005
    ..Some of these families display clonal hematopoiesis and other features previously only found in sporadic MPD. Elucidating the molecular defect(s) in these pedigrees will likely be relevant for understanding sporadic MPD pathogenesis...
  2. ncbi request reprint Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
    Robert Kralovics
    Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland
    Blood 108:1377-80. 2006
    ..Our results suggest that in a proportion of patients with MPDs, JAK2-V617F occurs on the background of clonal hematopoiesis caused by a somatic mutation in an as-yet-unknown gene...
  3. ncbi request reprint Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2
    Robert Kralovics
    Experimental Hematology, Department of Research, Division of Clinical Hematology, Division of Pneumology, Basel University Hospital, Switzerland
    Blood 106:3374-6. 2005
    ....
  4. doi request reprint Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F
    Franz X Schaub
    Department of Biomedicine, Experimental Hematology, University Hospital Basel, Basel, Switzerland
    Blood 113:2022-7. 2009
    ..The fact that rare somatic events, such as del20q or 9pLOH, occurred more than once in subclones from the same patients suggests that the myeloproliferative disorder clone carries a predisposition to acquiring such genetic alterations...
  5. ncbi request reprint A gain-of-function mutation of JAK2 in myeloproliferative disorders
    Robert Kralovics
    Department of Research, Experimental Hematology, University Hospital Basel, Basel, Switzerland
    N Engl J Med 352:1779-90. 2005
    ..The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors a mutation that contributes to the cause of clonal expansion of hematopoietic cells in these diseases...
  6. doi request reprint Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations
    Sai Li
    Department of Research, Experimental Hematology, University Hospital Basel, Switzerland
    Blood 111:3863-6. 2008
    ..The finding of clonal heterogeneity is compatible with the hypothesis that additional clonal events are involved in the pathogenesis of PV...
  7. doi request reprint A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family
    Kun Liu
    Department of Biomedicine, Experimental Hematology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland
    Haematologica 93:706-14. 2008
    ..Germline mutations in families with hereditary thrombocythemia have been identified in the gene for thrombopoietin (TPHO) and its receptor, MPL...
  8. ncbi request reprint Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders
    Robert Kralovics
    Department of Research, Experimental Hematology, Basel University Hospitals, Hebelstrasse 20, 4031 Basel, Switzerland
    Blood 102:1869-71. 2003
    ..Thus, altered c-MPL and PRV-1 expression also can arise through a molecular mechanism different from sporadic MPD...
  9. ncbi request reprint Clonal hematopoiesis in familial polycythemia vera suggests the involvement of multiple mutational events in the early pathogenesis of the disease
    Robert Kralovics
    Department of Research, Experimental Hematology, Basel University Hospital, Switzerland
    Blood 102:3793-6. 2003
    ..This finding, together with clonal hematopoiesis in the affected individuals, supports the hypothesis of multiple genetic defects involved in the early pathogenesis of PV...
  10. ncbi request reprint Endemic polycythemia in Russia: mutation in the VHL gene
    Sonny O Ang
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Blood Cells Mol Dis 28:57-62. 2002
    ..These findings strongly suggest that CP is a congenital disorder of oxygen homeostasis...
  11. ncbi request reprint The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera
    Eric Lippert
    Laboratoire d Hématologie du CHU de Bourdeaux, France
    Blood 108:1865-7. 2006
    ..Moreover, allelic ratios higher than 50% JAK2-V617F, indicating the presence of granulocytes homozygous for JAK2-V617F, were found in 70% of PV at diagnosis but never in ET...
  12. ncbi request reprint Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders
    Daniela Pietra
    Department of Hematology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy
    Blood 111:1686-9. 2008
    ..Moreover, a genetic predisposition to acquisition of different JAK2 mutations is inherited in families with myeloproliferative disorders...
  13. ncbi request reprint Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera
    Robert Kralovics
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Exp Hematol 30:229-36. 2002
    ..Clonal stem cell proliferation and increased erythrocyte mass are hallmarks of the myeloproliferative disorder polycythemia vera (PV). The molecular basis of PV is unknown...