Research Topics
Species | J P KraehenbuhlSummaryAffiliation: University of Lausanne Country: Switzerland Publications
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Detail Information
Publications
Immunology. Keeping the gut microflora at bayJean-Pierre Kraehenbuhl
Swiss Institute for Experimental Cancer Research, CH1066 Epalinges, Switzerland
Science 303:1624-5. 2004- Epithelial M cells: differentiation and functionJ P Kraehenbuhl
Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
Annu Rev Cell Dev Biol 16:301-32. 2000..In addition it synthesizes the available information on development and differentiation of organized lymphoid tissues and the specialized epithelium associated with these immune inductive sites... - Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patchesN Debard
Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
Gastroenterology 120:1173-82. 2001..Second, we investigated the role of lymphotoxin alphabeta signaling on M-cell formation, given its pivotal role in the development of mouse Peyer's patches... 
Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cellsF Sierro
Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Proc Natl Acad Sci U S A 98:13722-7. 2001..Our data show that crosstalk between bacterial flagellin and epithelial cells is essential for the recruitment of DCs, a mechanism that could be instrumental to initiate adaptive immune responses in the gut...- Live attenuated Salmonella: a paradigm of mucosal vaccinesJ C Sirard
Swiss Institute for Experimental Cancer Research, University of Lausanne, Epalinges, Switzerland
Immunol Rev 171:5-26. 1999..typhi, with special emphasis on the molecular pathogenesis of S. typhimurium and the host response. We then discuss how such knowledge constitutes the basis for the rational design of novel live mucosal vaccines... - Human papillomavirus type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in miceD Nardelli-Haefliger
Department of Gynecology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Infect Immun 65:3328-36. 1997..Recombinant attenuated Salmonella expressing HPV capsids may represent a promising vaccine candidate against genital HPV infection... - Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunitsI E Corthesy-Theulaz
Department of Internal Medicine CHUV, and Institute of Pathology, Lausanne University, Switzerland
Infect Immun 66:581-6. 1998..Our data demonstrate that H. pylori urease delivered nasally by using a vaccine strain of S. typhimurium can trigger Th1- and Th2-type responses and induce protective immunity against Helicobacter infection... - Oral and rectal immunization of adult female volunteers with a recombinant attenuated Salmonella typhi vaccine strainD Nardelli-Haefliger
Department of Gynecology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Infect Immun 64:5219-24. 1996..Our data show for the first time that it is possible to induce specific sIgA in the genital and rectal tracts of women by using an S. typhi vaccine strain... - Adhesion of Helicobacter pylori to polarized T84 human intestinal cell monolayers is pH dependentI Corthesy-Theulaz
Division of Gastroenterology, Center Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Infect Immun 64:3827-32. 1996..These data provide the first evidence that an acidic environment favors Helicobacter adhesion and that binding is followed by survival of the survival of the bacteria in pockets of the apical membrane... - Nasal immunisation with Salmonella typhimurium producing rotavirus VP2 and VP6 antigens stimulates specific antibody response in serum and milk but fails to protect offspringA Coste
Swiss Institute for Experimental Cancer Research, CH 1066, Epalinges, Switzerland
Vaccine 19:4167-74. 2001..However, these antibodies failed to passively protect the offspring against rotavirus-induced diarrhoea... - Epithelial transcytosis of immunoglobulinsW Hunziker
Institute of Biochemistry, University of Lausanne, BIL Research Center, Epalinges, Switzerland
J Mammary Gland Biol Neoplasia 3:287-302. 1998.... - A pathogen-specific epitope inserted into recombinant secretory immunoglobulin A is immunogenic by the oral routeB Corthesy
Institut Suisse de Recherches Expérimentales sur le Cancer et Institut de Biochimie, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
J Biol Chem 271:33670-7. 1996..Thus, neo-antigenized sIgA can serve as a mucosal vaccine delivery system inducing systemic and mucosal immune responses... - Protection from radiation-induced colitis requires MHC class II antigen expression by cells of hemopoietic originS Marguerat
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
J Immunol 163:4033-40. 1999..Moreover, our data imply that tolerization to enteric Ags requires MHC class II mediated presentation by APC of hemopoietic origin... - Development of Peyer's patches, follicle-associated epithelium and M cell: lessons from immunodeficient and knockout miceN Debard
Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, Epalinges, CH 1066, Switzerland
Semin Immunol 11:183-91. 1999..The development of MALT, FAE and probably M cells is a multistep process that requires signalling pathways common to all secondary lymphoid tissues, but also MALT-specific factors... - Systemic antibodies can inhibit mouse mammary tumor virus-driven superantigen response in mucosa-associated lymphoid tissuesD Velin
Swiss Institute for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland
J Virol 73:1729-33. 1999..This result clearly demonstrates that systemic antibodies can gain access to Peyer's patches or NALT... - Primary structure and functional expression of the mouse and frog alpha-subunit of the gastric H(+)-K(+)-ATPaseP M Mathews
Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland
Am J Physiol 268:C1207-14. 1995..Furthermore, H(+)-K(+)-ATPase-expressing oocytes show a Sch-28080 inhibitable proton extrusion. Our data indicate that the expressed H(+)-K(+)-ATPase behaves functionally in oocytes as in the gastric gland... - Formation of Peyer's patchesD Finke
Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, CH 1066, Epalinges, Switzerland
Curr Opin Genet Dev 11:561-7. 2001..Recent data using knockout mice provide insight into the molecular nature of the signals that mediate Peyer's patch ontogeny. These include members of the tumor-necrosis factor family and homeostatic chemokines... - Primary structure of an apical protein from Xenopus laevis that participates in amiloride-sensitive sodium channel activityO Staub
Swiss Institute for Experimental Cancer Research, University of Lausanne, Epalinges
J Cell Biol 119:1497-506. 1992..It may represent a subunit of the Xenopus laevis sodium channel or a regulatory protein essential for sodium channel function... - How the gut senses its contentArnaud Didierlaurent
Swiss Institute for Experimental Cancer Research and the Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
Cell Microbiol 4:61-72. 2002 - Dendritic cells: the host Achille's heel for mucosal pathogens?Florence Niedergang
Membrane and Cytoskeleton Dynamics Laboratory, UMR144 CNRS, Institut Curie, F 75248 Paris, France
Trends Microbiol 12:79-88. 2004..These pathogens hijack the recruited DCs to enable them to infect the host, escape the host's defense mechanisms and establish niches at remote sites... - Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type responseArnaud Didierlaurent
Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
J Immunol 172:6922-30. 2004..In conclusion, this study suggests that flagellin and, more generally, TLR ligands can control Th2 responses in a MyD88-dependent manner... - Lymphotoxin beta receptor signaling induces the chemokine CCL20 in intestinal epitheliumMartin Rumbo
Swiss Institute for Experimental Cancer Research, Lausanne Branch, Epalinges, Switzerland
Gastroenterology 127:213-23. 2004..The aim of this work was to test whether lymphotoxin beta receptor signaling (LTbetaR), which plays a central role in PPs' organogenesis, mediates CCL20 gene expression in intestinal epithelial cells... - How the gut links innate and adaptive immunityMartin Rumbo
Swiss Institute for Experimental Cancer Research, CH-1066 Epalinges, Switzerland
Ann N Y Acad Sci 1029:16-21. 2004..Immune cells recruited in epithelial tissues can, in turn, act upon the epithelial cells and change their phenotype in a process referred to as epithelial metaplasia... - Novel markers of the human follicle-associated epithelium identified by genomic profiling and microdissectionPascale Anderle
Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Gastroenterology 129:321-7. 2005..Most of the CCL20 -coregulated genes did not show FAE-specific expression, suggesting that other signaling pathways are critical to modulate FAE-specific gene expression... - Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5Martin Rumbo
UNLP, Laboratorio de Investigaciones en el Sistema Inmune, Facultad de Ciencias Exactas, La Plata, Argentina
FEBS Lett 580:2976-84. 2006..Finally, the contribution of TLRs in the induction and maintenance of mucosal homeostasis and commensal discrimination is discussed... - Molecular and cellular basis of microflora-host interactionsPetra Winkler
Institute for Physiology and Biochemistry of Nutrition, Federal Research Center for Nutrition and Food, D 24103 Kiel, Germany
J Nutr 137:756S-72S. 2007....