J P Kraehenbuhl

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. ncbi request reprint Immunology. Keeping the gut microflora at bay
    Jean Pierre Kraehenbuhl
    Swiss Institute for Experimental Cancer Research, CH1066 Epalinges, Switzerland
    Science 303:1624-5. 2004
  2. ncbi request reprint Epithelial M cells: differentiation and function
    J P Kraehenbuhl
    Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Annu Rev Cell Dev Biol 16:301-32. 2000
  3. ncbi request reprint Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches
    N Debard
    Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Gastroenterology 120:1173-82. 2001
  4. pmc Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells
    F Sierro
    Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 98:13722-7. 2001
  5. ncbi request reprint Live attenuated Salmonella: a paradigm of mucosal vaccines
    J C Sirard
    Swiss Institute for Experimental Cancer Research, University of Lausanne, Epalinges, Switzerland
    Immunol Rev 171:5-26. 1999
  6. pmc Human papillomavirus type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice
    D Nardelli-Haefliger
    Department of Gynecology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Infect Immun 65:3328-36. 1997
  7. pmc Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunits
    I E Corthesy-Theulaz
    Department of Internal Medicine CHUV, and Institute of Pathology, Lausanne University, Switzerland
    Infect Immun 66:581-6. 1998
  8. pmc Oral and rectal immunization of adult female volunteers with a recombinant attenuated Salmonella typhi vaccine strain
    D Nardelli-Haefliger
    Department of Gynecology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Infect Immun 64:5219-24. 1996
  9. pmc Adhesion of Helicobacter pylori to polarized T84 human intestinal cell monolayers is pH dependent
    I Corthesy-Theulaz
    Division of Gastroenterology, Center Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Infect Immun 64:3827-32. 1996
  10. ncbi request reprint Nasal immunisation with Salmonella typhimurium producing rotavirus VP2 and VP6 antigens stimulates specific antibody response in serum and milk but fails to protect offspring
    A Coste
    Swiss Institute for Experimental Cancer Research, CH 1066, Epalinges, Switzerland
    Vaccine 19:4167-74. 2001

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Immunology. Keeping the gut microflora at bay
    Jean Pierre Kraehenbuhl
    Swiss Institute for Experimental Cancer Research, CH1066 Epalinges, Switzerland
    Science 303:1624-5. 2004
  2. ncbi request reprint Epithelial M cells: differentiation and function
    J P Kraehenbuhl
    Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Annu Rev Cell Dev Biol 16:301-32. 2000
    ..In addition it synthesizes the available information on development and differentiation of organized lymphoid tissues and the specialized epithelium associated with these immune inductive sites...
  3. ncbi request reprint Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches
    N Debard
    Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Gastroenterology 120:1173-82. 2001
    ..Second, we investigated the role of lymphotoxin alphabeta signaling on M-cell formation, given its pivotal role in the development of mouse Peyer's patches...
  4. pmc Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells
    F Sierro
    Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 98:13722-7. 2001
    ..Our data show that crosstalk between bacterial flagellin and epithelial cells is essential for the recruitment of DCs, a mechanism that could be instrumental to initiate adaptive immune responses in the gut...
  5. ncbi request reprint Live attenuated Salmonella: a paradigm of mucosal vaccines
    J C Sirard
    Swiss Institute for Experimental Cancer Research, University of Lausanne, Epalinges, Switzerland
    Immunol Rev 171:5-26. 1999
    ..typhi, with special emphasis on the molecular pathogenesis of S. typhimurium and the host response. We then discuss how such knowledge constitutes the basis for the rational design of novel live mucosal vaccines...
  6. pmc Human papillomavirus type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice
    D Nardelli-Haefliger
    Department of Gynecology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Infect Immun 65:3328-36. 1997
    ..Recombinant attenuated Salmonella expressing HPV capsids may represent a promising vaccine candidate against genital HPV infection...
  7. pmc Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunits
    I E Corthesy-Theulaz
    Department of Internal Medicine CHUV, and Institute of Pathology, Lausanne University, Switzerland
    Infect Immun 66:581-6. 1998
    ..Our data demonstrate that H. pylori urease delivered nasally by using a vaccine strain of S. typhimurium can trigger Th1- and Th2-type responses and induce protective immunity against Helicobacter infection...
  8. pmc Oral and rectal immunization of adult female volunteers with a recombinant attenuated Salmonella typhi vaccine strain
    D Nardelli-Haefliger
    Department of Gynecology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Infect Immun 64:5219-24. 1996
    ..Our data show for the first time that it is possible to induce specific sIgA in the genital and rectal tracts of women by using an S. typhi vaccine strain...
  9. pmc Adhesion of Helicobacter pylori to polarized T84 human intestinal cell monolayers is pH dependent
    I Corthesy-Theulaz
    Division of Gastroenterology, Center Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Infect Immun 64:3827-32. 1996
    ..These data provide the first evidence that an acidic environment favors Helicobacter adhesion and that binding is followed by survival of the survival of the bacteria in pockets of the apical membrane...
  10. ncbi request reprint Nasal immunisation with Salmonella typhimurium producing rotavirus VP2 and VP6 antigens stimulates specific antibody response in serum and milk but fails to protect offspring
    A Coste
    Swiss Institute for Experimental Cancer Research, CH 1066, Epalinges, Switzerland
    Vaccine 19:4167-74. 2001
    ..However, these antibodies failed to passively protect the offspring against rotavirus-induced diarrhoea...
  11. ncbi request reprint Epithelial transcytosis of immunoglobulins
    W Hunziker
    Institute of Biochemistry, University of Lausanne, BIL Research Center, Epalinges, Switzerland
    J Mammary Gland Biol Neoplasia 3:287-302. 1998
    ....
  12. ncbi request reprint A pathogen-specific epitope inserted into recombinant secretory immunoglobulin A is immunogenic by the oral route
    B Corthesy
    Institut Suisse de Recherches Expérimentales sur le Cancer et Institut de Biochimie, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    J Biol Chem 271:33670-7. 1996
    ..Thus, neo-antigenized sIgA can serve as a mucosal vaccine delivery system inducing systemic and mucosal immune responses...
  13. ncbi request reprint Protection from radiation-induced colitis requires MHC class II antigen expression by cells of hemopoietic origin
    S Marguerat
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    J Immunol 163:4033-40. 1999
    ..Moreover, our data imply that tolerization to enteric Ags requires MHC class II mediated presentation by APC of hemopoietic origin...
  14. ncbi request reprint Development of Peyer's patches, follicle-associated epithelium and M cell: lessons from immunodeficient and knockout mice
    N Debard
    Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, Epalinges, CH 1066, Switzerland
    Semin Immunol 11:183-91. 1999
    ..The development of MALT, FAE and probably M cells is a multistep process that requires signalling pathways common to all secondary lymphoid tissues, but also MALT-specific factors...
  15. pmc Systemic antibodies can inhibit mouse mammary tumor virus-driven superantigen response in mucosa-associated lymphoid tissues
    D Velin
    Swiss Institute for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland
    J Virol 73:1729-33. 1999
    ..This result clearly demonstrates that systemic antibodies can gain access to Peyer's patches or NALT...
  16. ncbi request reprint Primary structure and functional expression of the mouse and frog alpha-subunit of the gastric H(+)-K(+)-ATPase
    P M Mathews
    Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland
    Am J Physiol 268:C1207-14. 1995
    ..Furthermore, H(+)-K(+)-ATPase-expressing oocytes show a Sch-28080 inhibitable proton extrusion. Our data indicate that the expressed H(+)-K(+)-ATPase behaves functionally in oocytes as in the gastric gland...
  17. ncbi request reprint Formation of Peyer's patches
    D Finke
    Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, CH 1066, Epalinges, Switzerland
    Curr Opin Genet Dev 11:561-7. 2001
    ..Recent data using knockout mice provide insight into the molecular nature of the signals that mediate Peyer's patch ontogeny. These include members of the tumor-necrosis factor family and homeostatic chemokines...
  18. pmc Primary structure of an apical protein from Xenopus laevis that participates in amiloride-sensitive sodium channel activity
    O Staub
    Swiss Institute for Experimental Cancer Research, University of Lausanne, Epalinges
    J Cell Biol 119:1497-506. 1992
    ..It may represent a subunit of the Xenopus laevis sodium channel or a regulatory protein essential for sodium channel function...
  19. ncbi request reprint How the gut senses its content
    Arnaud Didierlaurent
    Swiss Institute for Experimental Cancer Research and the Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Cell Microbiol 4:61-72. 2002
  20. ncbi request reprint Dendritic cells: the host Achille's heel for mucosal pathogens?
    Florence Niedergang
    Membrane and Cytoskeleton Dynamics Laboratory, UMR144 CNRS, Institut Curie, F 75248 Paris, France
    Trends Microbiol 12:79-88. 2004
    ..These pathogens hijack the recruited DCs to enable them to infect the host, escape the host's defense mechanisms and establish niches at remote sites...
  21. ncbi request reprint Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response
    Arnaud Didierlaurent
    Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    J Immunol 172:6922-30. 2004
    ..In conclusion, this study suggests that flagellin and, more generally, TLR ligands can control Th2 responses in a MyD88-dependent manner...
  22. ncbi request reprint Lymphotoxin beta receptor signaling induces the chemokine CCL20 in intestinal epithelium
    Martin Rumbo
    Swiss Institute for Experimental Cancer Research, Lausanne Branch, Epalinges, Switzerland
    Gastroenterology 127:213-23. 2004
    ..The aim of this work was to test whether lymphotoxin beta receptor signaling (LTbetaR), which plays a central role in PPs' organogenesis, mediates CCL20 gene expression in intestinal epithelial cells...
  23. ncbi request reprint How the gut links innate and adaptive immunity
    Martin Rumbo
    Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges, Switzerland
    Ann N Y Acad Sci 1029:16-21. 2004
    ..Immune cells recruited in epithelial tissues can, in turn, act upon the epithelial cells and change their phenotype in a process referred to as epithelial metaplasia...
  24. ncbi request reprint Novel markers of the human follicle-associated epithelium identified by genomic profiling and microdissection
    Pascale Anderle
    Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Gastroenterology 129:321-7. 2005
    ..In this study, we measured expression profiles of LTalpha1beta2-treated intestinal epithelial cells and selected CCL20 -coregulated genes to identify new FAE markers...
  25. ncbi request reprint Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5
    Martin Rumbo
    UNLP, Laboratorio de Investigaciones en el Sistema Inmune, Facultad de Ciencias Exactas, La Plata, Argentina
    FEBS Lett 580:2976-84. 2006
    ..Finally, the contribution of TLRs in the induction and maintenance of mucosal homeostasis and commensal discrimination is discussed...
  26. ncbi request reprint Molecular and cellular basis of microflora-host interactions
    Petra Winkler
    Institute for Physiology and Biochemistry of Nutrition, Federal Research Center for Nutrition and Food, D 24103 Kiel, Germany
    J Nutr 137:756S-72S. 2007
    ....