J Kovarik

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Optimization of vaccine responses in early life: the role of delivery systems and immunomodulators
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, Department of Pathology, University of Geneva, Switzerland
    Immunol Cell Biol 76:222-36. 1998
  2. ncbi request reprint CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland
    J Immunol 162:1611-7. 1999
  3. ncbi request reprint Limitations of in vivo IL-12 supplementation strategies to induce Th1 early life responses to model viral and bacterial vaccine antigens
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva Medical School, Geneva, Switzerland
    Virology 268:122-31. 2000
  4. ncbi request reprint The search for novel adjuvants for early life vaccinations: can "danger" motifs show us the way?
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
    Arch Immunol Ther Exp (Warsz) 49:209-15. 2001
  5. ncbi request reprint Induction of neonatal TH1 and CTL responses by live viral vaccines: a role for replication patterns within antigen presenting cells?
    C A Siegrist
    WHO Collaborating Centre for Neonatal Vaccinology, Department of Pathology, University of Geneva, Switzerland
    Vaccine 16:1473-8. 1998
  6. ncbi request reprint Determinants of infant responses to vaccines in presence of maternal antibodies
    C A Siegrist
    WHO Collaborating Centre for Neonatal Vaccinology, Department of Pathology, University of Geneva, Switzerland
    Vaccine 16:1409-14. 1998
  7. ncbi request reprint Induction of adult-like antibody, Th1, and CTL responses to measles hemagglutinin by early life murine immunization with an attenuated vaccinia-derived NYVAC(K1L) viral vector
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva Medical School, Geneva, Switzerland
    Virology 285:12-20. 2001
  8. ncbi request reprint Delayed and deficient establishment of the long-term bone marrow plasma cell pool during early life
    M Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    Eur J Immunol 31:939-46. 2001
  9. ncbi request reprint Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice
    C A Siegrist
    W H O Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
    Eur J Immunol 28:4138-48. 1998

Detail Information

Publications9

  1. ncbi request reprint Optimization of vaccine responses in early life: the role of delivery systems and immunomodulators
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, Department of Pathology, University of Geneva, Switzerland
    Immunol Cell Biol 76:222-36. 1998
    ..How such objectives might be achieved by several of the vaccine formulations currently in development is illustrated by reviewing data from experimental models and clinical studies, when available...
  2. ncbi request reprint CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland
    J Immunol 162:1611-7. 1999
    ..These observations could be important for the development of novel vaccines that will have to be effective early in life...
  3. ncbi request reprint Limitations of in vivo IL-12 supplementation strategies to induce Th1 early life responses to model viral and bacterial vaccine antigens
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva Medical School, Geneva, Switzerland
    Virology 268:122-31. 2000
    ..However, these immunomodulatory effects appear limited to certain antigen-presentation approaches and may not be broadly applicable to vaccines...
  4. ncbi request reprint The search for novel adjuvants for early life vaccinations: can "danger" motifs show us the way?
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
    Arch Immunol Ther Exp (Warsz) 49:209-15. 2001
    ..In this review, the authors discuss the promises and potential drawbacks that such novel adjuvants could hold for their use in experimental and clinical early life vaccinations...
  5. ncbi request reprint Induction of neonatal TH1 and CTL responses by live viral vaccines: a role for replication patterns within antigen presenting cells?
    C A Siegrist
    WHO Collaborating Centre for Neonatal Vaccinology, Department of Pathology, University of Geneva, Switzerland
    Vaccine 16:1473-8. 1998
    ....
  6. ncbi request reprint Determinants of infant responses to vaccines in presence of maternal antibodies
    C A Siegrist
    WHO Collaborating Centre for Neonatal Vaccinology, Department of Pathology, University of Geneva, Switzerland
    Vaccine 16:1409-14. 1998
    ....
  7. ncbi request reprint Induction of adult-like antibody, Th1, and CTL responses to measles hemagglutinin by early life murine immunization with an attenuated vaccinia-derived NYVAC(K1L) viral vector
    J Kovarik
    World Health Organization Collaborating Centre for Neonatal Vaccinology, University of Geneva Medical School, Geneva, Switzerland
    Virology 285:12-20. 2001
    ....
  8. ncbi request reprint Delayed and deficient establishment of the long-term bone marrow plasma cell pool during early life
    M Pihlgren
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, University of Geneva, Geneva, Switzerland
    Eur J Immunol 31:939-46. 2001
    ....
  9. ncbi request reprint Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice
    C A Siegrist
    W H O Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
    Eur J Immunol 28:4138-48. 1998
    ..It suggests that effective vaccine responses may be obtained earlier in presence of maternal antibodies through the use of appropriate immunization strategies using conventional or novel vaccines for early priming...