Eniko Kovari

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease
    E Kovari
    Department of Mental Health and Psychiatry, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Neuropathol Appl Neurobiol 39:498-509. 2013
  2. ncbi request reprint Familial frontotemporal dementia with ubiquitin inclusion bodies and without motor neuron disease
    E Kovari
    Department of Psychiatry, University of Geneva School of Medicine, Switzerland
    Acta Neuropathol 100:421-6. 2000
  3. doi request reprint Neuropathology of Lewy body disorders
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University Hospitals of Geneva, Switzerland
    Brain Res Bull 80:203-10. 2009
  4. pmc The Geneva brain collection
    Eniko Kovari
    Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland
    Ann N Y Acad Sci 1225:E131-46. 2011
  5. ncbi request reprint Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Acta Neuropathol 106:83-8. 2003
  6. ncbi request reprint Cortical microinfarcts and demyelination significantly affect cognition in brain aging
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Stroke 35:410-4. 2004
  7. doi request reprint Neuropathological spectrum of frontal lobe dementias
    Eniko Kovari
    Division of Neuropsychiatry, Department of Psychiatry, Geneva School of Medicine, Chene Bourg, Geneva, Switzerland
    Front Neurol Neurosci 24:149-59. 2009
  8. ncbi request reprint Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia
    E Kovari
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Switzerland
    Neurology 68:927-31. 2007
  9. ncbi request reprint Lewy body dysphagia
    Eniko Kovari
    Department of Psychiatry, University of Geneva School of Medicine, 1225, Geneva, Switzerland
    Acta Neuropathol 114:295-8. 2007
  10. ncbi request reprint Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm?
    Anouk Imhof
    Department of Psychiatry, HUG, Belle Idee, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 257:72-9. 2007

Collaborators

Detail Information

Publications37

  1. pmc The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease
    E Kovari
    Department of Mental Health and Psychiatry, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Neuropathol Appl Neurobiol 39:498-509. 2013
    ..The goal of our study was to define the frequency and distribution of CAA in a 1-year autopsy population (91 cases) from the Department of Internal Medicine, Rehabilitation, and Geriatrics, Geneva...
  2. ncbi request reprint Familial frontotemporal dementia with ubiquitin inclusion bodies and without motor neuron disease
    E Kovari
    Department of Psychiatry, University of Geneva School of Medicine, Switzerland
    Acta Neuropathol 100:421-6. 2000
    ..These observations support the existence of a familial form of FTDP with ubiquitin-positive intracytoplasmic inclusions (Swiss FTDP family)...
  3. doi request reprint Neuropathology of Lewy body disorders
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University Hospitals of Geneva, Switzerland
    Brain Res Bull 80:203-10. 2009
    ..The recent progress of neuropathology in this field made it possible to define clinical and neuropathological guidelines for the diagnosis. This review briefly describes the most important data of all Lewy body related disorders...
  4. pmc The Geneva brain collection
    Eniko Kovari
    Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland
    Ann N Y Acad Sci 1225:E131-46. 2011
    ..The large number of cases, including some very rare conditions, provides a unique resource and an opportunity for worldwide collaborations...
  5. ncbi request reprint Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Acta Neuropathol 106:83-8. 2003
    ..They also suggest that LB formation in limbic areas may be crucial for the development of PD dementia...
  6. ncbi request reprint Cortical microinfarcts and demyelination significantly affect cognition in brain aging
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Stroke 35:410-4. 2004
    ..To evaluate the cognitive consequences of such lesions, we prospectively investigated elderly individuals with various degrees of cognitive impairment but without significant neurofibrillary tangle pathology or macrovascular lesions...
  7. doi request reprint Neuropathological spectrum of frontal lobe dementias
    Eniko Kovari
    Division of Neuropsychiatry, Department of Psychiatry, Geneva School of Medicine, Chene Bourg, Geneva, Switzerland
    Front Neurol Neurosci 24:149-59. 2009
    ..The new neuropathological criteria could be a great help in the neuropathological diagnosis and in further clinicopathological studies, and the new discoveries are useful in understanding the underlying disease processes...
  8. ncbi request reprint Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia
    E Kovari
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Switzerland
    Neurology 68:927-31. 2007
    ..To investigate the possible synergistic effect of microvascular lesions with mild Alzheimer disease (AD) pathology in mixed cases...
  9. ncbi request reprint Lewy body dysphagia
    Eniko Kovari
    Department of Psychiatry, University of Geneva School of Medicine, 1225, Geneva, Switzerland
    Acta Neuropathol 114:295-8. 2007
    ..These findings confirm the existence of isolated LB dysphagia and emphasize the importance of detailed neuropathological and immunohistochemical examination in cases of dysphagia...
  10. ncbi request reprint Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm?
    Anouk Imhof
    Department of Psychiatry, HUG, Belle Idee, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 257:72-9. 2007
    ....
  11. ncbi request reprint Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia
    Gabriel Gold
    Department of Geriatrics, HUG Belle Idée, University of Geneva School of Medicine, Geneva, Switzerland
    Stroke 36:1184-8. 2005
    ....
  12. ncbi request reprint Identification of Alzheimer and vascular lesion thresholds for mixed dementia
    Gabriel Gold
    Department of Geriatrics, University of Geneva School of Medicine, Geneva
    Brain 130:2830-6. 2007
    ..Proposed thresholds for vascular and degenerative lesions predict the presence of dementia with great accuracy and provide a basis for distinguishing pure vascular dementia or AD from mixed cases...
  13. ncbi request reprint Sorting out the clinical consequences of ischemic lesions in brain aging: a clinicopathological approach
    Gabriel Gold
    Department of Geriatrics, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 257:17-22. 2007
    ..Vascular lesions are particularly common in the aged brain. However, it is still unclear whether all such lesions affect cognition...
  14. ncbi request reprint Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience
    Panteleimon Giannakopoulos
    Division of Geriatric Psychiatry, Department of Psychiatry, University of Geneva School of Medicine, 1225 Chene Bourg, Geneva, Switzerland
    Acta Neuropathol 113:1-12. 2007
    ....
  15. ncbi request reprint Validation of clinical criteria for possible vascular dementia in the oldest-old
    Jean Pierre Bacchetta
    Department of Psychiatry, University Hospitals of Geneva, Switzerland
    Neurobiol Aging 28:579-85. 2007
    ..Although their specificity was significantly lower in this age group compared to younger cohorts, all of them successfully exclude AD cases...
  16. doi request reprint Pathological substrates of cognitive decline in Alzheimer's disease
    Panteleimon Giannakopoulos
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Geneva, Switzerland
    Front Neurol Neurosci 24:20-9. 2009
    ..The present review discusses the complex structure/function relationships in brain aging and AD within the theoretical framework of the functional neuropathology of brain aging...
  17. ncbi request reprint Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22
    Armand Savioz
    Department of Psychiatry, University of Geneva School of Medicine, 1225 Geneva, Switzerland
    Neurobiol Dis 12:46-55. 2003
    ..Altogether, these data indicate principally that the Swiss kindred is unlinked to locus 17q21-22, and that tau is not at the origin of FTD in this family...
  18. doi request reprint Microvascular pathology in late-life depression
    Micaela Santos
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
    J Neurol Sci 322:46-9. 2012
    ..A more complex model in late-life depression combining different modalities could be an elucidating approach to the disease's etiopathogeny in the future...
  19. doi request reprint Differential impact of lacunes and microvascular lesions on poststroke depression
    Micaela Santos
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
    Stroke 40:3557-62. 2009
    ..We performed a detailed analysis of all types of microvascular lesions and lacunes in 41 prospectively documented and consecutively autopsied stroke cases...
  20. doi request reprint Small vascular and Alzheimer disease-related pathologic determinants of dementia in the oldest-old
    Lidia Sinka
    Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland
    J Neuropathol Exp Neurol 69:1247-55. 2010
    ..Most importantly, single cutoff scores for these variables that could be used in the future to formulate neuropathologic criteria for mixed dementia in this age group were identified...
  21. ncbi request reprint Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive status
    Constantin Bouras
    Departments of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
    J Neuropathol Exp Neurol 65:235-44. 2006
    ....
  22. ncbi request reprint Neuropathological analysis of an adult case of the Cornelia de Lange syndrome
    Nicolas Vuilleumier
    Department of Psychiatry, University of Geneva School of Medicine, 1225 Chene Bourg, Geneva, Switzerland
    Acta Neuropathol 104:327-32. 2002
    ..In the light of previous studies in younger CDLS patients, the vascular and degenerative lesions observed in the present case may be secondary to his severe congenital heart abnormalities and self-injury behavior, respectively...
  23. doi request reprint Microvascular burden and Alzheimer-type lesions across the age spectrum
    Alessandra Costanza
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Geneva, Switzerland
    J Alzheimers Dis 32:643-52. 2012
    ....
  24. ncbi request reprint Cortical ubiquitin-positive inclusions in frontotemporal dementia without motor neuron disease: a quantitative immunocytochemical study
    Eniko Kovari
    Departments of Psychiatry and Geriatrics, HUG Belle Idée, University of Geneva School of Medicine, 1225, Geneva, Switzerland
    Acta Neuropathol 108:207-12. 2004
    ..They also reveal that the development of ubiquitin-positive inclusion densities in the dentate gyrus may be associated with a more aggressive form of the disease...
  25. pmc The impact of vascular burden on late-life depression
    Micaela Santos
    Department of Psychiatry, University Hospitals and Faculty of Medicine of Geneva, Belle Idee, Switzerland
    Brain Res Rev 62:19-32. 2009
    ..Based on these observations, we propose that the accumulation of small vascular and microvascular lesions constitutes a common neuropathological platform for both cognitive decline and depressive episodes in old age...
  26. doi request reprint Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis
    Virginie Licker
    Neuroproteomics Group, University Medical Center, Faculty of Medicine, Geneva University, Geneva, Switzerland Translational Biomarker Group, University Medical Center, Faculty of Medicine, Geneva University, Geneva, Switzerland
    Proteomics 14:784-94. 2014
    ..All MS data have been deposited in the ProteomeXchange with identifier PXD000427 (http://proteomecentral.proteomexchange.org/dataset/PXD000427). ..
  27. ncbi request reprint Humoral immunity in brain aging and Alzheimer's disease
    Constantin Bouras
    Department of Psychiatry, University Hospitals of Geneva, 1225 Geneva, Switzerland
    Brain Res Brain Res Rev 48:477-87. 2005
    ..Subsequent experiments needed to test this new working hypothesis are addressed at the end of the review...
  28. doi request reprint Etiologies of Parkinsonism in a century-long autopsy-based cohort
    Judit Horvath
    Department of Neurology, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Brain Pathol 23:28-33. 2013
    ..7%. Of particular interest, we found that PD, while being the most frequent cause of Parkinsonism, was greatly overdiagnosed, with VaP and ATP being the most frequent confounding conditions...
  29. doi request reprint Electrophysiological markers of rapid cognitive decline in mild cognitive impairment
    Panteleimon Giannakopoulos
    Department of Psychiatry, University Hospitals of Geneva, Chene Bourg, Geneva, Switzerland
    Front Neurol Neurosci 24:39-46. 2009
    ....
  30. doi request reprint Clusterin in neurological disorders: molecular perspectives and clinical relevance
    Yves Charnay
    Department of Mental Health and Psychiatry, University Hospitals and School of Medicine, CH 1225 Chene Bourg, Switzerland
    Brain Res Bull 88:434-43. 2012
    ..In this review we provide a critical overview of the most recent data on the involvement of clusterin in neurodegenerative diseases with special reference to their putative clinical relevance...
  31. doi request reprint Neuropathological substrates and structural changes in late-life depression: the impact of vascular burden
    Aikaterini Xekardaki
    Department of Mental Health and Psychiatry, Faculty of Medicine, University Hospitals of Geneva, University of Geneva, Chene Bourg, Switzerland
    Acta Neuropathol 124:453-64. 2012
    ..These three paradigms are discussed in the light of the complex relationships between psychosocial determinants and biological vulnerability in affective disorders...
  32. pmc Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase
    Jocelyn D Laughton
    Department of Psychiatry, Service of Neuropsychiatry, University Hospitals of Geneva, Belle Idee, Switzerland
    BMC Neurosci 8:35. 2007
    ..1.1.27) that catalyses the interconversion of lactate and pyruvate and the pyruvate dehydrogenase complex that irreversibly funnels pyruvate towards the mitochondrial TCA and oxydative phosphorylation...
  33. pmc The neuroanatomical model of post-stroke depression: towards a change of focus?
    Micaela Santos
    Department of Psychiatry, HUG, Belle Idee, University of Geneva School of Medicine, Geneva, Switzerland
    J Neurol Sci 283:158-62. 2009
    ..We suggest that vascular burden due to the chronic accumulation of small macrovascular and microvascular lesions may be a crucial determinant of the development and evolution of PSD...
  34. doi request reprint Smooth muscle cells of human intracranial aneurysms assume phenotypic features similar to those of the atherosclerotic plaque
    Matteo Coen
    Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Cardiovasc Pathol 22:339-44. 2013
    ..Characterize the phenotypic features of smooth muscle cells (SMCs) in the wall of human saccular intracranial aneurysms (sIAs)...
  35. doi request reprint Neuroimaging of dementia in 2013: what radiologists need to know
    Sven Haller
    Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland
    Eur Radiol 23:3393-404. 2013
    ..The fifth and final part discusses the inter-individual variation in the neurocognitive reserve, which is a potential constraint for all proposed methods...
  36. doi request reprint Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease
    Virginie Licker
    Neuroproteomics Group, University Medical Center, Geneva, Switzerland
    J Proteomics 75:4656-67. 2012
    ..This article is part of a Special Issue entitled: Translational Proteomics...
  37. doi request reprint Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability
    Fabrizio Montecucco
    Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, Geneva University Hospitals, Geneva, Switzerland
    Eur Heart J 32:412-21. 2011
    ..The potential relationship between anti-ApoA-1 IgG and plaque vulnerability remains elusive. Thus, we aimed to investigate the role of anti-ApoA-1 IgG in plaque vulnerability...