T Kossmann

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue
    M C Morganti-Kossman
    Department of Surgery, University Hospital Zurich, Switzerland
    Mol Psychiatry 2:133-6. 1997
  2. ncbi Regulation of chemokines and chemokine receptors after experimental closed head injury
    V I Otto
    Divisions of Research and Trauma Surgery, Department of Surgery, University Hospital, CH-8091 Zurich, Switzerland
    Neuroreport 12:2059-64. 2001
  3. ncbi Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice
    P F Stahel
    Department of Surgery, Division of Trauma Surgery and Division of Research, University Hospital, CH 8091, Zurich, Switzerland
    J Neuroimmunol 109:164-72. 2000
  4. ncbi TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function
    M C Morganti-Kossmann
    Department of Surgery, University Hospital, Zurich, Switzerland
    J Neurotrauma 16:617-28. 1999
  5. ncbi S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury
    U E Pleines
    Division of Research, University Hospital Zurich, Switzerland
    J Neurotrauma 18:491-8. 2001
  6. ncbi sICAM-1 and TNF-alpha induce MIP-2 with distinct kinetics in astrocytes and brain microvascular endothelial cells
    V I Otto
    Division of Research, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    J Neurosci Res 60:733-42. 2000
  7. ncbi Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats
    M Rancan
    Division of Research, Department of Surgery, University Hospital, Zurich, Switzerland
    J Neurosci Res 63:438-46. 2001
  8. ncbi Role of cerebral inflammation after traumatic brain injury: a revisited concept
    M C Morganti-Kossmann
    Department of Surgery, University Hospital, Zurich, Switzerland
    Shock 16:165-77. 2001
  9. ncbi Increased interleukin-12 levels in human cerebrospinal fluid following severe head trauma
    P F Stahel
    Department of Surgery, University Hospital, Zurich, Switzerland
    Neurosci Lett 249:123-6. 1998
  10. ncbi The role of the complement system in traumatic brain injury
    P F Stahel
    Division of Trauma Surgery, Department of Surgery, University Hospital, CH 8091 Zurich, Switzerland
    Brain Res Brain Res Rev 27:243-56. 1998

Collaborators

Detail Information

Publications13

  1. ncbi Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue
    M C Morganti-Kossman
    Department of Surgery, University Hospital Zurich, Switzerland
    Mol Psychiatry 2:133-6. 1997
    ..Furthermore, we investigated the possible modulation of systemic reactions by IL-6 and the ability of IL-6 and IL-8 to promote the synthesis of nerve growth factor...
  2. ncbi Regulation of chemokines and chemokine receptors after experimental closed head injury
    V I Otto
    Divisions of Research and Trauma Surgery, Department of Surgery, University Hospital, CH-8091 Zurich, Switzerland
    Neuroreport 12:2059-64. 2001
    ..Contrarily, CCR5 expression remained constitutively low and was mainly localized to microglia. These results show that after CHI, chemokines and their receptors are regulated differentially and with independent kinetics...
  3. ncbi Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice
    P F Stahel
    Department of Surgery, Division of Trauma Surgery and Division of Research, University Hospital, CH 8091, Zurich, Switzerland
    J Neuroimmunol 109:164-72. 2000
    ..These data show that the posttraumatic neuronal expression of the C5aR is, at least in part, regulated by TNF and lymphotoxin-alpha at 7 days after trauma...
  4. ncbi TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function
    M C Morganti-Kossmann
    Department of Surgery, University Hospital, Zurich, Switzerland
    J Neurotrauma 16:617-28. 1999
    ..Thus, TGF-beta may function as a factor in the complex cytokine network following TBI, acting as an antiinflammatory and neuroprotective mediator...
  5. ncbi S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury
    U E Pleines
    Division of Research, University Hospital Zurich, Switzerland
    J Neurotrauma 18:491-8. 2001
    ..These results indicate that the elevation of these parameters in CSF depends on the extent of injury and that S-100beta may be a predictor of outcome after TBI, whereas NSE reflects better the inflammatory response...
  6. ncbi sICAM-1 and TNF-alpha induce MIP-2 with distinct kinetics in astrocytes and brain microvascular endothelial cells
    V I Otto
    Division of Research, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    J Neurosci Res 60:733-42. 2000
    ..If added together, sICAM-1 and TNF-alpha synergistically induced MIP-2 production suggesting the involvement of two different pathways for MIP-2 regulation...
  7. ncbi Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats
    M Rancan
    Division of Research, Department of Surgery, University Hospital, Zurich, Switzerland
    J Neurosci Res 63:438-46. 2001
    ..focal TBI...
  8. ncbi Role of cerebral inflammation after traumatic brain injury: a revisited concept
    M C Morganti-Kossmann
    Department of Surgery, University Hospital, Zurich, Switzerland
    Shock 16:165-77. 2001
    ..The possible reciprocal influence of peripheral and intrathecal activation of the immune system will also be discussed. To conclude, the future directions of research in the field of neurotrauma is considered...
  9. ncbi Increased interleukin-12 levels in human cerebrospinal fluid following severe head trauma
    P F Stahel
    Department of Surgery, University Hospital, Zurich, Switzerland
    Neurosci Lett 249:123-6. 1998
    ..Assessment of the IL-12 CSF/serum ratio and of the blood-brain barrier function, using the CSF/serum albumin ratio, suggest that elevated IL-12 CSF levels might be in part derived from intracerebral cytokine synthesis...
  10. ncbi The role of the complement system in traumatic brain injury
    P F Stahel
    Division of Trauma Surgery, Department of Surgery, University Hospital, CH 8091 Zurich, Switzerland
    Brain Res Brain Res Rev 27:243-56. 1998
    ..The present review summarizes the current understanding of the mechanisms of complement-mediated secondary brain injury after head trauma...
  11. ncbi Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injury
    P F Stahel
    Department of Surgery, University Hospital, Zurich, Switzerland
    J Neurotrauma 18:773-81. 2001
    ..998; p < 0.05). These data demonstrate for the first time that terminal pathway complement activation occurs after head injury and suggest a possible pathophysiological role of complement with regard to posttraumatic BBB dysfunction...
  12. ncbi Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines
    P F Stahel
    Department of Surgery, University Hospital, Zurich, Switzerland
    J Cereb Blood Flow Metab 20:369-80. 2000
    ..Nevertheless, the increased posttraumatic mortality in TNF/LT-alpha-deficient mice suggests a protective effect of these cytokines by mechanisms that have not been elucidated yet...
  13. pmc The use of a retractor system (SynFrame) for open, minimal invasive reconstruction of the anterior column of the thoracic and lumbar spine
    T Kossmann
    Department of Surgery, University Hospital of Zurich, Switzerland
    Eur Spine J 10:396-402. 2001
    ..This open, but minimal invasive, access technology offers, in our view, additional advantages to the "pure" endoscopic procedures of spinal surgery...