Malcolm Kohler

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. doi request reprint [Cardiovascular consequences of obstructive sleep apnoea syndrome]
    M Kohler
    Klinik fur Pneumologie, Universitatsspital Zurich, Zurich
    Praxis (Bern 1994) 99:117-22. 2010
  2. doi request reprint Mechanisms of vascular damage in obstructive sleep apnea
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Nat Rev Cardiol 7:677-85. 2010
  3. doi request reprint The effects of Provent on moderate to severe obstructive sleep apnoea during continuous positive airway pressure therapy withdrawal: a randomised controlled trial
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Thorax 68:854-9. 2013
  4. doi request reprint Effect of acetazolamide and autoCPAP therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: a randomized controlled trial
    Tsogyal D Latshang
    Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    JAMA 308:2390-8. 2012
  5. doi request reprint Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Am J Respir Crit Care Med 184:1192-9. 2011
  6. doi request reprint The effects of simulated obstructive apnea and hypopnea on arrhythmic potential in healthy subjects
    Giovanni Camen
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland
    Eur J Appl Physiol 113:489-96. 2013
  7. pmc Predicting daily physical activity in patients with chronic obstructive pulmonary disease
    Arnoldus J R VAN Gestel
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    PLoS ONE 7:e48081. 2012
  8. pmc Quantitative changes in the sleep EEG at moderate altitude (1630 m and 2590 m)
    Katrin Stadelmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zürich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e76945. 2013
  9. doi request reprint Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness
    Christian F Clarenbach
    Pulmonary Clinic, University Hospital Zurich, Zurich, Switzerland
    Hypertens Res 35:228-33. 2012
  10. doi request reprint The effects of continuous positive airway pressure therapy withdrawal on cardiac repolarization: data from a randomized controlled trial
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, Zurich, Switzerland
    Eur Heart J 33:2206-12. 2012

Collaborators

Detail Information

Publications27

  1. doi request reprint [Cardiovascular consequences of obstructive sleep apnoea syndrome]
    M Kohler
    Klinik fur Pneumologie, Universitatsspital Zurich, Zurich
    Praxis (Bern 1994) 99:117-22. 2010
    ..The results of multiple ongoing international multi-centre studies investigating the effects of OSAS therapy on cardiovascular event rate and mortality are thus anxiously awaited...
  2. doi request reprint Mechanisms of vascular damage in obstructive sleep apnea
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Nat Rev Cardiol 7:677-85. 2010
    ..More clinical interventional trials are needed to determine the magnitude of the effect OSA has on cardiovascular damage and to enable a comparison with conventional vascular risk factors...
  3. doi request reprint The effects of Provent on moderate to severe obstructive sleep apnoea during continuous positive airway pressure therapy withdrawal: a randomised controlled trial
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Thorax 68:854-9. 2013
    ..The aim of this study was to test the effectiveness of Provent, an expiratory nasal resistance valve, to prevent the recurrence of OSA following CPAP withdrawal...
  4. doi request reprint Effect of acetazolamide and autoCPAP therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: a randomized controlled trial
    Tsogyal D Latshang
    Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    JAMA 308:2390-8. 2012
    ..Many patients with obstructive sleep apnea syndrome (OSA) living near sea level travel to altitude, but this may expose them to hypoxemia and exacerbation of sleep apnea. The treatment in this setting is not established...
  5. doi request reprint Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Am J Respir Crit Care Med 184:1192-9. 2011
    ..To establish a new approach to investigate the physiological effects of obstructive sleep apnea (OSA), and to evaluate novel treatments, during a period of continuous positive airway pressure (CPAP) withdrawal...
  6. doi request reprint The effects of simulated obstructive apnea and hypopnea on arrhythmic potential in healthy subjects
    Giovanni Camen
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland
    Eur J Appl Physiol 113:489-96. 2013
    ..Therefore, negative intrathoracic pressure changes may be a contributory mechanism for the association between OSA and cardiac dysrhythmias...
  7. pmc Predicting daily physical activity in patients with chronic obstructive pulmonary disease
    Arnoldus J R VAN Gestel
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    PLoS ONE 7:e48081. 2012
    ..In routine clinical practice it would be useful to estimate PA in patients with chronic obstructive pulmonary disease (COPD) with more simple methods...
  8. pmc Quantitative changes in the sleep EEG at moderate altitude (1630 m and 2590 m)
    Katrin Stadelmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zürich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e76945. 2013
    ..Furthermore, the relationship between sleep EEG variables and central apneas and oxygen saturation are of great interest to understand the impact of hypoxia at moderate altitude on sleep...
  9. doi request reprint Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness
    Christian F Clarenbach
    Pulmonary Clinic, University Hospital Zurich, Zurich, Switzerland
    Hypertens Res 35:228-33. 2012
    ..Therefore, digital pulse wave analysis may be a valuable tool to estimate arterial stiffness in large clinical studies...
  10. doi request reprint The effects of continuous positive airway pressure therapy withdrawal on cardiac repolarization: data from a randomized controlled trial
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, Zurich, Switzerland
    Eur Heart J 33:2206-12. 2012
    ..The aim of the current trial was to assess the effects of continuous positive airway pressure (CPAP) therapy withdrawal on the measures of cardiac repolarization in patients with OSA...
  11. ncbi request reprint Is obstructive sleep apnea a risk factor for diabetes?
    Christian F Clarenbach
    Pulmonary Division, University Hospital Zurich, Switzerland
    Discov Med 12:17-24. 2011
    ..Further carefully conducted clinical studies and randomized controlled interventional CPAP trials are needed to determine the extent to which OSA is a risk factor for diabetes and its effect on glucose metabolism...
  12. doi request reprint Quantifying the speed of fluctuations in systolic blood pressure
    Arnoldus J R VAN Gestel
    1 Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland 2 Department of Health, Zurich University of Applied Sciences, Winterthur, Switzerland
    Hypertens Res 36:1039-44. 2013
    ..The speed of fluctuations in SBP rather than the degree of BPV is pronounced in patients with elevated cardiovascular risk. Increased speed of BP fluctuations may thus be a contributing mechanism to cardiovascular morbidity...
  13. ncbi request reprint Sympathetic overactivity and cardiovascular disease in patients with chronic obstructive pulmonary disease (COPD)
    Arnoldus J R VAN Gestel
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Discov Med 14:359-68. 2012
    ....
  14. pmc Effect of simulated obstructive hypopnea and apnea on thoracic aortic wall transmural pressures
    Christian F Clarenbach
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    J Appl Physiol (1985) 115:613-7. 2013
    ..Thus OSA may mechanically promote thoracic aortic dilatation and should be further investigated as a risk factor for the development or accelerated progression of thoracic aortic aneurysms. ..
  15. pmc Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation
    Anne Christin Stöwhas
    Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 8:e70081. 2013
    ..Travel to mountain areas is popular. However, the effects of acute exposure to moderate altitude on the cardiovascular system and metabolism are largely unknown...
  16. doi request reprint Vascular dysfunction in chronic obstructive pulmonary disease: current evidence and perspectives
    Christian F Clarenbach
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Expert Rev Respir Med 6:37-43. 2012
    ....
  17. doi request reprint Patients with obstructive sleep apnea syndrome benefit from acetazolamide during an altitude sojourn: a randomized, placebo-controlled, double-blind trial
    Yvonne Nussbaumer-Ochsner
    Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Chest 141:131-8. 2012
    ..Because the treatment of OSA at altitude has not been established, we tested the hypothesis that acetazolamide improves hypoxemia, sleep, and breathing disturbances in otherwise untreated patients with OSA at altitude...
  18. doi request reprint Does nasal decongestion improve obstructive sleep apnea?
    Christian F Clarenbach
    Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    J Sleep Res 17:444-9. 2008
    ..The reduced apnea/hypopnea index during maximal nasal decongestion by xylometazoline suggests a pathophysiologic link but the efficacy of nasal decongestion was not sufficient to provide a clinically substantial improvement of OSA...
  19. ncbi request reprint Pharmacological approaches to the treatment of obstructive sleep apnoea
    Malcolm Kohler
    University Hospital of Zurich, Sleep Disorders Centre and Pulmonary Division, Raemistrasse 100, Zurich 8091, Switzerland
    Expert Opin Investig Drugs 18:647-56. 2009
    ..Some patients with OSA do not tolerate CPAP or have insufficiently severe symptoms to justify its use; for these patients, drug therapy would be a desirable potential therapeutic alternative...
  20. doi request reprint Predictors of long-term compliance with continuous positive airway pressure
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Thorax 65:829-32. 2010
    ..There are very few data on objectively assessed long-term compliance with continuous positive airway pressure (CPAP). No single factor has been consistently identified as predictive of continued CPAP use...
  21. doi request reprint The impact of obstructive sleep apnea on aortic disease in Marfan's syndrome
    Malcolm Kohler
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Respiration 86:39-44. 2013
    ..Aortic dissection is a life-threatening manifestation of Marfan's syndrome. Preliminary evidence suggests that obstructive sleep apnea (OSA) is associated with aortic disease in Marfan's syndrome...
  22. doi request reprint Severity of peripheral arterial disease is associated with aortic pressure augmentation and subendocardial viability ratio
    Kathrin Mosimann
    Clinic for Angiology, University Hospital Zurich, Zurich, Switzerland
    J Clin Hypertens (Greenwich) 14:855-60. 2012
    ..036). Severity of lower limb perfusion impairment is related to central aortic pressure augmentation and to subendocardial viability ratio. This may be a potential pathophysiologic link that impacts cardiac prognosis in patients with PAD...
  23. doi request reprint Effects of obstructive sleep apnoea on heart rhythm
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Eur Respir J 41:1439-51. 2013
    ..In conclusion, there is preliminary evidence that OSA is associated with the development of cardiac arrhythmias. Data from randomised controlled studies are needed to definitively clarify the role of OSA in arrhythmogenesis...
  24. doi request reprint The effect of simulated obstructive apnea and hypopnea on aortic diameter and BP
    Anne Christin Stöwhas
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Chest 140:675-80. 2011
    ..The mechanisms through which OSA may promote thoracic aortic dilatation are incompletely understood. Therefore, we studied the acute effects of simulated apnea and hypopnea on aortic diameter and BP in humans...
  25. doi request reprint Pitfalls of clinical trials on pharmacological treatment for obstructive sleep apnoea: future directions
    Malcolm Kohler
    University Hospital of Zurich, Sleep Disorders Center and Pulmonary Division, Raemistrasse, Switzerland
    Expert Opin Investig Drugs 20:1033-7. 2011
    ..In this article, the pitfalls of clinical trials on pharmacological OSA therapy are summarised and potential solutions and directions for future studies are given...
  26. doi request reprint The role of the nose in the pathogenesis of obstructive sleep apnea
    Malcolm Kohler
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Curr Opin Otolaryngol Head Neck Surg 17:33-7. 2009
    ....
  27. doi request reprint Children at high altitude have less nocturnal periodic breathing than adults
    M Kohler
    Pulmonary Division, Dept of Internal Medicine, University Hospital of Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Eur Respir J 32:189-97. 2008
    ....