Malcolm Kohler

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. doi request reprint CPAP and measures of cardiovascular risk in males with OSAS
    M Kohler
    Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospitals, Churchill Hospital Campus, Headington, Oxford, OX3 7LJ, UK
    Eur Respir J 32:1488-96. 2008
  2. doi request reprint The impact of obstructive sleep apnea on aortic disease in Marfan's syndrome
    Malcolm Kohler
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Respiration 86:39-44. 2013
  3. doi request reprint Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea
    Malcolm Kohler
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, UK
    Am J Respir Crit Care Med 178:984-8. 2008
  4. doi request reprint Predictors of long-term compliance with continuous positive airway pressure
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Thorax 65:829-32. 2010
  5. doi request reprint Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Am J Respir Crit Care Med 184:1192-9. 2011
  6. ncbi request reprint Pharmacological approaches to the treatment of obstructive sleep apnoea
    Malcolm Kohler
    University Hospital of Zurich, Sleep Disorders Centre and Pulmonary Division, Raemistrasse 100, Zurich 8091, Switzerland
    Expert Opin Investig Drugs 18:647-56. 2009
  7. doi request reprint Continuous positive airway pressure and liver enzymes in obstructive sleep apnoea: data from a randomized controlled trial
    Malcolm Kohler
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, OX3 7LJ UK
    Respiration 78:141-6. 2009
  8. doi request reprint The prevalence of obstructive sleep apnoea and its association with aortic dilatation in Marfan's syndrome
    M Kohler
    Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospitals, Churchill Hospital Campus, Headington, Oxford OX3 7LJ, UK
    Thorax 64:162-6. 2009
  9. doi request reprint Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial
    M Kohler
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford, UK
    Thorax 64:67-73. 2009
  10. doi request reprint Pitfalls of clinical trials on pharmacological treatment for obstructive sleep apnoea: future directions
    Malcolm Kohler
    University Hospital of Zurich, Sleep Disorders Center and Pulmonary Division, Raemistrasse, Switzerland
    Expert Opin Investig Drugs 20:1033-7. 2011

Collaborators

Detail Information

Publications48

  1. doi request reprint CPAP and measures of cardiovascular risk in males with OSAS
    M Kohler
    Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospitals, Churchill Hospital Campus, Headington, Oxford, OX3 7LJ, UK
    Eur Respir J 32:1488-96. 2008
    ....
  2. doi request reprint The impact of obstructive sleep apnea on aortic disease in Marfan's syndrome
    Malcolm Kohler
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Respiration 86:39-44. 2013
    ..Aortic dissection is a life-threatening manifestation of Marfan's syndrome. Preliminary evidence suggests that obstructive sleep apnea (OSA) is associated with aortic disease in Marfan's syndrome...
  3. doi request reprint Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea
    Malcolm Kohler
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, UK
    Am J Respir Crit Care Med 178:984-8. 2008
    ..Moderate-severe obstructive sleep apnea (OSA) is associated with endothelial dysfunction, increased arterial stiffness, and hypertension. It is not known whether minimally symptomatic OSA is also associated with impaired vascular function...
  4. doi request reprint Predictors of long-term compliance with continuous positive airway pressure
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Thorax 65:829-32. 2010
    ..There are very few data on objectively assessed long-term compliance with continuous positive airway pressure (CPAP). No single factor has been consistently identified as predictive of continued CPAP use...
  5. doi request reprint Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Am J Respir Crit Care Med 184:1192-9. 2011
    ..To establish a new approach to investigate the physiological effects of obstructive sleep apnea (OSA), and to evaluate novel treatments, during a period of continuous positive airway pressure (CPAP) withdrawal...
  6. ncbi request reprint Pharmacological approaches to the treatment of obstructive sleep apnoea
    Malcolm Kohler
    University Hospital of Zurich, Sleep Disorders Centre and Pulmonary Division, Raemistrasse 100, Zurich 8091, Switzerland
    Expert Opin Investig Drugs 18:647-56. 2009
    ..Some patients with OSA do not tolerate CPAP or have insufficiently severe symptoms to justify its use; for these patients, drug therapy would be a desirable potential therapeutic alternative...
  7. doi request reprint Continuous positive airway pressure and liver enzymes in obstructive sleep apnoea: data from a randomized controlled trial
    Malcolm Kohler
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, OX3 7LJ UK
    Respiration 78:141-6. 2009
    ..Continuous positive airway pressure (CPAP) is the treatment for OSAS, but the effects of CPAP on liver enzymes have not been studied in a randomized controlled trial...
  8. doi request reprint The prevalence of obstructive sleep apnoea and its association with aortic dilatation in Marfan's syndrome
    M Kohler
    Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospitals, Churchill Hospital Campus, Headington, Oxford OX3 7LJ, UK
    Thorax 64:162-6. 2009
    ..Aortic dilatation and dissection are life threatening manifestations of Marfan's syndrome and case reports have suggested a possible association with OSA but data from cohort studies are not available...
  9. doi request reprint Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial
    M Kohler
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford, UK
    Thorax 64:67-73. 2009
    ..Continuous positive airway pressure (CPAP) is the treatment of choice for OSAS, but the impact of this intervention on systemic inflammation involved in the atherosclerotic process remains unclear...
  10. doi request reprint Pitfalls of clinical trials on pharmacological treatment for obstructive sleep apnoea: future directions
    Malcolm Kohler
    University Hospital of Zurich, Sleep Disorders Center and Pulmonary Division, Raemistrasse, Switzerland
    Expert Opin Investig Drugs 20:1033-7. 2011
    ..In this article, the pitfalls of clinical trials on pharmacological OSA therapy are summarised and potential solutions and directions for future studies are given...
  11. doi request reprint The effects of Provent on moderate to severe obstructive sleep apnoea during continuous positive airway pressure therapy withdrawal: a randomised controlled trial
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Thorax 68:854-9. 2013
    ..The aim of this study was to test the effectiveness of Provent, an expiratory nasal resistance valve, to prevent the recurrence of OSA following CPAP withdrawal...
  12. pmc Predicting daily physical activity in patients with chronic obstructive pulmonary disease
    Arnoldus J R VAN Gestel
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    PLoS ONE 7:e48081. 2012
    ..In routine clinical practice it would be useful to estimate PA in patients with chronic obstructive pulmonary disease (COPD) with more simple methods...
  13. doi request reprint Effect of acetazolamide and autoCPAP therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: a randomized controlled trial
    Tsogyal D Latshang
    Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    JAMA 308:2390-8. 2012
    ..Many patients with obstructive sleep apnea syndrome (OSA) living near sea level travel to altitude, but this may expose them to hypoxemia and exacerbation of sleep apnea. The treatment in this setting is not established...
  14. pmc Effects of continuous positive airway pressure on quality of life in patients with moderate to severe obstructive sleep apnea: data from a randomized controlled trial
    Massimiliano M Siccoli
    Sleep Unit, Centre for Respiratory Medicine, Churchill Hospital, Oxford, UK
    Sleep 31:1551-8. 2008
    ..Previous studies have shown that CPAP has a substantial impact on daytime symptoms and quality of life (QOL). It remains unclear which outcome measures best identify real CPAP effects and carry independent information...
  15. pmc Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation
    Anne Christin Stöwhas
    Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 8:e70081. 2013
    ..Travel to mountain areas is popular. However, the effects of acute exposure to moderate altitude on the cardiovascular system and metabolism are largely unknown...
  16. doi request reprint Augmentation index and central aortic blood pressure in patients with abdominal aortic aneurysms
    Gion Ruegg
    Department of Internal Medicine, University Hospital Zurich, Switzerland
    J Hypertens 28:2252-7. 2010
    ..We tested the hypothesis that AIx and CABP would be higher in patients with fast-progressing AAA...
  17. doi request reprint Leukoaraiosis on MRI in patients with minimally symptomatic obstructive sleep apnoea
    Ursula G Schulz
    Stroke Prevention Research Unit, Nuffield Department of Neurosciences, John Radcliffe Hospital, Oxford, UK
    Cerebrovasc Dis 35:363-9. 2013
    ..It may therefore also be associated with a higher risk of developing leukoaraiosis. Only few data about the prevalence of leukoaraiosis in patients with OSA, and any association between degrees of severity of either condition, exist...
  18. pmc Are nocturnal breathing, sleep, and cognitive performance impaired at moderate altitude (1,630-2,590 m)?
    Tsogyal D Latshang
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich
    Sleep 36:1969-76. 2013
    ..We evaluated the hypothesis that nocturnal breathing, sleep, and cognitive performance of lowlanders are impaired at moderate altitude...
  19. doi request reprint Determinants of endothelial function in patients with COPD
    Christian F Clarenbach
    University Hospital Zurich, Zurich
    Eur Respir J 42:1194-204. 2013
    ..A high level of physical activity seems to have a favourable effect on this association. ..
  20. doi request reprint The effects of simulated obstructive apnea and hypopnea on arrhythmic potential in healthy subjects
    Giovanni Camen
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland
    Eur J Appl Physiol 113:489-96. 2013
    ..Therefore, negative intrathoracic pressure changes may be a contributory mechanism for the association between OSA and cardiac dysrhythmias...
  21. doi request reprint Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness
    Christian F Clarenbach
    Pulmonary Clinic, University Hospital Zurich, Zurich, Switzerland
    Hypertens Res 35:228-33. 2012
    ..Therefore, digital pulse wave analysis may be a valuable tool to estimate arterial stiffness in large clinical studies...
  22. doi request reprint Obstructive sleep apnea in patients with abdominal aortic aneurysms: highly prevalent and associated with aneurysm expansion
    Rebecca H Mason
    Oxford Centre for Respiratory Medicine, Churchill Hospital, United Kingdom
    Am J Respir Crit Care Med 183:668-74. 2011
    ..Abdominal aortic aneurysms (AAA) are associated with life-threatening complications. The likelihood that an AAA will rupture is influenced by the aneurysm diameter and its expansion rate; reasons for rapid expansion are largely unknown...
  23. doi request reprint Continuous positive airway pressure treatment for obstructive sleep apnoea reduces resting heart rate but does not affect dysrhythmias: a randomised controlled trial
    Sonya Craig
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
    J Sleep Res 18:329-36. 2009
    ..Four weeks of CPAP therapy reduces mean 24-h heart rate possibly due to reduced sympathetic activation but did not result in a significant decrease in dysrhythmia frequency...
  24. doi request reprint Atherosclerosis and arterial stiffness in obstructive sleep apnea--a cardiovascular magnetic resonance study
    Ilias Kylintireas
    Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Atherosclerosis 222:483-9. 2012
    ..Our aim was to assess whether OSA is independently associated with atherosclerosis and vascular dysfunction as assessed by cardiovascular magnetic resonance (CMR)...
  25. pmc Quantitative changes in the sleep EEG at moderate altitude (1630 m and 2590 m)
    Katrin Stadelmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zürich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e76945. 2013
    ..Furthermore, the relationship between sleep EEG variables and central apneas and oxygen saturation are of great interest to understand the impact of hypoxia at moderate altitude on sleep...
  26. doi request reprint Elevated levels of endothelial cell-derived microparticles following short-term withdrawal of continuous positive airway pressure in patients with obstructive sleep apnea: data from a randomized controlled trial
    Lisa Ayers
    Department of Clinical Immunology, Churchill Hospital, Oxford, UK
    Respiration 85:478-85. 2013
    ..Cell-derived microparticles may provide a link between obstructive sleep apnea and endothelial dysfunction...
  27. doi request reprint The speed of blood pressure fluctuations in patients with chronic obstructive pulmonary disease
    Arnoldus J R VAN Gestel
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland Department of Health, Zurich University of Applied Sciences, Winterthur, Switzerland Electronic address
    Heart Lung Circ 23:280-6. 2014
    ..Therefore, the purpose of this study was to evaluate whether there is an association between severity of COPD and vSBP...
  28. doi request reprint Effects of obstructive sleep apnoea on heart rhythm
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Eur Respir J 41:1439-51. 2013
    ..In conclusion, there is preliminary evidence that OSA is associated with the development of cardiac arrhythmias. Data from randomised controlled studies are needed to definitively clarify the role of OSA in arrhythmogenesis...
  29. doi request reprint The effect of simulated obstructive apnea and hypopnea on aortic diameter and BP
    Anne Christin Stöwhas
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Chest 140:675-80. 2011
    ..The mechanisms through which OSA may promote thoracic aortic dilatation are incompletely understood. Therefore, we studied the acute effects of simulated apnea and hypopnea on aortic diameter and BP in humans...
  30. doi request reprint The role of the nose in the pathogenesis of obstructive sleep apnea
    Malcolm Kohler
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Curr Opin Otolaryngol Head Neck Surg 17:33-7. 2009
    ....
  31. doi request reprint Does nasal decongestion improve obstructive sleep apnea?
    Christian F Clarenbach
    Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    J Sleep Res 17:444-9. 2008
    ..The reduced apnea/hypopnea index during maximal nasal decongestion by xylometazoline suggests a pathophysiologic link but the efficacy of nasal decongestion was not sufficient to provide a clinically substantial improvement of OSA...
  32. doi request reprint Continuous positive airway pressure improves sleepiness but not calculated vascular risk in patients with minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised controlled trial
    Sonya Elizabeth Craig
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, UK
    Thorax 67:1090-6. 2012
    ..Continuous positive airway pressure (CPAP) for symptomatic obstructive sleep apnoea (OSA) improves sleepiness and reduces vascular risk, but such treatment for the more prevalent, minimally symptomatic disease is contentious...
  33. doi request reprint The effects of continuous positive airway pressure therapy withdrawal on cardiac repolarization: data from a randomized controlled trial
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, Zurich, Switzerland
    Eur Heart J 33:2206-12. 2012
    ..The aim of the current trial was to assess the effects of continuous positive airway pressure (CPAP) therapy withdrawal on the measures of cardiac repolarization in patients with OSA...
  34. doi request reprint Patients with obstructive sleep apnea syndrome benefit from acetazolamide during an altitude sojourn: a randomized, placebo-controlled, double-blind trial
    Yvonne Nussbaumer-Ochsner
    Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Chest 141:131-8. 2012
    ..Because the treatment of OSA at altitude has not been established, we tested the hypothesis that acetazolamide improves hypoxemia, sleep, and breathing disturbances in otherwise untreated patients with OSA at altitude...
  35. doi request reprint Quantifying the speed of fluctuations in systolic blood pressure
    Arnoldus J R VAN Gestel
    1 Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland 2 Department of Health, Zurich University of Applied Sciences, Winterthur, Switzerland
    Hypertens Res 36:1039-44. 2013
    ..The speed of fluctuations in SBP rather than the degree of BPV is pronounced in patients with elevated cardiovascular risk. Increased speed of BP fluctuations may thus be a contributing mechanism to cardiovascular morbidity...
  36. ncbi request reprint Sympathetic overactivity and cardiovascular disease in patients with chronic obstructive pulmonary disease (COPD)
    Arnoldus J R VAN Gestel
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Discov Med 14:359-68. 2012
    ....
  37. pmc Effect of simulated obstructive hypopnea and apnea on thoracic aortic wall transmural pressures
    Christian F Clarenbach
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    J Appl Physiol (1985) 115:613-7. 2013
    ..Thus OSA may mechanically promote thoracic aortic dilatation and should be further investigated as a risk factor for the development or accelerated progression of thoracic aortic aneurysms. ..
  38. doi request reprint Severity of peripheral arterial disease is associated with aortic pressure augmentation and subendocardial viability ratio
    Kathrin Mosimann
    Clinic for Angiology, University Hospital Zurich, Zurich, Switzerland
    J Clin Hypertens (Greenwich) 14:855-60. 2012
    ..036). Severity of lower limb perfusion impairment is related to central aortic pressure augmentation and to subendocardial viability ratio. This may be a potential pathophysiologic link that impacts cardiac prognosis in patients with PAD...
  39. doi request reprint Vascular dysfunction in chronic obstructive pulmonary disease: current evidence and perspectives
    Christian F Clarenbach
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Expert Rev Respir Med 6:37-43. 2012
    ....
  40. ncbi request reprint Is obstructive sleep apnea a risk factor for diabetes?
    Christian F Clarenbach
    Pulmonary Division, University Hospital Zurich, Switzerland
    Discov Med 12:17-24. 2011
    ..Further carefully conducted clinical studies and randomized controlled interventional CPAP trials are needed to determine the extent to which OSA is a risk factor for diabetes and its effect on glucose metabolism...
  41. doi request reprint The effect of continuous positive airway pressure treatment on physical activity in patients with obstructive sleep apnoea: A randomised controlled trial
    Sophie D West
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, UK
    Sleep Med 10:1056-8. 2009
    ..Continuous positive airway pressure (CPAP) improves daytime sleepiness in patients with obstructive sleep apnoea (OSA). The effect of CPAP on physical activity is unclear. We hypothesized that activity would increase after CPAP treatment...
  42. ncbi request reprint Monitoring of ventilation during exercise by a portable respiratory inductive plethysmograph
    Christian F Clarenbach
    Pulmonary Division, Department of Internal Medicine, University Hospital of Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Chest 128:1282-90. 2005
    ..To evaluate the accuracy of a portable respiratory inductive plethysmograph that allows the monitoring of ventilation without airway instrumentation during exercise in unrestrained subjects...
  43. ncbi request reprint Successful treatment of severe acute mountain sickness and excessive pulmonary hypertension with dexamethasone in a prepubertal girl
    Susi Kriemler
    Institute for Sports and Sport Science, University of Basel, Switzerland, Exercise Physiology, ETH University of Zurich, Switzerland
    High Alt Med Biol 7:256-61. 2006
  44. ncbi request reprint Quality of life, physical disability, and respiratory impairment in Duchenne muscular dystrophy
    Malcolm Kohler
    Pulmonary Division, Department of Internal Medicine, University Hospital of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Am J Respir Crit Care Med 172:1032-6. 2005
    ..The assumption that severe physical disability precludes an acceptable quality of life is common, but has not been specifically evaluated in DMD...
  45. doi request reprint Mechanisms of vascular damage in obstructive sleep apnea
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Nat Rev Cardiol 7:677-85. 2010
    ..More clinical interventional trials are needed to determine the magnitude of the effect OSA has on cardiovascular damage and to enable a comparison with conventional vascular risk factors...
  46. ncbi request reprint Side-selective, unobtrusive monitoring of nasal airflow and conductance
    Malcolm Kohler
    Department of Internal Medicine, Pulmonary Division, University Hospital of Zurich, Switzerland
    J Appl Physiol 101:1760-5. 2006
    ..One-time measurements at the beginning of sleep studies do not appropriately reflect the highly variable nasal conductance during an entire night...
  47. ncbi request reprint Diagnosis, treatment and long-term outcome of solitary fibrous tumours of the pleura
    Malcolm Kohler
    Division of Pulmonary Medicine, University Hospital of Zurich, Switzerland
    Eur J Cardiothorac Surg 32:403-8. 2007
    ..The aim of this study is to present new cases, and discuss up-to-date preoperative examinations, the role of video-assisted thoracic surgery and long-term outcome...
  48. doi request reprint Measurement of circulating cell-derived microparticles by flow cytometry: sources of variability within the assay
    Lisa Ayers
    Department of Clinical Immunology, Churchill Hospital, Oxford, UK
    Thromb Res 127:370-7. 2011
    ..The aim of this study was to establish a reliable flow cytometric assay to measure distinct subtypes of MPs in disease and to identify any significant causes of variability in MP quantification...