A G Kleber

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi Crosstalk between theoretical and experimental studies for the understanding of cardiac electrical impulse propagation
    André G Kléber
    Department of Physiology, University of Bern, Bern, Switzerland
    J Electrocardiol 40:S136-41. 2007
  2. ncbi The early years of cellular cardiac electrophysiology and Silvio Weidmann (1921-2005)
    André G Kléber
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Heart Rhythm 3:353-9. 2006
  3. ncbi Basic mechanisms of cardiac impulse propagation and associated arrhythmias
    André G Kléber
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Physiol Rev 84:431-88. 2004
  4. ncbi ST-segment elevation in the electrocardiogram: a sign of myocardial ischemia
    A G Kleber
    Department of Physiology, University of Bern, Switzerland
    Cardiovasc Res 45:111-8. 2000
  5. ncbi Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping. Role of tissue discontinuities
    V G Fast
    Department of Physiology, University of Berne, Switzerland
    Circ Res 79:115-27. 1996
  6. ncbi Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling
    S Rohr
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Science 275:841-4. 1997
  7. ncbi Real time, confocal imaging of Ca(2+) waves in arterially perfused rat hearts
    Andreas P Baader
    University of Bern, Department of Physiology, Buhlplatz 5, 3012 Bern, Switzerland
    Cardiovasc Res 53:105-15. 2002
  8. ncbi Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43
    Stuart P Thomas
    Department of Physiology, University of Bern, Bühlplatz5, CH 3012 Bern, Switzerland
    Circ Res 92:1209-16. 2003
  9. ncbi Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice
    Philippe Beauchamp
    Department of Physiology, University of Bern, Switzerland
    Circ Res 95:170-8. 2004
  10. ncbi Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes
    Philippe Beauchamp
    Department of Physiology, University of Bern, Switzerland
    Circ Res 99:1216-24. 2006

Collaborators

Detail Information

Publications14

  1. ncbi Crosstalk between theoretical and experimental studies for the understanding of cardiac electrical impulse propagation
    André G Kléber
    Department of Physiology, University of Bern, Bern, Switzerland
    J Electrocardiol 40:S136-41. 2007
  2. ncbi The early years of cellular cardiac electrophysiology and Silvio Weidmann (1921-2005)
    André G Kléber
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Heart Rhythm 3:353-9. 2006
  3. ncbi Basic mechanisms of cardiac impulse propagation and associated arrhythmias
    André G Kléber
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Physiol Rev 84:431-88. 2004
    ..This review attempts to synthesize results from computer simulations and experimental preparations to define mechanisms and biophysical principles that govern normal and abnormal conduction in the heart...
  4. ncbi ST-segment elevation in the electrocardiogram: a sign of myocardial ischemia
    A G Kleber
    Department of Physiology, University of Bern, Switzerland
    Cardiovasc Res 45:111-8. 2000
    ..e. the changes in the transmembrane action potential and the alteration in electrical cell-to-cell coupling...
  5. ncbi Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping. Role of tissue discontinuities
    V G Fast
    Department of Physiology, University of Berne, Switzerland
    Circ Res 79:115-27. 1996
    ..We suggest that in tissue with a nonuniform anisotropy, connective tissue separating fiber bundles or sites of inhomogeneous connexin distribution may represent predilective sites for block in transverse direction...
  6. ncbi Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling
    S Rohr
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Science 275:841-4. 1997
    ..It suggests that partial cellular uncoupling might prevent the initiation of cardiac arrhythmias that are dependent on the presence of unidirectional conduction block...
  7. ncbi Real time, confocal imaging of Ca(2+) waves in arterially perfused rat hearts
    Andreas P Baader
    University of Bern, Department of Physiology, Buhlplatz 5, 3012 Bern, Switzerland
    Cardiovasc Res 53:105-15. 2002
    ..The aim of this study was to characterize the spatio-temporal dynamics of slow Ca(2+) waves (SCW's) with cellular resolution in the arterially-perfused rat heart...
  8. ncbi Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43
    Stuart P Thomas
    Department of Physiology, University of Bern, Bühlplatz5, CH 3012 Bern, Switzerland
    Circ Res 92:1209-16. 2003
    ..The lack of changes in theta in this tissue is explained by the dominating role of myoplasmic resistance and the compensatory increase of dV/dtmax...
  9. ncbi Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice
    Philippe Beauchamp
    Department of Physiology, University of Bern, Switzerland
    Circ Res 95:170-8. 2004
    ..In summary, knockout of Cx43 in ventricular myocytes leads to very slow conduction dependent on the presence of Cx45. Electrical field effect transmission does not contribute to propagation in synthetic strands...
  10. ncbi Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes
    Philippe Beauchamp
    Department of Physiology, University of Bern, Switzerland
    Circ Res 99:1216-24. 2006
    ....
  11. ncbi Role of wavefront curvature in propagation of cardiac impulse
    V G Fast
    Department of Physiology, University of Berne, Switzerland
    Cardiovasc Res 33:258-71. 1997
    ....
  12. ncbi Mechanism of ventricular defibrillation. The role of tissue geometry in the changes in transmembrane potential in patterned myocyte cultures
    A M Gillis
    Department of Physiology, University of Bern, Bern, Switzerland
    Circulation 101:2438-45. 2000
    ..To test this hypothesis, specific nonlinear structures (bifurcations, expansions, and curved strands or "bends") were created in patterned cultures of neonatal rat myocytes...
  13. ncbi Activation of cardiac tissue by extracellular electrical shocks: formation of 'secondary sources' at intercellular clefts in monolayers of cultured myocytes
    V G Fast
    Department of Physiology, University of Berne, Switzerland
    Circ Res 82:375-85. 1998
    ..These data suggest that small inexcitable obstacles may contribute to the Vm changes during the application of strong extracellular electrical shocks in vivo...
  14. ncbi Effects of mechanical forces and mediators of hypertrophy on remodeling of gap junctions in the heart
    Jeffrey E Saffitz
    Center for Cardiovascular Research and the Department of Pathology, University of Bern, Bern, Switzerland
    Circ Res 94:585-91. 2004
    ..The molecular mechanisms responsible for the interaction between mechanical and functional cell-to-cell coupling remain to be elucidated...