Werner Kempf

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Micronodular Kaposi's sarcoma - a new variant of classic-sporadic Kaposi's sarcoma
    Werner Kempf
    Department of Dermatology, Institute for Clinical Pathology, University Hospital Zurich, Zurich, Switzerland
    Dermatology 208:255-8. 2004
  2. ncbi Cutaneous malignant lymphomas: update 2006
    Gunter Burg
    Dept of Dermatology, University Hospital, Zurich, Switzerland
    J Dtsch Dermatol Ges 4:914-33. 2006
  3. ncbi Swiss recommendations for the management of varicella zoster virus infections
    W Kempf
    Dermatologische Klinik, Universitatsspital Zurich, CH 8091 Zurich, Switzerland
    Swiss Med Wkly 137:239-51. 2007
  4. doi Merkel cell carcinoma with a follicular lymphocytic infiltrate: report of 2 cases
    Marina Vazmitel
    Academy of Medical Postgraduate Education of Belarus, Minsk, Republic of Belarus
    Am J Dermatopathol 30:389-91. 2008
  5. ncbi Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organization For Research and Treatment of Cancer (EORTC)
    Werner Kempf
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH 8091 Zurich, Switzerland
    Arch Dermatol 144:1609-17. 2008
  6. ncbi Human herpesvirus 7 in dermatology: what role does it play?
    Werner Kempf
    Department of Dermatology, University Hospital, Zurich, Switzerland
    Am J Clin Dermatol 3:309-15. 2002
  7. ncbi CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators
    Werner Kempf
    Department of Dermatology, University Hospital Zurich, Switzerland
    J Cutan Pathol 33:58-70. 2006
  8. ncbi HistoClinC: a Web-based telemedicine application for clinicopathologic correlations in dermatopathology
    Werner Kempf
    Department of Dermatology, University Hospital, Zurich, Switzerland
    Curr Probl Dermatol 32:213-20. 2003
  9. ncbi Detection of clonal rearrangement of T-cell receptor genes in the diagnosis of primary cutaneous CD30 lymphoproliferative disorders
    Johannes Greisser
    Department of Dermatology, University Hospital, Zurich, Switzerland
    J Cutan Pathol 33:711-5. 2006
  10. doi Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin
    Kirsten D Mertz
    Kempf and Pfaltz Histological Diagnostics, Research Unit, Zurich, Switzerland
    Hum Pathol 41:1369-79. 2010

Detail Information

Publications107 found, 100 shown here

  1. ncbi Micronodular Kaposi's sarcoma - a new variant of classic-sporadic Kaposi's sarcoma
    Werner Kempf
    Department of Dermatology, Institute for Clinical Pathology, University Hospital Zurich, Zurich, Switzerland
    Dermatology 208:255-8. 2004
    ..We propose the term 'micronodular KS' for this unusual clinical variant of KS mimicking capillary hemangioma...
  2. ncbi Cutaneous malignant lymphomas: update 2006
    Gunter Burg
    Dept of Dermatology, University Hospital, Zurich, Switzerland
    J Dtsch Dermatol Ges 4:914-33. 2006
    ..Besides the classical options for therapy, there are new and "experimental" strategies, the efficacy of which has to be studied in clinical trials...
  3. ncbi Swiss recommendations for the management of varicella zoster virus infections
    W Kempf
    Dermatologische Klinik, Universitatsspital Zurich, CH 8091 Zurich, Switzerland
    Swiss Med Wkly 137:239-51. 2007
    ..The aim was to improve the care of affected patients and to reduce complications...
  4. doi Merkel cell carcinoma with a follicular lymphocytic infiltrate: report of 2 cases
    Marina Vazmitel
    Academy of Medical Postgraduate Education of Belarus, Minsk, Republic of Belarus
    Am J Dermatopathol 30:389-91. 2008
    ..We present here 2 cases of MCC characterized by foci of a dense lymphocytic infiltrate with the formation of lymphoid follicles. This feature may produce a potential diagnostic pitfall, rendering a lymphomatous appearance to the tumor...
  5. ncbi Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organization For Research and Treatment of Cancer (EORTC)
    Werner Kempf
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH 8091 Zurich, Switzerland
    Arch Dermatol 144:1609-17. 2008
    ..We studied 19 patients with granulomatous CTCLs to further characterize the clinicopathological, therapeutic, and prognostic features...
  6. ncbi Human herpesvirus 7 in dermatology: what role does it play?
    Werner Kempf
    Department of Dermatology, University Hospital, Zurich, Switzerland
    Am J Clin Dermatol 3:309-15. 2002
    ..Nevertheless, the role of HHV-7 in various skin diseases and the clinical manifestations of reactivation of HHV-7 infection have still to be defined...
  7. ncbi CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators
    Werner Kempf
    Department of Dermatology, University Hospital Zurich, Switzerland
    J Cutan Pathol 33:58-70. 2006
    ..The term CD30+ pseudolymphoma is proposed to designate inflammatory processes with CD30+ T cells. The final diagnosis of CD30+ LPD is based on a synthesis of clinical, histologic, phenotypic, and molecular genetic findings...
  8. ncbi HistoClinC: a Web-based telemedicine application for clinicopathologic correlations in dermatopathology
    Werner Kempf
    Department of Dermatology, University Hospital, Zurich, Switzerland
    Curr Probl Dermatol 32:213-20. 2003
  9. ncbi Detection of clonal rearrangement of T-cell receptor genes in the diagnosis of primary cutaneous CD30 lymphoproliferative disorders
    Johannes Greisser
    Department of Dermatology, University Hospital, Zurich, Switzerland
    J Cutan Pathol 33:711-5. 2006
    ....
  10. doi Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin
    Kirsten D Mertz
    Kempf and Pfaltz Histological Diagnostics, Research Unit, Zurich, Switzerland
    Hum Pathol 41:1369-79. 2010
    ..Remarkably, some of the Merkel cell polyomavirus-positive common warts did not contain human papillomavirus. Furthermore, Merkel cell polyomavirus can be found in various skin neoplasms of the same individual...
  11. doi Angioinvasive lymphomatoid papulosis: a new variant simulating aggressive lymphomas
    Werner Kempf
    Kempf und Pfaltz, Histologische Diagnostik, Zurich, Switzerland
    Am J Surg Pathol 37:1-13. 2013
    ..This LyP variant should be distinguished from aggressive forms of angiocentric and angiodestructive and cytotoxic T-cell lymphomas. We propose the term LyP type E for this clinically and histologically unusual variant...
  12. ncbi Apoptosis in CD30-positive lymphoproliferative disorders of the skin
    Johannes Greisser
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Exp Dermatol 14:380-5. 2005
    ..Pro-apoptotic protein Bax is expressed at high levels in CD30+ CLPD and may play a crucial role in mediating apoptosis of tumour cells...
  13. ncbi Study of HHV-8 DNA sequences in archival biopsies from lesional skin of Kaposi's sarcoma, various mesenchymal tumors and related reactive conditions
    Dmitry V Kazakov
    Department of Dermatology, University Hospital, Zurich, Switzerland
    J Cutan Pathol 29:279-81. 2002
    ..The aim of the study was to ascertain the value of identification of HHV-8 viral DNA sequences in routinely processed, formalin-fixed, paraffin-embedded tissues for the diagnosis of Kaposi's sarcoma and other mesenchymal tumors...
  14. ncbi Superficial radiotherapy for patients with basal cell carcinoma: recurrence rates, histologic subtypes, and expression of p53 and Bcl-2
    Beate Zagrodnik
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Cancer 98:2708-14. 2003
    ..In the current article, the authors report recurrence rates among patients with BCC after superficial radiotherapy as well as Bcl-2 and p53 expression levels stratified by BCC subtype...
  15. ncbi Primary cutaneous B-cell lymphomas - clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fun
    Philippa Golling
    Department of Dermatology, Cutaneous Lymphoma Study Group, University Hospital, Zurich, Switzerland
    Leuk Lymphoma 49:1094-103. 2008
    ..Surgical excision or radiotherapy is highly effective in pcMZL and pcFCL...
  16. doi Clonality in sarcoidosis, granuloma annulare, and granulomatous mycosis fungoides
    Katrin Pfaltz
    Kempf and Pfaltz Histological Diagnostics, Zurich, Switzerland
    Am J Dermatopathol 33:659-62. 2011
    ..The analysis of T-cell clonality is a useful diagnostic adjunct in the differentiation between sarcoidosis and GA from granulomatous CTCLs...
  17. ncbi WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects
    Gunter Burg
    Department of Dermatology, University Hospital Zurich, Switzerland
    J Cutan Pathol 32:647-74. 2005
    ..These findings always have to be interpreted in the context of the clinical features and biologic behavior...
  18. doi Skin cancer in organ transplant recipients
    Werner Kempf
    Kempf and Pfaltz Histological Diagnostics, Zurich, Switzerland
    Pathobiology 80:302-9. 2013
    ..This review discusses the clinical and histopathological aspects of skin cancers in OTR, the impact of dermatopathological analysis on prognosis and the understanding of the pathogenesis of these neoplasms. ..
  19. ncbi Hepatitis C and G viruses in B-cell lymphomas of the skin
    Sonja Michaelis
    Unit of Dermatopathology, Department of Dermatology, University Hospital, Zurich, Switzerland
    J Cutan Pathol 30:369-72. 2003
    ..Most studies were performed in patients with known HCV infection, but the overall frequency of HCV- and HGV-RNA in tumoral tissue of primary cutaneous B-cell lymphomas (CBCLs) is unknown...
  20. ncbi Intra-lesional low-dose interferon alpha2a therapy for primary cutaneous marginal zone B-cell lymphoma
    Antonio Cozzio
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Leuk Lymphoma 47:865-9. 2006
    ..All other patients remained free of disease. Thus, intra-lesional IFNalpha2a may represent a valuable alternative to surgery and radiotherapy as first-line treatment of pcMZL...
  21. ncbi Extracutaneous transformation into a high-grade lymphoma: a potential pitfall in the management of patients with Sézary syndrome
    Sonja Michaelis
    Department of Dermatology, University Hospital, Zurich, Switzerland
    Int J Dermatol 45:277-9. 2006
    ..Transformation into a high-grade lymphoma in cutaneous T-cell lymphoma (CTCL) occurs in approximately 25% of cases and is associated with an aggressive clinical course...
  22. ncbi Multilineage progression of genetically unstable tumor subclones in cutaneous T-cell lymphoma
    Albert Rübben
    Department of Dermatology, Universitatsspital Zurich, Zurich, Switzerland
    Exp Dermatol 13:472-83. 2004
    ..Our results suggest that CTCL may evolve by multilineage progression and that tumor subclones in MF can be detected in early disease stages by mutation analysis of microsatellite DNA obtained from multiple microdissected areas...
  23. doi Primary cutaneous CD8(+) small- to medium-sized lymphoproliferative disorder in extrafacial sites: clinicopathologic features and concept on their classification
    Werner Kempf
    Kempf und Pfaltz Histologische Diagnostik, Zurich, Switzerland
    Am J Dermatopathol 35:159-66. 2013
    ....
  24. ncbi CD4/CD8 double negative mycosis fungoides with PD-1 (CD279) expression--a disease of follicular helper T-cells?
    Werner Kempf
    Kempf und Pfaltz, Histologische Diagnostik, Zurich, Switzerland
    Am J Dermatopathol 34:757-61. 2012
    ..Our observation may give an insight into the histogenesis of this unique MF variant and may also be of therapeutic significance because programmed death-1 may serve as a target for therapeutic intervention...
  25. doi Unilesional follicular mycosis fungoides: report of two cases with progression to tumor stage and review of the literature
    Werner Kempf
    Kempf und Pfaltz, Histologische Diagnostik, Zurich, Switzerland
    J Cutan Pathol 39:853-60. 2012
    ..Complete remission was achieved by local radiation therapy in both patients. The differential diagnoses, classification and implications for the treatment of unilesional FMF as well as the pertinent literature are discussed...
  26. doi Pre- and posttransplant management of solid organ transplant recipients: risk-adjusted follow-up
    Bahar Shafaeddin Schreve
    Dermatologische Klinik, Universitatsspital Zurich, Gloriastrasse 31, Zurich, Switzerland
    Curr Probl Dermatol 43:57-70. 2012
    ..The dermatological follow-up of SOTR should be integrated into the comprehensive posttransplant care...
  27. doi Constitutional intraepidermal ascent of melanocytes: a potential pitfall in the diagnosis of melanocytic lesions
    Katrin Kerl
    Department of Dermatology, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Arch Dermatol 148:235-8. 2012
    ..We discuss the value of TEM for the diagnosis of melanocytic tumors in a young patient previously diagnosed as having 11 cutaneous melanomas...
  28. ncbi Topical and systemic retinoid therapy for cutaneous T-cell lymphoma
    Werner Kempf
    Department of Dermatology, University Hospital, Gloriastrasse 31, CH 8091, Zurich, Switzerland
    Hematol Oncol Clin North Am 17:1405-19. 2003
    ..In addition, new agonists of RAR and RXR, either selective or pan agonists, will become available and will enlarge the spectrum of vitamin A analogs that have antitumoral properties...
  29. ncbi Topical photodynamic therapy in the treatment of actinic keratoses and Bowen's disease in transplant recipients
    Galya Dragieva
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Transplantation 77:115-21. 2004
    ..Topical photodynamic therapy (PDT) has been proven to be an effective treatment for AK and BD in immunocompetent patients, but no prospective trials in immunocompromised TR have been performed so far...
  30. ncbi The anti-MAGE antibody B57 as a diagnostic marker in melanocytic lesions
    Dmitry V Kazakov
    Unit of Dermatopathology, Department of Dermatology, University Hospital, Zurich, Switzerland
    Am J Dermatopathol 26:102-7. 2004
    ....
  31. ncbi Imiquimod induces complete clearance of a PUVA-resistant plaque in mycosis fungoides
    Reinhard Dummer
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Dermatology 207:116-8. 2003
    ..However, the plaque on the face was PUVA resistant. Local imiquimod treatment resulted in the complete clearance of the plaque. The patient has now been in complete remission for 12 months...
  32. ncbi Angiolymphoid hyperplasia with eosinophilia: evidence for a T-cell lymphoproliferative origin
    Werner Kempf
    Department of Dermatology, University Hospital Zurich, Switzerland
    Hum Pathol 33:1023-9. 2002
    ..These data suggest that ALHE or a subset of ALHE cases harboring a clonal T-cell population may represent a T-cell lymphoproliferative disorder of a benign or low-grade malignant nature...
  33. ncbi Junctional CD8+ cutaneous lymphomas with nonaggressive clinical behavior: a CD8+ variant of mycosis fungoides?
    Reinhard Dummer
    Department of Dermatology, University Hospital, Gloriastrasse 31, CH 8091 Zurich, Switzerland
    Arch Dermatol 138:199-203. 2002
    ..To evaluate the clinical and prognostic features in primary cutaneous CD8+ T-cell lymphomas, which are rare and considered to be aggressive cutaneous lymphoproliferative disorders...
  34. ncbi Proliferation of CD30+ T-helper 2 lymphoma cells can be inhibited by CD30 receptor cross-linking with recombinant CD30 ligand
    Jörg Willers
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Clin Cancer Res 9:2744-54. 2003
    ..Proliferation and apoptosis of cultured cells were measured by 5-bromo-2-desoxyuridine and propidium iodine incorporation...
  35. doi Primary cutaneous B-cell lymphomas
    Werner Kempf
    Department of Dermatology, University Hospital Zurich, Switzerland
    J Dtsch Dermatol Ges 10:12-22; quiz 23. 2012
    ..Clinico-pathologic correlation, histology with immunohistochemical profile and genotyping as well as staging examinations are crucial diagnostic elements in the work-up of CBCL...
  36. doi Spindle-cell variant of primary cutaneous follicle center lymphoma spreading to the hepatobiliary tree, mimicking Klatskin tumor
    Sima Rozati
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    J Cutan Pathol 40:56-60. 2013
    ..On the basis of the sparse published data on spindle-cell morphology of pcBCL, this growth pattern should elicit awareness of an increased risk of systemic involvement in the otherwise indolent pcFCL...
  37. doi Follicular lymphomatoid papulosis revisited: a study of 11 cases, with new histopathological findings
    Werner Kempf
    Kempf und Pfaltz, Histologische Diagnostik, Zurich, Switzerland
    J Am Acad Dermatol 68:809-16. 2013
    ..Follicular lymphomatoid papulosis (LyP) describes a variant of LyP with perifollicular infiltrates and some degree of folliculotropism of CD30(+) atypical lymphocytes. So far, only a few cases of follicular LyP have been described...
  38. ncbi Febrile ulceronecrotic Mucha-Habermann disease with clonality: a cutaneous T-cell lymphoma entity?
    Antonio Cozzio
    Department of Dermatology, University Hospital of Zurich, Switzerland
    J Am Acad Dermatol 51:1014-7. 2004
    ..Here, we report two cases of FUMHD with monoclonal T-cell population, as detected by Southern blot analysis. We propose that clonal FUMHD represents a cutaneous T-cell lymphoma entity...
  39. doi Critical skin cancer in organ transplant recipients--a dermatopathological view
    Werner Kempf
    Kempf and Pfaltz, Histological Diagnostics, University Hospital Zurich, Seminarstrasse 1, Zurich, Switzerland
    Curr Probl Dermatol 43:18-35. 2012
    ..This review discusses the histopathological aspects of skin cancers in OTR, the impact of dermatopathological analysis on prognosis and understanding of the pathogenesis of these neoplasms...
  40. doi Borrelia in granuloma annulare, morphea and lichen sclerosus: a PCR-based study and review of the literature
    Therese Zollinger
    Kempf und Pfaltz Histologische Diagnostik, Zurich, Switzerland
    J Cutan Pathol 37:571-7. 2010
    ..Thus, we examined skin biopsies of morphea, GA and LSA by PCR to assess the prevalence of Borrelia DNA in an endemic area and to compare our results with data in the literature...
  41. doi Primary cutaneous anaplastic large cell lymphoma with angioinvasive features and cytotoxic phenotype: a rare lymphoma variant within the spectrum of CD30+ lymphoproliferative disorders
    Werner Kempf
    Kempf und Pfaltz, Histologische Diagnostik, University Hospital, Zurich, Switzerland
    Dermatology 227:346-52. 2013
    ..Primary cutaneous anaplastic large cell lymphoma (PCALCL) presents with solitary or grouped exophytic tumors and cohesive infiltrates of large CD30+ T cells...
  42. ncbi Nephrogenic fibrosing dermopathy treated with extracorporeal photopheresis
    Severin Lauchli
    Department of Dermatology, University Hospital, Zurich, Switzerland
    Dermatology 208:278-80. 2004
    ..Two years after transplantation, she developed sclerodermiform brownish plaques on her extremities. The induration improved significantly after 4 cycles of extracorporeal photopheresis...
  43. doi Immunohistochemical dual staining as an adjunct in assessment of mitotic activity in melanoma
    Kristian Ikenberg
    Kempf and Pfaltz Histological Diagnostics, Zurich, Switzerland
    J Cutan Pathol 39:324-30. 2012
    ..The detection of a single mitotic figure changes the tumor stage in thin melanoma. We sought to address the value of a dual staining to facilitate the determination of the mitotic rate and to assign the mitotic activity to melanocytes...
  44. doi Necrotizing infundibular crystalline folliculitis: a clinicopathological study
    Natalja Denisjuk
    Kempf and Pfaltz, Histological Diagnostics, Zurich, Switzerland
    J Am Acad Dermatol 66:823-6. 2012
    ..There are only very few data published about this disorder of unknown origin...
  45. doi Classification of cutaneous lymphomas - an update
    Werner Kempf
    Kempf und Pfaltz, Histologische Diagnostik, University Hospital Zurich, Zurich, Switzerland
    Histopathology 56:57-70. 2010
    ..Recent changes in the terminology and staging, practical implications and future perspectives are discussed...
  46. pmc EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma
    Werner Kempf
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Blood 118:4024-35. 2011
    ..The recommendations represent the state-of-the-art management of CD30(+) LPDs and include definitions for clinical endpoints as well as response criteria for future clinical trials in CD30(+) LPDs...
  47. doi A rare case of atypical cellular neurothekeoma in a 68-year-old woman
    Kirsten D Mertz
    Kempf and Pfaltz Histological Diagnostics, Zurich, Switzerland
    J Cutan Pathol 36:1210-4. 2009
    ..Our report contributes to a better characterization of the clinical and morphologic features of atypical cellular neurothekeoma...
  48. ncbi Cutaneous lymphomas and pseudolymphomas: newly described entities
    Dmitry V Kazakov
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Recent Results Cancer Res 160:283-93. 2002
    ..In the context of pseudolymphomas, cutaneous follicular lymphoid hyperplasia with monotypic plasma cells, pleomorphic reactions in molluscum contagiosum, and CD30+ reactions to parapoxvirus are discussed...
  49. ncbi Primary cutaneous plasmacytoma: a clinicopathological study of two cases with a long-term follow-up and review of the literature
    Dmitry V Kazakov
    Department of Dermatology, University Hospital, Zurich, Switzerland
    J Cutan Pathol 29:244-8. 2002
    ..The disease is rare with only 30 cases reported so far...
  50. ncbi Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin
    Werner Kempf
    Department of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
    Carcinogenesis 24:301-6. 2003
  51. ncbi Allelic deletion at 9p21-22 in primary cutaneous CD30(+) large cell lymphoma
    R Boni
    Department of Dermatology, University Hospital, Zurich, Switzerland
    J Invest Dermatol 115:1104-7. 2000
    ..J Invest Dermatol 115:1104-1107 2000..
  52. ncbi Pyogenic lymphoma of the skin: a peculiar variant of primary cutaneous neutrophil-rich CD30+ anaplastic large-cell lymphoma. Clinicopathological study of four cases and review of the literature
    G Burg
    Department of Dermatology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Br J Dermatol 148:580-6. 2003
    ..The clinical behaviour of this type is the same as in primary cutaneous CD30+ ALCL with classical histological presentation...
  53. doi Pityriasis lichenoides et varioliformis acuta with numerous CD30(+) cells: a variant mimicking lymphomatoid papulosis and other cutaneous lymphomas. A clinicopathologic, immunohistochemical, and molecular biological study of 13 cases
    Werner Kempf
    Kempf und Pfaltz Histologische Diagnostik, Seminarstrasse 1, CH 8042 Zürich, Switzerland
    Am J Surg Pathol 36:1021-9. 2012
    ....
  54. ncbi Successful treatment of recalcitrant chronic actinic dermatitis with tacrolimus
    Christian Schuster
    Department of Dermatology, University Hospital Zurich, Switzerland
    Dermatology 209:325-8. 2004
    ..We present a case of chronic actinic dermatitis responding well to topically applied tacrolimus (Protopic) in combination with chemical and physical UV protection...
  55. doi Inflammatory monocytes are a reservoir for Merkel cell polyomavirus
    Kirsten D Mertz
    Kempf and Pfaltz Histological Diagnostics, Research Unit, Zurich, Switzerland
    J Invest Dermatol 130:1146-51. 2010
    ..This points to intervention strategies to contain MCPyV. Moreover, blood or urine tests may serve as ancillary tests to confirm MCPyV infection in a clinical setting...
  56. ncbi From inflammation to neoplasia: new concepts in the pathogenesis of cutaneous lymphomas
    Gunter Burg
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Recent Results Cancer Res 160:271-80. 2002
    ..g. environmental foreign antigens, bacterial superantigen, and/or endogenous factors, e.g. autocrine cytokine loops, CD40/CD40L and B7/CD28 interaction...
  57. doi Spitzoid melanoma and micrometastases in two lymph node regions: a critical situation
    Alexander A Navarini
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Eur J Dermatol 21:229-33. 2011
    ..Treatment decisions for atypical Spitz tumors are a major medical and ethical challenge due to the limited available data...
  58. doi Homozygosity for the c.917A→T (p.N306l) polymorphism in the EVER2/TMC8 gene of two sisters with epidermodysplasia verruciformis Lewandowsky-Lutz originally described by Wilhelm Lutz
    Andreas W Arnold
    Department of Dermatology, University Hospital Basel, Basel, Switzerland
    Dermatology 222:81-6. 2011
    ..We reinvestigated 2 patients originally described by Wilhelm Lutz in 1946 with the aim to document the natural course of the disease and confirm his diagnosis...
  59. doi Cutaneous lymphomas: an update. Part 1: T-cell and natural killer/t-cell lymphomas and related conditions
    Werner Kempf
    Dermatopathologist and Dermatologist, Kempf und Pfaltz, Histologische Diagnostik, Zurich, Switzerland Professor, Department of Dermatology, University Hospital Zurich, Switzerland Dermatopathologist and Dermatologist, Professor, Department of Pathology, Medical Faculty in Pilsen, Charles University, Prague, Czech Republic and Dermatopathologist and Dermatologist, Faculty Member, Department of Dermatology, University Hospital Zurich, Switzerland
    Am J Dermatopathol 36:105-23. 2014
    ..Clinicopathologic correlation is mandatory for the diagnosis of primary CLs. Analysis of genetic and epigenetic alterations in CLs revealed new diagnostic markers and putative targets for therapy of aggressive forms of CLs...
  60. doi Lobular panniculitis due to Borrelia burgdorferi infection mimicking subcutaneous panniculitis-like T-cell lymphoma
    Werner Kempf
    Kempf und Pfaltz, Histologische Diagnostik, Zurich, Switzerland
    Am J Dermatopathol 35:e30-3. 2013
    ..B. burgdorferi etiology was proven by positive polymerase chain reaction and serology and positive response to antibiotics...
  61. doi Detection of Merkel cell polyomavirus and human papillomaviruses in Merkel cell carcinoma combined with squamous cell carcinoma in immunocompetent European patients
    Christina Mitteldorf
    Department of Dermatology, Venereology and Allergology, Klinikum Hildesheim GmbH, Hildesheim, Germany
    Am J Dermatopathol 34:506-10. 2012
    ..In European patients, Merkel cell polyomavirus (MCPyV) is detectable in 60%-88% of the MCC tumors. In combined lesions, MCPyV was not detectable so far...
  62. doi Cutaneous lymphomas: an update. Part 2: B-cell lymphomas and related conditions
    Werner Kempf
    Kempf und Pfaltz, Histologische Diagnostik, Zurich, Switzerland Professor, Department of Dermatology, University Hospital Zurich, Zurich, Switzerland Professor, Department of Pathology, Medical Faculty in Pilsen, Pilsen, Charles University in Prague, Czech Republic and Doctor, Department of Dermatology, Klinikum Hildesheim GmbH, Hildesheim, Germany
    Am J Dermatopathol 36:197-208; quiz 209-10. 2014
    ....
  63. ncbi CO2 laser treatment of warts in immunosuppressed patients
    Severin Lauchli
    Department of Dermatology, University Hospital, Zurich, Switzerland
    Dermatology 206:148-52. 2003
    ..Furthermore, the incidence of nonmelanoma skin cancer is clearly elevated in this patient group and human papillomavirus is most likely to play a causal role in these neoplasms...
  64. ncbi HLA-G protein up-regulation in primary cutaneous lymphomas is associated with interleukin-10 expression in large cell T-cell lymphomas and indolent B-cell lymphomas
    Mirjana Urosevic
    Department of Dermatology, University Hospital Zurich, Switzerland
    Blood 99:609-17. 2002
    ..001). HLA-G up-regulation together with IL-10 expression in CL might additionally contribute to the evasion of immunosurveillance and facilitate the transition from low- to high-grade lymphomas...
  65. pmc Inadequate clearance of translocated bacterial products in HIV-infected humanized mice
    Ursula Hofer
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    PLoS Pathog 6:e1000867. 2010
    ..LPS levels reflect both intestinal barrier and LPS clearance. Macrophages are essential in controlling systemic bacterial translocation, and this function might be hindered in chronic HIV infection...
  66. pmc Disseminated molluscum contagiosum in a HIV-positive child. Improvement after therapy with 5% imiquimod
    Martin Theiler
    Department of Dermatology, University Hospital, Zurich, Switzerland
    J Dermatol Case Rep 5:19-23. 2011
    ..With the emergence of HIV/AIDS, a new patient group at risk has been identified with often extensive skin involvement and recalcitrant disease...
  67. ncbi Treatment of verrucous carcinoma with imiquimod and CO2 laser ablation
    L M Heinzerling
    University Hospital Zurich, Zurich, Switzerland
    Dermatology 207:119-22. 2003
    ..In a third session, tumor parts in the anal canal were vaporized. This case demonstrates that the combination of imiquimod and CO2 laser ablation is an effective treatment option for verrucous carcinoma...
  68. ncbi Atypical poorly differentiated cutaneous T-cell lymphoma with an angiocentric growth pattern presenting histologically as vasculitis
    B Laetsch
    Dermatologische Klinik, Universitatsspital Zurich, Zurich, Schweiz
    Dermatology 210:341-5. 2005
    ..This atypical poorly differentiated lymphoma was of a CD4+ CD8- CD56- phenotype and followed an unfavourable course. The patient died despite chemo- and immunotherapy 7 months after the first consideration of lymphoma as diagnosis...
  69. ncbi A case of Sézary's syndrome associated with granulomatous lesions, myelodysplastic syndrome and transformation into CD30-positive large-cell pleomorphic lymphoma
    P M Carrozza
    Department of Dermatology, University of Zurich Medical School, Gloriastr 31, CH 8091 Zurich, Switzerland
    Br J Dermatol 147:582-6. 2002
    ....
  70. ncbi Mycosis fungoides with mucinosis follicularis in childhood
    M Hess Schmid
    Department of Dermatology, University of Zurich, Switzerland
    Dermatology 198:284-7. 1999
    ..Mycosis fungoides should be considered in the differential diagnosis of chronic, scaling dermatoses in childhood. Moreover, follicular mucinosis in childhood can be associated with mycosis fungoides...
  71. ncbi Skin cancers in organ transplant recipients: two cases of virus-induced neoplasms
    G F Hofbauer
    Department of Dermatology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Dermatology 202:359-61. 2001
    ..The diagnostic approach, differential diagnosis and treatment options are discussed emphasizing the characteristics of cutaneous lesions in immunosuppressed transplant recipients...
  72. pmc Differential expression of cytotoxic molecules and killer cell inhibitory receptors in CD8+ and CD56+ cutaneous lymphomas
    J Kamarashev
    Department of Dermatology, University Hospital, Zurich, Switzerland
    Am J Pathol 158:1593-8. 2001
    ..Various subtypes of cytotoxic cutaneous lymphomas (CD8+ and CD56+) differ in regard to their phenotypic and functional profile, which may explain differences in their biological behavior...
  73. ncbi Unusual manifestation of specific cutaneous involvement by B-cell chronic lymphocytic leukemia: spontaneous regression with scar formation
    D V Kazakov
    Unit of Dermatopathology, Department of Dermatology, University Hospital, Zurich, Switzerland
    Dermatology 207:111-5. 2003
    ..The scars persisted and remained unchanged. We hypothesize that vascular injury combined with edema could have accounted for dermal ischemia and the subsequent development of the scarring lesions...
  74. ncbi Tumor-infiltrating T cells in primary cutaneous B-cell lympho-proliferative disorders
    J Kamarashev
    Department of Dermatology, , , Switzerland
    J Cutan Pathol 28:448-52. 2001
    ..However, due to an overlap of the number of TILs, this parameter cannot be employed as a diagnostic parameter for individual cases...
  75. ncbi Trichogerminoma: a rare cutaneous adnexal tumor with differentiation toward the hair germ epithelium
    D V Kazakov
    Unit of Dermatopathology, Department of Dermatology, University Hospital, Zurich, Switzerland
    Dermatology 205:405-8. 2002
    ..Histological differential diagnosis includes basal-cell carcinoma (pilar type), large nodular TB, trichoblastic fibroma, trichoepithelioma, tricholemmoma, pilomatricoma and matrical carcinoma...
  76. ncbi Multilesional primary cutaneous diffuse large B-cell lymphoma responsive to antibiotic treatment
    G F Hofbauer
    Department of Dermatology, University Hospital, , Switzerland
    Dermatology 203:168-70. 2001
    ..burgdorferi titers. After antibiotic therapy, clinical remission and a subsequent drop in B. burgdorferi antibody titers were obtained...
  77. ncbi [Granulomatous slack skin: partial remission following intralesional administration of interferon-alpha and PUVA]
    T Schmook
    Dermatologische Klinik, , Gloriastrasse 31,
    Hautarzt 52:985-8. 2001
    ..Skin lesions are characterized by pendulous folds. We report on the successful response of the lesions to intralesional interferon alpha combined with PUVA...
  78. ncbi T-zone lymphoma with cutaneous involvement: a case report and review of the literature
    D V Kazakov
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Br J Dermatol 146:1096-100. 2002
    ..We present a case of TZL with secondary skin infiltration, review the literature on cutaneous manifestations of TZL and discuss the differential diagnosis of TZL...
  79. ncbi Primary subcutaneous follicular centre cell lymphoma with involvement of the galea: a case report and short review of the literature
    D V Kazakov
    Unit of Dermatopathology, Department of Dermatology, University of Zurich Medical School, Gloriastr 31, CH 8091 Zurich, Switzerland
    Br J Dermatol 146:663-6. 2002
    ..We report the first case of primary FCCL located primarily in the deep subcutis with extension into the galea and review the literature on primary subcutaneous B-cell lymphomas...
  80. doi Swiss clinical practice guidelines for skin cancer in organ transplant recipients
    G F Hofbauer
    Dermatologische Klinik, Universitatsspital Zurich, Kantonsspital St Gallen, Zurich, Switzerland
    Swiss Med Wkly 139:407-15. 2009
    ..Chemoprevention with the retinoid acitretin reduces the recurrence rate of SCC. The dermatological follow-up of SOTRs should be integrated into the comprehensive post-transplant care...
  81. ncbi Photodynamic therapy--a new treatment option for epithelial malignancies of the skin
    G Dragieva
    Department of Dermatology, University Hospital of Zurich, Switzerland
    Onkologie 27:407-11. 2004
    ..The following article summarizes the main principles of PDT and provides a synopsis of the present status of the use of PDT for epithelial skin malignancies...
  82. ncbi A randomized controlled clinical trial of topical photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratoses in transplant recipients
    G Dragieva
    Department of Dermatology, University Hospital of Zurich, 31 Gloriastr, 8091 Zurich, Switzerland
    Br J Dermatol 151:196-200. 2004
    ..Transplant recipients have an increased propensity to develop multiple actinic keratoses, which demonstrate an increased transformation rate into invasive squamous cell carcinoma...
  83. ncbi Baseline staging in cutaneous malignant melanoma
    J Hafner
    Department of Dermatology, Institute of Social and Preventive Medicine, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Br J Dermatol 150:677-86. 2004
    ..Baseline staging in patients with primary cutaneous malignant melanoma (MM) is routine, but the diagnostic accuracy and the impact on clinical outcome are still unclear...
  84. ncbi Paraneoplastic pityriasis lichenoides in cutaneous lymphoma: case report and review of the literature on paraneoplastic reactions of the skin in lymphoma and leukaemia
    W Kempf
    Department of Dermatology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Br J Dermatol 152:1327-31. 2005
    ..In addition, we review the literature on paraneoplastic dermatoses of the skin which have been described in patients with leukaemias and primary cutaneous lymphomas...
  85. ncbi HLA-G expression in basal cell carcinomas of the skin recurring after radiotherapy
    M Urosevic
    Department of Dermatology, University Hospital Zurich, Switzerland
    Clin Exp Dermatol 30:422-5. 2005
    ..After radiotherapy, immunobiology of BCC may change resulting in the down-regulation of HLA-G expression on tumor and on tumor-infiltrating cells...
  86. ncbi Blastic natural killer-cell lymphoma of the skin associated with myelodysplastic syndrome or myelogenous leukaemia: a coincidence or more?
    D V Kazakov
    Unit of Dermatopathology, Department of Dermatology, University Hospital, Gloriastrasse 31, 8091 Zurich, Switzerland
    Br J Dermatol 149:869-76. 2003
    ....
  87. ncbi The spectrum of mesenchymal skin neoplasms reflected by the new WHO classification
    M Beyeler
    Department of Dermatology, University Hospital of Zurich, Switzerland
    Onkologie 27:401-6. 2004
    ..Early detection and removal is critical since mesenchymal skin tumors often cannot be cured by radiation or chemotherapy...
  88. ncbi Imiquimod in basal cell carcinoma: how does it work?
    R Dummer
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, CH 8091 Zurich, Switzerland
    Br J Dermatol 149:57-8. 2003
    ..Our findings demonstrate that imiquimod-induced BCC regression is associated with a strong activity of the innate immune response, mediated by cells of macrophage-monocyte origin and is associated with the induction of apoptosis...
  89. ncbi Therapy of cutaneous lymphoma--current practice and future developments
    R Dummer
    Department of Dermatology, University Hospital of Zurich, Switzerland
    Onkologie 26:366-72. 2003
    ..In advanced stages, systemic drugs such as interferon-alpha or bexarotene can be administered. Experimental approaches for cutaneous lymphomas include vaccination and gene therapy...
  90. ncbi Primary cutaneous B-cell lymphomas and pseudolymphomas: review of histopathological features
    D V Kazakov
    Unit of Dermatopathology, Department of Dermatology, University Hospital, Zurich, Switzerland
    Cesk Patol 38:147-54. 2002
    ..This article addresses the histopathological features of primary cutaneous B-cell lymphomas and B-cell pseudolymphomas and presents a modern approach to the diagnosis of these lymphoid neoplasms...
  91. ncbi HHV-8 DNA sequences in the peripheral blood and skin lesions of an HIV-negative patient with multiple eruptive dermatofibromas: implications for the detection of HHV-8 as a diagnostic marker for Kaposi's sarcoma
    D V Kazakov
    Department of Dermatology, University Hospital, Zurich, Switzerland
    Dermatology 206:217-21. 2003
    ..Whereas KS is strongly associated with human herpesvirus 8 (HHV-8), the virus has never been detected in MEDF until now...
  92. ncbi Fascin expression in CD30-positive cutaneous lymphoproliferative disorders
    Werner Kempf
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
    J Cutan Pathol 29:295-300. 2002
    ..Currently there is no marker to predict the development of systemic lymphomas in patients with LyP. Fascin, an actin bundling protein, has recently been shown to be a unique marker found in almost 100% of classical HL...
  93. ncbi Follicular lymphoma of the skin and superficial soft tissues associated with a prominent follicular dendritic cell proliferation: an unusual pattern which may represent a diagnostic pitfall
    Dmitry V Kazakov
    Laboratoire Spec Diagnostiky, Sikl s Department of Pathology, Medical Faculty Hospital, Charles University, Alej Svobody 80, 30460 Pilsen, Czech Republic
    Pathol Res Pract 200:557-65. 2004
    ..Such cases may represent a diagnostic pitfall, as FDC overgrowth can mask FL and give the neoplasm the appearance of FDC sarcoma/tumor. We believe that, in both cases, the FDC proliferation had a reactive character...
  94. ncbi Dyscrasias with "undetermined significance"
    Gunter Burg
    Arch Dermatol 141:382-4. 2005
  95. ncbi Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop
    Marco Santucci
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Cancer 97:610-27. 2003
    ....
  96. ncbi Hypertext atlas of dermatopathology with expert system for epithelial tumors of the skin
    Josef Feit
    Institute of Pathology, Masaryk University, University Hospital Jihlavska, Brno, Czech Republic
    J Cutan Pathol 32:433-7. 2005
    ..Distribution of such images over the Internet requires developing a suitable user's interface with access to the image details...
  97. ncbi Melanoma with prominent pigment synthesis (animal-type melanoma): a case report with ultrastructural studies
    Dmitry V Kazakov
    Sikl s Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic
    Am J Dermatopathol 26:290-7. 2004
    ..Melanophages were a minor component of the lesion. Our ultrastructural studies provide unequivocal evidence that ATM is a neoplasm of melanosome-producing cells. We also review the literature on ATM...
  98. pmc CD56-positive haematological neoplasms of the skin: a multicentre study of the Cutaneous Lymphoma Project Group of the European Organisation for Research and Treatment of Cancer
    Chalid Assaf
    Department of Dermatology, Charite, Berlin, Germany
    J Clin Pathol 60:981-9. 2007
    ..However, prognostic subsets within the CD56+ group have been difficult to identify due to the lack of uniform clinicopathological and immunophenotypical criteria...
  99. ncbi Primary cutaneous lymphoproliferative disorders with dual lineage rearrangement
    Dmitry V Kazakov
    Sikl s Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic
    Am J Dermatopathol 28:399-409. 2006
    ..Further reports are needed to identify these lesions to clarify their nature and biologic potential...
  100. ncbi Defining early mycosis fungoides
    Nicola Pimpinelli
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    J Am Acad Dermatol 53:1053-63. 2005
    ....
  101. ncbi Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma?
    Gabriele Palmedo
    DermPath, Friedrichshafen, Germany
    Am J Dermatopathol 29:231-6. 2007
    ..Therefore, the etiopathogenetic relevance of either translocation in PCMZL remains a matter of debate...