J Keiser

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections
    Lucienne Tritten
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1457. 2011
  2. pmc Orally active antischistosomal early leads identified from the open access malaria box
    Katrin Ingram-Sieber
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland
    PLoS Negl Trop Dis 8:e2610. 2014
  3. pmc Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial
    Benjamin Speich
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 6:e1685. 2012
  4. pmc Accuracy of the Kato-Katz method and formalin-ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy
    Men bao Qian
    University of Basel, Basel, Switzerland
    Parasit Vectors 6:314. 2013
  5. doi Activity of tribendimidine and praziquantel combination therapy against the liver fluke Opisthorchis viverrini in vitro and in vivo
    J Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    J Helminthol 87:252-6. 2013
  6. pmc Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 7:e2119. 2013
  7. pmc Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae
    David Wimmersberger
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P, O, Box, Basel, CH 4002, Switzerland
    Parasit Vectors 6:42. 2013
  8. doi Advances in the discovery and development of trematocidal drugs
    Jennifer Keiser
    Assistant Professors, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland 41 61 284 8218 41 61 284 8105
    Expert Opin Drug Discov 2:S9-S23. 2007
  9. ncbi Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH 4002 Basel, Switzerland
    Exp Parasitol 133:265-8. 2013
  10. pmc Prevalence of intestinal protozoa infection among school-aged children on Pemba Island, Tanzania, and effect of single-dose albendazole, nitazoxanide and albendazole-nitazoxanide
    Benjamin Speich
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, PO Box, CH 4002 Basel, Switzerland
    Parasit Vectors 6:3. 2013

Detail Information

Publications88

  1. pmc In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections
    Lucienne Tritten
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1457. 2011
    ..In the present work, we tested the efficacy of the veterinary drug monepantel, a potential drug development candidate compared to standard drugs in vitro and in parasite-rodent models of relevance to human soil-transmitted helminthiases...
  2. pmc Orally active antischistosomal early leads identified from the open access malaria box
    Katrin Ingram-Sieber
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland
    PLoS Negl Trop Dis 8:e2610. 2014
    ..Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs...
  3. pmc Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial
    Benjamin Speich
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 6:e1685. 2012
    ..The currently used anthelmintic drugs, in single oral application, have low efficacy against Trichuris trichiura infection, and hence novel anthelmintic drugs are needed. Nitazoxanide has been suggested as potential drug candidate...
  4. pmc Accuracy of the Kato-Katz method and formalin-ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy
    Men bao Qian
    University of Basel, Basel, Switzerland
    Parasit Vectors 6:314. 2013
    ..We assessed the diagnostic accuracy of the Kato-Katz method and the formalin-ether concentration technique (FECT) for C. sinensis diagnosis, and studied the effect of diagnostic approach on drug efficacy evaluation...
  5. doi Activity of tribendimidine and praziquantel combination therapy against the liver fluke Opisthorchis viverrini in vitro and in vivo
    J Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    J Helminthol 87:252-6. 2013
    ..Further studies are necessary to understand the striking differences between the in vitro and in vivo observations using combinations of praziquantel and tribendimidine on O. viverrini...
  6. pmc Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 7:e2119. 2013
    ..The re-evaluation of old, forgotten drugs is a promising strategy to identify alternative anthelminthic drug candidates or drug combinations...
  7. pmc Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae
    David Wimmersberger
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P, O, Box, Basel, CH 4002, Switzerland
    Parasit Vectors 6:42. 2013
    ..The objective of the present study was to develop a simple and cost-effective drug sensitivity assay using Trichuris muris first-stage larvae (L1)...
  8. doi Advances in the discovery and development of trematocidal drugs
    Jennifer Keiser
    Assistant Professors, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland 41 61 284 8218 41 61 284 8105
    Expert Opin Drug Discov 2:S9-S23. 2007
    ..Finally, postmarketing issues of trematocidal drugs are discussed and the authors conclude that innovative environments for the discovery and development of novel trematocidal drugs have emerged...
  9. ncbi Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH 4002 Basel, Switzerland
    Exp Parasitol 133:265-8. 2013
    ..05)h. In conclusion, IMC is useful to document drug effects on juvenile F. hepatica and since rapid technological developments in this field are occurring IMC might also hold promise to study adult F. hepatica in the near future...
  10. pmc Prevalence of intestinal protozoa infection among school-aged children on Pemba Island, Tanzania, and effect of single-dose albendazole, nitazoxanide and albendazole-nitazoxanide
    Benjamin Speich
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, PO Box, CH 4002 Basel, Switzerland
    Parasit Vectors 6:3. 2013
    ..Since diagnosis of these parasites is difficult, prevalence data on intestinal protozoa is scarce...
  11. pmc Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Parasit Vectors 5:292. 2012
    ..The discovery and development of novel efficacious drugs or drug combinations for the treatment of STH infections therefore has a high research priority...
  12. pmc Development of an in vitro drug screening assay using Schistosoma haematobium schistosomula
    Monika Marxer
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Parasit Vectors 5:165. 2012
    ..The aim of the present study was to develop a S. haematobium drug sensitivity assay based on newly transformed schistosomula (NTS)...
  13. ncbi Antimalarials in the treatment of schistosomiasis
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Curr Pharm Des 18:3531-8. 2012
    ....
  14. ncbi Anthelminthic properties of mangostin and mangostin diacetate
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitol Int 61:369-71. 2012
    ..mansoni and E. caproni in vivo, respectively. Pharmacokinetic studies would be helpful to understand the differences observed between in vitro and in vivo activities and lacking dose-response relationships...
  15. pmc Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni
    Jia V Li
    Section of Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    Parasit Vectors 4:179. 2011
    ..Here, we investigated the systems metabolic changes in the mouse upon S. mansoni infection by modeling the sequence of metabolic events in urine, plasma and faecal water...
  16. ncbi Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, CH 4002 Basel, Switzerland
    Res Vet Sci 88:107-10. 2010
    ..3% and 83.9%, respectively, were calculated in the three surviving sheep. In conclusion, the interesting fasciocidal properties of artesunate in sheep warrant further investigations with an emphasis on toxicity studies...
  17. doi Dose-response relationships and tegumental surface alterations in Opisthorchis viverrini following treatment with mefloquine in vivo and in vitro
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Parasitol Res 105:261-6. 2009
    ..In conclusion, we have documented promising opisthorchicidal activities in hamsters and in vitro with the tegument being an important drug target. Proof-of-concept studies with mefloquine could be considered in opisthorchiasis patients...
  18. pmc Mefloquine--an aminoalcohol with promising antischistosomal properties in mice
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 3:e350. 2009
    ..Here, we report that the antimalarial drug mefloquine possesses promising antischistosomal properties in mice...
  19. pmc Combination chemotherapy against Clonorchis sinensis: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in a rat model
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Antimicrob Agents Chemother 53:3770-6. 2009
    ..sinensis is confirmed, and combination chemotherapy with praziquantel produces synergistic and antagonistic effects depending on the doses administered. Further preclinical investigations are warranted...
  20. pmc Food-borne trematodiases
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, CH 4002 Basel, Switzerland
    Clin Microbiol Rev 22:466-83. 2009
    ..Current research needs are emphasized...
  21. doi Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Parasitol Res 103:517-22. 2008
    ..Further studies are warranted to assess the potential of additional artemisinin derivatives and other peroxidic compounds for the treatment of Fasciola spp. infections in different ruminants...
  22. ncbi Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, PO Box, CH 4002 Basel, Switzerland
    JAMA 299:1937-48. 2008
    ..Preventive chemotherapy is the mainstay of control, but only 4 drugs are available: albendazole, mebendazole, levamisole, and pyrantel pamoate...
  23. doi Fasciola hepatica: Surface tegumental responses to in vitro and in vivo treatment with the experimental fasciolicide OZ78
    Jennifer Keiser
    Swiss Tropical Institute, Medical Parasitology and Infection Biology, Socinstr 57, PO Box, CH 4002 Basel, Switzerland
    Exp Parasitol 119:87-93. 2008
    ..In conclusion, our experiments confirm the interesting fasciocidal properties of OZ78. The tegument of adult F. hepatica might play a role in the action of this drug...
  24. ncbi Update on the diagnosis and treatment of food-borne trematode infections
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Basel, Switzerland
    Curr Opin Infect Dis 23:513-20. 2010
    ..This review provides an update on recent developments in the diagnosis and treatment of food-borne trematodiases...
  25. pmc Strongyloides ratti: in vitro and in vivo activity of tribendimidine
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e136. 2008
    ..Strongyloidiasis is a truly neglected tropical disease, but its public health significance is far from being negligible. At present, only a few drugs are available for the treatment and control of strongyloidiasis...
  26. doi In vitro and in vivo trematode models for chemotherapeutic studies
    J Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, CH 4002 Basel, Switzerland
    Parasitology 137:589-603. 2010
    ..Examples of in vitro and in vivo evaluation of compounds for activity are presented. To boost the discovery pipeline for these diseases there is a need to develop validated, robust high-throughput in vitro systems with simple readouts...
  27. pmc Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 82:112-4. 2010
    ..1% and 85.3%, whereas mefloquine achieved total and female worm burden reductions of 80.4-97.8%. In conclusion, artemether and mefloquine act T-cell independently and no synergistic interaction with the immune response was involved...
  28. pmc Representation of authors and editors from countries with different human development indexes in the leading literature on tropical medicine: survey of current evidence
    Jennifer Keiser
    Office of Population Research, Princeton University, Princeton, NJ 08544, USA
    BMJ 328:1229-32. 2004
    ..To assess the current international representation of members of editorial and advisory boards and authors in the leading peer reviewed literature on tropical medicine...
  29. pmc In vivo activity of aryl ozonides against Schistosoma species
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Antimicrob Agents Chemother 56:1090-2. 2012
    ..05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound...
  30. pmc Efficacy and safety of artemether in the treatment of chronic fascioliasis in Egypt: exploratory phase-2 trials
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1285. 2011
    ..Triclabendazole is the only available drug for treatment. Laboratory studies have documented promising fasciocidal properties of the artemisinins (e.g., artemether)...
  31. doi Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH 4002 Basel, Switzerland
    J Antimicrob Chemother 66:1791-7. 2011
    ..The aim of this study was to evaluate activities of mefloquine/praziquantel combinations against Schistosoma mansoni in vitro and in vivo...
  32. doi Antiparasitic drugs for paediatrics: systematic review, formulations, pharmacokinetics, safety, efficacy and implications for control
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 138:1620-32. 2011
    ....
  33. doi Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland
    Vet Parasitol 173:228-35. 2010
    ..5±4.3 h and 56.5±36 h, respectively and the mean AUC was 219.1±74 μg min/ml. Further studies are needed to determine whether the excellent activity observed with OZ78 in the rat model can be translated into efficacy in larger mammals...
  34. pmc Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH 4002 Basel, Switzerland
    J Antimicrob Chemother 65:1991-5. 2010
    ..The antischistosomal properties of the marketed antiandrogens bicalutamide, flutamide, nilutamide and cyproterone acetate were studied both in vivo and in vitro...
  35. ncbi Effect of artemether, artesunate, OZ78, praziquantel, and tribendimidine alone or in combination chemotherapy on the tegument of Clonorchis sinensis
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Parasitol Int 59:472-6. 2010
    ..The effect of drug combinations against C. sinensis requires further scientific inquiry, e.g. in transmission electron microscopy studies and in the C. sinensis-rabbit model...
  36. ncbi Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Clin Infect Dis 50:1205-13. 2010
    ..Morbidity control of schistosomiasis relies on a single drug, praziquantel. The antimalarial drug mefloquine possesses interesting antischistosomal properties, yet no clinical studies have been performed...
  37. ncbi Opisthorchis viverrini: efficacy and tegumental alterations following administration of tribendimidine in vivo and in vitro
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitol Res 102:771-6. 2008
    ..0%. In conclusion, our experiments confirm that tribendimidine possesses interesting trematocidal properties, which warrant additional investigations and provide further data for subsequent clinical trials...
  38. doi Clonorchicidal properties of the synthetic trioxolane OZ78
    Jennifer Keiser
    Swiss Tropical Institute, Basel, Switzerland
    J Parasitol 93:1208-13. 2007
    ..sinensis, respectively. SEM observations revealed tegumental surface alterations, including blebbing and sloughing. OZ78 emerges as a new compound with a broad spectrum of activity against major foodborne trematode infections...
  39. ncbi Effect of irrigated rice agriculture on Japanese encephalitis, including challenges and opportunities for integrated vector management
    Jennifer Keiser
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Acta Trop 95:40-57. 2005
    ....
  40. ncbi The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica
    Jennifer Keiser
    Swiss Tropical Institute, CH 4002 Basel, Switzerland
    J Antimicrob Chemother 58:1193-7. 2006
    ..The trematocidal properties of a synthetic peroxide, 1,2,4-trioxolane (OZ78) were determined both in vivo and in vitro...
  41. ncbi Effect of tribendimidine on adult Echinostoma caproni harbored in mice, including scanning electron microscopic observations
    Jennifer Keiser
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    J Parasitol 92:858-62. 2006
    ..Our findings call for further investigations using tribendimidine in other trematode-animal models, because this compound shows promising trematocidal activity...
  42. ncbi Effect of artesunate and artemether against Clonorchis sinensis and Opisthorchis viverrini in rodent models
    Jennifer Keiser
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Int J Antimicrob Agents 28:370-3. 2006
    ..These findings provide a foundation for subsequent clinical trials. More laboratory investigations are warranted to investigate further the opisthorchicidal properties of the artemisinins...
  43. ncbi Artesunate and artemether are effective fasciolicides in the rat model and in vitro
    Jennifer Keiser
    Swiss Tropical Institute PO Box, CH 4002 Basel, Switzerland
    J Antimicrob Chemother 57:1139-45. 2006
    ..To study the fasciocidal properties of artesunate and artemether in the rat model and in vitro...
  44. ncbi Chemotherapy for major food-borne trematodes: a review
    Jennifer Keiser
    Swiss Tropical Institute, PO Box, CH 4002 Basel, Switzerland
    Expert Opin Pharmacother 5:1711-26. 2004
    ....
  45. pmc Trematocidal activity of praziquantel and artemisinin derivatives: in vitro and in vivo investigations with adult Echinostoma caproni
    Jennifer Keiser
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Antimicrob Agents Chemother 50:803-5. 2006
    ..In vivo, worm burden reductions of 100% were achieved with single oral doses of praziquantel, artesunate, and artemether at 50, 700, and 1,100 mg/kg of body weight, respectively...
  46. pmc Emerging foodborne trematodiasis
    Jennifer Keiser
    Swiss Tropical Institute, Basel, Switzerland
    Emerg Infect Dis 11:1507-14. 2005
    ..This is supported by reviewing aquaculture development in countries endemic for foodborne trematodiasis over the past 10-50 years. Future and sustainable control of foodborne trematodiasis is discussed...
  47. ncbi Urbanization in sub-saharan Africa and implication for malaria control
    Jennifer Keiser
    Office of Population Research, Princeton University, Princeton, New Jersey, 08544, USA
    Am J Trop Med Hyg 71:118-27. 2004
    ..Mitigation of the current burden of malaria in urban African settings, in turn, is a necessity for stimulating environmentally and socially sustainable development...
  48. ncbi Triclabendazole for the treatment of fascioliasis and paragonimiasis
    Jennifer Keiser
    Swiss Tropical Institute, CH 4002 Basel, Switzerland
    Expert Opin Investig Drugs 14:1513-26. 2005
    ....
  49. ncbi Reducing the burden of malaria in different eco-epidemiological settings with environmental management: a systematic review
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Lancet Infect Dis 5:695-708. 2005
    ..Lessons learned from these past successful programmes can inspire sound and sustainable malaria control approaches and strategies...
  50. ncbi Effect of irrigation and large dams on the burden of malaria on a global and regional scale
    Jennifer Keiser
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 72:392-406. 2005
    ..We conclude that in unstable malaria endemic areas, integrated malaria control measures, coupled with sound water management, are mandatory to mitigate the current burden of malaria in locations near irrigation or dam sites...
  51. pmc Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini
    Jennifer Keiser
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Antimicrob Agents Chemother 51:1096-8. 2007
    ..1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica...
  52. ncbi Artemisinins and synthetic trioxolanes in the treatment of helminth infections
    Jennifer Keiser
    Swiss Tropical Institute, Basel, Switzerland
    Curr Opin Infect Dis 20:605-12. 2007
    ....
  53. ncbi Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Trends Parasitol 23:555-62. 2007
    ..Lastly, prospects for the development of a safe, efficacious, inexpensive and broad-spectrum trematocidal drug are considered...
  54. ncbi Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Trans R Soc Trop Med Hyg 101:1219-22. 2007
    ..hepatica isolate, and hence these drugs might become useful in areas where triclabendazole resistance is common...
  55. ncbi Fasciola hepatica: tegumental alterations in adult flukes following in vitro and in vivo administration of artesunate and artemether
    Jennifer Keiser
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Exp Parasitol 118:228-37. 2008
    ..Concluding our experiments confirm that artemether and artesunate are potent fasciocidal drugs and the tegument of adult F. hepatica appears to be a target for the action of these drugs...
  56. ncbi Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model
    Jennifer Keiser
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 75:287-91. 2006
    ..mansoni strain. We conclude that triclabendazole and its main metabolites display weak and inconsistent schistosomicidal activities...
  57. ncbi Current progress in the development and use of artemether for chemoprophylaxis of major human schistosome parasites
    J Utzinger
    Swiss Tropical Institute, Basel, Switzerland
    Curr Med Chem 8:1841-60. 2001
    ....
  58. ncbi Urbanization and tropical health--then and now
    J Utzinger
    Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Ann Trop Med Parasitol 100:517-33. 2006
    ....
  59. ncbi The potential of intermittent irrigation for increasing rice yields, lowering water consumption, reducing methane emissions, and controlling malaria in African rice fields
    Jennifer Keiser
    Office of Population Research, Princeton University, Princeton, NJ 08544, USA
    J Am Mosq Control Assoc 18:329-40. 2002
    ..We explore and discuss under what conditions intermittent irrigation might be beneficial in new rice-growing areas and identify steps that have to be taken to expand such programs in the future...
  60. doi Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni
    T Manneck
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, CH 4002 Basel, Switzerland
    Parasitology 137:85-98. 2010
    ..SEM observations revealed extensive tegumental destruction, including blebbing, shrinking and sloughing, particularly following in vitro incubation and on the tegument of female worms...
  61. ncbi Association between Schistosoma mansoni and hookworm infections among schoolchildren in Côte d'Ivoire
    Jennifer Keiser
    Office of Population Research, Princeton University, NJ 08544, USA
    Acta Trop 84:31-41. 2002
    ..Complemented with other control interventions, these measures might significantly reduce the burden caused by S. mansoni and hookworm infections...
  62. ncbi Fasciola hepatica: comparison of the sedimentation and FLOTAC techniques for the detection and quantification of faecal egg counts in rats
    Urs Duthaler
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Exp Parasitol 126:161-6. 2010
    ..05). In view of the high sensitivity and efficiency, the FLOTAC technique holds promise for experimental work in the F. hepatica-rat model. Additional research is needed to determine the reasons for the observed differences in FECs...
  63. pmc Past, present, and future of Japanese encephalitis
    Tobias E Erlanger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Emerg Infect Dis 15:1-7. 2009
    ..On a global scale, however, the incidence of JE may decline as a result of large-scale vaccination programs implemented in China and India...
  64. ncbi Polyparasitism with Schistosoma mansoni, geohelminths, and intestinal protozoa in rural Côte d'Ivoire
    Jennifer Keiser
    Office of Population Research, Princeton University, New Jersey 08544, USA
    J Parasitol 88:461-6. 2002
    ..These findings call for integrated approaches to effectively control multiple parasitic and protozoan infections...
  65. ncbi Pharmacokinetic investigations in patients from northern Angola refractory to melarsoprol treatment
    C Burri
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Trop Med Int Health 6:412-20. 2001
    ..Serum and CSF concentrations for all patients were in the expected range. This result indicates that other underlying factors are responsible for treatment failures...
  66. doi Effect of dengue vector control interventions on entomological parameters in developing countries: a systematic review and meta-analysis
    T E Erlanger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Med Vet Entomol 22:203-21. 2008
    ..New research should assess the density-dependent effectiveness of each control measure in order to estimate whether reducing vector numbers has an impact on dengue transmission when populations are at a critical threshold...
  67. pmc Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery
    Jasmina Saric
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e254. 2008
    ....
  68. pmc Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials
    Jurg Utzinger
    Office of Population Research, Princeton University, Princeton, New Jersey 08544, USA
    Antimicrob Agents Chemother 47:1487-95. 2003
  69. ncbi Artemisinins for schistosomiasis and beyond
    Jurg Utzinger
    Swiss Tropical Institute, Department of Public Health and Epidemiology PO Box, CH 4002 Basel, Switzerland
    Curr Opin Investig Drugs 8:105-16. 2007
    ....
  70. ncbi New drugs for the treatment of human African trypanosomiasis: research and development
    J Keiser
    Swiss Tropical Institute, PO Box, CH-4002, Basel, Switzerland
    Trends Parasitol 17:42-9. 2001
    ..The absence of compounds in clinical development Phases I-III indicates no new drugs will become available in the next few years...
  71. ncbi Evaluation of quinolone derivatives for antitrypanosomal activity
    J Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Trop Med Int Health 6:369-89. 2001
    ....
  72. doi Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica
    Jennifer Keiser
    Swiss Tropical Institute, Basel, Switzerland
    J Antimicrob Chemother 63:543-9. 2009
    ....
  73. doi The drugs we have and the drugs we need against major helminth infections
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Adv Parasitol 73:197-230. 2010
    ..Issuing from our review are current research gaps and the need for concerted efforts to discover, develop and deploy the next generation of anthelminthic drugs...
  74. pmc Schistosoma mansoni tetraspanning orphan receptor (SmTOR): a new vaccine candidate against schistosomiasis
    C Lochmatter
    Immunonephrology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Clin Exp Immunol 170:342-57. 2012
    ..mansoni (2/20; 10%). These data suggest that, as opposed to the natural infection during which SmTOR induces antibodies only rarely, immunization with its smaller first extracellular domain might be more efficient...
  75. doi A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma
    E M Hodel
    Swiss Tropical Institute, Basel, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 877:867-86. 2009
    ..It may contribute to filling the current knowledge gaps in the pharmacokinetics/pharmacodynamics relationships of antimalarials and better define the therapeutic dose ranges in different patient populations...
  76. ncbi Effect of water resource development and management on lymphatic filariasis, and estimates of populations at risk
    Tobias E Erlanger
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 73:523-33. 2005
    ....
  77. ncbi Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control
    Jurg Utzinger
    Office of Population Research, Princeton University, Princeton University, NJ 08544, USA
    Expert Opin Pharmacother 5:263-85. 2004
    ....
  78. pmc Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse
    Jasmina Saric
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    J Proteome Res 8:3899-911. 2009
    ....
  79. ncbi Integrated urban malaria control: a case study in dar es salaam, Tanzania
    Marcia Caldas de Castro
    Office of Population Research, Princeton University, Princeton, New Jersey 08544, USA
    Am J Trop Med Hyg 71:103-17. 2004
    ..The Tanzania-Japan multiple-intervention malaria control program, adaptively implemented over time, is described and evaluated with implications for urban malaria control in sub-Saharan Africa more generally...
  80. ncbi Comparison of the Kato-Katz method and ether-concentration technique for the diagnosis of soil-transmitted helminth infections in the framework of a randomised controlled trial
    B Speich
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002, Basel, Switzerland
    Eur J Clin Microbiol Infect Dis 33:815-22. 2014
    ..The ether-concentration technique is a valuable alternative to the Kato-Katz method for helminth diagnosis...
  81. ncbi Acridine Orange for malaria diagnosis: its diagnostic performance, its promotion and implementation in Tanzania, and the implications for malaria control
    J Keiser
    Office of Population Research, Princeton University, Princeton, NJ 08544, USA
    Ann Trop Med Parasitol 96:643-54. 2002
    ..The results of this introduction, which are reviewed here and have several important implications, indicate that AO is a viable alternative technique for the laboratory diagnosis of malaria in highly endemic countries...
  82. ncbi Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk
    Peter Steinmann
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Lancet Infect Dis 6:411-25. 2006
    ....
  83. pmc Isothermal microcalorimetry to study drugs against Schistosoma mansoni
    Theresia Manneck
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    J Clin Microbiol 49:1217-25. 2011
    ..IMC is a useful tool for antischistosomal drug discovery that should be further validated. In addition, our data support the use of NTS in in vitro antischistosomal drug assays...
  84. ncbi Species variation in the fecal metabolome gives insight into differential gastrointestinal function
    Jasmina Saric
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    J Proteome Res 7:352-60. 2008
    ....
  85. doi Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis: a comparative in vivo study
    Shu Hua Xiao
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, People s Republic of China
    Acta Trop 106:54-9. 2008
    ..The in vivo results presented here with the artemisinins and tribendimidine provide further data for clinical investigations to assess the safety and efficacy of these drugs in clonorchiasis patients...
  86. pmc In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives
    Martin Spicher
    Institute of Parasitology, University of Bern, Langgass strasse 122, CH 3012 Bern, Switzerland
    Antimicrob Agents Chemother 52:3447-50. 2008
    ..However, combination treatments of both drugs with albendazole led to a substantial but statistically not significant reduction in parasite weight compared to results with albendazole alone...
  87. pmc In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species
    Shu Hua Xiao
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People s Republic of China
    Antimicrob Agents Chemother 51:1440-5. 2007
    ..2 to 100%. Our results, along with the low toxicity, metabolic stability, and good pharmacokinetic properties of the OZs, indicate the potential for the development of novel broad-spectrum antischistosomal OZ drug candidates...
  88. ncbi Opportunities and limiting factors of intensive vegetable farming in malaria endemic Côte d'Ivoire
    Olivier Girardin
    Centre Suisse de Recherches Scientifiques, 01 BP 1303, 01, Abidjan, Cote d Ivoire, Switzerland
    Acta Trop 89:109-23. 2004
    ..This calls for targeted interventions to facilitate agriculture-based rural development that might spur social and economic development and reduce inequities in sub-Saharan Africa...