Felicien Karege

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Decreased serum brain-derived neurotrophic factor levels in major depressed patients
    Felicien Karege
    Laboratory of Biochemistry, Division of Neuropsychiatry, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Psychiatry Res 109:143-8. 2002
  2. doi request reprint Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex
    Felicien Karege
    Geneva University Hospitals, Department of Medical Genetics and Laboratory, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    J Affect Disord 136:185-8. 2012
  3. doi request reprint Genetic overlap between schizophrenia and bipolar disorder: a study with AKT1 gene variants and clinical phenotypes
    Felicien Karege
    Geneva University Hospitals, Department of Medical Genetics and Laboratory ch Petit Bel Air 2 1225 Chêne Bourg, Switzerland
    Schizophr Res 135:8-14. 2012
  4. ncbi request reprint The cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorder
    Felicien Karege
    Geneva University Hospitals, Division of Neuropsychiatry, ch Petit Bel Air, 2 CH 1225 Chêne Bourg, Geneva, Switzerland
    J Affect Disord 79:187-92. 2004
  5. doi request reprint Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims
    Felicien Karege
    Department of Psychiatry, Geneva University Hospitals, Chene Bourg, Switzerland
    Neuropsychobiology 63:224-31. 2011
  6. ncbi request reprint Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims
    Felicien Karege
    Department of Psychiatry, Geneva University Hospitals, Chene Bourg, Geneva, Switzerland
    Biol Psychiatry 61:240-5. 2007
  7. ncbi request reprint Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
    Felicien Karege
    Geneva University Hospitals, Department of Psychiatry, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Brain Res Mol Brain Res 136:29-37. 2005
  8. ncbi request reprint Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
    Felicien Karege
    Service of Neuropsychiatry, Geneva University Hospitals Belle Idée, Chêne Bourg Geneva, Switzerland
    Biol Psychiatry 57:1068-72. 2005
  9. ncbi request reprint Drug-induced decrease of protein kinase a activity reveals alteration in BDNF expression of bipolar affective disorder
    Felicien Karege
    Geneva University Hospitals Belle Idée, Division of Neuropsychiatry, Chêne Bourg Geneva, Switzerland
    Neuropsychopharmacology 29:805-12. 2004
  10. doi request reprint Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder
    Anthony Carrard
    Geneva University Hospitals, Department of Medical Genetics and Laboratory, 2 ch Petit Bel Air, 1225 Chene Bourg, Switzerland
    J Affect Disord 132:450-3. 2011

Detail Information

Publications11

  1. ncbi request reprint Decreased serum brain-derived neurotrophic factor levels in major depressed patients
    Felicien Karege
    Laboratory of Biochemistry, Division of Neuropsychiatry, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Psychiatry Res 109:143-8. 2002
    ..These results suggest that major depression is characterized by low serum BDNF levels and support the hypothesis of neurotrophic factor involvement in affective disorders...
  2. doi request reprint Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex
    Felicien Karege
    Geneva University Hospitals, Department of Medical Genetics and Laboratory, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    J Affect Disord 136:185-8. 2012
    ..The Wnt/GSK3β signaling pathway was implicated in mood disorders. Beta-catenin is a protein targeted by this signaling axis. We aimed to examine whether there is an abnormality in this signaling axis in major depression...
  3. doi request reprint Genetic overlap between schizophrenia and bipolar disorder: a study with AKT1 gene variants and clinical phenotypes
    Felicien Karege
    Geneva University Hospitals, Department of Medical Genetics and Laboratory ch Petit Bel Air 2 1225 Chêne Bourg, Switzerland
    Schizophr Res 135:8-14. 2012
    ..In this study, our aim was to determine whether AKT1 gene variants are associated with particular phenotypes for schizophrenia (SCZ) and bipolar disorder (BPD)...
  4. ncbi request reprint The cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorder
    Felicien Karege
    Geneva University Hospitals, Division of Neuropsychiatry, ch Petit Bel Air, 2 CH 1225 Chêne Bourg, Geneva, Switzerland
    J Affect Disord 79:187-92. 2004
    ..Abnormalities in cAMP signaling and altered expression of downstream targets such as brain-derived neurotrophic factor (BDNF) have been postulated in patients with bipolar disorder (BD)...
  5. doi request reprint Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims
    Felicien Karege
    Department of Psychiatry, Geneva University Hospitals, Chene Bourg, Switzerland
    Neuropsychobiology 63:224-31. 2011
    ..The aim of the present study was to investigate possible impairment of the upstream regulators, namely phosphatidylinositol 3-kinase (PI3K) and PTEN...
  6. ncbi request reprint Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims
    Felicien Karege
    Department of Psychiatry, Geneva University Hospitals, Chene Bourg, Geneva, Switzerland
    Biol Psychiatry 61:240-5. 2007
    ..In this study, we aimed to examine possible abnormality in the Akt/glycogen synthase kinase-3beta (GSK-3beta) axis of depressed suicide victims' brains...
  7. ncbi request reprint Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
    Felicien Karege
    Geneva University Hospitals, Department of Psychiatry, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Brain Res Mol Brain Res 136:29-37. 2005
    ..A better understanding of the neurobiology of suicide could help detect populations at risk...
  8. ncbi request reprint Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
    Felicien Karege
    Service of Neuropsychiatry, Geneva University Hospitals Belle Idée, Chêne Bourg Geneva, Switzerland
    Biol Psychiatry 57:1068-72. 2005
    ..Decreased serum BDNF levels have been reported in major depression, but the cause of this decrease has not yet been investigated. The goal of this study was to assess blood BDNF and a platelet activation index, PF4...
  9. ncbi request reprint Drug-induced decrease of protein kinase a activity reveals alteration in BDNF expression of bipolar affective disorder
    Felicien Karege
    Geneva University Hospitals Belle Idée, Division of Neuropsychiatry, Chêne Bourg Geneva, Switzerland
    Neuropsychopharmacology 29:805-12. 2004
    ..These findings, combined with previous reports, provide a new insight to explain pharmacological features in different diagnostic groups...
  10. doi request reprint Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder
    Anthony Carrard
    Geneva University Hospitals, Department of Medical Genetics and Laboratory, 2 ch Petit Bel Air, 1225 Chene Bourg, Switzerland
    J Affect Disord 132:450-3. 2011
    ..The aim of this study was to investigate the methylation status of a promoter region of the 5HTR1A gene in BPD and SCZ patients...
  11. ncbi request reprint Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets
    Felicien Karege
    Geneva University Hospitals Belle Idée, Division of Neuropsychiatry, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Geneva, Switzerland
    Neurosci Lett 328:261-4. 2002
    ..81, P<0.01), especially in young animals. This study of ontogenic characteristics of BDNF in blood and central nervous system can help to shed more light on the role of platelet BDNF...