Felicien Karege

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint The cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorder
    Felicien Karege
    Geneva University Hospitals, Division of Neuropsychiatry, ch Petit Bel Air, 2 CH 1225 Chêne Bourg, Geneva, Switzerland
    J Affect Disord 79:187-92. 2004
  2. ncbi request reprint Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims
    Felicien Karege
    Department of Psychiatry, Geneva University Hospitals, Chene Bourg, Geneva, Switzerland
    Biol Psychiatry 61:240-5. 2007
  3. ncbi request reprint Differential changes of cAMP-dependent protein kinase activity and 3H-cAMP binding sites in rat hippocampus during maturation and aging
    F Karege
    Geneva University Hospital Belle Idée, Division of Neuropsychiatry, Chemin du Petit Bel Air 2, CH 1225 Chene Bourg, Geneva, Switzerland
    Neurosci Lett 315:89-92. 2001
  4. ncbi request reprint Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
    Felicien Karege
    Geneva University Hospitals, Department of Psychiatry, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Brain Res Mol Brain Res 136:29-37. 2005
  5. ncbi request reprint Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
    Felicien Karege
    Service of Neuropsychiatry, Geneva University Hospitals Belle Idée, Chêne Bourg Geneva, Switzerland
    Biol Psychiatry 57:1068-72. 2005
  6. ncbi request reprint Drug-induced decrease of protein kinase a activity reveals alteration in BDNF expression of bipolar affective disorder
    Felicien Karege
    Geneva University Hospitals Belle Idée, Division of Neuropsychiatry, Chêne Bourg Geneva, Switzerland
    Neuropsychopharmacology 29:805-12. 2004
  7. ncbi request reprint Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode
    Nicola Gervasoni
    Department of Psychiatry, Geneva University Hospital, 16 18 boulevard Saint Georges, CH 1205 Geneva, Switzerland
    Neuropsychobiology 51:234-8. 2005
  8. ncbi request reprint Decreased serum brain-derived neurotrophic factor levels in major depressed patients
    Felicien Karege
    Laboratory of Biochemistry, Division of Neuropsychiatry, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Psychiatry Res 109:143-8. 2002
  9. doi request reprint Genetic overlap between schizophrenia and bipolar disorder: a study with AKT1 gene variants and clinical phenotypes
    Felicien Karege
    Geneva University Hospitals, Department of Medical Genetics and Laboratory ch Petit Bel Air 2 1225 Chêne Bourg, Switzerland
    Schizophr Res 135:8-14. 2012
  10. doi request reprint Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex
    Felicien Karege
    Geneva University Hospitals, Department of Medical Genetics and Laboratory, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    J Affect Disord 136:185-8. 2012

Detail Information

Publications19

  1. ncbi request reprint The cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorder
    Felicien Karege
    Geneva University Hospitals, Division of Neuropsychiatry, ch Petit Bel Air, 2 CH 1225 Chêne Bourg, Geneva, Switzerland
    J Affect Disord 79:187-92. 2004
    ..Abnormalities in cAMP signaling and altered expression of downstream targets such as brain-derived neurotrophic factor (BDNF) have been postulated in patients with bipolar disorder (BD)...
  2. ncbi request reprint Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims
    Felicien Karege
    Department of Psychiatry, Geneva University Hospitals, Chene Bourg, Geneva, Switzerland
    Biol Psychiatry 61:240-5. 2007
    ..In this study, we aimed to examine possible abnormality in the Akt/glycogen synthase kinase-3beta (GSK-3beta) axis of depressed suicide victims' brains...
  3. ncbi request reprint Differential changes of cAMP-dependent protein kinase activity and 3H-cAMP binding sites in rat hippocampus during maturation and aging
    F Karege
    Geneva University Hospital Belle Idée, Division of Neuropsychiatry, Chemin du Petit Bel Air 2, CH 1225 Chene Bourg, Geneva, Switzerland
    Neurosci Lett 315:89-92. 2001
    ..001). It is suggested the changes in PKA R subunit levels reflect an adaptative role in maturing process, a role which is lost in aging phase...
  4. ncbi request reprint Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
    Felicien Karege
    Geneva University Hospitals, Department of Psychiatry, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Brain Res Mol Brain Res 136:29-37. 2005
    ..A better understanding of the neurobiology of suicide could help detect populations at risk...
  5. ncbi request reprint Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
    Felicien Karege
    Service of Neuropsychiatry, Geneva University Hospitals Belle Idée, Chêne Bourg Geneva, Switzerland
    Biol Psychiatry 57:1068-72. 2005
    ..Decreased serum BDNF levels have been reported in major depression, but the cause of this decrease has not yet been investigated. The goal of this study was to assess blood BDNF and a platelet activation index, PF4...
  6. ncbi request reprint Drug-induced decrease of protein kinase a activity reveals alteration in BDNF expression of bipolar affective disorder
    Felicien Karege
    Geneva University Hospitals Belle Idée, Division of Neuropsychiatry, Chêne Bourg Geneva, Switzerland
    Neuropsychopharmacology 29:805-12. 2004
    ..These findings, combined with previous reports, provide a new insight to explain pharmacological features in different diagnostic groups...
  7. ncbi request reprint Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode
    Nicola Gervasoni
    Department of Psychiatry, Geneva University Hospital, 16 18 boulevard Saint Georges, CH 1205 Geneva, Switzerland
    Neuropsychobiology 51:234-8. 2005
    ..These results suggest that antidepressant treatment has a positive effect on serum BDNF levels and support the hypothesis of neurotrophic factor involvement in affective disorders...
  8. ncbi request reprint Decreased serum brain-derived neurotrophic factor levels in major depressed patients
    Felicien Karege
    Laboratory of Biochemistry, Division of Neuropsychiatry, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Psychiatry Res 109:143-8. 2002
    ..These results suggest that major depression is characterized by low serum BDNF levels and support the hypothesis of neurotrophic factor involvement in affective disorders...
  9. doi request reprint Genetic overlap between schizophrenia and bipolar disorder: a study with AKT1 gene variants and clinical phenotypes
    Felicien Karege
    Geneva University Hospitals, Department of Medical Genetics and Laboratory ch Petit Bel Air 2 1225 Chêne Bourg, Switzerland
    Schizophr Res 135:8-14. 2012
    ..In this study, our aim was to determine whether AKT1 gene variants are associated with particular phenotypes for schizophrenia (SCZ) and bipolar disorder (BPD)...
  10. doi request reprint Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex
    Felicien Karege
    Geneva University Hospitals, Department of Medical Genetics and Laboratory, 2 ch Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    J Affect Disord 136:185-8. 2012
    ..The Wnt/GSK3β signaling pathway was implicated in mood disorders. Beta-catenin is a protein targeted by this signaling axis. We aimed to examine whether there is an abnormality in this signaling axis in major depression...
  11. ncbi request reprint Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets
    Felicien Karege
    Geneva University Hospitals Belle Idée, Division of Neuropsychiatry, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Geneva, Switzerland
    Neurosci Lett 328:261-4. 2002
    ..81, P<0.01), especially in young animals. This study of ontogenic characteristics of BDNF in blood and central nervous system can help to shed more light on the role of platelet BDNF...
  12. doi request reprint Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims
    Felicien Karege
    Department of Psychiatry, Geneva University Hospitals, Chene Bourg, Switzerland
    Neuropsychobiology 63:224-31. 2011
    ..The aim of the present study was to investigate possible impairment of the upstream regulators, namely phosphatidylinositol 3-kinase (PI3K) and PTEN...
  13. doi request reprint Early effects of mood stabilizers on the Akt/GSK-3beta signaling pathway and on cell survival and proliferation
    Jean Michel Aubry
    Department of Psychiatry, Bipolar Program, Geneva University Hospitals and University of Geneva, 6 8 rue du 31 Décembre, CH 1207 Geneva, Switzerland
    Psychopharmacology (Berl) 205:419-29. 2009
    ..Molecular targets and cellular events that mediate their effects have been described for these drugs but are only partially unraveled. Few comparative studies have been performed...
  14. ncbi request reprint Association of AKT1 gene variants and protein expression in both schizophrenia and bipolar disorder
    F Karege
    Department of Medical Genetics and Laboratory, Geneva University Hospitals and Geneva University, Chene Bourg, Switzerland
    Genes Brain Behav 9:503-11. 2010
    ....
  15. ncbi request reprint Lithium and haloperidol treatments differently affect the mononuclear leukocyte Galphas protein levels in bipolar affective disorder
    F Karege
    Division of Neuropsychiatry, Geneva University Hospitals, Chene Bourg, Switzerland
    Neuropsychobiology 39:181-6. 1999
    ..9 +/- 37%; NS). The data indicate that lithium and haloperidol affect the mechanism of Galphas protein signal transduction differently, consistent with previous animal studies...
  16. ncbi request reprint A non-radioactive assay for the cAMP-dependent protein kinase activity in rat brain homogenates and age-related changes in hippocampus and cortex
    F Karege
    Division of Neuropsychiatry, Laboratory of Biochemistry, Geneva University Hospitals, Chemin du Petit Bel Air 2, CH 1225 Chêne Bourg Geneva, Switzerland
    Brain Res 903:86-93. 2001
    ..The PKA ratio was higher in cytosol than in particulate fraction, and was decreased in hippocampal sample from old rats (P<0.05). This last result was interpreted as related to the loss of cognitive capacities in old animals...
  17. doi request reprint Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene
    Ilona Vincze
    Department of Psychiatry, University Hospital of Geneva, Geneva, Switzerland
    Bipolar Disord 10:580-7. 2008
    ..Our hypothesis is that some BDNF and 5HTT polymorphisms might confer increased risk for BD and SB and that both genes may interact with each other...
  18. ncbi request reprint The Tutsi genocide and transgenerational transmission of maternal stress: epigenetics and biology of the HPA axis
    Nader Perroud
    University Hospitals of Geneva, Department of Mental Health and Psychiatry, Geneva, Switzerland
    World J Biol Psychiatry 15:334-45. 2014
    ..Transmission of parental post-traumatic stress disorder (PTSD) to offspring might be explained by transmission of epigenetic processes such as methylation status of the glucocorticoid receptor (GR) gene (NR3C1)...
  19. doi request reprint Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder
    Anthony Carrard
    Geneva University Hospitals, Department of Medical Genetics and Laboratory, 2 ch Petit Bel Air, 1225 Chene Bourg, Switzerland
    J Affect Disord 132:450-3. 2011
    ..The aim of this study was to investigate the methylation status of a promoter region of the 5HTR1A gene in BPD and SCZ patients...