Research Topics
Genomes and Genes | Henrik KaessmannSummaryAffiliation: University of Lausanne Country: Switzerland Publications
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Detail Information
Publications
RNA-based gene duplication: mechanistic and evolutionary insightsHenrik Kaessmann
Center for Integrative Genomics, University of Lausanne, Genopode, CH 1015 Lausanne, Switzerland
Nat Rev Genet 10:19-31. 2009..For example, analyses of chromosomal gene movement patterns via RNA-based gene duplication have shed fresh light on the evolutionary origin and biology of our sex chromosomes...
Origins, evolution, and phenotypic impact of new genesHenrik Kaessmann
Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
Genome Res 20:1313-26. 2010..Consequently, it is now firmly established that new genes have indeed been major contributors to the origin of adaptive evolutionary novelties...- Mechanisms and evolutionary patterns of mammalian and avian dosage compensationPhilippe Julien
Center for Integrative Genomics, University of Lausanne, Switzerland
PLoS Biol 10:e1001328. 2012..Our findings suggest that dosage reductions imposed by sex chromosome differentiation events in amniotes were resolved in strikingly different ways... - Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selectionLia Rosso
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
PLoS Genet 4:e1000150. 2008..We suggest that rapid, selectively driven subcellular adaptation, as exemplified by GLUD2, represents a common route underlying the emergence of new gene functions... - Segmental copy number variation shapes tissue transcriptomesCharlotte N Henrichsen
The Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
Nat Genet 41:424-9. 2009..Dosage alterations of brain-expressed genes are less frequent than those of other genes and are buffered by tighter transcriptional regulation. Our study provides initial evidence that CNVs shape tissue transcriptomes on a global scale... 
Evolutionary simulations to detect functional lineage-specific genesIsabelle Dupanloup
Center for Integrative Genomics, University of Lausanne CH-1015 Lausanne, Switzerland
Bioinformatics 22:1815-22. 2006..AVAILABILITY: ReEVOLVER is available at http://www.unil.ch/cig/page7858.html...- Chromosomal gene movements reflect the recent origin and biology of therian sex chromosomesLukasz Potrzebowski
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, 2 INSERM U625, IFR 140, Universite Rennes I, Campus de Beaulieu, Rennes, France
PLoS Biol 6:e80. 2008.... - Birth and rapid subcellular adaptation of a hominoid-specific CDC14 proteinLia Rosso
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
PLoS Biol 6:e140. 2008..CDC14Bretro evolution represents a paradigm example of rapid, selectively driven subcellular relocalization, thus revealing a novel mode for the emergence of new gene function... - Emergence of young human genes after a burst of retroposition in primatesAna Claudia Marques
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
PLoS Biol 3:e357. 2005.... - Functional diversification of duplicate genes through subcellular adaptation of encoded proteinsAna C Marques
Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
Genome Biol 9:R54. 2008..Here, using yeast (Saccharomyces cerevisiae) as a model organism, we investigate a previously little considered mode for the functional diversification of duplicate genes: subcellular adaptation of encoded proteins... - Evolutionary fate of retroposed gene copies in the human genomeNicolas Vinckenbosch
Center for Integrative Genomics, University of Lausanne, , Switzerland
Proc Natl Acad Sci U S A 103:3220-5. 2006..Our results demonstrate that natural selection has been fundamental in shaping the retrocopy repertoire of the human genome... - The emergence of new genes on the young therian XLukasz Potrzebowski
Center for Integrative Genomics, University of Lausanne, Genopode Building, CH 1015 Lausanne, Switzerland
Trends Genet 26:1-4. 2010..Taken together, our observations suggest that the major sex-related functional remodeling of the X was completed relatively soon after the origination of therian sex chromosomes... - Loss of egg yolk genes in mammals and the origin of lactation and placentationDavid Brawand
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
PLoS Biol 6:e63. 2008.... - Birth and expression evolution of mammalian microRNA genesJulien Meunier
Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
Genome Res 23:34-45. 2013..Overall, our study thus provides detailed insights into the birth and evolution of mammalian miRNA genes and the associated selective forces... - The evolution of gene expression levels in mammalian organsDavid Brawand
Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
Nature 478:343-8. 2011.... - Patterns of evolution of host proteins involved in retroviral pathogenesisMillan Ortiz
Institute of Microbiology, University of Lausanne, Switzerland
Retrovirology 3:11. 2006..The strong sequence conservation of the TRIM19/PML sequences among primates suggests that this gene does not play a role in antiretroviral defense... - Evolutionary origin and functions of retrogene intronsMarie Fablet
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
Mol Biol Evol 26:2147-56. 2009..Our study provides novel insights regarding mechanisms underlying the origin of new introns, the evolutionary relevance of intron gain, and the origin of new gene promoters... - Concordance among digital gene expression, microarrays, and qPCR when measuring differential expression of microRNAsSylvain Pradervand
Genomic Technologies Facility, Center for Integrative Genomics, University of Lausanne, Genopode Building, Lausanne, Switzerland
Biotechniques 48:219-22. 2010.... - Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfactionVincent Croset
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
PLoS Genet 6:e1001064. 2010..Furthermore, this work identifies novel targets for manipulating chemosensory-driven behaviours of agricultural pests and disease vectors... - Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter fluxFabien Burki
Center for Integrative Genomics, University of Lausanne, BEP, 1015 Lausanne, Switzerland
Nat Genet 36:1061-3. 2004..The amino acid changes responsible for the unique brain-specific properties of the enzyme derived from GLUD2 occurred during a period of positive selection after the duplication event... - Mating system and avpr1a promoter variation in primatesLia Rosso
Center for Integrative Genomics, University of Lausanne, Genopode, Lausanne, Switzerland
Biol Lett 4:375-8. 2008..We suggest that such non-repetitive variation, either in indels or in sequence variation, are likely to be important in explaining interspecific variation in avpr1a expression...