Henrik Kaessmann

Summary

Affiliation: University of Lausanne
Country: Switzerland

Publications

  1. pmc RNA-based gene duplication: mechanistic and evolutionary insights
    Henrik Kaessmann
    Center for Integrative Genomics, University of Lausanne, Genopode, CH 1015 Lausanne, Switzerland
    Nat Rev Genet 10:19-31. 2009
  2. pmc Origins, evolution, and phenotypic impact of new genes
    Henrik Kaessmann
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Genome Res 20:1313-26. 2010
  3. pmc Mechanisms and evolutionary patterns of mammalian and avian dosage compensation
    Philippe Julien
    Center for Integrative Genomics, University of Lausanne, Switzerland
    PLoS Biol 10:e1001328. 2012
  4. pmc Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection
    Lia Rosso
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 4:e1000150. 2008
  5. pmc Birth and expression evolution of mammalian microRNA genes
    Julien Meunier
    Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
    Genome Res 23:34-45. 2013
  6. doi request reprint Segmental copy number variation shapes tissue transcriptomes
    Charlotte N Henrichsen
    The Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Nat Genet 41:424-9. 2009
  7. pmc Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein
    Lia Rosso
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Biol 6:e140. 2008
  8. pmc Chromosomal gene movements reflect the recent origin and biology of therian sex chromosomes
    Lukasz Potrzebowski
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, 2 INSERM U625, IFR 140, Universite Rennes I, Campus de Beaulieu, Rennes, France
    PLoS Biol 6:e80. 2008
  9. ncbi request reprint Evolutionary simulations to detect functional lineage-specific genes
    Isabelle Dupanloup
    Center for Integrative Genomics, University of Lausanne CH 1015 Lausanne, Switzerland
    Bioinformatics 22:1815-22. 2006
  10. pmc Evolution of the correlation between expression divergence and protein divergence in mammals
    Maria Warnefors
    Center for Integrative Genomics, University of Lausanne, Switzerland
    Genome Biol Evol 5:1324-35. 2013

Collaborators

Detail Information

Publications23

  1. pmc RNA-based gene duplication: mechanistic and evolutionary insights
    Henrik Kaessmann
    Center for Integrative Genomics, University of Lausanne, Genopode, CH 1015 Lausanne, Switzerland
    Nat Rev Genet 10:19-31. 2009
    ..For example, analyses of chromosomal gene movement patterns via RNA-based gene duplication have shed fresh light on the evolutionary origin and biology of our sex chromosomes...
  2. pmc Origins, evolution, and phenotypic impact of new genes
    Henrik Kaessmann
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Genome Res 20:1313-26. 2010
    ..Consequently, it is now firmly established that new genes have indeed been major contributors to the origin of adaptive evolutionary novelties...
  3. pmc Mechanisms and evolutionary patterns of mammalian and avian dosage compensation
    Philippe Julien
    Center for Integrative Genomics, University of Lausanne, Switzerland
    PLoS Biol 10:e1001328. 2012
    ..Our findings suggest that dosage reductions imposed by sex chromosome differentiation events in amniotes were resolved in strikingly different ways...
  4. pmc Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection
    Lia Rosso
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 4:e1000150. 2008
    ..We suggest that rapid, selectively driven subcellular adaptation, as exemplified by GLUD2, represents a common route underlying the emergence of new gene functions...
  5. pmc Birth and expression evolution of mammalian microRNA genes
    Julien Meunier
    Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
    Genome Res 23:34-45. 2013
    ..Overall, our study thus provides detailed insights into the birth and evolution of mammalian miRNA genes and the associated selective forces...
  6. doi request reprint Segmental copy number variation shapes tissue transcriptomes
    Charlotte N Henrichsen
    The Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Nat Genet 41:424-9. 2009
    ..Dosage alterations of brain-expressed genes are less frequent than those of other genes and are buffered by tighter transcriptional regulation. Our study provides initial evidence that CNVs shape tissue transcriptomes on a global scale...
  7. pmc Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein
    Lia Rosso
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Biol 6:e140. 2008
    ..CDC14Bretro evolution represents a paradigm example of rapid, selectively driven subcellular relocalization, thus revealing a novel mode for the emergence of new gene function...
  8. pmc Chromosomal gene movements reflect the recent origin and biology of therian sex chromosomes
    Lukasz Potrzebowski
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, 2 INSERM U625, IFR 140, Universite Rennes I, Campus de Beaulieu, Rennes, France
    PLoS Biol 6:e80. 2008
    ....
  9. ncbi request reprint Evolutionary simulations to detect functional lineage-specific genes
    Isabelle Dupanloup
    Center for Integrative Genomics, University of Lausanne CH 1015 Lausanne, Switzerland
    Bioinformatics 22:1815-22. 2006
    ..Supporting the functionality of recent duplicate gene copies is usually difficult, owing to high sequence similarity between duplicate counterparts and shallow phylogenies, which hamper both the statistical and experimental inference...
  10. pmc Evolution of the correlation between expression divergence and protein divergence in mammals
    Maria Warnefors
    Center for Integrative Genomics, University of Lausanne, Switzerland
    Genome Biol Evol 5:1324-35. 2013
    ..Taken together, our findings highlight many new aspects of the correlation between protein divergence and expression divergence, and attest to its role as a fundamental property of mammalian genome evolution. ..
  11. pmc Emergence of young human genes after a burst of retroposition in primates
    Ana Claudia Marques
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Biol 3:e357. 2005
    ....
  12. pmc Functional diversification of duplicate genes through subcellular adaptation of encoded proteins
    Ana C Marques
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Genome Biol 9:R54. 2008
    ..Here, using yeast (Saccharomyces cerevisiae) as a model organism, we investigate a previously little considered mode for the functional diversification of duplicate genes: subcellular adaptation of encoded proteins...
  13. pmc Loss of egg yolk genes in mammals and the origin of lactation and placentation
    David Brawand
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Biol 6:e63. 2008
    ....
  14. pmc Evolutionary fate of retroposed gene copies in the human genome
    Nicolas Vinckenbosch
    Center for Integrative Genomics, University of Lausanne, Genopode, Switzerland
    Proc Natl Acad Sci U S A 103:3220-5. 2006
    ..Our results demonstrate that natural selection has been fundamental in shaping the retrocopy repertoire of the human genome...
  15. doi request reprint The emergence of new genes on the young therian X
    Lukasz Potrzebowski
    Center for Integrative Genomics, University of Lausanne, Genopode Building, CH 1015 Lausanne, Switzerland
    Trends Genet 26:1-4. 2010
    ..Taken together, our observations suggest that the major sex-related functional remodeling of the X was completed relatively soon after the origination of therian sex chromosomes...
  16. doi request reprint The evolution of gene expression levels in mammalian organs
    David Brawand
    Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland
    Nature 478:343-8. 2011
    ....
  17. doi request reprint Cellular source and mechanisms of high transcriptome complexity in the mammalian testis
    Magali Soumillon
    Center for Integrative Genomics, University of Lausanne, Genopode, CH 1015, Lausanne, Switzerland
    Cell Rep 3:2179-90. 2013
    ....
  18. pmc Patterns of evolution of host proteins involved in retroviral pathogenesis
    Millan Ortiz
    Institute of Microbiology, University of Lausanne, Switzerland
    Retrovirology 3:11. 2006
    ....
  19. doi request reprint Concordance among digital gene expression, microarrays, and qPCR when measuring differential expression of microRNAs
    Sylvain Pradervand
    Genomic Technologies Facility, Center for Integrative Genomics, University of Lausanne, Genopode Building, Lausanne, Switzerland
    Biotechniques 48:219-22. 2010
    ....
  20. pmc Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction
    Vincent Croset
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 6:e1001064. 2010
    ..Furthermore, this work identifies novel targets for manipulating chemosensory-driven behaviours of agricultural pests and disease vectors...
  21. doi request reprint Evolutionary origin and functions of retrogene introns
    Marie Fablet
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Mol Biol Evol 26:2147-56. 2009
    ..Our study provides novel insights regarding mechanisms underlying the origin of new introns, the evolutionary relevance of intron gain, and the origin of new gene promoters...
  22. ncbi request reprint Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux
    Fabien Burki
    Center for Integrative Genomics, University of Lausanne, BEP, 1015 Lausanne, Switzerland
    Nat Genet 36:1061-3. 2004
    ..The amino acid changes responsible for the unique brain-specific properties of the enzyme derived from GLUD2 occurred during a period of positive selection after the duplication event...
  23. pmc Mating system and avpr1a promoter variation in primates
    Lia Rosso
    Center for Integrative Genomics, University of Lausanne, Genopode, Lausanne, Switzerland
    Biol Lett 4:375-8. 2008
    ..We suggest that such non-repetitive variation, either in indels or in sequence variation, are likely to be important in explaining interspecific variation in avpr1a expression...