Research Topics
| U JenalSummaryAffiliation: University of Basel Country: Switzerland Publications
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Detail Information
Publications
The Caulobacter cell cycle: timing, spatial organization and checkpointsUrs Jenal
Biozentrum, University of Basel, Klingelbergstrasse 70 4054, Basel, Switzerland
Curr Opin Microbiol 5:558-63. 2002....
Experimental evolution of aging in a bacteriumMartin Ackermann
Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
BMC Evol Biol 7:126. 2007..We tested the generality of this theory by experimental evolution with Caulobacter crescentus, a bacterium whose asymmetric division allows mother and daughter to be distinguished...- Mechanisms of cyclic-di-GMP signaling in bacteriaUrs Jenal
Biozentrum of the University of Basel, CH 4056 Basel, Switzerland
Annu Rev Genet 40:385-407. 2006..In addition, we examine several well-established model systems for c-di-GMP signaling, including Pseudomonas, Vibrio, Caulobacter, and Salmonella... - Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria?Urs Jenal
Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
Curr Opin Microbiol 7:185-91. 2004.... - Holdfast formation in motile swarmer cells optimizes surface attachment during Caulobacter crescentus developmentAssaf Levi
Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
J Bacteriol 188:5315-8. 2006..We present evidence that the timing of holdfast formation in swarmer cells is regulated posttranslationally and is dependent on the diguanylate cyclase PleD... - Single domain response regulators: molecular switches with emerging roles in cell organization and dynamicsUrs Jenal
Biozentrum, University of Basel, Switzerland
Curr Opin Microbiol 12:152-60. 2009..We review recent reports indicating that SD-RRs constitute a family of versatile molecular switches that contribute to cellular organization and dynamics as spatial organizer and/or as allosteric regulators of histidine protein kinases... 
The role of proteolysis in the Caulobacter crescentus cell cycle and developmentUrs Jenal
Biozentrum of the University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
Res Microbiol 160:687-95. 2009..Recent results highlight the importance of spatial organization for controlled proteolysis in C. crescentus...- Signal transduction mechanisms in Caulobacter crescentus development and cell cycle controlU Jenal
Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056, Basel, Switzerland
FEMS Microbiol Rev 24:177-91. 2000..These findings support the idea that the developmental program of C. crescentus is controlled at least in part by localized cues that act as checkpoints for the control of morphological changes and cell cycle progression... - Identification and transcriptional control of the genes encoding the Caulobacter crescentus ClpXP proteaseM Osteras
Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
J Bacteriol 181:3039-50. 1999..crescentus. Determination of the numbers of ClpP and ClpX molecules per cell suggested that ClpX is the limiting component compared with ClpP... - Precise amounts of a novel member of a phosphotransferase superfamily are essential for growth and normal morphology in Caulobacter crescentusT Fuchs
Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Mol Microbiol 39:679-92. 2001.... - The FtsH protease is involved in development, stress response and heat shock control in Caulobacter crescentusB Fischer
Division of Molecular Microbiology, Biozentrum, University of Basel, CH-4056, Switzerland
Mol Microbiol 44:461-78. 2002..Thus, directly or indirectly, the FtsH protease is involved in the inherent biological clock mechanism, which controls the timing of cell differentiation in C. crescentus... - An essential protease involved in bacterial cell-cycle controlU Jenal
Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
EMBO J 17:5658-69. 1998..In particular, CtrA negatively controls DNA replication and our findings suggest that specific degradation of the CtrA protein by the ClpXP protease contributes to G1-to-S transition in this organism... - Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progressionAnna Duerig
Biozentrum, University of Basel, 4056 Basel, Switzerland
Genes Dev 23:93-104. 2009..This is the first report that links cyclic di-GMP to protein dynamics and cell cycle control in bacteria... - DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentusMatthias Christen
Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
Proc Natl Acad Sci U S A 104:4112-7. 2007..crescentus by interfering with motor function rather than flagellar assembly. We present preliminary evidence implicating the flagellar motor protein FliL in DgrA-dependent cell motility control... - Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibitionPaul Wassmann
Core Program of Structural Biology and Biophysics, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
Structure 15:915-27. 2007..Here, a second mode is observed that crosslinks the DGC domains within a PleD dimer. Both modes cause noncompetitive product inhibition by domain immobilization... - Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTPMatthias Christen
Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
J Biol Chem 280:30829-37. 2005.... - The structure-function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domainJ G Malone
Division of Molecular Microbiology, Biozentrum, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
Microbiology 153:980-94. 2007..The RYGGEEF motif of WspR is functionally conserved, with almost every mutation abolishing function... - Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stressAlex Boehm
Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
Mol Microbiol 72:1500-16. 2009..Based on the important synergistic roles of ppGpp and c-di-GMP in this process, we suggest that interference with bacterial second messenger signalling might represent an effective means for biofilm control during chronic infections... - Structural and mechanistic determinants of c-di-GMP signallingTilman Schirmer
Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
Nat Rev Microbiol 7:724-35. 2009..Here, we review recent data on the structure and functional properties of the protein families that are involved in c-di-GMP signalling and discuss the mechanistic implications... - YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosaJacob G Malone
Biozentrum, University of Basel, Basel, Switzerland
PLoS Pathog 6:e1000804. 2010..This study establishes YfiBNR as an important player in P. aeruginosa persistence, and implicates a central role for c-di-GMP, and by extension the SCV phenotype in chronic infections... - Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domainRalf Paul
Division of Molecular Microbiology, Biozentrum, University of Basel, 4056 Basel, Switzerland
Genes Dev 18:715-27. 2004..We propose that the local action of this novel-type guanylate cyclase might constitute a general regulatory principle in bacterial growth and development... - Identification of the protease and the turnover signal responsible for cell cycle-dependent degradation of the Caulobacter FliF motor proteinBjörn Grünenfelder
Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
J Bacteriol 186:4960-71. 2004..Consistent with this, ClpA-dependent degradation was restored when a short stretch of hydrophobic amino acids was added to the C terminus of stable FliF mutant forms... - Second messenger-mediated adjustment of bacterial swimming velocityAlex Boehm
Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Cell 141:107-16. 2010..These experiments demonstrate that bacteria can modulate flagellar motor output and thus swimming velocity in response to environmental cues... - Allosteric control of cyclic di-GMP signalingBeat Christen
Biozentrum, University of Basel, Switzerland
J Biol Chem 281:32015-24. 2006.... - Role of the GGDEF regulator PleD in polar development of Caulobacter crescentusPhillip Aldridge
Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
Mol Microbiol 47:1695-708. 2003..Possible roles for PleD and its C-terminal output domain in modulating the polar cell surface of C. crescentus are discussed... - Role of the cytoplasmic C terminus of the FliF motor protein in flagellar assembly and rotationBjörn Grünenfelder
Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
J Bacteriol 185:1624-33. 2003..These results provide genetic support for a model in which only a short stretch of amino acids at the immediate C terminus of FliF is required for flagellar assembly through stable interaction with the FliG switch protein... - Structural basis of activity and allosteric control of diguanylate cyclaseCarmen Chan
Divisions of Structural Biology and Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Proc Natl Acad Sci U S A 101:17084-9. 2004..This allosteric site explains the observed noncompetitive product inhibition. We propose that product inhibition is due to domain immobilization and sets an upper limit for the concentration of this second messenger in the cell... - Proteomic analysis of the bacterial cell cycleB Grünenfelder
Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
Proc Natl Acad Sci U S A 98:4681-6. 2001..This is, to our knowledge, the first evidence for a global role of proteolysis in bacterial cell cycle control... - Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerizationRalf Paul
Biozentrum, University of Basel, Klingelbergstrasse 70, Basel CH 4056, Switzerland
J Biol Chem 282:29170-7. 2007.... - Sense and sensibility in bacteria. VIIIth International Conference on Bacterial Locomotion and Sensory TransductionUrs Jenal
Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland
EMBO Rep 6:615-9. 2005 - Allosteric regulation of histidine kinases by their cognate response regulator determines cell fateRalf Paul
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Cell 133:452-61. 2008..crescentus. Thus, single domain response regulators can facilitate crosstalk, feedback control, and long-range communication among members of the two-component network... - Regulation by proteolysis in bacterial cellsUrs Jenal
Division of Molecular Microbiology, Biozentrum, , Klingelbergstrasse 50/70, 4056 Basel, Switzerland
Curr Opin Microbiol 6:163-72. 2003..This information includes temporal and spatial cues, and recent research has revealed a striking potential for multiple signal integration... - Senescence in a bacterium with asymmetric divisionMartin Ackermann
Division of Molecular Microbiology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Science 300:1920. 2003 - Development of an aggregation assay to screen FimH antagonistsDaniela Abgottspon
Institute of Molecular Pharmacy, Pharmacenter, University of Basel, Switzerland
J Microbiol Methods 82:249-55. 2010..coli adherence and can therefore be employed to select candidates for experimental and clinical studies for treatment and prevention of urinary tract infections... - Regulation of D-xylose metabolism in Caulobacter crescentus by a LacI-type repressorCraig Stephens
Biology Department, Santa Clara University, 500 El Camino Real, Santa Clara, CA 95053, USA
J Bacteriol 189:8828-34. 2007..XylR also has an effect on glucose metabolism, as xylR mutants exhibit reduced expression of the Entner-Doudoroff operon and their ability to utilize glucose as a sole carbon and energy source is compromised... - Degradation of a Caulobacter soluble cytoplasmic chemoreceptor is ClpX dependentIsabel Potocka
Department of Biological Sciences, South Kensington Campus, Imperial College of Science, Technology and Medicine, London SW7 2AY, United Kingdom
J Bacteriol 184:6635-41. 2002..A green fluorescent protein (GFP) fusion bearing 58 amino acids from the C terminus of McpA, which contains this motif, is degraded, suggesting that the C-terminal sequence is sufficient to confer ClpXP protease susceptibility... - Proteome of Caulobacter crescentus cell cycle publicly accessible on SWICZ serverJiri Vohradsky
Institute of Microbiology, CAS, Prague, Czech Republic
Proteomics 3:1874-82. 2003..In its current state, the SWICZ proteome database provides a platform for the incorporation of new data emerging from extended functional studies on the C. crescentus proteome... - "Neural networks" in bacteria: making connectionsJudith P Armitage
Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, United Kingdom
J Bacteriol 187:26-36. 2005 - Genetic analysis of a novel pathway for D-xylose metabolism in Caulobacter crescentusCraig Stephens
Biology Department, Santa Clara University, Santa Clara, CA 95053, USA
J Bacteriol 189:2181-5. 2007..Enzymes of the C. crescentus pathway, including an NAD(+)-dependent xylose dehydrogenase, are encoded in the xylose-inducible xylXABCD operon (CC0823-CC0819)...