U Jenal

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint The Caulobacter cell cycle: timing, spatial organization and checkpoints
    Urs Jenal
    Biozentrum, University of Basel, Klingelbergstrasse 70 4054, Basel, Switzerland
    Curr Opin Microbiol 5:558-63. 2002
  2. pmc The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways
    Jacob G Malone
    Biozentrum of the University of Basel, Basel, Switzerland
    PLoS Pathog 8:e1002760. 2012
  3. pmc Experimental evolution of aging in a bacterium
    Martin Ackermann
    Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
    BMC Evol Biol 7:126. 2007
  4. doi request reprint The role of proteolysis in the Caulobacter crescentus cell cycle and development
    Urs Jenal
    Biozentrum of the University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Res Microbiol 160:687-95. 2009
  5. pmc Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics
    Urs Jenal
    Biozentrum, University of Basel, Switzerland
    Curr Opin Microbiol 12:152-60. 2009
  6. ncbi request reprint Mechanisms of cyclic-di-GMP signaling in bacteria
    Urs Jenal
    Biozentrum of the University of Basel, CH 4056 Basel, Switzerland
    Annu Rev Genet 40:385-407. 2006
  7. pmc Holdfast formation in motile swarmer cells optimizes surface attachment during Caulobacter crescentus development
    Assaf Levi
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Bacteriol 188:5315-8. 2006
  8. ncbi request reprint Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria?
    Urs Jenal
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Curr Opin Microbiol 7:185-91. 2004
  9. ncbi request reprint Signal transduction mechanisms in Caulobacter crescentus development and cell cycle control
    U Jenal
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056, Basel, Switzerland
    FEMS Microbiol Rev 24:177-91. 2000
  10. pmc Identification and transcriptional control of the genes encoding the Caulobacter crescentus ClpXP protease
    M Osteras
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Bacteriol 181:3039-50. 1999

Collaborators

Detail Information

Publications40

  1. ncbi request reprint The Caulobacter cell cycle: timing, spatial organization and checkpoints
    Urs Jenal
    Biozentrum, University of Basel, Klingelbergstrasse 70 4054, Basel, Switzerland
    Curr Opin Microbiol 5:558-63. 2002
    ....
  2. pmc The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways
    Jacob G Malone
    Biozentrum of the University of Basel, Basel, Switzerland
    PLoS Pathog 8:e1002760. 2012
    ..aeruginosa during chronic lung infections. These experiments uncover an important new principle of in vivo persistence, and identify the c-di-GMP network as a valid target for novel anti-infectives directed against chronic infections...
  3. pmc Experimental evolution of aging in a bacterium
    Martin Ackermann
    Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
    BMC Evol Biol 7:126. 2007
    ..We tested the generality of this theory by experimental evolution with Caulobacter crescentus, a bacterium whose asymmetric division allows mother and daughter to be distinguished...
  4. doi request reprint The role of proteolysis in the Caulobacter crescentus cell cycle and development
    Urs Jenal
    Biozentrum of the University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Res Microbiol 160:687-95. 2009
    ..Recent results highlight the importance of spatial organization for controlled proteolysis in C. crescentus...
  5. pmc Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics
    Urs Jenal
    Biozentrum, University of Basel, Switzerland
    Curr Opin Microbiol 12:152-60. 2009
    ..We review recent reports indicating that SD-RRs constitute a family of versatile molecular switches that contribute to cellular organization and dynamics as spatial organizer and/or as allosteric regulators of histidine protein kinases...
  6. ncbi request reprint Mechanisms of cyclic-di-GMP signaling in bacteria
    Urs Jenal
    Biozentrum of the University of Basel, CH 4056 Basel, Switzerland
    Annu Rev Genet 40:385-407. 2006
    ..In addition, we examine several well-established model systems for c-di-GMP signaling, including Pseudomonas, Vibrio, Caulobacter, and Salmonella...
  7. pmc Holdfast formation in motile swarmer cells optimizes surface attachment during Caulobacter crescentus development
    Assaf Levi
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Bacteriol 188:5315-8. 2006
    ..We present evidence that the timing of holdfast formation in swarmer cells is regulated posttranslationally and is dependent on the diguanylate cyclase PleD...
  8. ncbi request reprint Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria?
    Urs Jenal
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Curr Opin Microbiol 7:185-91. 2004
    ....
  9. ncbi request reprint Signal transduction mechanisms in Caulobacter crescentus development and cell cycle control
    U Jenal
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056, Basel, Switzerland
    FEMS Microbiol Rev 24:177-91. 2000
    ..These findings support the idea that the developmental program of C. crescentus is controlled at least in part by localized cues that act as checkpoints for the control of morphological changes and cell cycle progression...
  10. pmc Identification and transcriptional control of the genes encoding the Caulobacter crescentus ClpXP protease
    M Osteras
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Bacteriol 181:3039-50. 1999
    ..crescentus. Determination of the numbers of ClpP and ClpX molecules per cell suggested that ClpX is the limiting component compared with ClpP...
  11. ncbi request reprint Precise amounts of a novel member of a phosphotransferase superfamily are essential for growth and normal morphology in Caulobacter crescentus
    T Fuchs
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Microbiol 39:679-92. 2001
    ....
  12. ncbi request reprint The FtsH protease is involved in development, stress response and heat shock control in Caulobacter crescentus
    B Fischer
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056, Switzerland
    Mol Microbiol 44:461-78. 2002
    ..Thus, directly or indirectly, the FtsH protease is involved in the inherent biological clock mechanism, which controls the timing of cell differentiation in C. crescentus...
  13. pmc An essential protease involved in bacterial cell-cycle control
    U Jenal
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    EMBO J 17:5658-69. 1998
    ..In particular, CtrA negatively controls DNA replication and our findings suggest that specific degradation of the CtrA protein by the ClpXP protease contributes to G1-to-S transition in this organism...
  14. pmc Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression
    Anna Duerig
    Biozentrum, University of Basel, 4056 Basel, Switzerland
    Genes Dev 23:93-104. 2009
    ..This is the first report that links cyclic di-GMP to protein dynamics and cell cycle control in bacteria...
  15. ncbi request reprint Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition
    Paul Wassmann
    Core Program of Structural Biology and Biophysics, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Structure 15:915-27. 2007
    ..Here, a second mode is observed that crosslinks the DGC domains within a PleD dimer. Both modes cause noncompetitive product inhibition by domain immobilization...
  16. pmc DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus
    Matthias Christen
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 104:4112-7. 2007
    ..crescentus by interfering with motor function rather than flagellar assembly. We present preliminary evidence implicating the flagellar motor protein FliL in DgrA-dependent cell motility control...
  17. ncbi request reprint Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP
    Matthias Christen
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Biol Chem 280:30829-37. 2005
    ....
  18. ncbi request reprint The structure-function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain
    J G Malone
    Division of Molecular Microbiology, Biozentrum, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Microbiology 153:980-94. 2007
    ..The RYGGEEF motif of WspR is functionally conserved, with almost every mutation abolishing function...
  19. doi request reprint Structural and mechanistic determinants of c-di-GMP signalling
    Tilman Schirmer
    Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Nat Rev Microbiol 7:724-35. 2009
    ..Here, we review recent data on the structure and functional properties of the protein families that are involved in c-di-GMP signalling and discuss the mechanistic implications...
  20. ncbi request reprint Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress
    Alex Boehm
    Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Mol Microbiol 72:1500-16. 2009
    ..Based on the important synergistic roles of ppGpp and c-di-GMP in this process, we suggest that interference with bacterial second messenger signalling might represent an effective means for biofilm control during chronic infections...
  21. pmc Identification of the protease and the turnover signal responsible for cell cycle-dependent degradation of the Caulobacter FliF motor protein
    Björn Grünenfelder
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    J Bacteriol 186:4960-71. 2004
    ..Consistent with this, ClpA-dependent degradation was restored when a short stretch of hydrophobic amino acids was added to the C terminus of stable FliF mutant forms...
  22. pmc YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa
    Jacob G Malone
    Biozentrum, University of Basel, Basel, Switzerland
    PLoS Pathog 6:e1000804. 2010
    ..This study establishes YfiBNR as an important player in P. aeruginosa persistence, and implicates a central role for c-di-GMP, and by extension the SCV phenotype in chronic infections...
  23. doi request reprint Second messenger-mediated adjustment of bacterial swimming velocity
    Alex Boehm
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Cell 141:107-16. 2010
    ..These experiments demonstrate that bacteria can modulate flagellar motor output and thus swimming velocity in response to environmental cues...
  24. pmc Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain
    Ralf Paul
    Division of Molecular Microbiology, Biozentrum, University of Basel, 4056 Basel, Switzerland
    Genes Dev 18:715-27. 2004
    ..We propose that the local action of this novel-type guanylate cyclase might constitute a general regulatory principle in bacterial growth and development...
  25. ncbi request reprint Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus
    Phillip Aldridge
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Mol Microbiol 47:1695-708. 2003
    ..Possible roles for PleD and its C-terminal output domain in modulating the polar cell surface of C. crescentus are discussed...
  26. pmc Role of the cytoplasmic C terminus of the FliF motor protein in flagellar assembly and rotation
    Björn Grünenfelder
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Bacteriol 185:1624-33. 2003
    ..These results provide genetic support for a model in which only a short stretch of amino acids at the immediate C terminus of FliF is required for flagellar assembly through stable interaction with the FliG switch protein...
  27. ncbi request reprint Allosteric control of cyclic di-GMP signaling
    Beat Christen
    Biozentrum, University of Basel, Switzerland
    J Biol Chem 281:32015-24. 2006
    ....
  28. pmc Structural basis of activity and allosteric control of diguanylate cyclase
    Carmen Chan
    Divisions of Structural Biology and Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 101:17084-9. 2004
    ..This allosteric site explains the observed noncompetitive product inhibition. We propose that product inhibition is due to domain immobilization and sets an upper limit for the concentration of this second messenger in the cell...
  29. pmc Proteomic analysis of the bacterial cell cycle
    B Grünenfelder
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 98:4681-6. 2001
    ..This is, to our knowledge, the first evidence for a global role of proteolysis in bacterial cell cycle control...
  30. pmc Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate
    Ralf Paul
    Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Cell 133:452-61. 2008
    ..crescentus. Thus, single domain response regulators can facilitate crosstalk, feedback control, and long-range communication among members of the two-component network...
  31. pmc Sense and sensibility in bacteria. VIIIth International Conference on Bacterial Locomotion and Sensory Transduction
    Urs Jenal
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    EMBO Rep 6:615-9. 2005
  32. ncbi request reprint Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization
    Ralf Paul
    Biozentrum, University of Basel, Klingelbergstrasse 70, Basel CH 4056, Switzerland
    J Biol Chem 282:29170-7. 2007
    ....
  33. doi request reprint Development of an aggregation assay to screen FimH antagonists
    Daniela Abgottspon
    Institute of Molecular Pharmacy, Pharmacenter, University of Basel, Switzerland
    J Microbiol Methods 82:249-55. 2010
    ..coli adherence and can therefore be employed to select candidates for experimental and clinical studies for treatment and prevention of urinary tract infections...
  34. ncbi request reprint Senescence in a bacterium with asymmetric division
    Martin Ackermann
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Science 300:1920. 2003
  35. ncbi request reprint Regulation by proteolysis in bacterial cells
    Urs Jenal
    Division of Molecular Microbiology, Biozentrum, Universitat Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Curr Opin Microbiol 6:163-72. 2003
    ..This information includes temporal and spatial cues, and recent research has revealed a striking potential for multiple signal integration...
  36. pmc Regulation of D-xylose metabolism in Caulobacter crescentus by a LacI-type repressor
    Craig Stephens
    Biology Department, Santa Clara University, 500 El Camino Real, Santa Clara, CA 95053, USA
    J Bacteriol 189:8828-34. 2007
    ..XylR also has an effect on glucose metabolism, as xylR mutants exhibit reduced expression of the Entner-Doudoroff operon and their ability to utilize glucose as a sole carbon and energy source is compromised...
  37. ncbi request reprint Proteome of Caulobacter crescentus cell cycle publicly accessible on SWICZ server
    Jiri Vohradsky
    Institute of Microbiology, CAS, Prague, Czech Republic
    Proteomics 3:1874-82. 2003
    ..In its current state, the SWICZ proteome database provides a platform for the incorporation of new data emerging from extended functional studies on the C. crescentus proteome...
  38. pmc Degradation of a Caulobacter soluble cytoplasmic chemoreceptor is ClpX dependent
    Isabel Potocka
    Department of Biological Sciences, South Kensington Campus, Imperial College of Science, Technology and Medicine, London SW7 2AY, United Kingdom
    J Bacteriol 184:6635-41. 2002
    ..A green fluorescent protein (GFP) fusion bearing 58 amino acids from the C terminus of McpA, which contains this motif, is degraded, suggesting that the C-terminal sequence is sufficient to confer ClpXP protease susceptibility...
  39. pmc "Neural networks" in bacteria: making connections
    Judith P Armitage
    Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, United Kingdom
    J Bacteriol 187:26-36. 2005
  40. pmc Genetic analysis of a novel pathway for D-xylose metabolism in Caulobacter crescentus
    Craig Stephens
    Biology Department, Santa Clara University, Santa Clara, CA 95053, USA
    J Bacteriol 189:2181-5. 2007
    ..Enzymes of the C. crescentus pathway, including an NAD(+)-dependent xylose dehydrogenase, are encoded in the xylose-inducible xylXABCD operon (CC0823-CC0819)...