Research Topics
Genomes and Genes | Irmgard Irminger-FingerSummaryAffiliation: University of Geneva Country: Switzerland Publications
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Detail Information
Publications
Unusually stable abnormal karyotype in a highly aggressive melanoma negative for telomerase activitySarantis Gagos
Division of Genetics, Biomedical Research Foundation of the Academy of Athens, Greece BRFAA
Mol Cytogenet 1:20. 2008....
Is there more to BARD1 than BRCA1?Irmgard Irminger-Finger
Biology of Aging Laboratory, Department of Geriatrics, Geneva University and University Hospitals, 30, Bloulevard de la Cluse, CH 1211 Geneva, Switzerland
Nat Rev Cancer 6:382-91. 2006..BARD1 is indispensable for cell viability, so loss-of-function mutations are rare, but mutations and truncations that alter its function might be involved in the pathogenesis of breast cancer...- Science of cancer and agingIrmgard Irminger-Finger
Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland
J Clin Oncol 25:1844-51. 2007..From an intuitive point of view, there are phenomena that have traditionally been contributed to aging others to cancer-inducing factors and they are presented herein... - 3rd Geneva aging workshop 2002: cancer, apoptosis and agingIrmgard Irminger-Finger
Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, 2 chemin Petit Bel Air, 1225, Geneva, Switzerland
Biochim Biophys Acta 1653:41-5. 2003..The functions of telomere shortening and telomerase, extra cellular matrix, or epigenetic changes were presented in the light of their influence on aging and cancer risk... - BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulatedAnis Feki
Biology of Aging Laboratory, University Hospitals, CH 12225 Geneva, Switzerland
Biol Reprod 71:1614-24. 2004.... - BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinaseAnis Feki
Biology of Aging Laboratory, Department of Geriatrics, University of Geneva, Chemin de Petit Bel Air 2, CH 1225 Geneva Chêne Bourg, Switzerland
Oncogene 24:3726-36. 2005.... - Oncogenic BARD1 isoforms expressed in gynecological cancersLin Li
Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland
Cancer Res 67:11876-85. 2007..Thus, BARD1 isoform expression is required for cancer cell proliferation, which is compatible with the notion that BARD1 isoforms act as cancer maintenance genes... 
Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1Eva Dizin
Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland
Int J Biochem Cell Biol 42:693-700. 2010..Thus deficiencies of BRCA1 or BARD1 and/or upregulation of BARD1 isoforms lead to estrogen receptor alpha upregulation, providing a functional link between BRCA1 deficiency, estrogen signaling, and tumorigenesis...- Nuclear-cytoplasmic translocation of BARD1 is linked to its apoptotic activityCharles Edward Jefford
Biology of Aging Laboratory, Department of Geriatrics, University of Geneva, 1225 Geneva, Switzerland
Oncogene 23:3509-20. 2004..We suggest that nuclear and cytoplasmic localization of BARD1 reflect its dual function and that the increased cytoplasmic localization of BARD1 is associated with apoptosis... - BARD1: an independent predictor of survival in non-small cell lung cancerYong Qiang Zhang
Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, University Hospitals Geneva, Geneva, Switzerland
Int J Cancer 131:83-94. 2012..Thus, BARD1 isoforms might be involved in tumor initiation and invasive progression and might represent a novel prognostic marker for NSCLC... - BARD1, a possible biomarker for breast and ovarian cancerIrmgard Irminger-Finger
Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, University Hospitals Geneva, HUG Bld de la Cluse 30CH 1211 Geneva, Switzerland
Gynecol Oncol 117:211-5. 2010..The science behind BARD1 and its role in breast and ovarian cancer is explained in this article... - Identification of BARD1 splice-isoforms involved in human trophoblast invasionLin Li
Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Maternité, 30, Bld de la Cluse, CH 1211 Geneva, Switzerland
Int J Biochem Cell Biol 39:1659-72. 2007.... - Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosisJian Yu Wu
Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, Chemin de Petit Bel Air 2, CH 1225 Chne Bourg Geneva, Switzerland
Int J Cancer 118:1215-26. 2006..These data suggest that genetic and epigenetic changes might lead to elevated cytoplasmic expression of BARD1 and that cytoplasmic BARD1 might be a poor prognostic factor for breast and ovarian cancers... - BRCA1-dependent and independent functions of BARD1Irmgard Irminger-Finger
Louis Jeantet Laboratory of Aging Research, Department of Geriatrics, University of Geneva, Geneva, Switzerland
Int J Biochem Cell Biol 34:582-7. 2002..Elevated BARD1 expression in apoptotic tumor cells was found associated with anti-BARD1 immune response thus leading to new therapeutic approaches... - Mechanisms of chromosome instability in cancersCharles Edward Jefford
Biology of Aging Laboratory, Department of Geriatrics, University Hospitals Geneva HUG, Switzerland
Crit Rev Oncol Hematol 59:1-14. 2006.... - Chemokine-induced cell death in CCR5-expressing neuroblastoma cellsLaetitia Cartier
Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, 1225 Chene Bourg, Switzerland
J Neuroimmunol 145:27-39. 2003..In summary, CCR5 may act as a death receptor in cells of neuronal lineage and therefore be involved in inflammatory neurodegeneration... - Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2Stephan Ryser
Department of Gynecology and Obstetrics, Molecular Gynecology and Obstetrics Laboratory, University Hospitals Geneva, Geneva, Switzerland
Cancer Res 69:1125-34. 2009..Thus, loss of FL BARD1 and up-regulation of Aurora B, as observed in cancer cells, can be explained by an imbalance of FL BARD1 and BARD1beta... - Gene expression profiling of rat spermatogonia and Sertoli cells reveals signaling pathways from stem cells to niche and testicular cancer cells to surrounding stromaStephan Ryser
Molecular Gynecology and Obstetrics Laboratory, Geneva University Hospitals, Geneva, Switzerland
BMC Genomics 12:29. 2011.... - BARD1 content correlates with increased DNA fragmentation associated with muscle wasting in tumour-bearing ratsIrmgard Irminger-Finger
Biology of Aging Laboratory, Department of Geriatrics, University of Geneva, 1225 Geneva, Switzerland
Oncol Rep 15:1425-8. 2006..It is suggested that BARD1 acts as a modulator of muscle apoptosis or, alternatively, that BARD1 participates in the protein degradation by functioning as ubiquitin ligase... - Mutational spectrum of p53 mutations in primary breast and ovarian tumorsAnis Feki
Biology of Aging Laboratory and Monitoring Laboratory, Department of Geriatrics, University and University Hospitals of Geneva, Chemin de Petit Bel Air 2, , Geneva CH-1225, Switzerland
Crit Rev Oncol Hematol 52:103-16. 2004..Then, all this knowledge could be translated into effective screening, surveillance, prevention, and treatment strategies in the future... - Chromosome instability in neoplasia: chaotic roots to continuous growthSarantis Gagos
Laboratory of Genetics, Foundation for Biomedical Research of the Academy of Athens Greece, Soranou Efessiou 4, Athens 11527, Greece
Int J Biochem Cell Biol 37:1014-33. 2005..Finally, we will re-examine the longstanding hypothesis of the generation of aneuploidy in the context of telomere dysfunction and restoration... - Cancer therapy: new drugs are emerging based on molecular targeting but still many challengesLucia Altucci
Int J Biochem Cell Biol 39:1278-9. 2007 - Meeting report: Translational Research at the Aging and Cancer InterfaceChristopher C Benz
Buck Institute for Age Research, Novato, California, USA
Cancer Res 67:4560-3. 2007