Irmgard Irminger-Finger

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc Unusually stable abnormal karyotype in a highly aggressive melanoma negative for telomerase activity
    Sarantis Gagos
    Division of Genetics, Biomedical Research Foundation of the Academy of Athens, Greece BRFAA
    Mol Cytogenet 1:20. 2008
  2. ncbi Is there more to BARD1 than BRCA1?
    Irmgard Irminger-Finger
    Biology of Aging Laboratory, Department of Geriatrics, Geneva University and University Hospitals, 30, Bloulevard de la Cluse, CH 1211 Geneva, Switzerland
    Nat Rev Cancer 6:382-91. 2006
  3. ncbi Science of cancer and aging
    Irmgard Irminger-Finger
    Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland
    J Clin Oncol 25:1844-51. 2007
  4. ncbi 3rd Geneva aging workshop 2002: cancer, apoptosis and aging
    Irmgard Irminger-Finger
    Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, 2 chemin Petit Bel Air, 1225, Geneva, Switzerland
    Biochim Biophys Acta 1653:41-5. 2003
  5. ncbi Oncogenic BARD1 isoforms expressed in gynecological cancers
    Lin Li
    Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland
    Cancer Res 67:11876-85. 2007
  6. ncbi BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated
    Anis Feki
    Biology of Aging Laboratory, University Hospitals, CH 12225 Geneva, Switzerland
    Biol Reprod 71:1614-24. 2004
  7. doi Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1
    Eva Dizin
    Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland
    Int J Biochem Cell Biol 42:693-700. 2010
  8. ncbi Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis
    Jian Yu Wu
    Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, Chemin de Petit Bel Air 2, CH 1225 Chne Bourg Geneva, Switzerland
    Int J Cancer 118:1215-26. 2006
  9. ncbi BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase
    Anis Feki
    Biology of Aging Laboratory, Department of Geriatrics, University of Geneva, Chemin de Petit Bel Air 2, CH 1225 Geneva Chêne Bourg, Switzerland
    Oncogene 24:3726-36. 2005
  10. doi BARD1: an independent predictor of survival in non-small cell lung cancer
    Yong Qiang Zhang
    Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, University Hospitals Geneva, Geneva, Switzerland
    Int J Cancer 131:83-94. 2012

Collaborators

Detail Information

Publications23

  1. pmc Unusually stable abnormal karyotype in a highly aggressive melanoma negative for telomerase activity
    Sarantis Gagos
    Division of Genetics, Biomedical Research Foundation of the Academy of Athens, Greece BRFAA
    Mol Cytogenet 1:20. 2008
    ....
  2. ncbi Is there more to BARD1 than BRCA1?
    Irmgard Irminger-Finger
    Biology of Aging Laboratory, Department of Geriatrics, Geneva University and University Hospitals, 30, Bloulevard de la Cluse, CH 1211 Geneva, Switzerland
    Nat Rev Cancer 6:382-91. 2006
    ..BARD1 is indispensable for cell viability, so loss-of-function mutations are rare, but mutations and truncations that alter its function might be involved in the pathogenesis of breast cancer...
  3. ncbi Science of cancer and aging
    Irmgard Irminger-Finger
    Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland
    J Clin Oncol 25:1844-51. 2007
    ..From an intuitive point of view, there are phenomena that have traditionally been contributed to aging others to cancer-inducing factors and they are presented herein...
  4. ncbi 3rd Geneva aging workshop 2002: cancer, apoptosis and aging
    Irmgard Irminger-Finger
    Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, 2 chemin Petit Bel Air, 1225, Geneva, Switzerland
    Biochim Biophys Acta 1653:41-5. 2003
    ..The functions of telomere shortening and telomerase, extra cellular matrix, or epigenetic changes were presented in the light of their influence on aging and cancer risk...
  5. ncbi Oncogenic BARD1 isoforms expressed in gynecological cancers
    Lin Li
    Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland
    Cancer Res 67:11876-85. 2007
    ..Thus, BARD1 isoform expression is required for cancer cell proliferation, which is compatible with the notion that BARD1 isoforms act as cancer maintenance genes...
  6. ncbi BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated
    Anis Feki
    Biology of Aging Laboratory, University Hospitals, CH 12225 Geneva, Switzerland
    Biol Reprod 71:1614-24. 2004
    ....
  7. doi Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1
    Eva Dizin
    Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland
    Int J Biochem Cell Biol 42:693-700. 2010
    ..Thus deficiencies of BRCA1 or BARD1 and/or upregulation of BARD1 isoforms lead to estrogen receptor alpha upregulation, providing a functional link between BRCA1 deficiency, estrogen signaling, and tumorigenesis...
  8. ncbi Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis
    Jian Yu Wu
    Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, Chemin de Petit Bel Air 2, CH 1225 Chne Bourg Geneva, Switzerland
    Int J Cancer 118:1215-26. 2006
    ..These data suggest that genetic and epigenetic changes might lead to elevated cytoplasmic expression of BARD1 and that cytoplasmic BARD1 might be a poor prognostic factor for breast and ovarian cancers...
  9. ncbi BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase
    Anis Feki
    Biology of Aging Laboratory, Department of Geriatrics, University of Geneva, Chemin de Petit Bel Air 2, CH 1225 Geneva Chêne Bourg, Switzerland
    Oncogene 24:3726-36. 2005
    ....
  10. doi BARD1: an independent predictor of survival in non-small cell lung cancer
    Yong Qiang Zhang
    Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, University Hospitals Geneva, Geneva, Switzerland
    Int J Cancer 131:83-94. 2012
    ..Thus, BARD1 isoforms might be involved in tumor initiation and invasive progression and might represent a novel prognostic marker for NSCLC...
  11. ncbi Nuclear-cytoplasmic translocation of BARD1 is linked to its apoptotic activity
    Charles Edward Jefford
    Biology of Aging Laboratory, Department of Geriatrics, University of Geneva, 1225 Geneva, Switzerland
    Oncogene 23:3509-20. 2004
    ..We suggest that nuclear and cytoplasmic localization of BARD1 reflect its dual function and that the increased cytoplasmic localization of BARD1 is associated with apoptosis...
  12. doi BARD1, a possible biomarker for breast and ovarian cancer
    Irmgard Irminger-Finger
    Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, University Hospitals Geneva, HUG Bld de la Cluse 30CH 1211 Geneva, Switzerland
    Gynecol Oncol 117:211-5. 2010
    ..The science behind BARD1 and its role in breast and ovarian cancer is explained in this article...
  13. ncbi Identification of BARD1 splice-isoforms involved in human trophoblast invasion
    Lin Li
    Laboratory of Molecular Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Geneva University Hospitals, Maternité, 30, Bld de la Cluse, CH 1211 Geneva, Switzerland
    Int J Biochem Cell Biol 39:1659-72. 2007
    ....
  14. ncbi BRCA1-dependent and independent functions of BARD1
    Irmgard Irminger-Finger
    Louis Jeantet Laboratory of Aging Research, Department of Geriatrics, University of Geneva, Geneva, Switzerland
    Int J Biochem Cell Biol 34:582-7. 2002
    ..Elevated BARD1 expression in apoptotic tumor cells was found associated with anti-BARD1 immune response thus leading to new therapeutic approaches...
  15. ncbi Mechanisms of chromosome instability in cancers
    Charles Edward Jefford
    Biology of Aging Laboratory, Department of Geriatrics, University Hospitals Geneva HUG, Switzerland
    Crit Rev Oncol Hematol 59:1-14. 2006
    ....
  16. ncbi Chemokine-induced cell death in CCR5-expressing neuroblastoma cells
    Laetitia Cartier
    Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, 1225 Chene Bourg, Switzerland
    J Neuroimmunol 145:27-39. 2003
    ..In summary, CCR5 may act as a death receptor in cells of neuronal lineage and therefore be involved in inflammatory neurodegeneration...
  17. doi Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2
    Stephan Ryser
    Department of Gynecology and Obstetrics, Molecular Gynecology and Obstetrics Laboratory, University Hospitals Geneva, Geneva, Switzerland
    Cancer Res 69:1125-34. 2009
    ..Thus, loss of FL BARD1 and up-regulation of Aurora B, as observed in cancer cells, can be explained by an imbalance of FL BARD1 and BARD1beta...
  18. pmc Gene expression profiling of rat spermatogonia and Sertoli cells reveals signaling pathways from stem cells to niche and testicular cancer cells to surrounding stroma
    Stephan Ryser
    Molecular Gynecology and Obstetrics Laboratory, Geneva University Hospitals, Geneva, Switzerland
    BMC Genomics 12:29. 2011
    ....
  19. ncbi BARD1 content correlates with increased DNA fragmentation associated with muscle wasting in tumour-bearing rats
    Irmgard Irminger-Finger
    Biology of Aging Laboratory, Department of Geriatrics, University of Geneva, 1225 Geneva, Switzerland
    Oncol Rep 15:1425-8. 2006
    ..It is suggested that BARD1 acts as a modulator of muscle apoptosis or, alternatively, that BARD1 participates in the protein degradation by functioning as ubiquitin ligase...
  20. ncbi Mutational spectrum of p53 mutations in primary breast and ovarian tumors
    Anis Feki
    Biology of Aging Laboratory and Monitoring Laboratory, Department of Geriatrics, University and University Hospitals of Geneva, Chemin de Petit Bel Air 2, Chene Bourg, Geneva CH 1225, Switzerland
    Crit Rev Oncol Hematol 52:103-16. 2004
    ..Then, all this knowledge could be translated into effective screening, surveillance, prevention, and treatment strategies in the future...
  21. ncbi Chromosome instability in neoplasia: chaotic roots to continuous growth
    Sarantis Gagos
    Laboratory of Genetics, Foundation for Biomedical Research of the Academy of Athens Greece, Soranou Efessiou 4, Athens 11527, Greece
    Int J Biochem Cell Biol 37:1014-33. 2005
    ..Finally, we will re-examine the longstanding hypothesis of the generation of aneuploidy in the context of telomere dysfunction and restoration...
  22. ncbi Cancer therapy: new drugs are emerging based on molecular targeting but still many challenges
    Lucia Altucci
    Int J Biochem Cell Biol 39:1278-9. 2007
  23. ncbi Meeting report: Translational Research at the Aging and Cancer Interface
    Christopher C Benz
    Buck Institute for Age Research, Novato, California, USA
    Cancer Res 67:4560-3. 2007