B A Imhof

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. pmc Expression and function of junctional adhesion molecule-C in human and experimental arthritis
    Gaby Palmer
    Division of Rheumatology, Department of Internal Medicine, University Hospital, 26 Avenue Beau Sejour, 1211 Geneva 14, Switzerland
    Arthritis Res Ther 9:R65. 2007
  2. ncbi Intestinal CD8 alpha alpha and CD8 alpha beta intraepithelial lymphocytes are thymus derived and exhibit subtle differences in TCR beta repertoires
    B A Imhof
    Department of Pathology, Geneva University, Geneva, Switzerland
    J Immunol 165:6716-22. 2000
  3. ncbi Adhesion mechanisms regulating the migration of monocytes
    Beat A Imhof
    Centre Medical Universitaire, Department of Pathology and Immunology, 1 rue Michel Servet, 1204, Geneva, Switzerland
    Nat Rev Immunol 4:432-44. 2004
  4. ncbi Cross talk between alpha(v)beta3 and alpha4beta1 integrins regulates lymphocyte migration on vascular cell adhesion molecule 1
    B A Imhof
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:3242-52. 1997
  5. ncbi The parting of the endothelium: miracle, or simply a junctional affair?
    C Johnson-Leger
    Department of Pathology, Centre Medical Universitaire, Switzerland
    J Cell Sci 113:921-33. 2000
  6. ncbi Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members
    M Aurrand-Lions
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Blood 98:3699-707. 2001
  7. pmc CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium
    L Piali
    Basel Institute for Immunology, Switzerland
    J Cell Biol 130:451-60. 1995
  8. pmc Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration
    C Ballestrem
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Mol Biol Cell 11:2999-3012. 2000
  9. ncbi Basic mechanism of leukocyte migration
    B A Imhof
    Department of Pathology, CMU, Geneva
    Horm Metab Res 29:614-21. 1997
  10. ncbi JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration
    Guillaume Mandicourt
    Department of Pathology and Immunology, The University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 282:1830-7. 2007

Collaborators

Detail Information

Publications60

  1. pmc Expression and function of junctional adhesion molecule-C in human and experimental arthritis
    Gaby Palmer
    Division of Rheumatology, Department of Internal Medicine, University Hospital, 26 Avenue Beau Sejour, 1211 Geneva 14, Switzerland
    Arthritis Res Ther 9:R65. 2007
    ..Treatment of mice with an anti-JAM-C antibody significantly reduced the severity of AIA and delayed the onset of serum transfer-induced arthritis, suggesting a role for JAM-C in the pathogenesis of arthritis...
  2. ncbi Intestinal CD8 alpha alpha and CD8 alpha beta intraepithelial lymphocytes are thymus derived and exhibit subtle differences in TCR beta repertoires
    B A Imhof
    Department of Pathology, Geneva University, Geneva, Switzerland
    J Immunol 165:6716-22. 2000
    ..In conclusion, we show that while CD8 alpha alpha iIELs originate in the thymus, T cells acquire the expression of CD8 alpha alpha homodimers in the gut microenvironment...
  3. ncbi Adhesion mechanisms regulating the migration of monocytes
    Beat A Imhof
    Centre Medical Universitaire, Department of Pathology and Immunology, 1 rue Michel Servet, 1204, Geneva, Switzerland
    Nat Rev Immunol 4:432-44. 2004
  4. ncbi Cross talk between alpha(v)beta3 and alpha4beta1 integrins regulates lymphocyte migration on vascular cell adhesion molecule 1
    B A Imhof
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:3242-52. 1997
    ..This can explain how lymphocytes overcome tight adhesion to the vascular endothelium and start rapid migration along and through the endothelial lining of blood vessels into inflammatory tissue...
  5. ncbi The parting of the endothelium: miracle, or simply a junctional affair?
    C Johnson-Leger
    Department of Pathology, Centre Medical Universitaire, Switzerland
    J Cell Sci 113:921-33. 2000
    ..Passage of the leukocyte across the endothelium appears to require delocalization of certain endothelial cell molecules and proteolytic degradation of junctional complexes...
  6. ncbi Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members
    M Aurrand-Lions
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Blood 98:3699-707. 2001
    ..Furthermore, it was shown that JAM-1 and JAM-2 differentially regulate paracellular permeability, suggesting that the presence of JAM-1, -2, or -3 in vascular junctions may play a role in regulating vascular function in vivo...
  7. pmc CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium
    L Piali
    Basel Institute for Immunology, Switzerland
    J Cell Biol 130:451-60. 1995
    ..Identification of a further versatile adhesion pair broadens our current understanding of leukocyte-endothelial interactions and may provide the basis for the treatment of inflammatory disorders and metastasis formation...
  8. pmc Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration
    C Ballestrem
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Mol Biol Cell 11:2999-3012. 2000
    ..In conclusion, we demonstrate that the formation of lamellipodia can occur via actin polymerization independently of microtubules, but that microtubules are required for cell migration, tail retraction, and modulation of cell adhesion...
  9. ncbi Basic mechanism of leukocyte migration
    B A Imhof
    Department of Pathology, CMU, Geneva
    Horm Metab Res 29:614-21. 1997
    ..Finally, general therapeutic perspectives based on adhesion molecules leading to cure or prevention of chronic inflammation will be discussed...
  10. ncbi JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration
    Guillaume Mandicourt
    Department of Pathology and Immunology, The University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 282:1830-7. 2007
    ..These results highlight an unexpected function for JAM-C in controlling epithelial cell conversion from a static, polarized state to a pro-migratory phenotype...
  11. ncbi Stem cell factor presentation to c-Kit. Identification of a basolateral targeting domain
    B Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 276:12667-74. 2001
    ..Our findings therefore present mono-leucines as a novel type of protein sorting motif for transmembrane growth factors...
  12. pmc T cell precursor migration towards beta 2-microglobulin is involved in thymus colonization of chicken embryos
    D Dunon
    Basel Institute for Immunology, Switzerland
    EMBO J 9:3315-22. 1990
    ....
  13. ncbi The role of junctional adhesion molecule C (JAM-C) in acute pancreatitis
    A Vonlaufen
    Division of Gastroenterology, Department of Internal Medicine, University Hospitals, Geneva, Switzerland
    J Pathol 209:540-8. 2006
    ..It is proposed that JAM-C expressed by endothelial cells contributes to the pathophysiology of acute pancreatitis and could be considered a target for clinical applications...
  14. ncbi Current concepts in lymphocyte homing and recirculation
    G Wiedle
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Crit Rev Clin Lab Sci 38:1-31. 2001
    ..Current models in leukocyte homing and recirculation and the underlying molecular functions of implicated cell adhesion molecules, chemokines, and chemokine receptors are discussed...
  15. ncbi JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cells
    M Aurrand-Lions
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 Geneva, Switzerland
    J Biol Chem 276:2733-41. 2001
    ..Taken together, our results suggest that JAM-2 is a novel vascular molecule, which participates in interendothelial junctional complexes...
  16. pmc HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors
    O Vainio
    Basel Institute for Immunology, Switzerland
    J Cell Biol 135:1655-68. 1996
    ..Cross-linking of murine HEMCAM leads to cell spreading of T-lymphocyte progenitors adhering to the vascular adhesion molecules, PECAM-1 and VCAM-1. Thus, HEMCAM is likely to be involved in cellular adhesion and homing processes...
  17. pmc Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior
    C Ballestrem
    Department of Pathology, , Geneva, Switzerland
    J Cell Biol 155:1319-32. 2001
    ....
  18. ncbi Pulmonary dysfunction and impaired granulocyte homeostasis result in poor survival of Jam-C-deficient mice
    B A Imhof
    Department of Pathology and Immunology, Centre Medical Universitaire, 1 rue Michel Servet, 1204, Geneva, Switzerland
    J Pathol 212:198-208. 2007
    ....
  19. ncbi Junctional adhesion molecules and interendothelial junctions
    Michel Aurrand-Lions
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Cells Tissues Organs 172:152-60. 2002
    ..This is supported by the increased transmigration in vitro across endothelial cells overexpressing JAM-2 at intercellular contacts...
  20. pmc JAM-C regulates unidirectional monocyte transendothelial migration in inflammation
    Paul F Bradfield
    Department of Pathology and Immunology, University Medical Centre, Geneva, Switzerland
    Blood 110:2545-55. 2007
    ..All together, our results suggest a novel mechanism of reducing accumulation of monocytes at inflammation sites by disruption of JAM-C-mediated monocyte retention...
  21. pmc Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma
    L Piali
    Basel Institute for Immunology, Switzerland
    J Exp Med 181:811-6. 1995
    ..We propose that the downregulation of VCAM-1 is a mechanism by which vascularized melanoma and carcinoma avoid invasion by cytotoxic cells of the immune system...
  22. pmc Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion
    Chrystelle Lamagna
    Department of Pathology and Immunology, Centre Medical Universitaire, 1204 Geneva, Switzerland
    Mol Biol Cell 16:4992-5003. 2005
    ..We demonstrate that the modulation of JAM-C localization in junctional complexes is a new regulatory mechanism for alpha(M)beta2-dependent adhesion of leukocytes...
  23. ncbi Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?
    M A Aurrand-Lions
    Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
    Curr Top Microbiol Immunol 251:91-8. 2000
  24. pmc The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells
    Caroline Cluzel
    Department of Pathology and Immunlogy, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    J Cell Biol 171:383-92. 2005
    ..Thus, integrin clustering requires the formation of the ternary complex consisting of activated integrins, immobilized ligands, talin, and PI(4,5)P2. The dynamic remodeling of this ternary complex controls cell motility...
  25. doi Adaptive immune response in JAM-C-deficient mice: normal initiation but reduced IgG memory
    Claudia Zimmerli
    Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland
    J Immunol 182:4728-36. 2009
    ..Taken together, these data suggest that JAM-C deficiency affects the adaptive humoral immune response against pathogens, in addition to the innate immune system...
  26. ncbi Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth
    Chrystelle Lamagna
    Department of Pathology and Immunology, Centre Medical Universitaire, Geneva, Switzerland
    Cancer Res 65:5703-10. 2005
    ..Importantly, the antibody does not induce pathologic side effects in vivo. These findings show for the first time a role for JAM-C in angiogenesis and define JAM-C as a valuable target for antitumor therapies...
  27. ncbi Junctional adhesion molecule C (JAM-C) distinguishes CD27+ germinal center B lymphocytes from non-germinal center cells and constitutes a new diagnostic tool for B-cell malignancies
    C Ody
    Department of Pathology and Immunology, University Medical Center, Geneva, Switzerland
    Leukemia 21:1285-93. 2007
    ..Therefore, we propose JAM-C as a new identification tool in B-cell lymphoma diagnosis...
  28. ncbi Integrin alpha(v)beta(3) expression in colon carcinoma correlates with survival
    A Vonlaufen
    Department of Pathology, Centre Medical Universitaire, 1, rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Mod Pathol 14:1126-32. 2001
    ..Moreover, the expression level of alpha(v)beta(3) integrin correlated with the presence of liver metastases. In conclusion, we propose vascular expression of alpha(v)beta(3) integrin as a prognostic indicator for colon carcinoma...
  29. ncbi Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation
    Michel Aurrand-Lions
    Department of Pathology and Immunology, Medical University Center, Geneva, Switzerland
    J Immunol 174:6406-15. 2005
    ..Thus, JAM-C participates in the later steps of the leukoendothelial adhesion cascade...
  30. ncbi Haemangiomas are formed by cells expressing high levels of alphavbeta3 integrin and lacking acetylated LDL uptake
    Michel Aurrand-Lions
    Department of Pathology, University Medical Centre, Geneva, Switzerland
    J Pathol 203:700-9. 2004
    ..These data suggest that Ac-LDL uptake and the level of alphavbeta3 integrin expression are linked to the ability of endothelial cells to form large haemangiomas in vivo...
  31. ncbi Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration
    Caroline A Johnson-Léger
    Department of Pathology, University Medical Centre, 1, rue Michel Servet, Geneva, Switzerland
    Blood 100:2479-86. 2002
    ..Furthermore, we show that JAM-2 is expressed on HEVs in human tonsil and on a subset of human leukocytes, suggesting that JAM-2 plays a central role in the regulation of transendothelial migration...
  32. ncbi Actin, microtubules and focal adhesion dynamics during cell migration
    Bernhard Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 4, Geneva, Switzerland
    Int J Biochem Cell Biol 35:39-50. 2003
    ..We discuss here the cross-talk of the actin cytoskeleton with the microtubule network and the potential mechanisms that control the differential behavior of focal adhesions sites during cell migration...
  33. ncbi Role of interendothelial adhesion molecules in the control of vascular functions
    Michel Aurrand-Lions
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1204 Geneva, Switzerland
    Vascul Pharmacol 39:239-46. 2002
    ..Understanding of the function of vascular adhesion molecules is further complicated as they transduce signals to the endothelium and interact with the cytoskeleton and adaptor proteins...
  34. ncbi Integrin-dependent pathologies
    Bernhard Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Pathol 200:481-7. 2003
    ..Here we explain how integrins mediate cell migration and how genetic defects of integrins and their adaptors lead to cellular dysfunction and generate pathological situations...
  35. pmc Ontogenic appearance of MHC class I (B-F) antigens during chicken embryogenesis
    D Dunon
    Basel Institute for Immunology, Switzerland
    Dev Immunol 1:127-35. 1990
    ..The percentage of B-F+ cells in spleen and bone marrow decreased around hatching, which could reflect either cell flows in these organs during this period or the sensitivity of hemopoietic cells to hatching stress...
  36. ncbi Alpha 6 integrins participate in pro-T cell homing to the thymus
    P Ruiz
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 25:2034-41. 1995
    ..These data suggest that alpha 6 integrins are involved in the homing of pro-T cells to the developing thymus by mediating adhesion of pro-T cells to the vascular endothelium...
  37. pmc PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis
    C W Wong
    Department of Pathology, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    Mol Biol Cell 11:3109-21. 2000
    ..However, based on cocapping experiments performed on proT cells, we provide evidence that the integrin alphavbeta3 associates with PECAM-1 on the same cell surface as in a cis manner...
  38. ncbi LPS differentially regulates adhesion and transendothelial migration of human monocytes under static and flow conditions
    Paul F Bradfield
    Department of Pathology and Immunology, University Medical Centre, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Int Immunol 20:247-57. 2008
    ..This occurs during the early stages of sepsis, and in turn may modulate the severity of the pathophysiology...
  39. doi Vascular and epithelial junctions: a barrier for leucocyte migration
    Sarah Garrido-Urbani
    Centre Medical Universitaire, Pathology and Immunology Department, Geneva, Switzerland
    Biochem Soc Trans 36:203-11. 2008
    ..The purpose of this review is to discuss the role of these molecules in leucocyte transmigration and how they contribute to the different mechanisms that regulate leucocyte trafficking...
  40. ncbi Forging the endothelium during inflammation: pushing at a half-open door?
    Caroline Johnson-Leger
    Department of Pathology, University of Geneva, CMU, Rue Michel Servet 1, 1211, Geneva, Switzerland
    Cell Tissue Res 314:93-105. 2003
    ..We show that the final "open" signals that lead to the formation of clefts between adjacent endothelial cells may be derived from inflamed tissue underlying the endothelium and from activated leukocytes...
  41. ncbi A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface
    Frédérique Paulhe
    Department of Pathology and Immunology, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 279:55545-55. 2004
    ..It is responsible for the capture of Kitl at coat protein complex II-coated ER exit sites, leading to subsequent cell surface transport under physiological conditions...
  42. ncbi JAM family and related proteins in leukocyte migration (Vestweber series)
    Paul F Bradfield
    Department of Pathology and Immunology, University Medical Centre, CH 1211, Geneva 4, Switzerland
    Arterioscler Thromb Vasc Biol 27:2104-12. 2007
    ..However, research on all JAM family members has demonstrated recurring themes with striking similarities in the many diverse processes they are now known to regulate...
  43. doi Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain
    Frédérique Paulhe
    Department of Cellular Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    FASEB J 23:3037-48. 2009
    ..Thus, transmembrane-mediated association of membrane-anchored growth factors consists of a novel mechanism to improve paracrine signaling and morphogenesis...
  44. doi Sushi repeat protein X-linked 2, a novel mediator of angiogenesis
    Marijana Miljkovic-Licina
    Department of Pathology and Immunology, Centre Medical Universitaire, Rue Michel Servet 1, CH 1211 Geneva 4, Switzerland
    FASEB J 23:4105-16. 2009
    ..Immunostaining revealed coexpression of the Srpx2 and uPAR on vascular endothelium. These findings suggest that Srpx2 regulates endothelial cell migration and tube formation and provides a new target for modulating angiogenesis...
  45. ncbi Dual role of macrophages in tumor growth and angiogenesis
    Chrystelle Lamagna
    Department of Pathology and Immunology, Centre Medical Universitaire, 1204, Geneva, Switzerland
    J Leukoc Biol 80:705-13. 2006
    ..Tumor-associated macrophages are indeed key protagonists during angiogenesis and promote each step of the angiogenesis cascade...
  46. doi Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node
    Friederike Pfeiffer
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 38:2142-55. 2008
    ....
  47. pmc Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves
    Christoph Scheiermann
    National Heart and Lung Institute, Imperial College London, London, UK
    Science 318:1472-5. 2007
    ..These results demonstrate that JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves...
  48. ncbi The last molecular fortress in leukocyte trans-endothelial migration
    Michel Aurrand-Lions
    Nat Immunol 3:116-8. 2002
  49. ncbi Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent
    Monica Sircar
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:5879-87. 2007
    ..These data suggest that JAM-C has a minimal role, if any, in PMN transmigration in this model and that ICAM-1 is the preferred endothelial-expressed ligand for PMN beta(2) integrins during transendothelial migration...
  50. ncbi The alpha v beta 3 integrin as a tumor homing ligand for lymphocytes
    Daniel F Legler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Epalinges, Switzerland
    Eur J Immunol 34:1608-16. 2004
    ..These painted lymphocytes specifically bound to alpha v beta 3 in vitro and homed to vascularized, solid tumors in vivo. This novel strategy may provide a significant advance in anti-tumor treatment such as adoptive immune therapy...
  51. pmc Junctional adhesion molecule a serves as a receptor for prototype and field-isolate strains of mammalian reovirus
    Jacquelyn A Campbell
    Department of Microbiology and Immunology, Elizabeth B Lamb Center for Pediatric Research, D7235 MCN, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Virol 79:7967-78. 2005
    ..Mapping of these residues onto the crystal structure of sigma1 identified regions of conservation and variability, suggesting a likely mode of JAM-A binding via a conserved surface at the base of the sigma1 head domain...
  52. pmc Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice
    Eriko Fujita
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Oawahigashi machi 4 1 1, Kodaira, Tokyo 187 8502, Japan
    Am J Pathol 171:1800-10. 2007
    ..The lack of the ternary complex in the Ra175(-/-) elongating spermatid may cause the defect of the specialized adhesion structures, resulting in the oligo-astheno-teratozoospermia...
  53. ncbi The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity
    Klaus Ebnet
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    J Cell Sci 116:3879-91. 2003
    ..Our findings suggest that JAM-2 affects endothelial cell junctions by its regulated clustering at intercellular contacts, and they support a role for JAM-2, and possibly JAM-3, in tight junction formation of endothelial cells...
  54. ncbi Leukocyte migration to rheumatoid joints: Enzymes take over
    Gaby Palmer
    Arthritis Rheum 54:2707-10. 2006
  55. ncbi Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion
    Dirk Lehnert
    Department of Biology, University of Konstanz, Universitaetstrasse 10, 78457 Konstanz, Germany
    J Cell Sci 117:41-52. 2004
    ..Knowledge of these geometrical limits is essential for an understanding of cell adhesion and migration, and for the design of artificial surfaces that optimally interact with cells in a living tissue...
  56. pmc Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding
    Andrea E Prota
    Laboratory of Developmental Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 100:5366-71. 2003
    ..Because both receptors are located at regions of cell-cell contact, this similarity suggests that reovirus and adenovirus use conserved mechanisms of entry and pathways of infection...
  57. ncbi Angiogenesis and inflammation face off
    Beat A Imhof
    Nat Med 12:171-2. 2006
  58. ncbi Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C
    Georgia Gliki
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nature 431:320-4. 2004
    ..We found that Jam-C is essential for the polarization of round spermatids, a function that we attribute to its role in the assembly of a cell polarity complex...
  59. ncbi New therapeutic targets in vascular biology
    Beat A Imhof
    Thromb Haemost 90:557-9. 2003
  60. doi Lymphocyte transmigration in the brain: a new way of thinking
    Boris P L Lee
    Nat Immunol 9:117-8. 2008