E B Hunziker

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    Osteoarthritis Cartilage 7:15-28. 1999
  2. ncbi Growth-factor-induced healing of partial-thickness defects in adult articular cartilage
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    Osteoarthritis Cartilage 9:22-32. 2001
  3. ncbi Quantitative structural organization of normal adult human articular cartilage
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, P O Box 30, Switzerland
    Osteoarthritis Cartilage 10:564-72. 2002
  4. ncbi Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, Switzerland
    Osteoarthritis Cartilage 10:432-63. 2002
  5. ncbi Chondrogenic potential of human synovial mesenchymal stem cells in alginate
    T Kurth
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Bern, Switzerland
    Osteoarthritis Cartilage 15:1178-89. 2007
  6. ncbi Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    J Bone Joint Surg Am 78:721-33. 1996
  7. ncbi VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo
    E Wernike
    Department of Clinical Research, University of Bern, Bern, Switzerland
    Eur Cell Mater 19:30-40. 2010
  8. doi Osseointegration: the slow delivery of BMP-2 enhances osteoinductivity
    E B Hunziker
    Center of Regenerative Medicine for Skeletal Tissues, Department of Orthopaedic Surgery and Clinical Research, University of Bern, Switzerland
    Bone 51:98-106. 2012
  9. ncbi Delivery mode and efficacy of BMP-2 in association with implants
    Y Liu
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Switzerland
    J Dent Res 86:84-9. 2007
  10. ncbi Differential effects of dexamethasone on the chondrogenesis of mesenchymal stromal cells: influence of microenvironment, tissue origin and growth factor
    N Shintani
    Center of Regenerative Medicine for Skeletal Tissues, Department of Clinical Research, University of Bern, Bern, Switzerland
    Eur Cell Mater 22:302-19; discussion 319-20. 2011

Collaborators

Detail Information

Publications29

  1. ncbi Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    Osteoarthritis Cartilage 7:15-28. 1999
    ..Thus far, the application of cell suspensions has always been combined with the grafting of a periosteal flap. The strengths and weaknesses of each concept are discussed...
  2. ncbi Growth-factor-induced healing of partial-thickness defects in adult articular cartilage
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    Osteoarthritis Cartilage 9:22-32. 2001
    ..We now wished to ascertain whether these synovial cells could be stimulated to transform into chondrocytes, and thus to lay down cartilage tissue, by the timely introduction of a differentiation factor...
  3. ncbi Quantitative structural organization of normal adult human articular cartilage
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, P O Box 30, Switzerland
    Osteoarthritis Cartilage 10:564-72. 2002
    ..A comprehensive set of such baseline data is, however, not available for humans. It was the purpose of the present study to furnish the necessary information...
  4. ncbi Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, Switzerland
    Osteoarthritis Cartilage 10:432-63. 2002
    ..Current scientific trends and possible directions for the future will also be discussed...
  5. ncbi Chondrogenic potential of human synovial mesenchymal stem cells in alginate
    T Kurth
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Bern, Switzerland
    Osteoarthritis Cartilage 15:1178-89. 2007
    ..The purpose of the present study was to establish the conditions under which synovial MSCs derived from aging human donors can be induced to undergo chondrogenic differentiation using the same alginate system...
  6. ncbi Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    J Bone Joint Surg Am 78:721-33. 1996
    ..At forty-eight weeks, the entire cavity of the defect remained filled with a fibrous connective tissue...
  7. ncbi VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo
    E Wernike
    Department of Clinical Research, University of Bern, Bern, Switzerland
    Eur Cell Mater 19:30-40. 2010
    ..Sustained release of VEGF increased the efficacy of VEGF delivery demonstrating that a prolonged bioavailability of low concentrations of VEGF is beneficial for bone regeneration...
  8. doi Osseointegration: the slow delivery of BMP-2 enhances osteoinductivity
    E B Hunziker
    Center of Regenerative Medicine for Skeletal Tissues, Department of Orthopaedic Surgery and Clinical Research, University of Bern, Switzerland
    Bone 51:98-106. 2012
    ....
  9. ncbi Delivery mode and efficacy of BMP-2 in association with implants
    Y Liu
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Switzerland
    J Dent Res 86:84-9. 2007
    ..When BMP-2 was incorporated into calcium-phosphate coatings, it was a potent bone-inducer, whose efficacy was compromised, not potentiated, by the additional deposition of an adsorbed pool...
  10. ncbi Differential effects of dexamethasone on the chondrogenesis of mesenchymal stromal cells: influence of microenvironment, tissue origin and growth factor
    N Shintani
    Center of Regenerative Medicine for Skeletal Tissues, Department of Clinical Research, University of Bern, Bern, Switzerland
    Eur Cell Mater 22:302-19; discussion 319-20. 2011
    ..Their influence is context dependent (tissue source of the MSCs, their microenvironment and the nature of the growth-factor). This finding has important implications for MSC based approaches to cartilage repair...
  11. ncbi Surface and subsurface morphology of bovine humeral articular cartilage as assessed by atomic force and transmission electron microscopy
    J S Jurvelin
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    J Struct Biol 117:45-54. 1996
    ..It confirms the existence of an amorphous, nonfibrous articular surface which may be vital for its normal lubrication and wearing properties in vivo...
  12. pmc Surgical suturing of articular cartilage induces osteoarthritis-like changes
    E B Hunziker
    DST Research Center, Department of Clinical Research, University of Bern, Murtenstrasse 35, P O Box 54, 3010 Bern, Switzerland
    Osteoarthritis Cartilage 16:1067-73. 2008
    ..We hypothesize that the suturing of articular cartilage is associated with a loss of chondrocytes from, and osteoarthritis-like changes within, the perisutural area...
  13. ncbi Matrix and cell injury due to sub-impact loading of adult bovine articular cartilage explants: effects of strain rate and peak stress
    T M Quinn
    M E Mueller Institute for Biomechanics, University of Bern, Switzerland
    J Orthop Res 19:242-9. 2001
    ..These patterns of injury may also differ in terms of their long-term implications for progression of degradative disease and possibilities for cartilage repair...
  14. ncbi BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultured in three-dimensional alginate hydrogel
    Y Park
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, P O Box 54, 3010 Bern, Switzerland
    Osteoarthritis Cartilage 13:527-36. 2005
    ..In order to assess the usefulness of synovium-derived progenitor cells for the purposes of cartilage tissue engineering, we explored their requirements for the expression of chondrocyte-specific genes after expansion in vitro...
  15. ncbi The structural architecture of adult mammalian articular cartilage evolves by a synchronized process of tissue resorption and neoformation during postnatal development
    E B Hunziker
    University of Bern, ITI Research Institute for Dental and Skeletal Biology, Murtenstrasse 35, PO Box 54, Bern, Switzerland
    Osteoarthritis Cartilage 15:403-13. 2007
    ..We also wished to pinpoint the articular cartilage source of the stem cells for clonal expansion and the zonal location of the chondrocyte pool with high proliferative activity...
  16. ncbi Cell-mediated protein release from calcium-phosphate-coated titanium implants
    Y M Liu
    ITI Research Institute for Dental and Skeletal Biology, Bern University, Murtenstrasse 35, 3010 Bern, Switzerland
    J Control Release 101:346-7. 2005
  17. ncbi Functional barrier principle for growth-factor-based articular cartilage repair
    E B Hunziker
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, P O Box 54, CH 3010 Bern, Switzerland
    Osteoarthritis Cartilage 11:320-7. 2003
    ....
  18. ncbi Proteoglycan deposition around chondrocytes in agarose culture: construction of a physical and biological interface for mechanotransduction in cartilage
    T M Quinn
    Biomedical Engineering Laboratory, Swiss Federal Institute of Technology, Lausanne, Switzerland
    Biorheology 39:27-37. 2002
    ..These findings provide cell-scale insight into the mechanisms of assembly of matrix proteins and proteoglycans in de novo matrix, and may aid in the development of tissue engineering methods for cartilage repair...
  19. pmc Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) is closely associated with the chondrocyte nucleus in human articular cartilage
    E B Hunziker
    ITI Research Institute for Dental and Skeletal Biology, Bern, Switzerland
    Osteoarthritis Cartilage 16:185-94. 2008
    ..These studies were undertaken to localize IGFBP-3 in human articular cartilage, particularly within cells...
  20. ncbi Structural characterization and reliable biomechanical assessment of integrative cartilage repair
    M Moretti
    Department of Surgery, Institute for Surgical Research and Hospital Management, University Hospital Basel, Hebelstrasse 20, ZLF, Room 405, 4031 Basel, Switzerland
    J Biomech 38:1846-54. 2005
    ....
  21. ncbi GDF-5 deficiency in mice leads to disruption of tail tendon form and function
    R T Clark
    Department of Orthopaedic Surgery, University of Virginia, USA
    Connect Tissue Res 42:175-86. 2001
    ..These findings provide additional evidence to support the conclusion that GDF-5 may play a role in tendon homeostasis in mice...
  22. ncbi Altered hypertrophic chondrocyte kinetics in GDF-5 deficient murine tibial growth plates
    B Mikic
    Picker Engineering Program, Smith College, 51 College Lane, Northampton, MA 01063, USA
    J Orthop Res 22:552-6. 2004
    ..006). These data suggest that one way in which GDF-5 might modulate the rate of endochondral bone growth could be by affecting the duration of the hypertrophic phase in growth plate chondrocytes...
  23. ncbi Osteoinductive implants: the mise-en-scène for drug-bearing biomimetic coatings
    Y Liu
    ITI Research Institute, Bern University, Switzerland
    Ann Biomed Eng 32:398-406. 2004
    ..This feature enhances the capacity of these coatings to act as a carrier system for osteogenic agents...
  24. pmc Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage
    P Patwari
    Continuum Electromechanics Lab, Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Osteoarthritis Cartilage 12:245-52. 2004
    ..For comparison, the TUNEL assay was also performed...
  25. ncbi GDF-5 deficiency in mice alters the ultrastructure, mechanical properties and composition of the Achilles tendon
    B Mikic
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville 22908, USA
    J Orthop Res 19:365-71. 2001
    ..Our findings suggest that increased tendon and ligament laxity may be the cause of the joint dislocations seen in patients with Hunter-Thompson and Grebe type dysplasia, rather than developmental abnormalities in the joints themselves...
  26. ncbi Mechanical anisotropy of the human knee articular cartilage in compression
    J S Jurvelin
    Department of Applied Physics, University of Kuopio, Kuopio, Finland
    Proc Inst Mech Eng H 217:215-9. 2003
    ..Anisotropy during compression may be essential for normal cartilage function. This property has to be considered when developing advanced theoretical models for cartilage biomechanics...
  27. ncbi The role of collagen II and cartilage fibril-associated molecules in skeletal development
    A Aszodi
    Department of Experimental Pathology, Lund University, Sweden
    Osteoarthritis Cartilage 9:S150-9. 2001
    ..To understand the role some of these molecules in skeletal development, we have generated transgenic mouse strains harboring ablated genes for collagens II and IX, and matrilin-1...
  28. ncbi Importance of the superficial tissue layer for the indentation stiffness of articular cartilage
    R K Korhonen
    Department of Applied Physics, University of Kuopio, Kuopio, Finland
    Med Eng Phys 24:99-108. 2002
    ..The present results suggest that indentation testing is an efficient technique for the characterization of the superficial degeneration of articular cartilage...
  29. ncbi GDF-5 deficiency in mice delays Achilles tendon healing
    A Chhabra
    Department of Orthopaedics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Orthop Res 21:826-35. 2003
    ....