U Hubscher

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi Eukaryotic DNA polymerases
    Ulrich Hubscher
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Annu Rev Biochem 71:133-63. 2002
  2. ncbi [DNA replication: mechanism and significance for general practice]
    U Hubscher
    Institut für Veterinärbiochemie, Universitat Zurich Irchel
    Schweiz Med Wochenschr 128:1284-90. 1998
  3. ncbi Replication of the lagging strand: a concert of at least 23 polypeptides
    U Hubscher
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Switzerland
    Mol Cells 12:149-57. 2001
  4. ncbi Eukaryotic DNA polymerases, a growing family
    U Hubscher
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Trends Biochem Sci 25:143-7. 2000
  5. pmc Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen
    Z O Jónsson
    Department of Veterinary Biochemistry, University Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    EMBO J 17:2412-25. 1998
  6. ncbi DNA ligase I selectively affects DNA synthesis by DNA polymerases delta and epsilon suggesting differential functions in DNA replication and repair
    R Mossi
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol Chem 273:14322-30. 1998
  7. ncbi Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300
    S Hasan
    Institute of Veterinary Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Mol Cell 7:1221-31. 2001
  8. ncbi A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation
    S Koundrioukoff
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Biol Chem 275:22882-7. 2000
  9. ncbi Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen
    R Mossi
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol Chem 272:1769-76. 1997
  10. ncbi Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2)
    R Hindges
    Department of Veteninary Biochemistry, University of Zurich Irchel, Switzerland
    Genomics 44:45-51. 1997

Collaborators

Detail Information

Publications16

  1. ncbi Eukaryotic DNA polymerases
    Ulrich Hubscher
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Annu Rev Biochem 71:133-63. 2002
    ..These are the lesion-replicating enzymes pol zeta, pol eta, pol iota, pol kappa, and Rev1, and a group of pols called pol theta;, pol lambda, pol micro, pol sigma, and pol phi that fulfill a variety of other tasks...
  2. ncbi [DNA replication: mechanism and significance for general practice]
    U Hubscher
    Institut für Veterinärbiochemie, Universitat Zurich Irchel
    Schweiz Med Wochenschr 128:1284-90. 1998
    ..Exact knowledge of these protein-protein interactions will eventually open up novel therapeutic strategies against cancer...
  3. ncbi Replication of the lagging strand: a concert of at least 23 polypeptides
    U Hubscher
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Switzerland
    Mol Cells 12:149-57. 2001
    ..In this minireview we summarize our current knowledge of the components involved in the execution and regulation of DNA replication at the lagging strand of the replication fork...
  4. ncbi Eukaryotic DNA polymerases, a growing family
    U Hubscher
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Trends Biochem Sci 25:143-7. 2000
    ..In the last two years, the number of known DNA polymerases has increased to at least nine (called alpha, beta, gamma, delta, epsilon, zeta, eta, t and iota), and yeast Saccharomyces cerevisiae contains REV1 deoxycytidyl transferase...
  5. pmc Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen
    Z O Jónsson
    Department of Veterinary Biochemistry, University Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    EMBO J 17:2412-25. 1998
    ....
  6. ncbi DNA ligase I selectively affects DNA synthesis by DNA polymerases delta and epsilon suggesting differential functions in DNA replication and repair
    R Mossi
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol Chem 273:14322-30. 1998
    ..This might be of importance in the selective involvement in DNA transactions such as DNA replication and various mechanisms of DNA repair...
  7. ncbi Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300
    S Hasan
    Institute of Veterinary Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Mol Cell 7:1221-31. 2001
    ..Our results identify acetylation as a novel regulatory modification of Fen1 and implicate that p300 is not only a component of the chromatin remodeling machinery but might also play a critical role in regulating DNA metabolic events...
  8. ncbi A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation
    S Koundrioukoff
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Biol Chem 275:22882-7. 2000
    ..Based on our results, we propose the model that PCNA brings Cdk2 to proteins involved in DNA replication and possibly might act as an "adaptor" for Cdk2-cyclin A to PCNA-binding DNA replication proteins...
  9. ncbi Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen
    R Mossi
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol Chem 272:1769-76. 1997
    ..The RF-C large subunit from a third species, namely Drosophila melanogaster, interacted similarly with the modified human PCNA, indicating that the interaction between RF-C and PCNA is conserved through eukaryotic evolution...
  10. ncbi Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2)
    R Hindges
    Department of Veteninary Biochemistry, University of Zurich Irchel, Switzerland
    Genomics 44:45-51. 1997
    ....
  11. ncbi Germ line transformation of mammals by pronuclear microinjection
    T Rülicke
    Institute of Laboratory Animal Science, University of Zurich, Switzerland
    Exp Physiol 85:589-601. 2000
    ..In this article we will emphasize some peculiarities which have to be taken into account for the successful performance of transgenesis by pronuclear microinjection...
  12. ncbi Calf thymus Hsc70 and Hsc40 can substitute for DnaK and DnaJ function in protein renaturation but not in bacteriophage DNA replication
    A Ziemienowicz
    Department of Veterinary Biochemistry, University of Zurich, Zurich, Switzerland
    FEBS Lett 507:11-5. 2001
    ..Surprisingly, ctHsc70/ctHsc40 chaperones were found to reactivate the denatured prokaryotic and eukaryotic enzymes but not to promote bacteriophage lambda DNA replication, suggesting species specificity in DNA replication...
  13. ncbi Anti-HIV-1 activity in vitro of ceftazidime degradation products
    R Hobi
    Institute of Veterinary Biochemistry, University of Zurich Irchel, Zurich, Switzerland
    Antivir Chem Chemother 12:109-18. 2001
    ..Despite a lack of a direct effect of the CD4/gp120 interaction, HIV-1 mediated cell fusion was inhibited by the hydrolysed ceftazidime, suggesting that the active principle acts in a very early stage of the viral life-cycle...
  14. pmc The large subunit of HIV-1 reverse transcriptase interacts with beta-actin
    M Hottiger
    Department of Veterinary Biochemistry, University of Zurich Irchel, Switzerland
    Nucleic Acids Res 23:736-41. 1995
    ..The reverse transcriptase/beta-actin interaction might be important for the secretion of HIV-1 virions...
  15. ncbi Cloning of a mouse cDNA encoding DNA polymerase delta: refinement of the homology boxes
    G Cullmann
    Institut für Veterinärbiochemie, Universitat Zurich Irchel, Switzerland
    Gene 134:191-200. 1993
    ..Polyclonal antibodies raised against a 31-aa synthetic peptide deduced from the ORF specifically recognize Pol delta polymerases from human cells and calf thymus in an immunoblot...
  16. pmc Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radiodurans
    Melanie Blasius
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich Irchel, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    BMC Mol Biol 8:69. 2007
    ..We expect that DNA ligases and end-processing enzymes play an important role in Deinococcus radiodurans DNA strand-break repair...