L C Huber
Affiliation: University Hospital
- Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosisLars C Huber
Center of Experimental Rheumatism, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
Arthritis Rheum 56:2755-64. 2007..In this study, we investigated the antifibrogenic effects of the histone deacetylase inhibitor trichostatin A (TSA) on cytokine-driven fibrotic responses in vitro and in vivo...
- Caveolin-1 Expression and Hemodynamics in COPD PatientsLars C Huber
Working Group for Pulmonary Hypertension, Department for Internal Medicine, University Hospital Zurich, Zurich, Switzerland
Open Respir Med J 3:73-8. 2009..Our results thus emphasize a potential novel player in the pathogenesis of COPD-associated pulmonary hypertension...
- A low resting heart rate at diagnosis predicts favourable long-term outcome in pulmonary arterial and chronic thromboembolic pulmonary hypertension. A prospective observational studyFlorian F Hildenbrand
Department of Heart, Vessel, Thorax, University Hospital of Zurich, Zurich, 8091, Switzerland
Respir Res 13:76. 2012..In this study we investigated the impact of HR at diagnosis on long-term outcome in patients with differently classified precapillary pulmonary hypertension (pPH)...
- Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional studySilvia Ulrich
Department of Internal Medicine, Pulmonary Hypertension Clinic, University Hospital of Zurich, Zurich, Switzerland
Respir Res 9:20. 2008..The purpose of the present work was therefore to comparatively analyze peripheral blood B lymphocyte RNA expression characteristics in IPAH and healthy controls...
- Epigenetics in inflammatory rheumatic diseasesLars C Huber
University Hospital Zurich, Zurich Center for Integrative Human Physiology, Zurich, Switzerland
Arthritis Rheum 56:3523-31. 2007
- Effects of a novel tyrosine kinase inhibitor in rheumatoid arthritis synovial fibroblastsL C Huber
Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 25, CH 8091 Zurich, Switzerland
Ann Rheum Dis 67:389-94. 2008..In the present study, we investigated the effects of GW282974, a novel compound directed against tyrosine kinase activity with respect to the potential suppression of inflammation and destruction...
- Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patientsLars C Huber
Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, Zurich, Switzerland
Arthritis Rheum 56:1087-93. 2007..We undertook this study to investigate the balance of histone acetylase and HDA activity in synovial tissue from RA patients compared with that from patients with osteoarthritis (OA) and normal controls...
- The role of membrane lipids in the induction of macrophage apoptosis by microparticlesLars C Huber
Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 23, CH 8091, Zurich, Switzerland
Apoptosis 12:363-74. 2007....
- Antisense strategies in degenerative joint diseases: sense or nonsense?Lars C Huber
Center of Experimental Rheumatology, WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, University of Zurich, University Hospital Zurich, Gloriastr 23, CH 8091 Zurich, Switzerland
Adv Drug Deliv Rev 58:285-99. 2006..To introduce these therapies in clinical practice, however, several hurdles still have to be overcome...
- Synovial fibroblasts: key players in rheumatoid arthritisL C Huber
Center of Experimental Rheumatology, University Hospital Zurich, Gloriastrasse 23CH 8091 Zürich, Switzerland
Rheumatology (Oxford) 45:669-75. 2006..As a consequence, RASFs are no longer considered passive bystanders but active players in the complex intercellular network of RA...
- The release of microparticles by apoptotic cells and their effects on macrophagesJ H W Distler
Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, CH 8091, Switzerland
Apoptosis 10:731-41. 2005..The release of microparticles from apoptotic cells may therefore represent a novel amplification loop of cell death...
- The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticlesJörg H W Distler
Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, CH 8091 Zurich, Switzerland
Proc Natl Acad Sci U S A 102:2892-7. 2005..These data provide evidence for a novel mechanism by which vesicles derived from activated or apoptotic immune cells can promote the destructive activity of synovial fibroblasts in rheumatoid arthritis...
- Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblastsCaroline Ospelt
University Hospital, Zurich, Switzerland
Arthritis Rheum 62:1224-35. 2010....
- Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosisHossein Hemmatazad
Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Arthritis Rheum 60:1519-29. 2009..The purpose of this study was to analyze the silencing of histone deacetylase 7 (HDAC-7) as a possible mechanism by which TSA exerts its antifibrotic function...
- Insufficient medication documentation at hospital admission of cardiac patients: a challenge for medication reconciliationPascal Frei
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
J Cardiovasc Pharmacol 54:497-501. 2009..Medication errors may occur when hospital doctors are not adequately informed about a patient's prescribed drugs...
- Platelet serotonin content and transpulmonary platelet serotonin gradient in patients with pulmonary hypertensionSilvia Ulrich
Department of Medicine and Pulmonology, Clinic and Policlinic of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland
Respiration 81:211-6. 2011..Objective: To comparatively analyze plasmatic and intrathrombocytic serotonin levels in arterial and mixed venous blood of patients with PH and unaffected controls to elucidate pulmonary serotonin metabolisms...
- Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1Astrid Jungel
Zurich Center of Integrative Human Physiology, and University Hospital Zurich, Zurich, Switzerland
Arthritis Rheum 56:3564-74. 2007..The goal of these studies was to elucidate the mechanisms by which microparticles activate synovial fibroblasts to express a proinflammatory phenotype...
- Gene targeting: roadmap to future therapiesLars C Huber
WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies, Department of Rheumatology, University Hospital, Gloriastrasse 25, CH 8091 Zurich, Switzerland
Curr Rheumatol Rep 6:323-5. 2004
- The relationship between plasma microparticles and disease manifestations in patients with systemic sclerosisSerena Guiducci
University Hospital Zurich, Zurich, Switzerland
Arthritis Rheum 58:2845-53. 2008..The aim of the present study was to analyze the profile of microparticles in the blood of patients with systemic sclerosis (SSc; scleroderma) and healthy controls...
- Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosisJörg H W Distler
University of Erlangen Nuremberg, Erlangen, Germany
Arthritis Rheum 56:311-22. 2007..This study was undertaken to test the potential use of imatinib mesylate as an antifibrotic drug for the treatment of dermal fibrosis in systemic sclerosis (SSc)...
- Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseasesJörg H W Distler
Institute for Clinical Immunology and Rheumatology, Dept of Internal Medicine III, University of Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Arthritis Rheum 52:3337-48. 2005
- Microparticles as mediators of cellular cross-talk in inflammatory diseaseJörg H W Distler
Department of Internal Medicine 3, University of Erlangen, Erlangen, Germany
Autoimmunity 39:683-90. 2006..Together, these findings point to novel signaling pathways of cellular cross-talk that may operate along the spectrum of soluble cytokines and mediators of direct cell-cell contact...
- [Molecular pathways in aseptic loosening of orthopaedic endoprosthesis]Philipp Drees
Orthopädische Klinik und Poliklinik der Johannes Gutenberg Universität, Mainz, Deutschland
Biomed Tech (Berl) 53:93-103. 2008..In this article, we review the molecular mechanisms and signal pathways that were unravelled as responsible factors for loosening orthopaedic implants. Finally, we discuss possible novel strategies for future therapeutic approaches...