Thorsten Hornemann

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase
    Thorsten Hornemann
    Institute for Clinical Chemistry, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    J Biol Chem 281:37275-81. 2006
  2. doi request reprint Palmitoylation and depalmitoylation defects
    Thorsten Hornemann
    Institute for Clinical Chemistry, University Hospital Zurich, Raemistrasse 100, CH 8091, Zurich, Switzerland
    J Inherit Metab Dis 38:179-86. 2015
  3. pmc Altered sphingoid base profiles in type 1 compared to type 2 diabetes
    Nancy Wei
    MGH Neuroscience Center, Department of Neurology, Harvard Medical School, 55 Fruit Street ACC 708, Boston, MA 02114, USA
    Lipids Health Dis 13:161. 2014
  4. doi request reprint Sphingolipids and atherosclerosis
    Thorsten Hornemann
    Inst for Clinical Chemistry, University Hospital Zuerich, Raemistrasse 100, 8091 Zuerich, Switzerland
    Atherosclerosis 226:16-28. 2013
  5. pmc The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases
    Thorsten Hornemann
    Institute for Clinical Chemistry, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Biol Chem 284:26322-30. 2009
  6. doi request reprint A systematic comparison of all mutations in hereditary sensory neuropathy type I (HSAN I) reveals that the G387A mutation is not disease associated
    Thorsten Hornemann
    Department for Clinical Chemistry, University Hospital Zurich, Raemistrasse 100, 8051, Zurich, Switzerland
    Neurogenetics 10:135-43. 2009
  7. pmc Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?
    Thorsten Hornemann
    Institute for Clinical Chemistry, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Biochem J 405:157-64. 2007
  8. pmc Deoxysphingoid bases as plasma markers in diabetes mellitus
    Mariana Bertea
    Institute for Clinical Chemistry, University Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Lipids Health Dis 9:84. 2010
  9. pmc An improved method to determine serine palmitoyltransferase activity
    Markus F Rütti
    Institute for Clinical Chemistry, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Lipid Res 50:1237-44. 2009
  10. pmc Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids
    Anke Penno
    Institute for Clinical Chemistry, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Biol Chem 285:11178-87. 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase
    Thorsten Hornemann
    Institute for Clinical Chemistry, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    J Biol Chem 281:37275-81. 2006
    ..The expression of two SPT isoforms could be a cellular mechanism to adjust SPT activity to tissue-specific requirements of sphingolipid synthesis...
  2. doi request reprint Palmitoylation and depalmitoylation defects
    Thorsten Hornemann
    Institute for Clinical Chemistry, University Hospital Zurich, Raemistrasse 100, CH 8091, Zurich, Switzerland
    J Inherit Metab Dis 38:179-86. 2015
    ..This review intends to give an overview on the pathological changes which are associated with defects in the palmitoylation/depalmitoylation process. ..
  3. pmc Altered sphingoid base profiles in type 1 compared to type 2 diabetes
    Nancy Wei
    MGH Neuroscience Center, Department of Neurology, Harvard Medical School, 55 Fruit Street ACC 708, Boston, MA 02114, USA
    Lipids Health Dis 13:161. 2014
    ..It is unknown whether 1-deoxySL in patients with diabetes type 1 (T1DM) are similarly elevated...
  4. doi request reprint Sphingolipids and atherosclerosis
    Thorsten Hornemann
    Inst for Clinical Chemistry, University Hospital Zuerich, Raemistrasse 100, 8091 Zuerich, Switzerland
    Atherosclerosis 226:16-28. 2013
    ..Here we discuss recent mechanistic insights obtained in animal and epidemiological studies that have greatly enhanced our understanding of mechanisms how sphingolipids affect the atherosclerotic process...
  5. pmc The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases
    Thorsten Hornemann
    Institute for Clinical Chemistry, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Biol Chem 284:26322-30. 2009
    ..In conclusion, we show that the SPTLC3 subunit generates C(16)-sphingoid bases and that sphingolipids with a C(16) backbone constitute a significant proportion of human plasma sphingolipids...
  6. doi request reprint A systematic comparison of all mutations in hereditary sensory neuropathy type I (HSAN I) reveals that the G387A mutation is not disease associated
    Thorsten Hornemann
    Department for Clinical Chemistry, University Hospital Zurich, Raemistrasse 100, 8051, Zurich, Switzerland
    Neurogenetics 10:135-43. 2009
    ..These findings were genetically confirmed by the identification of a nuclear HSAN family which showed segregation of the G387A variant as a non-synonymous SNP...
  7. pmc Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?
    Thorsten Hornemann
    Institute for Clinical Chemistry, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Biochem J 405:157-64. 2007
    ..The observed dynamic composition of the SPT complex could provide a cellular mechanism to adjust SPT activity to tissue specific requirements in sphingolipid synthesis...
  8. pmc Deoxysphingoid bases as plasma markers in diabetes mellitus
    Mariana Bertea
    Institute for Clinical Chemistry, University Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Lipids Health Dis 9:84. 2010
    ....
  9. pmc An improved method to determine serine palmitoyltransferase activity
    Markus F Rütti
    Institute for Clinical Chemistry, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Lipid Res 50:1237-44. 2009
    ..The suggested HPLC method offers several advantages, most importantly, a 20-fold lower detection limit compared with the radioactive assay and the possibility to use an internal standard to correct for variation in the extraction...
  10. pmc Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids
    Anke Penno
    Institute for Clinical Chemistry, University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Biol Chem 285:11178-87. 2010
    ..Based on these observations, we conclude that HSAN1 is caused by a gain of function mutation, which results in the formation of two atypical and neurotoxic sphingolipid metabolites...
  11. pmc Novel HSAN1 mutation in serine palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificity
    Daniela Ernst
    Institute for Clinical Chemistry, University Hospital Zurich, CH 8091, Zurich, Switzerland
    Neuromolecular Med 17:47-57. 2015
    ..In summary, our data show that S384F is a novel mutation in HSAN1 and that the substrate specificity of wild-type SPT might by dynamically regulated by a phosphorylation at this position. ..
  12. doi request reprint Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells
    Richard A Zuellig
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland
    Diabetes 63:1326-39. 2014
    ..Thus, targeting deoxysphingolipid synthesis may complement the currently available therapies for diabetes. ..
  13. doi request reprint Plasma C20-Sphingolipids predict cardiovascular events independently from conventional cardiovascular risk factors in patients undergoing coronary angiography
    Alaa Othman
    Institute for Clinical Chemistry, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Lubeck, Germany
    Atherosclerosis 240:216-21. 2015
    ....
  14. doi request reprint Lack of paraoxonase 1 alters phospholipid composition, but not morphology and function of the mouse retina
    Jadwiga Oczos
    Lab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 55:4714-27. 2014
    ..Here, we used Pon1(-/-) mice to study the influence of PON1 on retinal physiology and to reveal the potential impact of PON1 on AMD etiology...
  15. doi request reprint Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats
    Alaa Othman
    Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland Competence Centre for Systems Physiology and Metabolic Diseases, Zurich, Switzerland
    Diabetes 64:1035-45. 2015
    ..In summary, our data support the hypothesis that 1-deoxySLs are involved in the pathology of DN and that an oral L-serine supplementation could be a novel therapeutic option for treating DN. ..
  16. doi request reprint Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking
    Phing How Lou
    From the Department of Anesthesiology and Pain Medicine and Department of Pharmacology, University of Alberta, Edmonton, Canada Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Canada Department of Clinical Chemistry, University Children s Hospital Zurich, Zurich, Switzerland Department of Pharmacology, University of Alberta, Edmonton, Canada and Department of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Anesth Analg 120:329-40. 2015
    ..The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown...
  17. pmc SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter
    Norimasa Tamehiro
    Lipid Metabolism Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Biochemistry 47:6138-47. 2008
    ..In composite, these results indicate that the physical interaction of ABCA1 and SPTLC1 results in reduction of ABCA1 activity and that inhibition of this interaction produces enhanced cholesterol efflux...