Georg A Hollander

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Emerging strategies to boost thymic function
    Georg A Hollander
    Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, The University Children s Hospital UKBB, Mattenstrasse 28, 4058 Basel, Switzerland
    Curr Opin Pharmacol 10:443-53. 2010
  2. ncbi Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function
    Saulius Zuklys
    Department of Clinical Biological Sciences, Laboratory of Pediatric Immunology, University of Basel, and Basel University Children s Hospital, Basel, Switzerland
    J Immunol 182:2997-3007. 2009
  3. doi Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis
    Linda Kenins
    Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Eur J Immunol 40:81-90. 2010
  4. pmc Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells
    Lukas T Jeker
    Department of Biomedicine, Laboratory of Pediatric Immunology, University of Basel and The University Children s Hospital, Basel, Switzerland
    Blood 112:3688-95. 2008
  5. pmc MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection
    Saulius Zuklys
    Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel and Basel University Children s Hospital, Basel 4031, Switzerland
    J Immunol 189:3894-904. 2012
  6. ncbi The role of the thymus in allogeneic hematopoietic stem cell transplantation
    Werner Krenger
    Department of Biomedicine, University of Basel, and Basel University Children s Hospital UKBB, Basel, Switzerland
    Swiss Med Wkly 140:w13051. 2010
  7. pmc TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution
    Mathias M Hauri-Hohl
    Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical Biological Sciences, University of Basel and The University Children s Hospital UKBB, Basel, Switzerland
    Blood 112:626-34. 2008
  8. doi Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD
    Simone Dertschnig
    Department of Biomedicine, University of Basel and Basel University Children s Hospital, Mattenstrasse 28, Basel, Switzerland
    Blood 122:837-41. 2013
  9. pmc Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation
    Mathias M Hauri-Hohl
    Department of Clinical Biological Sciences, Laboratory of Pediatric Immunology, University of Basel Children s Hospital, Mattenstrasse 28, 4058 Basel, Switzerland
    Blood 109:4080-8. 2007
  10. pmc Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells
    Simona W Rossi
    Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical Biological Sciences, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland
    Blood 109:3803-11. 2007

Collaborators

Detail Information

Publications19

  1. pmc Emerging strategies to boost thymic function
    Georg A Hollander
    Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, The University Children s Hospital UKBB, Mattenstrasse 28, 4058 Basel, Switzerland
    Curr Opin Pharmacol 10:443-53. 2010
    ....
  2. ncbi Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function
    Saulius Zuklys
    Department of Clinical Biological Sciences, Laboratory of Pediatric Immunology, University of Basel, and Basel University Children s Hospital, Basel, Switzerland
    J Immunol 182:2997-3007. 2009
    ..These results suggest that a precise regulation of canonical Wnt signaling in thymic epithelia is essential for normal thymus development and function...
  3. doi Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis
    Linda Kenins
    Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Eur J Immunol 40:81-90. 2010
    ..Together, these results show that FL expression by thymic stromal fibroblasts interacting with Flt3+ T-cell progenitors is important for the physiological maintenance of early T-cell development...
  4. pmc Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells
    Lukas T Jeker
    Department of Biomedicine, Laboratory of Pediatric Immunology, University of Basel and The University Children s Hospital, Basel, Switzerland
    Blood 112:3688-95. 2008
    ..Our observations hence place Smad4 within the signaling events in TECs that determine total thymus cellularity by controlling the number of early T-lineage progenitors...
  5. pmc MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection
    Saulius Zuklys
    Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel and Basel University Children s Hospital, Basel 4031, Switzerland
    J Immunol 189:3894-904. 2012
    ....
  6. ncbi The role of the thymus in allogeneic hematopoietic stem cell transplantation
    Werner Krenger
    Department of Biomedicine, University of Basel, and Basel University Children s Hospital UKBB, Basel, Switzerland
    Swiss Med Wkly 140:w13051. 2010
    ....
  7. pmc TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution
    Mathias M Hauri-Hohl
    Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical Biological Sciences, University of Basel and The University Children s Hospital UKBB, Basel, Switzerland
    Blood 112:626-34. 2008
    ..Hence, inhibition of TGF-beta signaling decelerates the process of age-related thymic involution and may hasten the reconstitution of regular thymopoiesis after hematopoietic stem cell transplantation...
  8. doi Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD
    Simone Dertschnig
    Department of Biomedicine, University of Basel and Basel University Children s Hospital, Mattenstrasse 28, Basel, Switzerland
    Blood 122:837-41. 2013
    ..Taken together, our data provide a mechanism for how autoimmunity may develop in the context of antecedent alloimmunity. ..
  9. pmc Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation
    Mathias M Hauri-Hohl
    Department of Clinical Biological Sciences, Laboratory of Pediatric Immunology, University of Basel Children s Hospital, Mattenstrasse 28, 4058 Basel, Switzerland
    Blood 109:4080-8. 2007
    ..Hence, strategies that protect TECs may be necessary to improve immune reconstitution following allogeneic bone marrow transplantation...
  10. pmc Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells
    Simona W Rossi
    Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical Biological Sciences, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland
    Blood 109:3803-11. 2007
    ..Signaling via the canonical BMP pathway is critical for the KGF effects. Taken together, these data provide new insights into the mechanism(s) of action of exogenous KGF on TEC function and thymopoiesis...
  11. ncbi Leydig cell injury as a consequence of an acute graft-versus-host reaction
    Anna Margaretha Wagner
    Department of Research, Center for Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Blood 105:2988-90. 2005
    ..These results demonstrate impairment of testosterone-producing Leydig cells during a local alloresponse, thus representing a mechanism that contributes to gonadal insufficiency following allogeneic HSCT...
  12. pmc Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation
    Linda Kenins
    Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland
    J Exp Med 205:523-31. 2008
    ....
  13. pmc Thymic T-cell development in allogeneic stem cell transplantation
    Werner Krenger
    Department of Biomedicine, University of Basel, and Basel University Children s Hospital, Basel, Switzerland
    Blood 117:6768-76. 2011
    ....
  14. ncbi The thymus in GVHD pathophysiology
    Werner Krenger
    Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland
    Best Pract Res Clin Haematol 21:119-28. 2008
    ..The present review focuses on recent insight into how GVHD affects thymic function and how this knowledge aides the design of new strategies to improve immune reconstitution following allogeneic HSCT...
  15. ncbi The immunopathology of thymic GVHD
    Werner Krenger
    Department of Biomedicine, University of Basel, Basel, 4005, Switzerland
    Semin Immunopathol 30:439-56. 2008
    ..The present review focuses on recent insight into how GVHD affects thymic structure and function and how this knowledge may aid in the design of new strategies to improve T-cell reconstitution following allogeneic HSCT...
  16. ncbi GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis
    Javier Lopez-Rios
    Developmental Genetics, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    Dev Cell 22:837-48. 2012
    ..Thus, Gli3 is a negative regulator of the proliferative expansion of digit progenitors and acts as a gatekeeper for the exit to chondrogenic differentiation...
  17. ncbi On the relevance of TCR rearrangement circles as molecular markers for thymic output during experimental graft-versus-host disease
    Werner Krenger
    Pediatric Immunology, Departments of Research and Clinical Biological Sciences, University of Basel, and University Children s Hospital of Basel, Kantonsspital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    J Immunol 172:7359-67. 2004
    ..From our data, we substantiate that thymic output and peripheral division of newly generated T cells are diminished in the presence of acute GVHD in an experimental radiation/allogeneic HSCT model...
  18. doi Clearing the AIRE: on the pathophysiological basis of the autoimmune polyendocrinopathy syndrome type-1
    Noriko Shikama
    Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel and The University Children s Hospital UKBB, Basel, Switzerland
    Endocrinol Metab Clin North Am 38:273-88, vii. 2009
    ..In this article, we discuss the role of AIRE in autoimmune polyendocrine syndrome type-1 and identify issues that still need to be addressed to fully understand the molecular pathophysiology of this complex syndrome...
  19. ncbi Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice
    Gina Balciunaite
    Pediatric Immunology, Department of Research and Clinical biological Sciences, and The Children s Hospital, University of Basel, Basel, Switzerland
    Nat Immunol 3:1102-8. 2002
    ..Wnt molecules therefore provide regulatory signals critical for thymic function...