Ursula Hofer

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus
    Ursula Hofer
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Virol 82:12145-53. 2008
  2. doi request reprint Disturbance of the gut-associated lymphoid tissue is associated with disease progression in chronic HIV infection
    Ursula Hofer
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Semin Immunopathol 31:257-66. 2009
  3. pmc Inadequate clearance of translocated bacterial products in HIV-infected humanized mice
    Ursula Hofer
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    PLoS Pathog 6:e1000867. 2010
  4. pmc Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1
    Marc Nischang
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    PLoS ONE 7:e38853. 2012
  5. doi request reprint Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology
    Stefan Baenziger
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    Blood 113:377-88. 2009
  6. doi request reprint Evaluation of the immunomodulatory and antiviral effects of the cytokine combination IFN-α and IL-7 in the lymphocytic choriomeningitis virus and Friend retrovirus mouse infection models
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University of Zurich, Zurich, Switzerland
    Viral Immunol 24:375-85. 2011

Collaborators

Detail Information

Publications6

  1. pmc RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus
    Ursula Hofer
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    J Virol 82:12145-53. 2008
    ..The humanized mice showed low levels of human engraftment in the intestinal tract and seem to be resistant to rectal transmission of HIV, and thus they are an unsuitable model for this application...
  2. doi request reprint Disturbance of the gut-associated lymphoid tissue is associated with disease progression in chronic HIV infection
    Ursula Hofer
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Semin Immunopathol 31:257-66. 2009
    ..Maintaining a healthy GALT may be the key to reducing the pathogenic potential of HIV...
  3. pmc Inadequate clearance of translocated bacterial products in HIV-infected humanized mice
    Ursula Hofer
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    PLoS Pathog 6:e1000867. 2010
    ..LPS levels reflect both intestinal barrier and LPS clearance. Macrophages are essential in controlling systemic bacterial translocation, and this function might be hindered in chronic HIV infection...
  4. pmc Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1
    Marc Nischang
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland
    PLoS ONE 7:e38853. 2012
    ..Furthermore, they should disclose whether viral breakthrough and emergence of resistance occurs similar as in HIV-infected patients when ART is insufficient...
  5. doi request reprint Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology
    Stefan Baenziger
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    Blood 113:377-88. 2009
    ..Thus, manipulation of TLR7 signaling may be a potential strategy to reduce chronic hyper-immune activation and, thereby, disease progression in HIV infection...
  6. doi request reprint Evaluation of the immunomodulatory and antiviral effects of the cytokine combination IFN-α and IL-7 in the lymphocytic choriomeningitis virus and Friend retrovirus mouse infection models
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, University of Zurich, Zurich, Switzerland
    Viral Immunol 24:375-85. 2011
    ..e., beyond day 34 pi). Finally, IFN-α/IL-7 may inhibit the replication of other viruses. Thus it might be worth testing these cytokines in other in vivo models of chronic viral infections...