Christoph Hock

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi request reprint Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Neuroreport 16:839-42. 2005
  2. pmc Volumetric associations between uncinate fasciculus, amygdala, and trait anxiety
    Volker Baur
    Division Neuropsychology, Institute of Psychology, University of Zurich, Switzerland
    BMC Neurosci 13:4. 2012
  3. doi request reprint Sexual dimorphism in the parietal substrate associated with visuospatial cognition independent of general intelligence
    Jürgen Hänggi
    Division of Neuropsychology, Institute of Psychology, University of Zurich, Binzmuehlestrasse 14 PO Box 25, 8050 Zurich, Switzerland
    J Cogn Neurosci 22:139-55. 2010
  4. doi request reprint Volumes of lateral temporal and parietal structures distinguish between healthy aging, mild cognitive impairment, and Alzheimer's disease
    Jürgen Hänggi
    Division Neuropsychology, Institute of Psychology, University of Zurich, Zurich, Switzerland
    J Alzheimers Dis 26:719-34. 2011
  5. doi request reprint Structural neuroplasticity in the sensorimotor network of professional female ballet dancers
    Jürgen Hänggi
    Institute of Psychology, University of Zurich, Switzerland
    Hum Brain Mapp 31:1196-206. 2010
  6. doi request reprint A CYP46 T/C SNP modulates parahippocampal and hippocampal morphology in young subjects
    Jürgen Hänggi
    Division of Neuropsychology, Institute of Psychology, University of Zurich, Binzmühlestr 14 25, 8050 Zurich, Switzerland
    Neurobiol Aging 32:1023-32. 2011
  7. doi request reprint The multiple synaesthete E.S.: neuroanatomical basis of interval-taste and tone-colour synaesthesia
    Jürgen Hänggi
    Division of Neuropsychology, Institute of Psychology, University of Zurich, Zurich, Switzerland
    Neuroimage 43:192-203. 2008
  8. doi request reprint Prion protein M129V polymorphism affects retrieval-related brain activity
    Andreas Buchmann
    Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
    Neuropsychologia 46:2389-402. 2008
  9. ncbi request reprint A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 66:940-7. 2005
  10. ncbi request reprint Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:233-41. 2005

Detail Information

Publications42

  1. ncbi request reprint Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Neuroreport 16:839-42. 2005
    ..In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory...
  2. pmc Volumetric associations between uncinate fasciculus, amygdala, and trait anxiety
    Volker Baur
    Division Neuropsychology, Institute of Psychology, University of Zurich, Switzerland
    BMC Neurosci 13:4. 2012
    ..Since UF volumetric measures are newly applied measures, it is necessary to cross-validate them using further neural and behavioral indicators of anxiety...
  3. doi request reprint Sexual dimorphism in the parietal substrate associated with visuospatial cognition independent of general intelligence
    Jürgen Hänggi
    Division of Neuropsychology, Institute of Psychology, University of Zurich, Binzmuehlestrasse 14 PO Box 25, 8050 Zurich, Switzerland
    J Cogn Neurosci 22:139-55. 2010
    ....
  4. doi request reprint Volumes of lateral temporal and parietal structures distinguish between healthy aging, mild cognitive impairment, and Alzheimer's disease
    Jürgen Hänggi
    Division Neuropsychology, Institute of Psychology, University of Zurich, Zurich, Switzerland
    J Alzheimers Dis 26:719-34. 2011
    ..g., language and visuospatial abilities, may be tested more extensively to obtain additional information that might enhance the diagnostic accuracy further...
  5. doi request reprint Structural neuroplasticity in the sensorimotor network of professional female ballet dancers
    Jürgen Hänggi
    Institute of Psychology, University of Zurich, Switzerland
    Hum Brain Mapp 31:1196-206. 2010
    ..Reductions in brain activity are accompanied by local decreases in GM and WM volumes and decreased FA...
  6. doi request reprint A CYP46 T/C SNP modulates parahippocampal and hippocampal morphology in young subjects
    Jürgen Hänggi
    Division of Neuropsychology, Institute of Psychology, University of Zurich, Binzmühlestr 14 25, 8050 Zurich, Switzerland
    Neurobiol Aging 32:1023-32. 2011
    ..The exact cellular mechanisms that translate the CYP46 allelic variation into volumetric brain differences in the parahippocampal gyrus and hippocampus are still unknown and need to be further investigated...
  7. doi request reprint The multiple synaesthete E.S.: neuroanatomical basis of interval-taste and tone-colour synaesthesia
    Jürgen Hänggi
    Division of Neuropsychology, Institute of Psychology, University of Zurich, Zurich, Switzerland
    Neuroimage 43:192-203. 2008
    ..Our findings might have implications for the understanding of multimodal integration and may encourage similar research into dysfunctional perceptual phenomenon such as hallucinations in schizophrenics or in Charles Bonnet syndrome...
  8. doi request reprint Prion protein M129V polymorphism affects retrieval-related brain activity
    Andreas Buchmann
    Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
    Neuropsychologia 46:2389-402. 2008
    ..Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours...
  9. ncbi request reprint A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 66:940-7. 2005
    ..Polygenic diseases are related to the complex interplay of genetic variations. We evaluated whether clusters of cholesterol- and lipid-related genetic variations are associated with Alzheimer's disease...
  10. ncbi request reprint Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:233-41. 2005
    ....
  11. ncbi request reprint Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006
    ..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease...
  12. ncbi request reprint Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers
    Valerie Treyer
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 35:766-70. 2008
    ..In this study, we assessed the whole-body biodistribution and radiation dosimetry of the new glutamatergic ligand (11)C-ABP688. This ligand binds specifically to the metabotropic glutamatergic receptor of subtype 5 (mGluR5)...
  13. ncbi request reprint Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers
    Christian R A Mondadori
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Cereb Cortex 17:1934-47. 2007
    ..We suggest that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans...
  14. ncbi request reprint Effects of memory consolidation on human hippocampal activity during retrieval
    Simone Bosshardt
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Cortex 41:486-98. 2005
    ..These fMRI results in the human hippocampal formation may correspond to the neurobiological results in the animal hippocampal formation of a strengthening and growth of synaptic connections within 24 h...
  15. ncbi request reprint No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lengstrasse 31, 8029 Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 132:21-3. 2005
    ..Although PLAU may be pathophysiologially related to AD, the contribution of common genetic variants of this gene to the risk for developing AD is likely to be low...
  16. ncbi request reprint Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Neuron 38:547-54. 2003
    ..Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease...
  17. ncbi request reprint Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42
    Alessia Maddalena
    Division of Psychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:1202-6. 2003
    ....
  18. ncbi request reprint One month of human memory consolidation enhances retrieval-related hippocampal activity
    Simone Bosshardt
    Division of Psychiatry Research, University of Zurich, Switzerland
    Hippocampus 15:1026-40. 2005
    ....
  19. ncbi request reprint A functional genetic variation of the 5-HT2a receptor affects human memory
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Nat Neurosci 6:1141-2. 2003
    ..Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant...
  20. ncbi request reprint Glucocorticoid-related genetic susceptibility for Alzheimer's disease
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 13:47-52. 2004
    ..Our results indicate that a functional variation in the glucocorticoid system increases the risk for AD, which may have important implications for the diagnosis and treatment of this disease...
  21. ncbi request reprint Implicit associative learning engages the hippocampus and interacts with explicit associative learning
    Nadia Degonda
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neuron 46:505-20. 2005
    ..These findings suggest that implicit semantic associative learning engages the hippocampus and influences explicit memory...
  22. ncbi request reprint Genetic association study on colony-stimulating factor 1 in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 3:334-7. 2006
    ..The human CSF1 gene maps to chromosome 1p21-p13, a region previously linked to Alzheimer's disease (AD). Thus, CSF1 is a functional and positional candidate gene for AD...
  23. ncbi request reprint ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008, Zurich, Switzerland
    Neurobiol Aging 24:421-6. 2003
    ..We conclude that genetic variability of ABCA1 influences the development of AD, possibly by interfering with CNS cholesterol homeostasis...
  24. ncbi request reprint Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology
    Alessia S Maddalena
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:231-5. 2004
    ..Quantitation revealed that CSF levels of Abeta1-38 were significantly decreased in AD as compared to CTR subjects. The CSF profile of Abeta peptides may be used for diagnostic and therapeutic purposes in clinical studies...
  25. ncbi request reprint The prion gene is associated with human long-term memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Hum Mol Genet 14:2241-6. 2005
    ..These results suggest a role for the prion protein in the formation of long-term memory in humans...
  26. ncbi request reprint Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Eur J Neurosci 17:1296-302. 2003
    ....
  27. ncbi request reprint Low-dose cortisol for symptoms of posttraumatic stress disorder
    Amanda Aerni
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Am J Psychiatry 161:1488-90. 2004
    ....
  28. ncbi request reprint Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomy
    Katharina Henke
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neuroreport 14:1197-202. 2003
    ..There was no significant postoperative reallocation of ipsilateral memory functions to the contralateral MTL...
  29. ncbi request reprint Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...
  30. ncbi request reprint Association study of cholesterol-related genes in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurogenetics 8:179-88. 2007
    ..004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples...
  31. ncbi request reprint Clinical observations with AN-1792 using TAPIR analyses
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:273-6. 2005
    ..We briefly summarize here how the proof of concept was established and why it provides the basis for a potential cure for Alzheimer's disease...
  32. ncbi request reprint Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe
    Katharina Henke
    Division of Psychiatry Research, Psychiatric University Hospital, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
    Neuropsychologia 41:863-76. 2003
    ....
  33. doi request reprint Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice
    Barbara Biscaro
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Neurosci 29:14108-19. 2009
    ....
  34. ncbi request reprint Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
    Amyloid 10:1-6. 2003
    ..967 ng/ml, respectively; p < 0.05). These data show that treatment with the m1 agonist talsaclidine reduced A beta peptides, and particularly A beta 42, in AD patients, suggesting it as a potential amyloid lowering therapy of AD...
  35. doi request reprint Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy
    Roger M Nitsch
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurotherapeutics 5:415-20. 2008
    ....
  36. doi request reprint Transforming growth factor-beta inhibits the expression of clock genes
    Heidemarie Gast
    Department of Neurology, Inselspital, University Hospital Berne, University of Berne, Berne, Switzerland
    Ann N Y Acad Sci 1261:79-87. 2012
    ..TGF-β2-induced dysregulation of clock genes may alter neuronal pathways, which may be causally related to abnormal sleep-wake rhythms in AD patients...
  37. ncbi request reprint Evaluation of the metabotropic glutamate receptor subtype 5 using PET and 11C-ABP688: assessment of methods
    Valerie Treyer
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    J Nucl Med 48:1207-15. 2007
    ..The purpose of this study was to evaluate different methods for the analysis of human (11)C-ABP688 data acquired from 6 healthy, young volunteers...
  38. pmc Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation
    Florian Riese
    Division of Psychiatry Research and Psychogeriatric Medicine, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e76094. 2013
    ..Together with the adaptor protein Fe65 and the histone acetyltransferase Tip60, AICD forms nuclear multiprotein complexes (AFT complexes) that function in transcriptional regulation...
  39. ncbi request reprint Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Psychiatr Genet 12:155-60. 2002
    ..In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD...
  40. ncbi request reprint Evidence of a genetic basis of Morgagni-Stewart-Morel syndrome. A case report of identical twins
    Michael F Koller
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:56-60. 2005
    ..The symptoms common to both twins appear to correspond to the Morgagni-Stewart-Morel syndrome and indicate a genetic basis of this disorder as these features occur in genetically identical patients...
  41. doi request reprint Deletion of the ageing gene p66(Shc) reduces early stroke size following ischaemia/reperfusion brain injury
    Remo D Spescha
    Cardiovascular Research, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur Heart J 34:96-103. 2013
    ..Hence, we hypothesized that p66(Shc) may be involved in ischaemia/reperfusion brain damage. To this end, we investigated whether genetic deletion of p66(Shc) protects from ischaemia/reperfusion brain injury...
  42. ncbi request reprint Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Med 8:1270-5. 2002
    ..Whether vaccination to produce antibodies against beta-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time...