Research Topics
Genomes and Genes
| Christoph HockSummaryAffiliation: University of Zurich Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memoryAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Neuroreport 16:839-42. 2005..In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory...
Volumetric associations between uncinate fasciculus, amygdala, and trait anxietyVolker Baur
Division Neuropsychology, Institute of Psychology, University of Zurich, Switzerland
BMC Neurosci 13:4. 2012..Since UF volumetric measures are newly applied measures, it is necessary to cross-validate them using further neural and behavioral indicators of anxiety...
A CYP46 T/C SNP modulates parahippocampal and hippocampal morphology in young subjectsJürgen Hänggi
Division of Neuropsychology, Institute of Psychology, University of Zurich, Binzmühlestr 14 25, 8050 Zurich, Switzerland
Neurobiol Aging 32:1023-32. 2011..The exact cellular mechanisms that translate the CYP46 allelic variation into volumetric brain differences in the parahippocampal gyrus and hippocampus are still unknown and need to be further investigated...- Sexual dimorphism in the parietal substrate associated with visuospatial cognition independent of general intelligenceJürgen Hänggi
Division of Neuropsychology, Institute of Psychology, University of Zurich, Binzmuehlestrasse 14 PO Box 25, 8050 Zurich, Switzerland
J Cogn Neurosci 22:139-55. 2010.... - The multiple synaesthete E.S.: neuroanatomical basis of interval-taste and tone-colour synaesthesiaJürgen Hänggi
Division of Neuropsychology, Institute of Psychology, University of Zurich, Zurich, Switzerland
Neuroimage 43:192-203. 2008..Our findings might have implications for the understanding of multimodal integration and may encourage similar research into dysfunctional perceptual phenomenon such as hallucinations in schizophrenics or in Charles Bonnet syndrome... - Structural neuroplasticity in the sensorimotor network of professional female ballet dancersJürgen Hänggi
Institute of Psychology, University of Zurich, Switzerland
Hum Brain Mapp 31:1196-206. 2010..Reductions in brain activity are accompanied by local decreases in GM and WM volumes and decreased FA... - Volumes of lateral temporal and parietal structures distinguish between healthy aging, mild cognitive impairment, and Alzheimer's diseaseJürgen Hänggi
Division Neuropsychology, Institute of Psychology, University of Zurich, Zurich, Switzerland
J Alzheimers Dis 26:719-34. 2011..g., language and visuospatial abilities, may be tested more extensively to obtain additional information that might enhance the diagnostic accuracy further... - Prion protein M129V polymorphism affects retrieval-related brain activityAndreas Buchmann
Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
Neuropsychologia 46:2389-402. 2008..Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours... - A cluster of cholesterol-related genes confers susceptibility for Alzheimer's diseaseAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
J Clin Psychiatry 66:940-7. 2005..Polygenic diseases are related to the complex interplay of genetic variations. We evaluated whether clusters of cholesterol- and lipid-related genetic variations are associated with Alzheimer's disease... - Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteersValerie Treyer
PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
Eur J Nucl Med Mol Imaging 35:766-70. 2008..In this study, we assessed the whole-body biodistribution and radiation dosimetry of the new glutamatergic ligand (11)C-ABP688. This ligand binds specifically to the metabotropic glutamatergic receptor of subtype 5 (mGluR5)... - Better memory and neural efficiency in young apolipoprotein E epsilon4 carriersChristian R A Mondadori
Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
Cereb Cortex 17:1934-47. 2007..We suggest that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans... - Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, Switzerland
Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease... - Effects of memory consolidation on human hippocampal activity during retrievalSimone Bosshardt
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Cortex 41:486-98. 2005..These fMRI results in the human hippocampal formation may correspond to the neurobiological results in the animal hippocampal formation of a strengthening and growth of synaptic connections within 24 h... - Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's diseaseAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 2:233-41. 2005.... - A functional genetic variation of the 5-HT2a receptor affects human memoryDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Nat Neurosci 6:1141-2. 2003..Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant... - Antibodies against beta-amyloid slow cognitive decline in Alzheimer's diseaseChristoph Hock
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
Neuron 38:547-54. 2003..Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease... - One month of human memory consolidation enhances retrieval-related hippocampal activitySimone Bosshardt
Division of Psychiatry Research, University of Zurich, Switzerland
Hippocampus 15:1026-40. 2005.... - Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42Alessia Maddalena
Division of Psychiatry Research, University of Zurich, Switzerland
Arch Neurol 60:1202-6. 2003..CONCLUSION: The diagnostic usefulness of the CSF ratio of phospho-tau to Abeta42 is superior to either measure alone and can be recommended as an aid to evaluating individuals suspected of having dementia... - No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traitsAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Lengstrasse 31, 8029 Zurich, Switzerland
Am J Med Genet B Neuropsychiatr Genet 132:21-3. 2005..Although PLAU may be pathophysiologially related to AD, the contribution of common genetic variants of this gene to the risk for developing AD is likely to be low... - Glucocorticoid-related genetic susceptibility for Alzheimer's diseaseDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Hum Mol Genet 13:47-52. 2004..Our results indicate that a functional variation in the glucocorticoid system increases the risk for AD, which may have important implications for the diagnosis and treatment of this disease... - ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008, Zurich, Switzerland
Neurobiol Aging 24:421-6. 2003..We conclude that genetic variability of ABCA1 influences the development of AD, possibly by interfering with CNS cholesterol homeostasis... - Genetic association study on colony-stimulating factor 1 in Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 3:334-7. 2006..The human CSF1 gene maps to chromosome 1p21-p13, a region previously linked to Alzheimer's disease (AD). Thus, CSF1 is a functional and positional candidate gene for AD... - Implicit associative learning engages the hippocampus and interacts with explicit associative learningNadia Degonda
Division of Psychiatry Research, University of Zurich, Switzerland
Neuron 46:505-20. 2005..These findings suggest that implicit semantic associative learning engages the hippocampus and influences explicit memory... - The prion gene is associated with human long-term memoryAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
Hum Mol Genet 14:2241-6. 2005..These results suggest a role for the prion protein in the formation of long-term memory in humans... - Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomyKatharina Henke
Division of Psychiatry Research, University of Zurich, Switzerland
Neuroreport 14:1197-202. 2003..There was no significant postoperative reallocation of ipsilateral memory functions to the contralateral MTL... - Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphismAndreas Papassotiropoulos
Division of Pychiatry Research, University of Zurich, Switzerland
Arch Neurol 60:29-35. 2003..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain... - Low-dose cortisol for symptoms of posttraumatic stress disorderAmanda Aerni
Division of Psychiatry Research, University of Zurich, Lenggstr. 31, 8029 Zurich, Switzerland
Am J Psychiatry 161:1488-90. 2004..CONCLUSIONS: The results of this pilot study indicate that low-dose cortisol treatment reduces the cardinal symptoms of PTSD... - Association study of cholesterol-related genes in Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
Neurogenetics 8:179-88. 2007..004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples... - Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobeDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Eur J Neurosci 17:1296-302. 2003.... - Clinical observations with AN-1792 using TAPIR analysesChristoph Hock
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 2:273-6. 2005..We briefly summarize here how the proof of concept was established and why it provides the basis for a potential cure for Alzheimer's disease... - Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobeKatharina Henke
Division of Psychiatry Research, Psychiatric University Hospital, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
Neuropsychologia 41:863-76. 2003.... - Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 miceBarbara Biscaro
Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
J Neurosci 29:14108-19. 2009.... - Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapyRoger M Nitsch
Division of Psychiatry Research, University of Zurich, Switzerland
Neurotherapeutics 5:415-20. 2008.... - Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's diseaseChristoph Hock
Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
Amyloid 10:1-6. 2003..967 ng/ml, respectively; p < 0.05). These data show that treatment with the m1 agonist talsaclidine reduced A beta peptides, and particularly A beta 42, in AD patients, suggesting it as a potential amyloid lowering therapy of AD... - Transforming growth factor-beta inhibits the expression of clock genesHeidemarie Gast
Department of Neurology, Inselspital, University Hospital Berne, University of Berne, Berne, Switzerland
Ann N Y Acad Sci 1261:79-87. 2012..TGF-β2-induced dysregulation of clock genes may alter neuronal pathways, which may be causally related to abnormal sleep-wake rhythms in AD patients... - Evaluation of the metabotropic glutamate receptor subtype 5 using PET and 11C-ABP688: assessment of methodsValerie Treyer
PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
J Nucl Med 48:1207-15. 2007..The purpose of this study was to evaluate different methods for the analysis of human (11)C-ABP688 data acquired from 6 healthy, young volunteers... - Evidence of a genetic basis of Morgagni-Stewart-Morel syndrome. A case report of identical twinsMichael F Koller
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 2:56-60. 2005..The symptoms common to both twins appear to correspond to the Morgagni-Stewart-Morel syndrome and indicate a genetic basis of this disorder as these features occur in genetically identical patients... - Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, Switzerland
Psychiatr Genet 12:155-60. 2002..In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD... - Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer diseaseChristoph Hock
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Nat Med 8:1270-5. 2002..Whether vaccination to produce antibodies against beta-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time...