C Hock

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease
    C Hock
    Department of Psychiatry PUK, University of Basel, Switzerland
    Neurosci Lett 241:151-4. 1998
  2. ncbi Histological markers in nasal mucosa of patients with Alzheimer's disease
    C Hock
    Department of Psychiatry, University of Basel, Switzerland
    Eur Neurol 40:31-6. 1998
  3. ncbi Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease
    E Savaskan
    Department of Psychiatry, University of Basel, Switzerland
    Eur Neurol 44:172-80. 2000
  4. ncbi Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia
    E Savaskan
    Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4054, Basel, Switzerland
    Neurobiol Aging 22:541-6. 2001
  5. ncbi Alzheimer's disease, depression and normal ageing: merit of simple psychomotor and visuospatial tasks
    M Hofman
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Int J Geriatr Psychiatry 15:31-9. 2000
  6. ncbi Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity
    C Hock
    Department of Psychiatry, University of Basel, Switzerland
    Eur Neurol 39:111-8. 1998
  7. ncbi Dependence of cerebrospinal fluid Tau protein levels on apolipoprotein E4 allele frequency in patients with Alzheimer's disease
    S Golombowski
    Department of Psychiatry PUK, University of Basel, Switzerland
    Neurosci Lett 225:213-5. 1997
  8. ncbi Rapid cortical hemoglobin deoxygenation after heroin and methadone injection in humans: a preliminary report
    R Stohler
    Department of Psychiatry, University of Zurich, Switzerland
    Drug Alcohol Depend 57:23-8. 1999
  9. ncbi Cytokines and neurotrophins interact in normal and diseased states
    U Otten
    Department of Physiology, University of Basel, Vesalgasse 1, CH 4051 Basel, Switzerland
    Ann N Y Acad Sci 917:322-30. 2000
  10. ncbi Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
    M A Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 8:635-8. 2003

Collaborators

Detail Information

Publications22

  1. ncbi Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease
    C Hock
    Department of Psychiatry PUK, University of Basel, Switzerland
    Neurosci Lett 241:151-4. 1998
    ..These results reveal a central specific role of the high affinity NGF receptor during neurodegeneration in AD...
  2. ncbi Histological markers in nasal mucosa of patients with Alzheimer's disease
    C Hock
    Department of Psychiatry, University of Basel, Switzerland
    Eur Neurol 40:31-6. 1998
    ..These results are consistent with other reports showing that cytoskeletal changes and tau pathology in the olfactory epithelium are not primary (or specific) features of AD and may occur predominantly in late stages of the disease...
  3. ncbi Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease
    E Savaskan
    Department of Psychiatry, University of Basel, Switzerland
    Eur Neurol 44:172-80. 2000
    ..In addition, cerebellar Purkinje cells revealed a distinct immunoreactivity for trk C both in control and AD cases, suggesting trk C may be important in the maintenance of these cells in the aged brain...
  4. ncbi Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia
    E Savaskan
    Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4054, Basel, Switzerland
    Neurobiol Aging 22:541-6. 2001
    ..In addition, a prominent perivascular ACE and angiotensin II immunoreactivity surrounding some cortical vessels in aged controls and AD patients points to an underlying microvascular pathology in the process of neurodegeneration...
  5. ncbi Alzheimer's disease, depression and normal ageing: merit of simple psychomotor and visuospatial tasks
    M Hofman
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Int J Geriatr Psychiatry 15:31-9. 2000
    ..The purpose was to investigate the discriminative value of simple psychomotor and visuospatial tasks that were implemented in a computer-assisted test battery...
  6. ncbi Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity
    C Hock
    Department of Psychiatry, University of Basel, Switzerland
    Eur Neurol 39:111-8. 1998
    ..Thus, CSF levels of Abeta are not useful for the differentiation of AD from major depression. However, CSF levels of Abeta reflect the severity of dementia and may be useful as biological markers of the stage of the disease...
  7. ncbi Dependence of cerebrospinal fluid Tau protein levels on apolipoprotein E4 allele frequency in patients with Alzheimer's disease
    S Golombowski
    Department of Psychiatry PUK, University of Basel, Switzerland
    Neurosci Lett 225:213-5. 1997
    ..71, P = 0.007). This finding may be in agreement with reports of a lesser binding of apoE4 to Tau, compared to apoE2 and apoE3, resulting in higher levels of unbound Tau in CSF...
  8. ncbi Rapid cortical hemoglobin deoxygenation after heroin and methadone injection in humans: a preliminary report
    R Stohler
    Department of Psychiatry, University of Zurich, Switzerland
    Drug Alcohol Depend 57:23-8. 1999
    ..Saline had no effects. Opioid-induced acute deoxygenation of cortical hemoglobin is most likely associated with respiratory depression. Thorough medical monitoring is strongly recommended in intravenous opioid maintenance treatments...
  9. ncbi Cytokines and neurotrophins interact in normal and diseased states
    U Otten
    Department of Physiology, University of Basel, Vesalgasse 1, CH 4051 Basel, Switzerland
    Ann N Y Acad Sci 917:322-30. 2000
    ..This indicates that the IL-6 system mediates a local supply of NTs that participate in diverse CNS functions, such as protection of neurons from insults, neuronal survival, and neuroimmune responses...
  10. ncbi Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
    M A Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 8:635-8. 2003
    ..005). This polymorphism of SOAT1 is also associated with reduced risk for Alzheimer's disease in ethnically distinct populations (P=0.0001, odds ratio: 0.6, 95% confidence interval 0.4-0.8)...
  11. ncbi Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2
    U Finckh
    Institut fur Humangenetik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Neurogenetics 4:213-7. 2003
    ..Odds ratio for LOAD due to homozygosity C/C was 1.89 (95% confidence interval 1.37-2.61). PLAU is a promising new candidate gene for LOAD, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection...
  12. pmc Saitohin gene is not associated with Alzheimer's disease
    J R Streffer
    Division of Psychiatry Research, University of Zurich, Switzerland
    J Neurol Neurosurg Psychiatry 74:362-3. 2003
    ....
  13. ncbi Galantamine provides broad benefits in patients with 'advanced moderate' Alzheimer's disease (MMSE < or = 12) for up to six months
    D G Wilkinson
    Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
    Int J Clin Pract 56:509-14. 2002
    ..5 ADAS-cog points. Cognitive and functional abilities were maintained around baseline; behavioural symptoms were delayed. Over 6 months, galantamine provided a broad spectrum of benefits to patients with 'advanced moderate' AD...
  14. ncbi A multinational, randomised, 12-week, comparative study of donepezil and rivastigmine in patients with mild to moderate Alzheimer's disease
    D G Wilkinson
    Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, UK
    Int J Clin Pract 56:441-6. 2002
    ..Thus, using the recommended dosing schedules, donepezil was better tolerated with fewer discontinuations due to AEs, and both agents improved cognition to a similar extent...
  15. ncbi Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
    J M Orgogozo
    Federation of Neurology, CHU Pellegrin, Bordeaux, France
    Neurology 61:46-54. 2003
    ..A Phase I study in AD patients demonstrated good safety and tolerability of multiple injections of aggregated Abeta42 (AN1792) with QS-21 as adjuvant...
  16. ncbi [Rational therapy of Alzheimer dementia based on current clinical studies]
    B Zoller
    Abteilung für Psychiatrische Forschung, Psychiatrische Universitatsklinik, Zurich
    Praxis (Bern 1994) 90:827-34. 2001
    ..Based on the documentation presented here, only the approved acetylcholinesterase inhibitors are currently to be recommended under strict scientific criteria for use in the treatment of Alzheimer's dementia...
  17. ncbi Non-replication of association between cathepsin D genotype and late onset Alzheimer disease
    G Menzer
    Department of Human Genetics, University Hospital Hamburg Eppendorf, Germany
    Am J Med Genet 105:179-82. 2001
    ..Post hoc data analyses suggested that there might be a stronger effect of CTSD genotype on AD risk in males, and an interaction between CTSD and APOE genotypes in males but not females...
  18. ncbi Cytosolic free [Ca2+] in mononuclear blood cells from demented patients and healthy controls
    B Bondy
    Department of Neurochemistry, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 243:224-8. 1994
    ..However, there might be some difference in [Ca2+]i values between early- and late-onset AD, which could have pathophysiological importance...
  19. ncbi Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease
    U Finckh
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Arch Neurol 57:1579-83. 2000
    ..To determine whether the cystatin C gene (CST3) is genetically associated with late-onset Alzheimer disease (AD)...
  20. ncbi Risk factors and differential diagnosis of Alzheimer's disease
    F Muller-Spahn
    Psychiatrische Universitatsklinik, Basel, Switzerland
    Eur Arch Psychiatry Clin Neurosci 249:37-42. 1999
    ..Various genetic and non-genetic risk factors play a role in influencing age of onset and disease progression...
  21. pmc High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes
    U Finckh
    Department of Human Genetics, University Hospital Eppendorf, University of Hamburg, Germany
    Am J Hum Genet 66:110-7. 2000
    ..We conclude that because of the lack of specific antemortem diagnostic markers for FAD and hereditary prion disease, all four genes should be included in a molecular diagnostic program in patients with EOD who had PFH...
  22. ncbi Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia
    J Wiltfang
    Molecular Neurobiology Lab, Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    World J Biol Psychiatry 6:69-84. 2005
    ..Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed...