C Hock

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi request reprint Treatment with the selective muscarinic agonist talsaclidine decreases cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease
    C Hock
    Department of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zürich 8, Switzerland
    Ann N Y Acad Sci 920:285-91. 2000
  2. ncbi request reprint Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas
    C Hock
    Department of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zürich 8, Switzerland
    Arch Neurol 57:846-51. 2000
  3. ncbi request reprint [Diagnosis and therapy of behavior disorders in dementia]
    C Hock
    Abteilung für Psychiatrische Forschung, Universitat Zurich
    Praxis (Bern 1994) 89:1907-13. 2000
  4. ncbi request reprint Clinical observations with AN-1792 using TAPIR analyses
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:273-6. 2005
  5. ncbi request reprint Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Neuron 38:547-54. 2003
  6. ncbi request reprint Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
    Amyloid 10:1-6. 2003
  7. ncbi request reprint Increased cerebrospinal fluid levels of neurotrophin 3 (NT-3) in elderly patients with major depression
    C Hock
    Department of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 5:510-3. 2000
  8. ncbi request reprint Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
    M A Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 8:635-8. 2003
  9. pmc Saitohin gene is not associated with Alzheimer's disease
    J R Streffer
    Division of Psychiatry Research, University of Zurich, Switzerland
    J Neurol Neurosurg Psychiatry 74:362-3. 2003
  10. ncbi request reprint [Rational therapy of Alzheimer dementia based on current clinical studies]
    B Zoller
    Abteilung für Psychiatrische Forschung, Psychiatrische Universitatsklinik, Zurich
    Praxis (Bern 1994) 90:827-34. 2001

Detail Information

Publications49

  1. ncbi request reprint Treatment with the selective muscarinic agonist talsaclidine decreases cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease
    C Hock
    Department of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zürich 8, Switzerland
    Ann N Y Acad Sci 920:285-91. 2000
    ..We conclude that treatment with selective M1 agonists may reduce A beta production and may thus be further evaluated as a potential amyloid-lowering therapy of AD...
  2. ncbi request reprint Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas
    C Hock
    Department of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zürich 8, Switzerland
    Arch Neurol 57:846-51. 2000
    ....
  3. ncbi request reprint [Diagnosis and therapy of behavior disorders in dementia]
    C Hock
    Abteilung für Psychiatrische Forschung, Universitat Zurich
    Praxis (Bern 1994) 89:1907-13. 2000
    ..g. haloperidol) or the tricyclic antidepressants. For that reason, these newer products should usually be preferred over the conventional agents...
  4. ncbi request reprint Clinical observations with AN-1792 using TAPIR analyses
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:273-6. 2005
    ..We briefly summarize here how the proof of concept was established and why it provides the basis for a potential cure for Alzheimer's disease...
  5. ncbi request reprint Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Neuron 38:547-54. 2003
    ..Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease...
  6. ncbi request reprint Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
    Amyloid 10:1-6. 2003
    ..967 ng/ml, respectively; p < 0.05). These data show that treatment with the m1 agonist talsaclidine reduced A beta peptides, and particularly A beta 42, in AD patients, suggesting it as a potential amyloid lowering therapy of AD...
  7. ncbi request reprint Increased cerebrospinal fluid levels of neurotrophin 3 (NT-3) in elderly patients with major depression
    C Hock
    Department of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 5:510-3. 2000
    ..NT-3 may constitute a biochemical candidate marker for clinical diagnosis and for the evaluation of therapeutic strategies in DE...
  8. ncbi request reprint Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
    M A Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 8:635-8. 2003
    ..005). This polymorphism of SOAT1 is also associated with reduced risk for Alzheimer's disease in ethnically distinct populations (P=0.0001, odds ratio: 0.6, 95% confidence interval 0.4-0.8)...
  9. pmc Saitohin gene is not associated with Alzheimer's disease
    J R Streffer
    Division of Psychiatry Research, University of Zurich, Switzerland
    J Neurol Neurosurg Psychiatry 74:362-3. 2003
    ....
  10. ncbi request reprint [Rational therapy of Alzheimer dementia based on current clinical studies]
    B Zoller
    Abteilung für Psychiatrische Forschung, Psychiatrische Universitatsklinik, Zurich
    Praxis (Bern 1994) 90:827-34. 2001
    ..Based on the documentation presented here, only the approved acetylcholinesterase inhibitors are currently to be recommended under strict scientific criteria for use in the treatment of Alzheimer's dementia...
  11. doi request reprint Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice
    A C Santuccione
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Mol Psychiatry 18:358-68. 2013
    ..Together, these data established a role for ankG in the human adaptive immune response against resident brain proteins, and they show that ankG immunization reduces brain β-amyloid and its related neuropathology...
  12. ncbi request reprint Genetics of interleukin 6: implications for Alzheimer's disease
    A Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurobiol Aging 22:863-71. 2001
    ....
  13. ncbi request reprint Rapid cortical hemoglobin deoxygenation after heroin and methadone injection in humans: a preliminary report
    R Stohler
    Department of Psychiatry, University of Zurich, Switzerland
    Drug Alcohol Depend 57:23-8. 1999
    ..Saline had no effects. Opioid-induced acute deoxygenation of cortical hemoglobin is most likely associated with respiratory depression. Thorough medical monitoring is strongly recommended in intravenous opioid maintenance treatments...
  14. ncbi request reprint Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease
    U Finckh
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Arch Neurol 57:1579-83. 2000
    ..To determine whether the cystatin C gene (CST3) is genetically associated with late-onset Alzheimer disease (AD)...
  15. ncbi request reprint The prion gene is associated with human long-term memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Hum Mol Genet 14:2241-6. 2005
    ..These results suggest a role for the prion protein in the formation of long-term memory in humans...
  16. ncbi request reprint A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 66:940-7. 2005
    ..Polygenic diseases are related to the complex interplay of genetic variations. We evaluated whether clusters of cholesterol- and lipid-related genetic variations are associated with Alzheimer's disease...
  17. ncbi request reprint One month of human memory consolidation enhances retrieval-related hippocampal activity
    Simone Bosshardt
    Division of Psychiatry Research, University of Zurich, Switzerland
    Hippocampus 15:1026-40. 2005
    ....
  18. ncbi request reprint Effects of memory consolidation on human hippocampal activity during retrieval
    Simone Bosshardt
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Cortex 41:486-98. 2005
    ..These fMRI results in the human hippocampal formation may correspond to the neurobiological results in the animal hippocampal formation of a strengthening and growth of synaptic connections within 24 h...
  19. ncbi request reprint Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006
    ..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease...
  20. pmc Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease
    Giancarlo V De Ferrari
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 104:9434-9. 2007
    ..Our study unveils a genetic relationship between LRP6 and APOE and supports the hypothesis that altered Wnt/beta-catenin signaling may be involved in this neurodegenerative disease...
  21. ncbi request reprint Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:233-41. 2005
    ....
  22. doi request reprint Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy
    Roger M Nitsch
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurotherapeutics 5:415-20. 2008
    ....
  23. ncbi request reprint Enhanced brain activity may precede the diagnosis of Alzheimer's disease by 30 years
    Christian R A Mondadori
    Division of Psychiatry Research University of Zurich, Switzerland
    Brain 129:2908-22. 2006
    ....
  24. ncbi request reprint Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers
    Christian R A Mondadori
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Cereb Cortex 17:1934-47. 2007
    ..We suggest that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans...
  25. doi request reprint Prion protein M129V polymorphism affects retrieval-related brain activity
    Andreas Buchmann
    Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
    Neuropsychologia 46:2389-402. 2008
    ..Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours...
  26. ncbi request reprint Genetic association study on colony-stimulating factor 1 in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 3:334-7. 2006
    ..The human CSF1 gene maps to chromosome 1p21-p13, a region previously linked to Alzheimer's disease (AD). Thus, CSF1 is a functional and positional candidate gene for AD...
  27. ncbi request reprint Association study of cholesterol-related genes in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurogenetics 8:179-88. 2007
    ..004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples...
  28. ncbi request reprint Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Neuroreport 16:839-42. 2005
    ..In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory...
  29. ncbi request reprint Implicit associative learning engages the hippocampus and interacts with explicit associative learning
    Nadia Degonda
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neuron 46:505-20. 2005
    ..These findings suggest that implicit semantic associative learning engages the hippocampus and influences explicit memory...
  30. ncbi request reprint No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lengstrasse 31, 8029 Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 132:21-3. 2005
    ..Although PLAU may be pathophysiologially related to AD, the contribution of common genetic variants of this gene to the risk for developing AD is likely to be low...
  31. ncbi request reprint Biochemical markers of Alzheimer's disease: wish and reality
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurobiol Aging 23:513-4. 2002
  32. ncbi request reprint Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Biol Chem 277:33012-7. 2002
    ....
  33. ncbi request reprint Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Psychiatr Genet 12:155-60. 2002
    ..In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD...
  34. ncbi request reprint Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Med 8:1270-5. 2002
    ..Whether vaccination to produce antibodies against beta-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time...
  35. ncbi request reprint Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...
  36. ncbi request reprint ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008, Zurich, Switzerland
    Neurobiol Aging 24:421-6. 2003
    ..We conclude that genetic variability of ABCA1 influences the development of AD, possibly by interfering with CNS cholesterol homeostasis...
  37. ncbi request reprint Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe
    Katharina Henke
    Division of Psychiatry Research, Psychiatric University Hospital, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
    Neuropsychologia 41:863-76. 2003
    ....
  38. ncbi request reprint Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Eur J Neurosci 17:1296-302. 2003
    ....
  39. ncbi request reprint Interactive computer-training as a therapeutic tool in Alzheimer's disease
    Marc Hofmann
    Department of Psychiatry, University Basle, Basle, Switzerland
    Compr Psychiatry 44:213-9. 2003
    ..New interactive media, therefore, may yield interesting opportunities for rehabilitation and (psycho)therapeutic interventions...
  40. ncbi request reprint Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomy
    Katharina Henke
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neuroreport 14:1197-202. 2003
    ..There was no significant postoperative reallocation of ipsilateral memory functions to the contralateral MTL...
  41. ncbi request reprint Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42
    Alessia Maddalena
    Division of Psychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:1202-6. 2003
    ....
  42. ncbi request reprint A functional genetic variation of the 5-HT2a receptor affects human memory
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Nat Neurosci 6:1141-2. 2003
    ..Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant...
  43. ncbi request reprint Glucocorticoid-related genetic susceptibility for Alzheimer's disease
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 13:47-52. 2004
    ..Our results indicate that a functional variation in the glucocorticoid system increases the risk for AD, which may have important implications for the diagnosis and treatment of this disease...
  44. ncbi request reprint Low-dose cortisol for symptoms of posttraumatic stress disorder
    Amanda Aerni
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Am J Psychiatry 161:1488-90. 2004
    ....
  45. ncbi request reprint Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease
    Claudia Günther
    Department of Human Genetics, University Hospital Hamburg Eppendorf, Butenfeld 42, 22529 Hamburg, Germany
    Neurosci Lett 369:219-23. 2004
    ..The findings suggest that a TFAM haplotype containing rs1937 G (for S12) may be a moderate risk factor for AD...
  46. ncbi request reprint Decline in long-term circadian rest-activity cycle organization in a patient with dementia
    Esther Werth
    Centre for Chronobiology and Alzheimer s Research Group, Psychiatric University Clinic Basel, Switzerland
    J Geriatr Psychiatry Neurol 15:55-9. 2002
    ..Pacing, a nonphotic zeitgeber strengthening, led to improved synchronization of the rest-activity cycle...
  47. ncbi request reprint Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers
    Valerie Treyer
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 35:766-70. 2008
    ..In this study, we assessed the whole-body biodistribution and radiation dosimetry of the new glutamatergic ligand (11)C-ABP688. This ligand binds specifically to the metabotropic glutamatergic receptor of subtype 5 (mGluR5)...
  48. ncbi request reprint Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology
    Alessia S Maddalena
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:231-5. 2004
    ..Quantitation revealed that CSF levels of Abeta1-38 were significantly decreased in AD as compared to CTR subjects. The CSF profile of Abeta peptides may be used for diagnostic and therapeutic purposes in clinical studies...