F Hirth

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging
    R Leemans
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Genome Biol 2:RESEARCH0015. 2001
  2. ncbi request reprint An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila
    Frank Hirth
    Institute of Zoology, Biozentrum Pharmazentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 130:2365-73. 2003
  3. pmc Transcriptional signature of an adult brain tumor in Drosophila
    Thomas Loop
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstr, 50, CH 4056 Basel, Switzerland
    BMC Genomics 5:24. 2004
  4. ncbi request reprint Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 128:4781-8. 2001
  5. ncbi request reprint Homeotic gene action in embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, University of Basel, Basel, Switzerland
    Development 125:1579-89. 1998
  6. ncbi request reprint Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development
    L Kammermeier
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Mech Dev 103:71-8. 2001
  7. ncbi request reprint Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila
    S Leuzinger
    Zoological Institute, University of Basel, Basel, Switzerland
    Development 125:1703-10. 1998
  8. ncbi request reprint Expression, regulation and function of the homeobox gene empty spiracles in brain and ventral nerve cord development of Drosophila
    B Hartmann
    Institute of Zoology, University of Basel, Rheinsprung 9, 4051, Basel, Switzerland
    Mech Dev 90:143-53. 2000
  9. pmc Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays
    R Leemans
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 97:12138-43. 2000
  10. ncbi request reprint Expression and function of the LIM homeodomain protein Apterous during embryonic brain development of Drosophila
    M C Herzig
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Dev Genes Evol 211:545-54. 2001

Collaborators

Detail Information

Publications21

  1. pmc Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging
    R Leemans
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Genome Biol 2:RESEARCH0015. 2001
    ..Here we use a functional genomic approach to identify candidate target genes of the Drosophila homeodomain transcription factor Labial...
  2. ncbi request reprint An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila
    Frank Hirth
    Institute of Zoology, Biozentrum Pharmazentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 130:2365-73. 2003
    ..This suggests that a tripartite organization of the embryonic brain was already established in the last common urbilaterian ancestor of protostomes and deuterostomes...
  3. pmc Transcriptional signature of an adult brain tumor in Drosophila
    Thomas Loop
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstr, 50, CH 4056 Basel, Switzerland
    BMC Genomics 5:24. 2004
    ....
  4. ncbi request reprint Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 128:4781-8. 2001
    ..This suggests that in embryonic brain development, differences in Hox gene action rely mainly on cis-acting regulatory elements and not on Hox protein specificity...
  5. ncbi request reprint Homeotic gene action in embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, University of Basel, Basel, Switzerland
    Development 125:1579-89. 1998
    ..Our findings demonstrate that the action of the homeotic genes labial and Deformed are required for neuronal differentiation in the developing brain of Drosophila...
  6. ncbi request reprint Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development
    L Kammermeier
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Mech Dev 103:71-8. 2001
    ..In contrast, targeted misexpression of ey, but not of toy, resulted in profound axonal abnormalities in the embryonic ventral nerve cord and brain...
  7. ncbi request reprint Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila
    S Leuzinger
    Zoological Institute, University of Basel, Basel, Switzerland
    Development 125:1703-10. 1998
    ....
  8. ncbi request reprint Expression, regulation and function of the homeobox gene empty spiracles in brain and ventral nerve cord development of Drosophila
    B Hartmann
    Institute of Zoology, University of Basel, Rheinsprung 9, 4051, Basel, Switzerland
    Mech Dev 90:143-53. 2000
    ..In the posterior brain and VNC ems is necessary for correct axonal pathfinding of specific interneurons. Rescue experiments indicate that the murine Emx2 gene can partially replace the fly ems gene in CNS development...
  9. pmc Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays
    R Leemans
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 97:12138-43. 2000
    ..These results demonstrate that high-density oligonucleotide arrays are sensitive, efficient, and quantitative instruments for the analysis of large scale gene expression in Drosophila embryos...
  10. ncbi request reprint Expression and function of the LIM homeodomain protein Apterous during embryonic brain development of Drosophila
    M C Herzig
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Dev Genes Evol 211:545-54. 2001
    ..Thus, in brain development, Ap is required for correct axon guidance and fasciculation of interneurons, and Ap-expressing cells may also be involved in the brain neuroendocrine system...
  11. ncbi request reprint Hox gene cross-regulatory interactions in the embryonic brain of Drosophila
    Simon G Sprecher
    Institute of Zoology, Biocenter Pharmacenter University of Basel, Klingelbergstr 50, CH 4056 Basel, Switzerland
    Mech Dev 121:527-36. 2004
    ....
  12. ncbi request reprint The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila
    Bruno Bello
    Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 133:2639-48. 2006
    ....
  13. ncbi request reprint Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila
    F Hirth
    Laboratory of Neurobiology, University of Basel, Switzerland
    Neuron 15:769-78. 1995
    ....
  14. ncbi request reprint Conserved genetic programs in insect and mammalian brain development
    F Hirth
    Institute of Zoology, University of Basel, Rheinsprung 9, CH 4051 Basel, Switzerland
    Bioessays 21:677-84. 1999
    ....
  15. ncbi request reprint The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila
    Simon G Sprecher
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Development 133:4331-9. 2006
    ..Taken together, our results indicate that vnd is required for the genesis and proper identity specification of tritocerebral neural lineages during embryonic brain development of Drosophila...
  16. ncbi request reprint ventral veins lacking is required for specification of the tritocerebrum in embryonic brain development of Drosophila
    Stefan Meier
    Biozentrum Pharmazentrum, University of Basel, CH 4056 Basel, Switzerland
    Mech Dev 123:76-83. 2006
    ..Our results indicate that vvl acts downstream of the Hox gene lab and regulates specific aspects of neuronal differentiation within the tritocerebral neuromere during embryonic brain development of Drosophila...
  17. ncbi request reprint Embryonic development of the Drosophila brain: formation of commissural and descending pathways
    S Therianos
    Laboratory of Neurobiology, Institute of Zoology, University of Basel, Switzerland
    Development 121:3849-60. 1995
    ....
  18. ncbi request reprint Asymmetric stem cell division in development and cancer
    Emmanuel Caussinus
    Division of Cell Biology, Biozemtrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Prog Mol Subcell Biol 45:205-25. 2007
    ..Taken together, these data indicate that evolutionary conserved mechanisms regulate stem and progenitor cell self-renewal and tumor suppression via asymmetric cell division control...
  19. pmc Loss of heterozygosity of TRIM3 in malignant gliomas
    Jean Louis Boulay
    Department of Biomedicine, University Hospital, Basel, Switzerland
    BMC Cancer 9:71. 2009
    ..TRIM3 is located within the loss of allelic heterozygosity (LOH) hotspot of chromosome segment 11p15.5, indicating a potential role in tumor suppression...
  20. ncbi request reprint Expression and function of the columnar patterning gene msh in late embryonic brain development of Drosophila
    Simon G Sprecher
    Biozentrum, University of Basel, Basel, Switzerland
    Dev Dyn 235:2920-9. 2006
    ....
  21. ncbi request reprint A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis
    Bruno C Bello
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Neuron 37:209-19. 2003
    ..These studies identify a mechanism linking the Hox axial patterning system to neural proliferation, and this involves temporal regulation of precursor cell death rather than the cell cycle...