Hans H Hirsch

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations
    Hans H Hirsch
    Transplantation Virology, Institute for Medical Microbiology and Div Infectious Diseases, Universitatsspital Basel, Switzerland
    Transplantation 79:1277-86. 2005
  2. pmc Comparing effects of BK virus agnoprotein and herpes simplex-1 ICP47 on MHC-I and MHC-II expression
    Michela Cioni
    Transplantation and Clinical Virology, Department Biomedicine Haus Petersplatz, University of Basel, Petersplatz 10, CH 4003 Basel, Switzerland
    Clin Dev Immunol 2013:626823. 2013
  3. pmc Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology
    Rainer Gosert
    Transplantation Virology and Molecular Diagnostic Laboratory, Institute for Medical Microbiology, Department of Biomedicine, University of Basel, CH 4003 Basel, Switzerland
    J Exp Med 205:841-52. 2008
  4. doi request reprint The human JC polyomavirus (JCPyV): virological background and clinical implications
    Hans H Hirsch
    Transplantation and Clinical Virology, Department Biomedicine Haus Petersplatz, University of Basel, Basel, Switzerland
    APMIS 121:685-727. 2013
  5. doi request reprint BK polyomavirus in solid organ transplantation
    H H Hirsch
    Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    Am J Transplant 13:179-88. 2013
  6. pmc Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study
    H H Hirsch
    Transplantation and Clinical Virology, Department Biomedicine Building Petersplatz, University of Basel, Switzerland
    Am J Transplant 13:136-45. 2013
  7. pmc Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus
    Hans H Hirsch
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland
    Clin Infect Dis 56:258-66. 2013
  8. pmc An international multicenter performance analysis of cytomegalovirus load tests
    Hans H Hirsch
    Transplantation and Clinical Virology, Department Biomedicine Haus Petersplatz, University of Basel, Switzerland
    Clin Infect Dis 56:367-73. 2013
  9. pmc Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report
    Halvor Naess
    Department of Neurology, Haukeland University Hospital, N 5021 Bergen, Norway
    BMC Neurol 10:32. 2010
  10. ncbi request reprint BK virus: opportunity makes a pathogen
    Hans H Hirsch
    Department of Clinical Biological Sciences, University of Basel, University Hospital Basel, Basel, Switzerland
    Clin Infect Dis 41:354-60. 2005

Detail Information

Publications73

  1. ncbi request reprint Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations
    Hans H Hirsch
    Transplantation Virology, Institute for Medical Microbiology and Div Infectious Diseases, Universitatsspital Basel, Switzerland
    Transplantation 79:1277-86. 2005
    ..25-0.33 mg/kg intravenously biweekly) without probenicid should be considered for refractory cases. Retransplantation after renal allograft loss to PVAN remains a treatment option for patients clearing polyomavirus replication...
  2. pmc Comparing effects of BK virus agnoprotein and herpes simplex-1 ICP47 on MHC-I and MHC-II expression
    Michela Cioni
    Transplantation and Clinical Virology, Department Biomedicine Haus Petersplatz, University of Basel, Petersplatz 10, CH 4003 Basel, Switzerland
    Clin Dev Immunol 2013:626823. 2013
    ..We hypothesized that agnoprotein might contribute to BKV immune evasion by downregulating HLA expression, similar to Herpes simplex virus-1 ICP47...
  3. pmc Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology
    Rainer Gosert
    Transplantation Virology and Molecular Diagnostic Laboratory, Institute for Medical Microbiology, Department of Biomedicine, University of Basel, CH 4003 Basel, Switzerland
    J Exp Med 205:841-52. 2008
    ..Thus, rr-NCCR BKV emergence in plasma is linked to increased replication capacity and disease in KTs...
  4. doi request reprint The human JC polyomavirus (JCPyV): virological background and clinical implications
    Hans H Hirsch
    Transplantation and Clinical Virology, Department Biomedicine Haus Petersplatz, University of Basel, Basel, Switzerland
    APMIS 121:685-727. 2013
    ..Given the increasing number of immunologically vulnerable patients, a critical reappraisal of JCPyV infection, replication and disease seems warranted...
  5. doi request reprint BK polyomavirus in solid organ transplantation
    H H Hirsch
    Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    Am J Transplant 13:179-88. 2013
    ..Retransplantation after PyVAN is largely successful, but requires close monitoring for recurrent BKV viremia...
  6. pmc Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study
    H H Hirsch
    Transplantation and Clinical Virology, Department Biomedicine Building Petersplatz, University of Basel, Switzerland
    Am J Transplant 13:136-45. 2013
    ..The data suggest a dynamic risk factor evolution of BKV viremia consisting of higher corticosteroids until month 3, Tac-MPA compared to CsA-MPA at month 6 and Tac-MPA, older age, male gender at month 12 posttransplant...
  7. pmc Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus
    Hans H Hirsch
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Switzerland
    Clin Infect Dis 56:258-66. 2013
    ..Owing to differences in screening, clinical presentation, and therapy for influenza and adenovirus, ECIL-4 recommendations are summarized for CARVs other than influenza and adenovirus...
  8. pmc An international multicenter performance analysis of cytomegalovirus load tests
    Hans H Hirsch
    Transplantation and Clinical Virology, Department Biomedicine Haus Petersplatz, University of Basel, Switzerland
    Clin Infect Dis 56:367-73. 2013
    ..Quantification of cytomegalovirus (CMV) load is central to the management of CMV infections in immunocompromised patients, but quantitative results currently differ significantly across methods and laboratories...
  9. pmc Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report
    Halvor Naess
    Department of Neurology, Haukeland University Hospital, N 5021 Bergen, Norway
    BMC Neurol 10:32. 2010
    ..To report the clinical course of PML in an apparently immunocompetent patient treated with cidofovir...
  10. ncbi request reprint BK virus: opportunity makes a pathogen
    Hans H Hirsch
    Department of Clinical Biological Sciences, University of Basel, University Hospital Basel, Basel, Switzerland
    Clin Infect Dis 41:354-60. 2005
    ..This article discusses current views of pathogenesis, diagnosis, and treatment...
  11. ncbi request reprint Polyomavirus BK
    Hans H Hirsch
    Division of Infectious Diseases, Department of Internal Medicine, University Hospitals Basel, and Transplantation Virology Laboratory, Institute of Medical Microbiology, University of Basel, Switzerland
    Lancet Infect Dis 3:611-23. 2003
    ..Case series suggest that cidofovir might be effective, especially when combined with reduced immunosuppression...
  12. ncbi request reprint Polyomavirus BK nephropathy: a (re-)emerging complication in renal transplantation
    Hans H Hirsch
    Department of Internal Medicine, University of Basel, Switzerland
    Am J Transplant 2:25-30. 2002
    ..Current management aims at the judicious modification and/or reduction of immunosuppression which, in view of preceding or concurrent rejection, is not without risk...
  13. ncbi request reprint Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients
    Hans H Hirsch
    Division of Infectious Diseases, University of Basel, Basel, Switzerland
    N Engl J Med 347:488-96. 2002
    ....
  14. ncbi request reprint [Viral infections after transplantation]
    H H Hirsch
    Abteilung für Infektiologie am Kantonsspital Basel und Transplantations Virologie am Institut für Medizinische Mikrobiologie, Universitat Basel
    Ther Umsch 60:641-9. 2003
    ....
  15. pmc JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    J Virol 83:4404-11. 2009
    ..JCV-specific T-cell and IgG responses may serve as prognostic markers for patients at risk...
  16. ncbi request reprint Cytomegalovirus and polyomavirus BK posttransplant
    Adrian Egli
    Transplantation Virology, Institute for Medical Microbiology, Department of Clinical and Biological Sciences, Petersplatz 10, CH 4003 Basel, Switzerland
    Nephrol Dial Transplant 22:viii72-viii82. 2007
    ..In this review, we discuss diagnostic and therapeutic aspects of CMV and BKV replication and disease posttransplantation...
  17. pmc Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients
    Adrian Egli
    Transplantation Virology, Institute for Medical Microbiology, University of Basel, Petersplatz 10, 4003 Basel, Switzerland
    J Transl Med 6:29. 2008
    ..We hypothesized that low CMV-specific T-cell responses are associated with increased risk of CMV replication in R(+)-patients with D(+) or D(-) donors...
  18. pmc CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes
    Rainer Gosert
    Transplantation Virology, Institute for Medical Microbiology, Department of Biomedicine, University of Basel, and Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersplatz 10, CH 4003 Basel, Switzerland
    Antimicrob Agents Chemother 55:2129-36. 2011
    ..67 μM; SI50, 6.7; CC90, 12.2 μM; SI90, 16.5) at 5 dpi. We conclude that CMX001 inhibits JCV replication at concentrations in vitro that can be attained by oral administration without significant side effects in clinical studies...
  19. ncbi request reprint Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors
    Adrian Egli
    Transplantation Virology, Institute for Medical Microbiology, Department of Biomedicine, University of Basel, Switzerland
    J Infect Dis 199:837-46. 2009
    ....
  20. ncbi request reprint Transient allograft dysfunction from immune reconstitution in a patient with polyoma BK-virus-associated nephropathy
    Stefan Schaub
    Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Switzerland
    Nephrol Dial Transplant 22:2386-90. 2007
  21. doi request reprint Evidence for a bidirectional relationship between cytomegalovirus replication and acute graft-versus-host disease
    Nathan Cantoni
    Division of Hematology, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    Biol Blood Marrow Transplant 16:1309-14. 2010
    ..65, P < .01). These data confirm that GVHD and its therapy can induce CMV replication. They further demonstrate the reciprocal novel finding that patients are at significantly increased risk of developing aGVHD during CMV replication...
  22. doi request reprint Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008
    Luigia Elzi
    University Hospital Basel, Switzerland
    Arch Intern Med 170:57-65. 2010
    ..Adverse effects of combination antiretroviral therapy (CART) commonly result in treatment modification and poor adherence...
  23. pmc Human polyomavirus type 1 (BK virus) agnoprotein is abundantly expressed but immunologically ignored
    David Leuenberger
    Transplantation Virology, Institute for Medical Microbiology, Department of Clinical and Biological Sciences, University of Basel, Petersplatz 10, CH 4003 Basel, Switzerland
    Clin Vaccine Immunol 14:959-68. 2007
    ..We conclude that BKV agnoprotein, though abundantly expressed in vivo, is poorly recognized immunologically...
  24. doi request reprint Inhibition of polyomavirus BK-specific T-Cell responses by immunosuppressive drugs
    Adrian Egli
    ransplantation and Clinical Virology, Institute for Medical Microbiology, Department of Biomedicine, University of Basel, Basel, Switzerland
    Transplantation 88:1161-8. 2009
    ..Reducing immunosuppression is the treatment of choice for polyomavirus-associated nephropathy in kidney transplant (KT) patients, but strategies and targets are uncertain...
  25. pmc Antibody responses to recombinant polyomavirus BK large T and VP1 proteins in young kidney transplant patients
    Sohrab Bodaghi
    Institute for Medical Microbiology, Department of Biomedicine, University of Basel, Switzerland
    J Clin Microbiol 47:2577-85. 2009
    ..In KTP, anti-BKVLP responds to recent BKV viruria and viremia, whereas anti-BKLTD1 may indicate emerging BKV-specific immune control...
  26. pmc 1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells
    Christine Hanssen Rinaldo
    Transplantation Virology, Institute for Medical Microbiology, Department of Biomedicine, University of Basel, Petersplatz 10, Basel, Switzerland
    Antimicrob Agents Chemother 54:4714-22. 2010
    ..We conclude that CMX001 inhibits BKV replication with a longer-lasting effect than cidofovir at 400× lower levels, with fewer side effects on relevant host cells in vitro...
  27. pmc A HCMV pp65 polypeptide promotes the expansion of CD4+ and CD8+ T cells across a wide range of HLA specificities
    Maurizio Provenzano
    Institute of Surgical Research and Hospital Management, and Department of Biomedicine, University Hospital Basel, Switzerland
    J Cell Mol Med 13:2131-47. 2009
    ..These data suggest that a single reagent might qualify as synthetic immunogen for potentially large populations exposed to HCMV infection or reactivation...
  28. doi request reprint Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study
    Nina Khanna
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Basel, Basel, Switzerland
    Clin Infect Dis 48:1459-66. 2009
    ..We investigated the incidence and outcome of progressive multifocal leukoencephalopathy (PML) in human immunodeficiency virus (HIV)-infected individuals before and after the introduction of combination antiretroviral therapy (cART) in 1996...
  29. doi request reprint Comparison of a UL111a real-time PCR and pp65 antigenemia for the detection of cytomegalovirus
    Christiane Beckmann
    Department of Biomedicine, University of Basel, Switzerland
    J Med Virol 83:2143-50. 2011
    ..Thus, CMV UL111aPCR provides more sensitive quantitation of CMV replication than pp65Ag, however, discordant results can occur at very low viral loads...
  30. pmc HIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts
    Olivier Gasser
    Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland
    PLoS Med 4:e96. 2007
    ....
  31. pmc Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients
    Adrian Egli
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland
    PLoS ONE 8:e51983. 2013
    ..A protective role of mannan-binding lectin (MBL) and ficolins against CMV disease has been reported after transplantation, but the impact in HIV-infected patients is unclear...
  32. pmc Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals--the Swiss HIV Cohort Study
    Jan Fehr
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    J Transl Med 9:14. 2011
    ..The aim was to investigate whether the addition of rPRT to genotypic resistance testing (GRT) compared to GRT alone is beneficial for obtaining a virological response in heavily pre-treated HIV-infected patients...
  33. pmc Rearranged JC virus noncoding control regions found in progressive multifocal leukoencephalopathy patient samples increase virus early gene expression and replication rate
    Rainer Gosert
    Transplantation Virology, Institute for Medical Microbiology, Department of Biomedicine, University of Basel, CH 4003 Basel, Switzerland
    J Virol 84:10448-56. 2010
    ..We conclude that naturally occurring JCV rr-NCCR variants from PML patients confer increased early gene expression and higher replication rates compared to those of at-NCCR JCV and thereby increase cytopathology...
  34. doi request reprint Respiratory syncytial virus infection in patients with hematological diseases: single-center study and review of the literature
    Nina Khanna
    Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland
    Clin Infect Dis 46:402-12. 2008
    ..Respiratory syncytial virus (RSV) causes significant mortality in patients with hematological diseases, but diagnosis and treatment are uncertain...
  35. ncbi request reprint The natural history, risk factors and outcomes of polyomavirus BK-associated nephropathy after renal transplantation
    Hans H Hirsch
    University of Basel, Switzerland
    Nat Clin Pract Nephrol 2:240-1. 2006
  36. doi request reprint A retrospective analysis of nosocomial viral gastrointestinal and respiratory tract infections
    Jan A Sidler
    Division of Pediatric Infectious Diseases, University Children s Hospital, Basel, Switzerland
    Pediatr Infect Dis J 31:1233-8. 2012
    ..Few studies are dedicated to this topic. We aimed to determine incidence and characteristics of these specific viral NIs at our hospital...
  37. ncbi request reprint Polyomavirus-associated nephropathy in renal transplantation: critical issues of screening and management
    Hans H Hirsch
    University of Basel, Switzerland
    Adv Exp Med Biol 577:160-73. 2006
    ..The response to intervention should be monitored using plasma DNA or urine mRNA load...
  38. doi request reprint The polyomavirus BK agnoprotein co-localizes with lipid droplets
    Gunhild Unterstab
    Transplantation Virology, Institute for Medical Microbiology, Department of Biomedicine, University of Basel, CH 4003 Basel, Switzerland
    Virology 399:322-31. 2010
    ..However, changing the phosphorylation site serine-11 to alanine or aspartic acid did not alter LD co-localization. Our findings provide new clues to unravel agnoprotein function...
  39. ncbi request reprint Viral dynamics in transplant patients: implications for disease
    Georg A Funk
    Transplantation Virology, Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    Lancet Infect Dis 7:460-72. 2007
    ..We discuss the implications of viral kinetics for organ pathology as well as for the evaluation of antiviral interventions in transplant patients...
  40. pmc Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy
    Bojana Durovic
    Immunobiology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    J Virol 87:6526-9. 2013
    ..In addition, EBV-negative donors presented with a history of tonsillectomy more often than EBV-positive donors...
  41. doi request reprint Antiretroviral therapy during pregnancy and premature birth: analysis of Swiss data
    C Rudin
    Division of Infectious Diseases, University Children s Hospital, Basel, Switzerland
    HIV Med 12:228-35. 2011
    ..There is an ongoing debate as to whether combined antiretroviral treatment (cART) during pregnancy is an independent risk factor for prematurity in HIV-1-infected women...
  42. doi request reprint Hemolytic uremic syndrome in a 65-Year-old male linked to a very unusual type of stx2e- and eae-harboring O51:H49 shiga toxin-producing Escherichia coli
    Dominique Fasel
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    J Clin Microbiol 52:1301-3. 2014
    ..The strains isolated harbored stx2e and eae, a very unusual and new virulence profile for an HUS-associated enterohemorrhagic E. coli. ..
  43. ncbi request reprint Epstein-Barr virus load correlating with clinical manifestation and treatment response in a patient with angioimmunoblastic T-cell lymphoma
    Manuel Battegay
    Division of Infectious Diseases, Department of Internal Medicine and Research, University Hospital of Basel, Basel, Switzerland
    Antivir Ther 9:453-9. 2004
    ..This case report demonstrates the close association of EBVL and AITL and a beneficial effect of antiviral therapy at an initial stage of disease manifestation...
  44. ncbi request reprint Immune reconstitution in HIV-infected patients
    Hans H Hirsch
    Division of Infectious Diseases, University Hospital Basel, Switzerland
    Clin Infect Dis 38:1159-66. 2004
    ..Specific antimicrobial therapy, nonsteroidal anti-inflammatory drugs, and/or steroids for managing immune reconstitution syndrome should be considered...
  45. ncbi request reprint Relapsing severe anaemia due to primary parvovirus B19 infection after renal transplantation: a case report and review of the literature
    Angelika Beckhoff
    Clinic for Transplantation Immunology and Nephrology, Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    Nephrol Dial Transplant 22:3660-3. 2007
  46. pmc Pan-dengue virus detection by PCR for travelers returning from the tropics
    Alexis Dumoulin
    Department of Biomedicine, Division of Diagnostics, Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    J Clin Microbiol 46:3104-6. 2008
    ..DENV loads significantly decreased with increasing times of disease and were higher in immunoglobulin M-negative samples. In the first week of disease, pan-DENV RT-PCR is the test of choice...
  47. ncbi request reprint Once-daily directly observed therapy lopinavir/ritonavir plus indinavir as a protease inhibitor-only salvage therapy in heavily pretreated HIV-1-infected patients: a pilot study
    Luigia Elzi
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    AIDS 20:129-31. 2006
    ..Pharmacokinetic data indicated therapeutic concentrations for both protease inhibitors in most patients...
  48. ncbi request reprint Acute renal failure on immune reconstitution in an HIV-positive patient with miliary tuberculosis
    Andreas W Jehle
    Division of Transplantation Immunology and Nephrology, University Hospitals Basel, Basel, Switzerland
    Clin Infect Dis 38:e32-5. 2004
    ..The diagnostic workup and further course of disease implicated immune reconstitution syndrome as the cause of acute renal failure...
  49. pmc Reactivation of hepatitis B virus with mutated hepatitis B surface antigen in a liver transplant recipient receiving a graft from an antibody to hepatitis B surface antigen- and antibody to hepatitis B core antigen-positive donor
    Annette Blaich
    Division of Clinical Microbiology, University Hospital Basel, Basel, Switzerland
    Transfusion 52:1999-2006. 2012
    ..These anti-HBs may lead to a misinterpretation of the actual hepatitis B immune status. Furthermore, they may not only confer protection against hepatitis B virus (HBV), but may also favor the selection of HBsAg mutants...
  50. pmc Co-infection of Influenza B and Streptococci causing severe pneumonia and septic shock in healthy women
    Timothy Aebi
    Medical Intensive Care Unit, University Hospital Basel, Basel, Switzerland
    BMC Infect Dis 10:308. 2010
    ....
  51. doi request reprint Outcome of influenza infections in outpatients after allogeneic hematopoietic stem cell transplantation
    N Khanna
    Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    Transpl Infect Dis 11:100-5. 2009
    ..Influenza can cause significant morbidity and mortality in patients after hematopoietic stem cell transplantation (HSCT). The diagnostic methods and antiviral treatment have scarcely been investigated...
  52. ncbi request reprint Late Aspergillus fumigatus endomyocarditis with brain abscess as a lethal complication after heart transplantation
    Florian Rueter
    University Clinic for Cardiothoracic Surgery, Department of Surgery, University Clinics Basel, Basel, Switzerland
    J Heart Lung Transplant 21:1242-5. 2002
    ..Primary cytomegalovirus infection (donor+/recipient-) and toxoplasmosis reactivation (donor+/recipient+) occurring at 1 and 2 months post-transplantation were successfully treated...
  53. pmc Reevaluating and optimizing polyomavirus BK and JC real-time PCR assays to detect rare sequence polymorphisms
    A Dumoulin
    Transplantation Virology and Division of Diagnostics, Institute for Medical Microbiology, Department of Biomedicine, University of Basel, Basel, Switzerland
    J Clin Microbiol 49:1382-8. 2011
    ..We conclude that our JCV and updated BKV real-time PCR assays are robust and detect rare variants possibly encountered in the clinical routine...
  54. ncbi request reprint Drug hypersensitivity syndrome to carbamazepine and human herpes virus 6 infection: case report and literature review
    A Zeller
    Outpatient Dept of Internal Medicine, University Hospital Basel, Switzerland
    Infection 31:254-6. 2003
    ..The potential role of HHV-6 regarding the drug-induced hypersensitivity syndrome is discussed and the main clinical features of this potentially fatal adverse drug reaction are highlighted...
  55. doi request reprint First wave of the influenza A/H1N1v pandemic in Switzerland
    C H Nickel
    Emergency Department, University Hospital, Basel, Switzerland
    Swiss Med Wkly 139:731-7. 2009
    ..To describe the disease burden, clinical pattern and outcome of influenza-related cases presenting to a Swiss Emergency Department (ED), during the first wave of the 2009 pandemic...
  56. ncbi request reprint Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6
    M Buess
    Institute for Medical Microbiology, University of Basel, Switzerland
    Oncogene 18:1487-94. 1999
    ..One transcript, expressed in the precursor but downregulated in the tumor cells, was cloned and identified as the murine calcium channel mtrp6...
  57. ncbi request reprint Cytomegalovirus-associated chorioretinitis after liver transplantation: case report and review of the literature
    A Egli
    Transplantation Virology, Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    Transpl Infect Dis 10:27-43. 2008
    ..7 weeks post transplant. CMV-associated opthalmologic complications late post transplantation may possibly involve 2 different entities of cytopathic retinitis and IRS-like chorioretinitis-vitritis...
  58. ncbi request reprint VP1 messenger RNA levels in urine for diagnosing BK virus nephropathy?
    Hans H Hirsch
    Transplantation 75:2160. 2003
  59. doi request reprint Kidney retransplantation following graft loss to polyoma virus-associated nephropathy: an effective treatment option in simultaneous pancreas and kidney transplant recipients
    Martina Mindlova
    Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Transpl Int 21:353-6. 2008
    ..Use of interventions designed to reduce active viral replication, including pre-emptive nephrectomy of the failed graft, should be considered before reKT...
  60. ncbi request reprint Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation
    Cinthia B Drachenberg
    Department of Pathology, Medicine and Pediatrics, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Transplantation 84:323-30. 2007
    ..Few cases of PVAN have been attributed to JCV. Systematic studies on JCV replication in KT are lacking...
  61. ncbi request reprint BK virus-associated nephropathy in renal allograft recipients: rescue therapy by sirolimus-based immunosuppression
    Ravinder K Wali
    Division of Nephrology, Department of Internal Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Transplantation 78:1069-73. 2004
    ..BK virus nephritis (BKN) in recipients of renal allografts has reemerged during the past 5 years. Despite increased incidence, therapeutic options remain limited and progression of the disease often leads to allograft failure...
  62. ncbi request reprint Polyomavirus disease in renal transplantation: review of pathological findings and diagnostic methods
    Cinthia B Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Hum Pathol 36:1245-55. 2005
    ..Also discussed in the context of their clinical significance are the main virological and epidemiological aspects of the BK, JC, and SV40 polyomavirus infections...
  63. ncbi request reprint Antivirals for the treatment of polyomavirus BK replication
    Christine Hanssen Rinaldo
    University Hospital of North Norway, Department of Microbiology and Infection Control, PO Box 56, N 9038 Tromsø, Norway
    Expert Rev Anti Infect Ther 5:105-15. 2007
    ....
  64. ncbi request reprint Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load
    Cinthia B Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Transplant 4:2082-92. 2004
    ..0002, 0.0001 and 0.0006). Due to the focal nature of PVAN, correlation of biopsy results with viruria and viremia are required for diagnosis...
  65. ncbi request reprint Leflunomide treatment for polyomavirus BK-associated nephropathy after kidney transplantation
    Stanislas Faguer
    Nephrology, Dialysis, and Multiorgan Transplant Unit, University Hospital, CHU Rangueil, Toulouse, France
    Transpl Int 20:962-9. 2007
    ..This limited efficacy contrasts with other reports and falls short of expectation. We conclude that active screening, earlier diagnosis and intervention remain the cornerstones of treatment...
  66. ncbi request reprint Successful outcome of progressive multifocal leukoencephalopathy in a renal transplant patient
    Clinton D Crowder
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Transplant 5:1151-8. 2005
    ..The patient returned to hemodialysis 3 months after immunosuppression was discontinued. We also present a review of the literature on PML in renal transplant recipients...
  67. ncbi request reprint BK virus infection, replication, and diseases in pediatric kidney transplantation
    Philip D Acott
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Pediatr Nephrol 22:1243-50. 2007
    ....
  68. ncbi request reprint Comparison of two dosages of thymoglobulin used as a short-course for induction in kidney transplantation
    Waichi Wong
    Renal and Transplantation Units, Massachusetts General Hospital and Harvard Medical School Boston, Boston, MA 02114, USA
    Transpl Int 19:629-35. 2006
    ..5 mg/kg/day regimen. A more profound T-cell clearance within the first 6 months postinduction therapy may translate into a decreased risk of immunological injury and improved long-term outcome after kidney transplantation...
  69. ncbi request reprint Rapid dynamics of polyomavirus type BK in renal transplant recipients
    Georg A Funk
    School of Biological Sciences, Royal Holloway University of London, Egham, UK
    J Infect Dis 193:80-7. 2006
    ..In patients with PVAN, a high BK virus (BKV) load is detectable in plasma. However, the relationship between BKV replication and disease is not well understood...
  70. ncbi request reprint A controlled trial of granulocyte macrophage-colony stimulating factor during interruption of HAART
    Catherine Fagard
    Divisions of Infectious Diseases, University Hospital, Geneva, Geneva, Switzerland
    AIDS 17:1487-92. 2003
    ..To explore the effect of granulocyte macrophage colony stimulating factor (GM-CSF) on viral load and CD4 cell count during interruption of highly active antiretroviral therapy (HAART)...
  71. doi request reprint Predicting the evolution of Kaposi sarcoma, in the highly active antiretroviral therapy era
    Emmanuelle Boffi El Amari
    Geneva University Hospital, Geneva, Switzerland
    AIDS 22:1019-28. 2008
    ..While many patients do well on highly active antiretroviral therapy, others have progressive disease and need chemotherapy. In order to predict which patients are at risk of unfavorable evolution, we established a prognostic score...
  72. ncbi request reprint Negative impact of human leukocyte antigen matching in the outcome of polyomavirus nephropathy
    Cinthia B Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Transplantation 80:276-8. 2005
    ..An adequately developed antiviral cellular immunity may lead to significant tissue damage and graft loss even if the viral infection is eventually controlled...
  73. doi request reprint Multifocal thrombophlebitis and deep vein thrombosis in primary cytomegalovirus infection--a histopathological analysis
    Christina Jeanneret
    Kantonsspital, Batteriestrasse 1, Bruderholz, Switzerland
    Thromb Haemost 99:445-7. 2008