Martin Hersberger

Summary

Affiliation: University Children's Hospital
Country: Switzerland

Publications

  1. pmc Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages
    Claudio Gemperle
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich, Zurich, Switzerland
    PLoS ONE 7:e50195. 2012
  2. ncbi request reprint Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins
    Martin Hersberger
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Clin Chem Lab Med 48:1063-73. 2010
  3. doi request reprint Association of STR polymorphisms in CMA1 and IL-4 with asthma and atopy: the SAPALDIA cohort
    Martin Hersberger
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Hum Immunol 71:1154-60. 2010
  4. doi request reprint No association of two functional polymorphisms in human ALOX15 with myocardial infarction
    Martin Hersberger
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Atherosclerosis 205:192-6. 2009
  5. doi request reprint Characterization of the promoter and the transcriptional regulation of the lipoxin A4 receptor (FPR2/ALX) gene in human monocytes and macrophages
    Vanessa Waechter
    Division of Clinical Chemistry and Biochemistry, Children s Research Center, University Children s Hospital Zurich, CH 8032 Zurich, Switzerland
    J Immunol 188:1856-67. 2012
  6. ncbi request reprint Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-contro
    Michael Zaugg
    Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Anesthesiology 107:33-44. 2007
  7. ncbi request reprint Sequence variants in BMPR2 and genes involved in the serotonin and nitric oxide pathways in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: relation to clinical parameters and comparison with left heart diseas
    Silvia Ulrich
    Clinic of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland
    Respiration 79:279-87. 2010
  8. doi request reprint Serum creatinine, cystatin C, and beta-trace protein in diagnostic staging and predicting progression of primary nondiabetic chronic kidney disease
    Katharina Susanne Spanaus
    Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Clin Chem 56:740-9. 2010
  9. doi request reprint Expression and regulation of 12/15-lipoxygenases in human primary macrophages
    Sophia J A Wuest
    Division of Clinical Chemistry and Biochemistry, Children s Research Center, University Children s Hospital Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Atherosclerosis 225:121-7. 2012
  10. ncbi request reprint Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1
    Jonas Wittwer
    Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland
    Hum Mutat 27:78-87. 2006

Detail Information

Publications31

  1. pmc Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages
    Claudio Gemperle
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich, Zurich, Switzerland
    PLoS ONE 7:e50195. 2012
    ..These results show that M2 macrophages will not react to triggering of FPR1, limiting the role for FPR1 to chemotaxis and superoxide production of resting and pro-inflammatory M1 macrophages...
  2. ncbi request reprint Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins
    Martin Hersberger
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Clin Chem Lab Med 48:1063-73. 2010
    ..In this review, the biosynthesis of these lipid mediators, their biological effects and the evidence for their possible role in atherosclerosis are discussed with an emphasis on human disease...
  3. doi request reprint Association of STR polymorphisms in CMA1 and IL-4 with asthma and atopy: the SAPALDIA cohort
    Martin Hersberger
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Hum Immunol 71:1154-60. 2010
    ..These results support previous findings suggesting a role for CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general...
  4. doi request reprint No association of two functional polymorphisms in human ALOX15 with myocardial infarction
    Martin Hersberger
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Atherosclerosis 205:192-6. 2009
    ..These data suggest that ALOX15 may play a less prominent role during later stages of atherosclerosis involving atherothrombotic mechanisms than eventually during early plaque development...
  5. doi request reprint Characterization of the promoter and the transcriptional regulation of the lipoxin A4 receptor (FPR2/ALX) gene in human monocytes and macrophages
    Vanessa Waechter
    Division of Clinical Chemistry and Biochemistry, Children s Research Center, University Children s Hospital Zurich, CH 8032 Zurich, Switzerland
    J Immunol 188:1856-67. 2012
    ..These data support a model in which FPR2/ALX plays a role in chemotaxis and activation of monocytes; however, they also suggest that its function in resident tissue macrophages is limited...
  6. ncbi request reprint Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-contro
    Michael Zaugg
    Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Anesthesiology 107:33-44. 2007
    ..Neuraxial blockade is used as primary anesthetic technique in one third of surgical procedures. The authors tested whether bisoprolol would protect patients at risk for cardiovascular complications undergoing surgery with spinal block...
  7. ncbi request reprint Sequence variants in BMPR2 and genes involved in the serotonin and nitric oxide pathways in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: relation to clinical parameters and comparison with left heart diseas
    Silvia Ulrich
    Clinic of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland
    Respiration 79:279-87. 2010
    ..BMPR2 mutations are important in the pathogenesis of IPAH, but little is known about the genetic background in CTEPH...
  8. doi request reprint Serum creatinine, cystatin C, and beta-trace protein in diagnostic staging and predicting progression of primary nondiabetic chronic kidney disease
    Katharina Susanne Spanaus
    Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Clin Chem 56:740-9. 2010
    ....
  9. doi request reprint Expression and regulation of 12/15-lipoxygenases in human primary macrophages
    Sophia J A Wuest
    Division of Clinical Chemistry and Biochemistry, Children s Research Center, University Children s Hospital Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Atherosclerosis 225:121-7. 2012
    ..In cells involved in atherosclerosis the 12-lipoxygenase ALOX12 and the two 15-lipoxygenases, ALOX15 and ALOX15B may be expressed but their expression has not yet been investigated in detail...
  10. ncbi request reprint Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1
    Jonas Wittwer
    Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland
    Hum Mutat 27:78-87. 2006
    ..This may lead to an increase in ALOX15-mediated lipid metabolites, which play a role in inflammation...
  11. ncbi request reprint The two faces of the 15-lipoxygenase in atherosclerosis
    Jonas Wittwer
    Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Raemistrasse 100, CH 8091, Zurich, Switzerland
    Prostaglandins Leukot Essent Fatty Acids 77:67-77. 2007
    ..This will now allow large studies to investigate an association of 15-LOX with coronary artery disease and to answer the question whether 15-LOX is pro- or anti-atherogenic in humans...
  12. pmc Deoxysphingoid bases as plasma markers in diabetes mellitus
    Mariana Bertea
    Institute for Clinical Chemistry, University Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Lipids Health Dis 9:84. 2010
    ....
  13. ncbi request reprint Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006
    ..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease...
  14. ncbi request reprint The CAG repeat polymorphism in the androgen receptor gene is associated with HDL-cholesterol but not with coronary atherosclerosis or myocardial infarction
    Martin Hersberger
    Institute of Clinical Chemistry, University Hospital, Zurich, Switzerland
    Clin Chem 51:1110-5. 2005
    ..The genomic effect of androgens is mediated by the androgen receptor (AR), which has a polymorphic CAG repeat in exon 1. The number of repeats is inversely related to the transcriptional activity of the AR on target genes...
  15. ncbi request reprint Toll-like receptor 4 gene polymorphism modulates phenotypic expression in patients with hereditary hemochromatosis
    Pierre Alexandre Krayenbuehl
    Division of Internal Medicine, Medical Clinic and Policlinic, University Hospital of Zurich, Zurich, Switzerland
    Eur J Gastroenterol Hepatol 22:835-41. 2010
    ..We hypothesized that it might be modified by factors involved in the cellular immune response, such as toll-like receptors (TLRs) or nucleotide oligomerization domain proteins (NODs)...
  16. ncbi request reprint The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective
    Jonas Wittwer
    Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland
    Clin Chem Lab Med 45:487-92. 2007
    ..We found a C>T substitution at position c.-292 in the ALOX15 promoter that created a novel binding site for the transcription factor SPI1 and increased ALOX15 mRNA levels in monocytes from c.-292CT heterozygous volunteers...
  17. ncbi request reprint Low dose aspirin is associated with plasma chemerin levels and may reduce adipose tissue inflammation
    Magdalena Herova
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland Children s Research Center, University Children s Hospital Zurich, Zurich, Switzerland Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Atherosclerosis 235:256-62. 2014
    ....
  18. ncbi request reprint Sugar-sweetened beverages with moderate amounts of fructose, but not sucrose, induce Fatty Acid synthesis in healthy young men: a randomized crossover study
    Michel Hochuli
    Division of Endocrinology, Diabetes, and Clinical Nutrition M Ho, i A, P A G, G A S, K B, University Hospital Zurich, 8091 Zurich, Switzerland Division of Clinical Chemistry and Biochemistry A W, M He, H T, University Children s Hospital Zurich, 8032 Zurich, Switzerland Human Nutrition Laboratory I A, Institute of Food, Nutrition, and Health and Competence Center for Systems Physiology and Metabolic Diseases P A G, G A S, ETH Zurich, 8092 Zurich, Switzerland Zurich Center for Integrative Human Physiology K B, 8057 Zurich, Switzerland
    J Clin Endocrinol Metab 99:2164-72. 2014
    ..The impact of sugar-sweetened beverages (SSB) on lipid metabolism when consumed in moderate amounts by normal weight subjects is debated...
  19. doi request reprint Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes
    Marius Keel
    Departments of Trauma Surgery, University Hospital Zurich, Zurich, Switzerland
    Crit Care Med 37:1642-8. 2009
    ..However, after stress (e.g., anesthesia), PSP/reg levels are increased transiently in animals without pancreatic injury. Therefore, we aimed to determine whether PSP/reg is an acute-phase protein after nonpancreatic trauma...
  20. pmc High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation
    Gisela Adrienne Weiss
    Clinical Chemistry and Biochemistry, Children s Research Center, University Children s Hospital Zurich, Zurich, Switzerland
    Lipids Health Dis 12:89. 2013
    ..Additionally, the LCPUFAs arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are precursors for lipid mediators which regulate inflammation...
  21. ncbi request reprint Plasma B-type natriuretic peptide levels in children with heart disease
    Walter Knirsch
    Division of Pediatric Cardiology, University Children s Hospital Zurich, Zurich, Switzerland
    Acta Paediatr 100:1213-6. 2011
    ..To determine plasma B-type natriuretic peptide (BNP) levels in children with heart diseases before medical or surgical treatment for monitoring therapeutic efficacy in an observational prospective clinical trial at tertiary care centre...
  22. ncbi request reprint Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents
    Stefanie B Murer
    Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland
    J Nutr 144:193-201. 2014
    ..The study was registered at clinicaltrials.gov as NCT01316081...
  23. ncbi request reprint Association of polymorphisms in the ALOX15B gene with coronary artery disease
    Sophia J A Wuest
    Division of Clinical Chemistry and Biochemistry, Children s Research Center, University Children s Hospital Zurich and Center for Integrative Human Physiology, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Clin Biochem 47:349-55. 2014
    ..Recently the epidermis-type 15-lipoxygenase 2 (ALOX15B) has been identified in human atherosclerotic plaques but its role in human atherosclerosis is still unclear...
  24. ncbi request reprint B-type natriuretic peptide concentrations predict the progression of nondiabetic chronic kidney disease: the Mild-to-Moderate Kidney Disease Study
    Katharina Susanne Spanaus
    Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Clin Chem 53:1264-72. 2007
    ..We examined the relevance of BNP and NT-proBNP as predictors of CKD progression...
  25. ncbi request reprint Detection of the Arg702Trp, Gly908Arg and Leu1007fsinsC polymorphisms of the NOD2/CARD15 gene by real-time PCR with melting curve analysis
    Christian Rüegg
    Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Clin Chem Lab Med 42:494-8. 2004
    ..The sequencing of such DNAs confirmed the accuracy of the assays. In conclusion, we present three rapid and robust assays to detect the Arg702Trp, the Gly908Arg and the Leu1007fsinsC ins mutations in the NOD2/CARD15 gene [corrected]..
  26. pmc Clinical criteria replenish high-sensitive troponin and inflammatory markers in the stratification of patients with suspected acute coronary syndrome
    Barbara Elisabeth Stähli
    Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 9:e98626. 2014
    ..30-day cardiac events (CE) were defined as early coronary revascularization, subsequent myocardial infarction, or cardiovascular death within 30 days...
  27. ncbi request reprint Gene regulatory control of myocardial energy metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery: inhalational versus intravenous anesthetics
    Eliana Lucchinetti
    Institute of Anesthesiology, University Hospital Zurich, and Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Anesthesiology 106:444-57. 2007
    ..This study aimed at identifying myocardial transcriptional phenotypes to predict cardiovascular biomarkers and function in patients undergoing off-pump coronary artery bypass graft surgery...
  28. doi request reprint Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis
    Stefan Freigang
    Institute of Molecular Health Sciences, Swiss Federal Institute of Technology ETH Zurich, Zurich, Switzerland
    Nat Immunol 14:1045-53. 2013
    ....
  29. doi request reprint Genetic polymorphisms of the serotonin transporter, but not the 2a receptor or nitric oxide synthetase, are associated with pulmonary hypertension in chronic obstructive pulmonary disease
    Silvia Ulrich
    Clinics of Internal Medicine and Pulmonology, University Hospital Zurich, Zurich, Switzerland
    Respiration 79:288-95. 2010
    ..Pulmonary hypertension (PH) is prognosti- cally important in chronic obstructive pulmonary disease (COPD). Since PH only weakly correlates with hypoxemia, other factors must play a role...
  30. ncbi request reprint Urinary catecholamine and metanephrine to creatinine ratios in healthy dogs at home and in a hospital environment and in 2 dogs with pheochromocytoma
    Peter H Kook
    Clinic for Small Animal Internal Medicine Vetsuisse Faculty, University of Zurich, Switzerland
    J Vet Intern Med 21:388-93. 2007
    ..Measurement of high concentrations of urine catecholamines and metanephrines is useful in diagnosing pheochromocytoma in humans. Stress increases catecholamine excretion in urine...
  31. ncbi request reprint HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+ T cells in relation to HIV RNA load
    Annette Oxenius
    Institute for Microbiology, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
    J Infect Dis 189:1199-208. 2004
    ..Slower progression was not related to polymorphisms in CCR genes, HLA genotype, or GB virus C coinfection. These data suggest that HIV-specific T cell responses are involved in protecting the host from disease progression...