D M Hermann

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia
    Annett Spudich
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Nat Neurosci 9:487-8. 2006
  2. ncbi request reprint Reversible opsoclonus after diphenhydramine misuse
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Eur Neurol 53:46-7. 2005
  3. ncbi request reprint Evolution of neurological, neuropsychological and sleep-wake disturbances after paramedian thalamic stroke
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Stroke 39:62-8. 2008
  4. ncbi request reprint Implications of ATP-binding cassette transporters for brain pharmacotherapies
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Trends Pharmacol Sci 28:128-34. 2007
  5. ncbi request reprint Biodistribution processes as underestimated confounders in translational stroke research
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Curr Med Chem 14:3179-84. 2007
  6. ncbi request reprint Expression of c-jun, mitogen-activated protein kinase phosphatase-1, caspase-3 and glial fibrillary acidic protein following cortical cold injury in rats: relationship to metabolic disturbances and delayed cell death
    D M Hermann
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Neuroscience 123:371-9. 2004
  7. ncbi request reprint Role of drug efflux carriers in the healthy and diseased brain
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Switzerland
    Ann Neurol 60:489-98. 2006
  8. ncbi request reprint Aggravation of ischemic brain injury by prion protein deficiency: role of ERK-1/-2 and STAT-1
    Annett Spudich
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Neurobiol Dis 20:442-9. 2005
  9. doi request reprint TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration
    Ulkan Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Neurobiol Dis 31:33-40. 2008
  10. ncbi request reprint Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways
    Ulkan Kilic
    Department of Neurology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Neurosci 26:12439-46. 2006

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia
    Annett Spudich
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Nat Neurosci 9:487-8. 2006
    ..We predict that Mdr-1 inhibition may greatly facilitate neuroprotective therapies...
  2. ncbi request reprint Reversible opsoclonus after diphenhydramine misuse
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Eur Neurol 53:46-7. 2005
  3. ncbi request reprint Evolution of neurological, neuropsychological and sleep-wake disturbances after paramedian thalamic stroke
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Stroke 39:62-8. 2008
    ..The clinical features and natural course of paramedian thalamic stroke is poorly known. The aim of this study was to characterize the evolution of neurological, neuropsychological, and sleep-wake deficits after paramedian thalamic stroke...
  4. ncbi request reprint Implications of ATP-binding cassette transporters for brain pharmacotherapies
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Trends Pharmacol Sci 28:128-34. 2007
    ..This approach should markedly enhance the overall success of new drugs and foster progress in neurological therapies...
  5. ncbi request reprint Biodistribution processes as underestimated confounders in translational stroke research
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Curr Med Chem 14:3179-84. 2007
    ..This might lead to better dose selections and higher success rates of future pharmacological trials...
  6. ncbi request reprint Expression of c-jun, mitogen-activated protein kinase phosphatase-1, caspase-3 and glial fibrillary acidic protein following cortical cold injury in rats: relationship to metabolic disturbances and delayed cell death
    D M Hermann
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Neuroscience 123:371-9. 2004
    ..The dissociated responses of c-jun, mkp-1 and caspase-3 mRNAs may represent important factors influencing tissue viability...
  7. ncbi request reprint Role of drug efflux carriers in the healthy and diseased brain
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Switzerland
    Ann Neurol 60:489-98. 2006
    ..We predict that strategies aiming at circumventing drug efflux may greatly facilitate progress in neurological therapies...
  8. ncbi request reprint Aggravation of ischemic brain injury by prion protein deficiency: role of ERK-1/-2 and STAT-1
    Annett Spudich
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Neurobiol Dis 20:442-9. 2005
    ..Our data suggest a role of cytosolic signaling pathways in Prnp(0/0)-induced cell death...
  9. doi request reprint TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration
    Ulkan Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Neurobiol Dis 31:33-40. 2008
    ..Our data indicate that innate immunity may represent an attractive target for neuroprotective treatments in stroke and neurodegeneration...
  10. ncbi request reprint Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways
    Ulkan Kilic
    Department of Neurology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Neurosci 26:12439-46. 2006
    ..In view that axotomy-induced RGC death occurs slowly and considering that RGCs are CNS-derived neurons, we predict the clinical implementation of VEGF in neurodegenerative diseases of both brain and retina...
  11. ncbi request reprint VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena
    Yaoming Wang
    Department of Neurology, University Hospital Zurich, Switzerland
    Brain 128:52-63. 2005
    ..g. by VEGF overexpression, may worsen rather than improve cerebral haemodynamics after stroke...
  12. ncbi request reprint Sleep EEG changes after middle cerebral artery infarcts in mice: different effects of striatal and cortical lesions
    Christian R Baumann
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Sleep 29:1339-44. 2006
    ..The correlation between these changes and stroke extent remains unclear. In the absence of experimental data, we assessed sleep EEG changes after focal cerebral ischemia of different extensions in mice...
  13. doi request reprint ABCC1: a gateway for pharmacological compounds to the ischaemic brain
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Brain 131:2679-89. 2008
    ..Our data indicate that ABCC1 acts as gateway for pharmacological compounds to the stroke brain. We suggest that the tailoring of compounds binding to abluminal but not luminal ABC transporters may facilitate stroke pharmacotherapy...
  14. doi request reprint Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms
    Marco Bacigaluppi
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Brain 132:2239-51. 2009
    ..These processes may efficaciously be antagonized by (stem) cell-based strategies at time-points far beyond established therapeutic windows for pharmacological neuroprotection...
  15. doi request reprint Gamma-hydroxybutyrate accelerates functional recovery after focal cerebral ischemia
    Bo Gao
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Cerebrovasc Dis 26:413-9. 2008
    ..This study aimed to assess recovery-promoting effects of GHB at a low dose similar to that used in patients...
  16. ncbi request reprint New technologies and concepts for rehabilitation in the acute phase of stroke: a collaborative matrix
    E M Siekierka
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Neurodegener Dis 4:57-69. 2007
    ..We also outline the neuroscientific basis of our approach, present our detailed clinical assessment protocol and provide preliminary results from patient testing of each of the three systems showing their viability for patient use...
  17. ncbi request reprint The superoxide dismutase1 (SOD1) G93A mutation does not promote neuronal injury after focal brain ischemia and optic nerve transection in mice
    E Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091, Switzerland
    Neuroscience 128:359-64. 2004
    ..Thus, the G93A mutation may be counterbalanced in non-motor neurons of young animals, and region-specific and age-related factors may be necessary so that neurodegeneration is re-enforced...
  18. ncbi request reprint Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1/-2
    U Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Neuroscience 134:901-6. 2005
    ..Our results indicate that rosuvastatin may have utility not only as stroke prophylaxis but also as acute therapy inhibiting executive cell death pathways...
  19. ncbi request reprint Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich USZ, Zurich, Switzerland
    FASEB J 19:2026-8. 2005
    ..On the basis of our data, the dual activation of ERK-1/-2 and Akt is crucial for Epo's neuroprotective activity...
  20. doi request reprint Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Pineal Res 45:142-8. 2008
    ..The robust functional neurologic improvements encourage proof-of-concept studies with melatonin in human stroke patients...
  21. ncbi request reprint Intravenously administered recombinant tissue-plasminogen activator attenuates neuronal injury after mild focal cerebral ischemia in mice
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Neuroreport 15:687-9. 2004
    ..05). Our data argue against major detrimental actions of t-PA after mild focal ischemia...
  22. ncbi request reprint Poxvirus-derived cytokine response modifier A (CrmA) does not protect against focal cerebral ischemia in mice
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Brain Res 1185:293-300. 2007
    ..Our data argue against a therapeutic effect of CrmA in ischemic stroke...
  23. ncbi request reprint Tissue plasminogen activator-induced ischemic injury is reversed by NMDA antagonist MK-801 in vivo
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Neurodegener Dis 2:49-55. 2005
    ..Our study provides in vivo evidence in a model of focal cerebral ischemia that t-PA-induced brain injury involves an NMDA receptor-dependent mechanism...
  24. ncbi request reprint The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    FASEB J 20:1185-7. 2006
    ....
  25. ncbi request reprint TAT-GDNF in neurodegeneration and ischemic stroke
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    CNS Drug Rev 11:369-78. 2005
    ..These findings demonstrate the in vivo efficacy of fusion proteins in clinically relevant disease models, raising hopes that neuroprotection may become eventually feasible in human patients...
  26. ncbi request reprint Aggravation of focal cerebral ischemia by tissue plasminogen activator is reversed by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor but does not depend on endothelial NO synthase
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Switzerland
    Stroke 36:332-6. 2005
    ..We hypothesized that tPA induces an inhibition of endothelial NO synthase (eNOS) after focal ischemia that is responsible for ischemic damage and may be restored by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors...
  27. ncbi request reprint Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Pineal Res 36:171-6. 2004
    ..Our data demonstrate that melatonin reduces disseminated neuronal injury in the striatum after mild focal ischemia. Brain protection is independent of hemodynamic changes and involves inhibition of caspase-3...
  28. ncbi request reprint Prophylactic use of melatonin protects against focal cerebral ischemia in mice: role of endothelin converting enzyme-1
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich USZ, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    J Pineal Res 37:247-51. 2004
    ..Our data suggest that melatonin, given at pharmacological doses, may be suitable as a prophylaxis against stroke. Tissue protection may involve an inhibition of ECE-1, which improves vasodilation, after ischemia...
  29. ncbi request reprint Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2
    Ulkan Kilic
    Department of Neurology, University Hospital Zurich, Switzerland
    FASEB J 19:249-51. 2005
    ....
  30. ncbi request reprint Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice
    Ulkan Kilic
    Department of Neurology, University Hospital Zurich USZ, Zurich, Switzerland
    J Pineal Res 38:67-71. 2005
    ..Our data suggest a role of phosphatidyl inositol-3 kinase/Akt signaling in acute melatonin-induced neuroprotection, while ERK-1/-2 and/or JNK-1/-2 rather appear to be involved in melatonin's long-term effects...
  31. ncbi request reprint Tissue-plasminogen activator-induced ischemic brain injury is reversed by melatonin: role of iNOS and Akt
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Pineal Res 39:151-5. 2005
    ..That melatonin reversed these signaling changes and the t-PA-induced brain injury makes this indole attractive as an add-on treatment with thrombolytics...
  32. ncbi request reprint TAT fusion proteins against ischemic stroke: current status and future perspectives
    Ertugrul Kilic
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, CH 8091 Zurich, Switzerland
    Front Biosci 11:1716-21. 2006
    ..The development of clinically-applicable treatments for ischemic stroke based on fusion protein technologies deserves concerted efforts in the future...
  33. doi request reprint New targets of neuroprotection in ischemic stroke
    Marco Bacigaluppi
    Department of Neurology, University Hospital Zurich USZ, CH 8091 Zurich, Switzerland
    ScientificWorldJournal 8:698-712. 2008
    ..From this point of view, we will try to develop ideas of how causative treatments in ischemic stroke may be established...
  34. ncbi request reprint Blood pressure evolution after acute ischemic stroke in patients with and without sleep apnea
    Claudia Selic
    Neurology Department, University Hospital of Zurich, Zurich, Switzerland
    Stroke 36:2614-8. 2005
    ..The effects of SA on blood pressure (BP) and stroke outcome in the acute stroke phase are essentially unknown...
  35. ncbi request reprint Increased balloon-induced inflammation, proliferation, and neointima formation in apolipoprotein E (ApoE) knockout mice
    Christian M Matter
    Cardiovascular Research, Institute of Physiology, Zurich University and Cardiology CardioVascular Center, University Hospital Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Stroke 37:2625-32. 2006
    ..Our aim was to study the effects of hypercholesterolemia in a mouse vascular injury model that mimics human balloon angioplasty...
  36. ncbi request reprint Central periodic breathing during sleep in acute ischemic stroke
    Dirk M Hermann
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Stroke 38:1082-4. 2007
    ..It has been suggested that central periodic breathing during sleep (CPBS) may develop in unilateral supratentorial stroke without cardiopulmonary disease and disturbed consciousness. Not many data existed about such patients...
  37. ncbi request reprint Neuroprotection by hypoxic preconditioning: HIF-1 and erythropoietin protect from retinal degeneration
    C Grimm
    Laboratory of Retinal Cell Biology, University Eye Hospital Zurich, CH 8091 Zurich, Switzerland
    Semin Cell Dev Biol 16:531-8. 2005
    ..Here, we summarize recent work on neuroprotection of retinal photoreceptors and ganglion cells induced by hypoxic preconditioning or by systemically elevated levels of Epo in mouse plasma...
  38. doi request reprint Central periodic breathing during sleep in 74 patients with acute ischemic stroke - neurogenic and cardiogenic factors
    M M Siccoli
    Dept of Neurology, University Hospital of Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland
    J Neurol 255:1687-92. 2008
    ..The aims of our study were 1) to better characterize central periodic breathing during sleep (CPBS) and its clinical relevance in acute stroke, 2) to better define the role of brain damage in its pathogenesis...
  39. ncbi request reprint Neural stem/precursor cells for the treatment of ischemic stroke
    Marco Bacigaluppi
    Department of Neurology, University Hospital Zurich USZ, Frauenklinikstr, 26, CH 8091 Zurich, Switzerland
    J Neurol Sci 265:73-7. 2008
    ..Here we discuss, with special emphasis on neural stem/precursor cells, potential mechanisms that may be involved in the action of cell-based therapies in stroke...
  40. ncbi request reprint Sleep-disordered breathing and stroke
    Dirk M Hermann
    Department of Neurology, University Hospital, Zurich, Switzerland
    Curr Opin Neurol 16:87-90. 2003
    ..This review summarizes recent data on this issue, pointing out existing evidence but also defining issues that still need to be clarified...
  41. ncbi request reprint Intravenous TAT-Bcl-Xl is protective after middle cerebral artery occlusion in mice
    Ertugrul Kilic
    Department of Neurology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Ann Neurol 52:617-22. 2002
    ..Thus, fusion proteins may open fascinating perspectives for future research...
  42. ncbi request reprint Adenovirus-mediated Bcl-X(L) expression using a neuron-specific synapsin-1 promoter protects against disseminated neuronal injury and brain infarction following focal cerebral ischemia in mice
    Ertugrul Kilic
    Department of Neurology, University of Gottingen, D 37075 Gottingen, Germany
    Neurobiol Dis 11:275-84. 2002
    ..The present data demonstrate that an adenoviral Bcl-X(L) expression with a neuron-specific synapsin-1 promoter provides a powerful tool, which not only diminishes disseminated neuronal injury, but also protects against tissue infarction...
  43. ncbi request reprint Effects of pinealectomy and melatonin on the retrograde degeneration of retinal ganglion cells in a novel model of intraorbital optic nerve transection in mice
    Ertugrul Kilic
    Department of Neurology, University of Tubingen, Germany
    J Pineal Res 32:106-11. 2002
    ..g. in the aged brain, when melatonin synthesis and secretion have decreased...
  44. doi request reprint Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brain
    Gaël F Hédou
    Brain Research Institute, Medical Faculty, University of Zurich and Department of Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 28:154-62. 2008
    ....
  45. ncbi request reprint Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin
    Jorge Soliz
    Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Am J Physiol Regul Integr Comp Physiol 293:R1702-10. 2007
    ..All together, these findings are relevant for understanding the cross-talk between the ventilatory and erythropoietic systems exposed to hypoxia...
  46. doi request reprint Therapeutic potential and possible risks of pleiotropic growth factors in ischemic stroke
    Dirk M Hermann
    Stroke 39:e182; author reply e183. 2008
  47. ncbi request reprint Tissue plasminogen activator-induced reperfusion injury after stroke revisited
    Dirk M Hermann
    Circulation 116:363-5. 2007
  48. ncbi request reprint Neuroprotection in the SAINT-II aftermath
    Dirk M Hermann
    Ann Neurol 62:677-8; author reply 678. 2007